南极磷虾中砷的研究进展
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摘要
南极磷虾广泛分布于南极区域,具有生物储存量大,分布范围广,营养价值高等优点,受到全世界范围的广泛关注。然而,南极磷虾及其产品中砷含量高,在很大程度上限制了其食用价值的开发。如何科学地评价高砷给食用安全带来的局限性,已成为亟待解决的科学问题。本文就南极磷虾中砷的含量、赋存形态以及毒性研究进行综述,目的是为南极磷虾产业发展提供参考依据。
Euphausia superba widely distributed in the Antarctic region, with a large amount of biological storage, a wide range of distribution, high nutritional value, has attracted worldwide attention. However, E. superba and its products contain high arsenic content, which limits the development of its edible value to a large extent. How to scientifically evaluate the limitations of high arsenic to food safety has been an urgent problem to be solved. In this paper, the content, speciation and toxicity of arsenic in krill were reviewed, and the aim is to provide reference for the development of E. superba industry.
Euphausia superba widely distributed in the Antarctic region, with a large amount of biological storage, a wide range of distribution, high nutritional value, has attracted worldwide attention. However, E. superba and its products contain high arsenic content, which limits the development of its edible value to a large extent. How to scientifically evaluate the limitations of high arsenic to food safety has been an urgent problem to be solved. In this paper, the content, speciation and toxicity of arsenic in krill were reviewed, and the aim is to provide reference for the development of E. superba industry.
引文
[1]冯迪娜,袁玥,苏学峰,等.南极磷虾资源综合利用研究现状[J].食品研究与开发, 2015, 36(8):120-122.
[2]赵传凯,姜国良,赵静,等.南极大磷虾油脂的提取及其脂肪酸组成分析[J].食品工业科技, 2012, 33(3):207-209.
[3] VIGERUST N F, BJ覫RNDAL B, BOHOV P, et al. Krill oil versus fish oil in modulation of inflammation and lipid metabolism in mice transgenic for TNF-α[J]. European Journal of Nutrition, 2013, 52(4):1 315-1 325.
[4]冯迪娜,袁玥,朱晓丽.南极磷虾油生理功能的研究进展[J].食品研究与开发, 2015, 36(7):115-117.
[5]贺瑞坤,罗海吉.南极磷虾油对人类健康的作用[J].食品研究与开发, 2013, 34(20):130-133.
[6]徐吟梅,邱卫华,余丽萍,等.南极磷虾粉的营养与功能[J].现代渔业信息, 2010, 25(8):14-16.
[7] SALLY J P, BOBBY J P. Trace element concentrations in Antarctic krill, Euphausia superba[J]. Polar Biology, 1995, 15:283-288.
[8]朱元元,尹雪斌,周守标.南极磷虾硒及矿质营养的初步研究[J].极地研究, 2010, 22(2):135-140.
[9]孙来娣,高华,刘坤,等.南极磷虾油关键质量指标检测及对比分析[J].中国油脂, 2013(12):80-83.
[10]董丽臻,崔鹤,单宝田,等.电感耦合等离子质谱法测定南极磷虾制品中21种元素[J].农产品加工月刊, 2015(5):34-37.
[11]王松, LI Ke,崔鹤,等.南极磷虾油中总砷含量及砷形态分析[J].分析化学, 2016, 44(5):767-772.
[12]杨钊,范莹,迟少云,等.七种藻类中总砷和无机砷含量的测定[J].中国海洋药物杂志, 2007, 26(2):43-46.
[13]朱亚尔,李俊,李世敏.不同产地的几种海藻中砷的形态和含量分析[J].环境化学, 2005, 24(4):478-480.
[14] WHALEY-MARTIN K J, KOCH I, REIMER K J. Determination of arsenic species in edible periwinkles(Littorina littorea)by HPLC-ICPMS and XAS along a contamination gradient[J]. Science of the Total Environment, 2013, 456-457:148-153.
[15] RODOLFO G W, JORGELINA C A, PATRICIA S, et al. Investigation of arsenic speciation in algae of the Antarctic region by HPLC-ICP-MS and HPLC-ESI-Ion Trap MS[J]. Journal of Analytical Atomic Spectrometry, 2006, 21(11):1 214-1 223.
