健脾养阴法干预2型糖尿病前期的临床研究
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摘要
目的:探讨健脾养阴法干预2型糖尿病前期患者的临床疗效。方法:选取气阴两虚证糖尿病前期患者64例,采用密闭信封法将患者随机分为对照组和观察组,各32例。对照组给予单纯生活方式干预,观察组在对照组基础上给予健脾养阴中药袋泡剂口服。比较两组患者干预3个月后血糖和胰岛功能的变化。结果:干预后,两组的FPG、2 h PG以及HbA1c均较干预前下降(P<0.05),观察组的FPG、2 h PG及HbA1c均低于对照组(P<0.05)。干预后,两组的HOMA-IR均较干预前降低(P<0.05),HOMA-β均较干预前升高(P<0.05);观察组的HOMA-IR低于对照组(P<0.05),而HOMA-β高于对照组(P<0.05)。结论:健脾养阴法能有效降低气阴两虚证糖尿病前期患者的血糖水平,并对胰岛功能有恢复作用,具有较好的临床应用前景。
Objective:To investigate the efficacy of invigorating spleen and nourishing yin method intervention of type Ⅱ prediabetes.Method:64 prediabetic patients with syndrome of deficiency of both qi and yin who were selected,according to sealed envelope method,they were divided into control group and observation group,32 cases in each group.The control group was given simple lifestyle intervention,while the observation group was treated with invigorating spleen and nourishing yin Chinese medicine bag oral group basis.The changes of blood glucose and pancreatic islet function were compared between the two groups after 3 months.Result:After intervention,FPG,2 h PG and HbA1c of the two groups were lower than those before intervention(P<0.05),the FPG, 2 h PG and HbA1c of the observation group were lower than those in control group(P<0.05).After intervention,the HOMA-IR of the two groups were lower than before the intervention(P<0.05),and HOMA-βwere higher than before the intervention(P<0.05),the HOMA-IR of the observation group was lower than that of the control group(P<0.05),while the HOMA-β was higher than that of the control group(P<0.05).Conclusion:Invigorating spleen and nourishing yin method can effectively reduce the blood sugar levels of prediabetic patients with syndrome of deficiency of both qi and yin,and the effect on the recovery of islet function,has good clinical application prospect.
Objective:To investigate the efficacy of invigorating spleen and nourishing yin method intervention of type Ⅱ prediabetes.Method:64 prediabetic patients with syndrome of deficiency of both qi and yin who were selected,according to sealed envelope method,they were divided into control group and observation group,32 cases in each group.The control group was given simple lifestyle intervention,while the observation group was treated with invigorating spleen and nourishing yin Chinese medicine bag oral group basis.The changes of blood glucose and pancreatic islet function were compared between the two groups after 3 months.Result:After intervention,FPG,2 h PG and HbA1c of the two groups were lower than those before intervention(P<0.05),the FPG, 2 h PG and HbA1c of the observation group were lower than those in control group(P<0.05).After intervention,the HOMA-IR of the two groups were lower than before the intervention(P<0.05),and HOMA-βwere higher than before the intervention(P<0.05),the HOMA-IR of the observation group was lower than that of the control group(P<0.05),while the HOMA-β was higher than that of the control group(P<0.05).Conclusion:Invigorating spleen and nourishing yin method can effectively reduce the blood sugar levels of prediabetic patients with syndrome of deficiency of both qi and yin,and the effect on the recovery of islet function,has good clinical application prospect.
引文
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[11]方朝晖,赵进东,王建和,等.基于三早防治体系采取中医综合方案干预糖耐量减低的临床应用[J].成都中医药大学学报,2013,6(3):90-92.
[12]仝小林,倪青,魏军平,等.糖尿病前期中医诊疗标准[J].世界中西医结合杂志,2011,6(5):446-449.
[13]李洪皎,仝小林,吴洁,等.肥胖2型糖尿病前期、早期病机证治探讨[J].中国中医基础医学杂志,2007,13(7):529-530.
[14]杨新位.中西医结合治疗2型糖尿病的临床疗效分析[J].河南医学研究,2013,22(4):571-572.
[15]刘云雅,叶文平,张捷.健脾化湿方治疗糖尿病前期50例临床观察[J].中国民族民间医药,2016,25(5):79-80.
[2]吕仁和.消渴病(糖尿病)的分期[J].中国中医药现代远程教育,2006,4(2):18-19.
[3]吕仁和.糖尿病及其并发症中西医诊治学[M].北京:人民卫生出版社,1997:129.
[4]ZY/T001.1-94,中华人民共和国中医药行业标准《中医病证诊断疗效标准》[S].北京:国家中医药管理局,1994.
[5]Da R F J,Ogurtsova K,Linnenkamp U,et al.IDF Diabetes Atlas estimates of 2014 global health expenditures on diabetes[J].Diabetes Research&Clinical Practice,2016,117:48-54.
[6]Yang W,Lu J,Weng J,et al.Prevalence of diabetes among men and women in China[J].N Engl J Med,2010,362(12):1090-1101.
[7]杨敏,柳洁.中国糖尿病防治现状[J].中国医学创新,2014,11(7):149-151.
[8]肖艳,王红,罗世坤,等.社区糖尿病前期(IGR)人群健康教育效果评价[J].中国医学创新,2012,9(18):151-152.
[9]赵洪彪,陈清光,顾逸梦,等.糖尿病前期干预研究进展[J].中国医药科学,2013,3(9):39-43.
[10]方朝晖,赵进东,石国斌,等.脾瘅(糖尿病前期)中医综合防治方案及其临床研究[J].天津中医药,2014,4(10):583-587.
[11]方朝晖,赵进东,王建和,等.基于三早防治体系采取中医综合方案干预糖耐量减低的临床应用[J].成都中医药大学学报,2013,6(3):90-92.
[12]仝小林,倪青,魏军平,等.糖尿病前期中医诊疗标准[J].世界中西医结合杂志,2011,6(5):446-449.
[13]李洪皎,仝小林,吴洁,等.肥胖2型糖尿病前期、早期病机证治探讨[J].中国中医基础医学杂志,2007,13(7):529-530.
[14]杨新位.中西医结合治疗2型糖尿病的临床疗效分析[J].河南医学研究,2013,22(4):571-572.
[15]刘云雅,叶文平,张捷.健脾化湿方治疗糖尿病前期50例临床观察[J].中国民族民间医药,2016,25(5):79-80.