晚期糖基化终末产物与阿尔茨海默病的关系研究进展
摘要
<正>阿尔茨海默病(AD)是一种与年龄相关的神经系统退行性疾病,包括记忆、定向、计算、语言、执行和视空间能力等认知域损伤,晚期常伴有精神行为异常,为目前最常见的痴呆类型,其典型病理特征包括老年斑、神经元纤维缠结(NFTs)的形成和神经元丢失。AD的发病机制涉及基因突变、β-淀粉样蛋白(Aβ)沉积、Tau蛋白过度磷酸化、氧化应激、胆碱能损伤、神经血管功能障碍及蛋白质翻译后的异常修饰等~([1-2])。
引文
[1]MATTSON MP.Pathways towards and away from Alzheimer′s disease[J].Nature,2004,430(7000):631-639.
[2]陈庆华,张凤强,李立新,等.阿尔茨海默病发病机制和诊断技术研究进展[J].中华老年心脑血管病杂志,2018,20(1):108-110.
[3]陈以丽.痴呆与轻度认知障碍的流行病学、发病机制和诊治分析[J].临床合理用药杂志,2017,10(1):172-173.
[4]International Working Group.Advancing research diagnostic criteria for Alzheimer′s disease:the IWG-2criteria[J].Lancet Neurol,2014,13(6):614-629.
[5]LI J,LIU D,SUN L,et al.Advanced glycation end products and neurodegenerative diseases:mechanisms and perspective[J].JNeurol Sci,2012,317(1/2):1-5.
[6]KO SY,KO HA,CHU KH,et al.The Possible mechanism of advanced glycation end products(AGEs)for Alzheimer′s disease[J].PLoS One,2015,10(11):e0143345.
[7]XANTHIS A,HATZITOLIOS A,KOLIAKOS G,et al.Advanced glycosylation end products and nutrition-A possible relation with diabetic atherosclerosis and how to prevent it[J].J Food Sci,2007,72(8):125-129.
[8]SENATUS LM,SCHMIDT AM.The AGE-RAGE Axis:implications for age-associated arterial diseases[J].Front Genet,2017,8:187.
[9]ASSIRI A,KAMEL H,ALREFAI A.Critical appraisal of advanced glycation end products(ages)and circulating soluble receptors for advanced glycation end products(srage)as a predictive biomarkers for cardiovascular disease in hemodialysis patients[J].Med Sci(Basel),2018,6(2):E38.
[10]DEN DEKKER MA,ZWIERS M,VAN DEN HEUVEL ER,et al.Skin autofluorescence,a non-invasive marker for AGE accumulation,is associated with the degree of atherosclerosis[J].PLoS One,2013,8(12):e83084.
[11]付文萍.晚期糖基化终末产物与2型糖尿病患者骨代谢及骨密度的相关性研究[J].中国全科医学,2013,16(2):154-157.
[12]SEBEKOVK,SOMOZA V.Dietary advanced glycation endproducts(AGEs)and their health effects-PRO[J].Mol Nutr Food Res,2007,51(9):1079-1084.
[13]SREY C,HULL GLJ,CONNOLLY L,et al.Effect of inhibitor compounds on Nε-(carboxymethyl)lysine(CML)and Nε-(carboxyethyl)lysine(CEL)formation in model foods[J].J Agric Food Chem,2010,58(22):12036-12041.
[14]汪佳琦,姜文月,张琳,等.胡芦巴中皂苷、黄酮和多糖组分不同配伍对1型糖尿病大鼠的降血糖作用[J].吉林大学学报(医学版),2016,42(6):1081-1086..
[15]NAU JY.100years later,what to know about Maillard reaction and French fries toxicity?[J].Rev Med Suisse,2014,10(424):772-773.
[16]URIBARRI J,TUTTLE KR.Advanced glycation end products and nephrotoxicity of high-protein diets[J].Clin J Am Soc Nephrol,2006,1(6):1293-1299.
[17]HEROLD K,MOSER B,CHEN Y,et al.Receptor for advanced glycation end products(RAGE)in a dash to the rescue:inflammatory signals gone away in the primal response to stress[J].J Leukoc Biol,2007,82(2):204-212.
[18]YAMAGISHI S,MATSUI TK,NAKAMURA K.Possible involvement of tobacco-derived advanced glycation end products(AGEs)in an increased risk for developing cancers and cardiovascular disease in former smokers[J].Med Hypotheses,2008,71(2):259-261.
[19]郭宏伟,张武昌,杨金凤,等.晚期糖基化终末产物在阿尔茨海默病患者中的变化及影响因素的分析[J].中风与神经疾病,2012,29(9):808-811.