[16] HIRANO S, KOBAYASHI Y, CUI Xin, et al. The accumulation and toxicity of methylated arsenicals in endothelial cells:important roles of thiol compounds[J]. Toxicol Appl Pharm, 2004, 198:458-467.
[17] World Health organization, International Ageney for Researehon Caneer(IARC). Arsenic and arsenic compounds[Z]//Some Metals and Metallic compounds. JARC Monographs, Evaluation of the Carcinogenic Risk of Chemicals to Hamans. 1980, 23:29.
[18] MAGELLAN K, BARRAL-FRAGA L, ROVIRA M, et al. Behavioural and physical effects of arsenic exposure in fish are aggravated by aquatic algae[J]. Aquatic Toxicology, 2014, 156:116-124.
[19] RAHMAN M A, HASEGAWA H, LIM R P. Bioaccumulation, biotransformation and trophic transfer of arsenic in the aquatic food chain[J]. Environmental Research, 2012, 116:118-135.
[20] TAYLOR A, BRANCH S, DAY M P, et al. Atomic spectrometry update. Clinical and biological materials, foods and beverages[J]. Journal of Analytical Atomic Spectrometry, 2010, 25(4):453-492.
[21] CULLEN W R. Chemical mechanism of arsenic biomethylation[J]. Chemical Research in Toxicology, 2014, 27(4):457-461.
[22] ULLRICH-EBERIUS C I, SANZ A, NOVACKY A J. Evaluation of arsenate and vanadate-associated changes of electrical membrane potential and phosphate transport in lemna gibba G1[J]. Journal of Experimental Botany, 2015, 40(1):119-128.
[23] COHEN S M, ARNOLD L L, BECK B D, et al. Evaluation of the carcinogenicity of inorganic arsenic[J]. Critical Reviews in Toxicology, 2013, 43(9):711.
[24] GARC魱ASALGADO S, QUIJANO M A, BONILLA M M. Arsenic speciation in edible alga samples by microwave-assisted extraction and high performance liquid chromatography coupled to atomic fluorescence spectrometry[J]. Analytica Chimica Acta,2012, 714(3):38.
[25] DUNCAN E G, MAHER W A, FOSTER S D. Contribution of arsenic species in unicellular algae to the cycling of arsenic in marine ecosystems[J]. Environmental Science&Technology, 2015, 49(1):33.
[26]张兵,王利红,徐玉新,等.集胞藻(Synechocystis sp. PCC6803)对砷吸收转化特性的初步研究[J].生态毒理学报, 2011,6(6):629-633.
[27] DUNCAN E G, MAHER W A, FOSTER S D. Contribution ofarsenic species in unicellular algae to the cycling of arsenic in marine ecosystems[J]. Environ Sci Technol, 2015, 49:33-50.
[28] GONG Zhilong, LU Xiufen, MA Mingsheng, et al. Arsenic speciation analysis[J]. Talanta, 2002, 58(1):77-96.
[29] SHARMA V K, SOHN M. Aquatic arsenic:Toxicity, apeciation, transformation, and remediation[J]. Enviroment International,2009, 35:743-759.
[30] GROTTI M, SOGGIA F, GOESSLER W, et al. Arsenic species in certified reference material MURST-ISS-A2(Antarctic krill)[J]. Talanta, 2010, 80(3):1 441-1 444.
[31] TSENG W P, CHU H M, HOW S W, et al. Prevalence of skin cancer in an endemic area of chronic arsenicism in Taiwan[J].Journal of the National Cancer Institute, 1968, 40(3):453-463.
[32] HARTMANN A, SPEIT G. Comparative investigations of the genotoxic effects of metals in the single cells gel(SCG)assay and the sister chromatid exchange(SCE)test[J]. Environmental&Molecular Mutagenesis, 1994, 23(4):299-305.
[33] FERM V H, SAXON A, SMITH B M. The Teratogenic Profile of Sodium Arsenate in the Golden Hamster[J]. Archives of Environmental Health, 1971, 22(5):557-560.
