美洛昔康联合甲氨蝶呤对类风湿关节炎临床症状和实验室指标的影响
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摘要
目的探讨美洛昔康联合甲氨蝶呤对类风湿性关节炎临床症状和实验室指标的影响。方法选取130例类风湿性关节炎患者进行研究,将患者以随机数字表法分为两组,对照组65例,采用单纯甲氨蝶呤治疗;观察组65例,采用美洛昔康联合甲氨蝶呤;比较两组患者的治疗效果。结果观察组患者临床总有效率明显高于对照组(P <0. 05);治疗后两组患者各症状及实验室指标比较差异均有统计学意义(P <0. 05);两组不良反应情况比较差异无统计学意义(P> 0. 05)。结论以美洛昔康与甲氨蝶呤联合治疗方式对类风湿性关节炎患者实施治疗效果显著,有利于改善病情。
Objective To investigate the effects of meloxicam combined with methotrexate on clinical symptoms and laboratory indexes of rheumatoid arthritis. Methods A total of 130 patients with rheumatoid arthritis were selected for the study. The patients were divided into two groups by random number table method. The 65 patients in the control group were treated with methotrexate alone,and the other 65 patients in the observation group were treated with meloxicam combined with methotrexate. The therapeutic effects of the two groups were compared. Results The total clinical effective rate of the observation group was significantly higher than that of the control group( P < 0. 05). After treatment,there were significant differences in symptoms and laboratory indicators between the two groups( P < 0. 05),and no significant difference in adverse reactions between the two groups( P > 0. 05). Conclusion Meloxicam combined with methotrexate are effective in the treatment of patients with rheumatoid arthritis,which is conducive to improve the condition and symptoms.
Objective To investigate the effects of meloxicam combined with methotrexate on clinical symptoms and laboratory indexes of rheumatoid arthritis. Methods A total of 130 patients with rheumatoid arthritis were selected for the study. The patients were divided into two groups by random number table method. The 65 patients in the control group were treated with methotrexate alone,and the other 65 patients in the observation group were treated with meloxicam combined with methotrexate. The therapeutic effects of the two groups were compared. Results The total clinical effective rate of the observation group was significantly higher than that of the control group( P < 0. 05). After treatment,there were significant differences in symptoms and laboratory indicators between the two groups( P < 0. 05),and no significant difference in adverse reactions between the two groups( P > 0. 05). Conclusion Meloxicam combined with methotrexate are effective in the treatment of patients with rheumatoid arthritis,which is conducive to improve the condition and symptoms.
引文
[1]端淑杰,刘健,王孝飞,等.类风湿关节炎中医外治法研究进展[J].中国临床保健杂志,2016,19(1):96-100.
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[3]吕芳,李兴福. 2010年美国风湿病学会联合欧洲抗风湿病联盟的类风湿关节炎分类标准解读[J].诊断学理论与实践,2010,9(4):307-310.
[4]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:35.
[5] BODIAN C A,FREEDMAN G,HOSSAIN S,et al. The visual analog scale for pain:clinical significance in postoperative patients[J]. Anesthesiology,2001,95(6):1356-1361.
[6]张文,赵岩.类风湿关节炎治疗进展[J].中华内科杂志,2010,5(49):450.
[7]路海侠,盛荣.依那西普治疗类风湿关节炎患者的观察与护理[J].上海护理,2013,13(1):39-40.
[8]陈楠,王振刚.类风湿关节炎治疗的核心药物———甲氨蝶呤[J].中国医刊,2013,48(7):3-5.
[2]韩武臣,黄源.来氟米特联合美洛昔康对类风湿关节炎患者病情活动指标的影响[J].医学综述,2016,22(17):3510-3512.
[3]吕芳,李兴福. 2010年美国风湿病学会联合欧洲抗风湿病联盟的类风湿关节炎分类标准解读[J].诊断学理论与实践,2010,9(4):307-310.
[4]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:35.
[5] BODIAN C A,FREEDMAN G,HOSSAIN S,et al. The visual analog scale for pain:clinical significance in postoperative patients[J]. Anesthesiology,2001,95(6):1356-1361.
[6]张文,赵岩.类风湿关节炎治疗进展[J].中华内科杂志,2010,5(49):450.
[7]路海侠,盛荣.依那西普治疗类风湿关节炎患者的观察与护理[J].上海护理,2013,13(1):39-40.
[8]陈楠,王振刚.类风湿关节炎治疗的核心药物———甲氨蝶呤[J].中国医刊,2013,48(7):3-5.