[34] BROWN J L, KITCHIN K T, GEORGE M. Dimethylarsinic acid treatment alters six different rat biochemical parameters:relevance to arsenic carcinogenesis[J]. Teratog Carcinog Mutagen, 1997, 17(2):71-84.
[35] JOMOVA K, JENISOVA Z, FESZTEROVA M, et al. Arsenic:toxicity, oxidative stress and human disease[J]. Journal of Applied Toxicology, 2015, 31(2):95-107.
[36] LAWLEY S D, MOLLY C, HALL M N, et al. Mathematical model insights into arsenic detoxification[J]. Theoretical Biology&Medical Modelling, 2011, 8(1):31.
[37] HUGHES M F. Arsenic toxicity and potential mechanisms of action[J]. Toxicology letters, 2002, 133(1):1-16.
[38] LIU Yaping, DUAN Dongzhu, YAO Juan, et al. Dithiaarsanes induce oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase[J]. Journal of Medicinal Chemistry, 2014, 57(12):5 203-5 211.
[39] ANTONELLI R, SHAO K, THOMAS D J, et al. AS3MT, GSTO, and PNP polymorphisms:impact on arsenic methylation and implications for disease susceptibility[J]. Environmental Research, 2014, 132:156.
[40] WANG Lisu, KOU Meichun, WENG Chingyi, et al. Arsenic modulates heme oxygenase-1, interleukin-6, and vascular endothelial growth factor expression in endothelial cells:roles of ROS, NF-κB, and MAPK pathways[J]. Archives of Toxicology,2012, 86(6):879-896.
[41] BROBERG K, AHMED S, ENGSTR魻M K, et al. Arsenic exposure in early pregnancy alters genome-wide DNA methylation in cord blood, particularly in boys[J]. Journal of Developmental Origins of Health&Disease, 2014, 5(4):288-298.
[42] KAISE T, WATANABE S, ITOH K. The acute toxicity of arsenobetaine[J]. Chemosphere, 1985, 14(9):1 327-1 332.
[43]葛龙,刘嘉鸣,夏荣香,等.染砷大鼠脑砷代谢研究[J].新疆医科大学学报, 2015, 38(3):283-287.
[44] PETRICK J S, AYALA F F, CULLEN W R, et al. Monomethyl arsonous acid(MMAIII)is more toxic than arsenite in Chang human hepatocytes[J]. Toxicology and Applied Pharmacology, 163:203-207.
[45] NARANMANDURA H, REHMAN K, LE X C, et al. Formation of methylated oxyarsenicals and thioarsenicals in wild-type and arsenic(+3 oxidation state)methyltransferase knockout mice exposed to arsenate[J]. Analytical&Bioanalytical Chemistry,2013, 405(6):1 885-1 891.
[46] KITCHIN K T. Recent Advances in Arsenic Carcinogenesis:Modes of Action, Animal Model Systems, and Methylated Arsenic Metabolites[J]. Toxicology&Applied Pharmacology, 2001, 172(3):249.
[2]赵传凯,姜国良,赵静,等.南极大磷虾油脂的提取及其脂肪酸组成分析[J].食品工业科技, 2012, 33(3):207-209.
[3] VIGERUST N F, BJ覫RNDAL B, BOHOV P, et al. Krill oil versus fish oil in modulation of inflammation and lipid metabolism in mice transgenic for TNF-α[J]. European Journal of Nutrition, 2013, 52(4):1 315-1 325.
[4]冯迪娜,袁玥,朱晓丽.南极磷虾油生理功能的研究进展[J].食品研究与开发, 2015, 36(7):115-117.
[5]贺瑞坤,罗海吉.南极磷虾油对人类健康的作用[J].食品研究与开发, 2013, 34(20):130-133.
[6]徐吟梅,邱卫华,余丽萍,等.南极磷虾粉的营养与功能[J].现代渔业信息, 2010, 25(8):14-16.
[7] SALLY J P, BOBBY J P. Trace element concentrations in Antarctic krill, Euphausia superba[J]. Polar Biology, 1995, 15:283-288.
[8]朱元元,尹雪斌,周守标.南极磷虾硒及矿质营养的初步研究[J].极地研究, 2010, 22(2):135-140.
[9]孙来娣,高华,刘坤,等.南极磷虾油关键质量指标检测及对比分析[J].中国油脂, 2013(12):80-83.
[10]董丽臻,崔鹤,单宝田,等.电感耦合等离子质谱法测定南极磷虾制品中21种元素[J].农产品加工月刊, 2015(5):34-37.
[11]王松, LI Ke,崔鹤,等.南极磷虾油中总砷含量及砷形态分析[J].分析化学, 2016, 44(5):767-772.
[12]杨钊,范莹,迟少云,等.七种藻类中总砷和无机砷含量的测定[J].中国海洋药物杂志, 2007, 26(2):43-46.
[13]朱亚尔,李俊,李世敏.不同产地的几种海藻中砷的形态和含量分析[J].环境化学, 2005, 24(4):478-480.
[14] WHALEY-MARTIN K J, KOCH I, REIMER K J. Determination of arsenic species in edible periwinkles(Littorina littorea)by HPLC-ICPMS and XAS along a contamination gradient[J]. Science of the Total Environment, 2013, 456-457:148-153.
[15] RODOLFO G W, JORGELINA C A, PATRICIA S, et al. Investigation of arsenic speciation in algae of the Antarctic region by HPLC-ICP-MS and HPLC-ESI-Ion Trap MS[J]. Journal of Analytical Atomic Spectrometry, 2006, 21(11):1 214-1 223.
[16] HIRANO S, KOBAYASHI Y, CUI Xin, et al. The accumulation and toxicity of methylated arsenicals in endothelial cells:important roles of thiol compounds[J]. Toxicol Appl Pharm, 2004, 198:458-467.
[17] World Health organization, International Ageney for Researehon Caneer(IARC). Arsenic and arsenic compounds[Z]//Some Metals and Metallic compounds. JARC Monographs, Evaluation of the Carcinogenic Risk of Chemicals to Hamans. 1980, 23:29.
[18] MAGELLAN K, BARRAL-FRAGA L, ROVIRA M, et al. Behavioural and physical effects of arsenic exposure in fish are aggravated by aquatic algae[J]. Aquatic Toxicology, 2014, 156:116-124.
[19] RAHMAN M A, HASEGAWA H, LIM R P. Bioaccumulation, biotransformation and trophic transfer of arsenic in the aquatic food chain[J]. Environmental Research, 2012, 116:118-135.
[20] TAYLOR A, BRANCH S, DAY M P, et al. Atomic spectrometry update. Clinical and biological materials, foods and beverages[J]. Journal of Analytical Atomic Spectrometry, 2010, 25(4):453-492.
[21] CULLEN W R. Chemical mechanism of arsenic biomethylation[J]. Chemical Research in Toxicology, 2014, 27(4):457-461.
[22] ULLRICH-EBERIUS C I, SANZ A, NOVACKY A J. Evaluation of arsenate and vanadate-associated changes of electrical membrane potential and phosphate transport in lemna gibba G1[J]. Journal of Experimental Botany, 2015, 40(1):119-128.
[23] COHEN S M, ARNOLD L L, BECK B D, et al. Evaluation of the carcinogenicity of inorganic arsenic[J]. Critical Reviews in Toxicology, 2013, 43(9):711.
[24] GARC魱ASALGADO S, QUIJANO M A, BONILLA M M. Arsenic speciation in edible alga samples by microwave-assisted extraction and high performance liquid chromatography coupled to atomic fluorescence spectrometry[J]. Analytica Chimica Acta,2012, 714(3):38.
[25] DUNCAN E G, MAHER W A, FOSTER S D. Contribution of arsenic species in unicellular algae to the cycling of arsenic in marine ecosystems[J]. Environmental Science&Technology, 2015, 49(1):33.
[26]张兵,王利红,徐玉新,等.集胞藻(Synechocystis sp. PCC6803)对砷吸收转化特性的初步研究[J].生态毒理学报, 2011,6(6):629-633.
[27] DUNCAN E G, MAHER W A, FOSTER S D. Contribution ofarsenic species in unicellular algae to the cycling of arsenic in marine ecosystems[J]. Environ Sci Technol, 2015, 49:33-50.
[28] GONG Zhilong, LU Xiufen, MA Mingsheng, et al. Arsenic speciation analysis[J]. Talanta, 2002, 58(1):77-96.
[29] SHARMA V K, SOHN M. Aquatic arsenic:Toxicity, apeciation, transformation, and remediation[J]. Enviroment International,2009, 35:743-759.
[30] GROTTI M, SOGGIA F, GOESSLER W, et al. Arsenic species in certified reference material MURST-ISS-A2(Antarctic krill)[J]. Talanta, 2010, 80(3):1 441-1 444.
[31] TSENG W P, CHU H M, HOW S W, et al. Prevalence of skin cancer in an endemic area of chronic arsenicism in Taiwan[J].Journal of the National Cancer Institute, 1968, 40(3):453-463.
[32] HARTMANN A, SPEIT G. Comparative investigations of the genotoxic effects of metals in the single cells gel(SCG)assay and the sister chromatid exchange(SCE)test[J]. Environmental&Molecular Mutagenesis, 1994, 23(4):299-305.
[33] FERM V H, SAXON A, SMITH B M. The Teratogenic Profile of Sodium Arsenate in the Golden Hamster[J]. Archives of Environmental Health, 1971, 22(5):557-560.
[34] BROWN J L, KITCHIN K T, GEORGE M. Dimethylarsinic acid treatment alters six different rat biochemical parameters:relevance to arsenic carcinogenesis[J]. Teratog Carcinog Mutagen, 1997, 17(2):71-84.
[35] JOMOVA K, JENISOVA Z, FESZTEROVA M, et al. Arsenic:toxicity, oxidative stress and human disease[J]. Journal of Applied Toxicology, 2015, 31(2):95-107.
[36] LAWLEY S D, MOLLY C, HALL M N, et al. Mathematical model insights into arsenic detoxification[J]. Theoretical Biology&Medical Modelling, 2011, 8(1):31.
[37] HUGHES M F. Arsenic toxicity and potential mechanisms of action[J]. Toxicology letters, 2002, 133(1):1-16.
[38] LIU Yaping, DUAN Dongzhu, YAO Juan, et al. Dithiaarsanes induce oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase[J]. Journal of Medicinal Chemistry, 2014, 57(12):5 203-5 211.
[39] ANTONELLI R, SHAO K, THOMAS D J, et al. AS3MT, GSTO, and PNP polymorphisms:impact on arsenic methylation and implications for disease susceptibility[J]. Environmental Research, 2014, 132:156.
[40] WANG Lisu, KOU Meichun, WENG Chingyi, et al. Arsenic modulates heme oxygenase-1, interleukin-6, and vascular endothelial growth factor expression in endothelial cells:roles of ROS, NF-κB, and MAPK pathways[J]. Archives of Toxicology,2012, 86(6):879-896.
[41] BROBERG K, AHMED S, ENGSTR魻M K, et al. Arsenic exposure in early pregnancy alters genome-wide DNA methylation in cord blood, particularly in boys[J]. Journal of Developmental Origins of Health&Disease, 2014, 5(4):288-298.
[42] KAISE T, WATANABE S, ITOH K. The acute toxicity of arsenobetaine[J]. Chemosphere, 1985, 14(9):1 327-1 332.
[43]葛龙,刘嘉鸣,夏荣香,等.染砷大鼠脑砷代谢研究[J].新疆医科大学学报, 2015, 38(3):283-287.
[44] PETRICK J S, AYALA F F, CULLEN W R, et al. Monomethyl arsonous acid(MMAIII)is more toxic than arsenite in Chang human hepatocytes[J]. Toxicology and Applied Pharmacology, 163:203-207.
[45] NARANMANDURA H, REHMAN K, LE X C, et al. Formation of methylated oxyarsenicals and thioarsenicals in wild-type and arsenic(+3 oxidation state)methyltransferase knockout mice exposed to arsenate[J]. Analytical&Bioanalytical Chemistry,2013, 405(6):1 885-1 891.
[46] KITCHIN K T. Recent Advances in Arsenic Carcinogenesis:Modes of Action, Animal Model Systems, and Methylated Arsenic Metabolites[J]. Toxicology&Applied Pharmacology, 2001, 172(3):249.