[20]薛金山,林勇.阻塞性睡眠呼吸暂停低通气综合征患者血清糖基化终末产物的变化[J].中华结核和呼吸杂志,2007,30(2):155-156.
[21]DICKSON DW,SINICROPI S,YEN SH,et al.Glycation and microglial reaction in lesions of Alzheimer′s disease[J].Neurobiol Aging,1996,17(5):733-743.
[22]URIBARRI J,WOODRUFF S,GOODMAN S,et al.Advanced glycation end products in foods and a practical guide to their reduction in the diet[J].J Am Diet Assoc,2010,110(6):911-916.
[23]VLASSARA H.Advanced glycation in health and disease:role of the modern environment[J].Ann N Y Acad Sci,2005,1043:452-460.
[24]KRAUTWALD M,MNCH G.Advanced glycation end products as biomarkers and gerontotoxins-A basis to explore methylglyoxal-lowering agents for Alzheimer′s disease?[J].Exp Gerontol,2010,45(10):744-751.
[25]DEANE R,BELL RD,SAGARE A,et al.Clearance of amyloidbeta peptide across the blood-brain barrier:implication for therapies in Alzheimer′s disease[J].CNS Neurol Disord Drug Targets,2009,8(1):16-30.
[26]DEANE RJ.Is RAGE still a therapeutic target for Alzheime′s disease?[J].Future Med Chem,2012,4(7):915-925.
[27]LTH HJ,OGUNLADE V,KUHLA B,et al.Age-and stage-dependent accumulation of advanced glycation end products in intracellular deposits in normal and Alzheimer′s disease brains[J].Cereb Cortex,2005,15(2):211-220.
[28]赵方圆.关于晚期糖基化终末产物的研究进展[J].山东医学高等专科学校学报,2013,35(5):394-396.
[29]HORIE K,MIYATA T,YASUDA T,et al.Immunohistochemical localization of advanced glycation end products,pentosidine,and carboxymethyllysine in lipofuscin pigments of Alzheimer′s disease and aged neurons[J].Biochem Biophys Res Commun,1997,236(2):327-332.
[30]KUDO T,IMAIZUMI K,TANIMUKAI H,et al.Are cerebrovascular factors involved in Alzheimer′s disease?[J].Neurobiol Aging,2000,21(2):215-224.
[31]LI XH,LV BL,XIE JZ,et al.AGEs induce Alzheimer-like tau pathology and memory deficit via RAGE-mediated GSK-3activation[J].Neurobiol Aging,2012,33(7):1400-1410.
[32]TAKEUCHI M,YAMAGISHI S.Possible involvement of advanced glycation endproducts(AGEs)in the pathogenesis of Alzheimer′s disease[J].Curr Pharm Des,2008,14(10):973-978.
[33]PIPERI C,ADAMOPOULOS C,PAPAVASSILIOU AG.Potential of glycative stress targeting for cancer prevention[J].Cancer Lett,2017,390:153-159.
[34]HOU X,HU Z,XU H,et al.Advanced glycation endproducts trigger autophagy in cadiomyocyte via RAGE/PI3K/AKT/mTOR pathway[J].Cardiovasc Diabetol,2014,13:78.
[35]GUGLIELMOTTO M,ARAGNO M,TONOGNO E,et al.AGEs/RAGE complex upregulates BACE1via NF-κB pathway activation[J].Neurobiol Aging,2012,33(1):196.
[36]孔卫娜,安胜军,柴锡庆.晚期糖基化终产物受体与β-淀粉样蛋白的相互作用促进阿尔茨海默病的发展[J].中国药理学通报,2009,25(4):424-428.
[37]CHO HJ,SON SM,JIN SM,et al.RAGE regulates BACE1and Abeta generation via NFAT1activation in Alzheimer′s disease animal model[J].FASEB J,2009,23(8):2639-2649.
[38]GHAZALEH K,MAHSA D,FARZANEH R,et al.Role of p38/MAPKs in Alzheimer′s disease:implications for amyloid beta toxicity targeted therapy[J].Neurosciences,2018:1-22.
[39]WEI Y,HAN C,WANG Y,et al.Ribosylation triggering Alzheimer′s disease-like Tau hyperphosphorylation via activation of CaMKII[J].Aging Cell,2015,14(5):754-763.
[40]RIVERA-CERVANTES MC,CASTAEDA-ARELLANO R,CASTRO-TORRES RD,et al.P38 MAPK inhibition protects against glutamate neurotoxicity and modifies nmda and ampa receptor subunit expression[J].J Mol Neurosci,2015,55(3):596-608.
[41]朱金林,陈信良.血清β-淀粉样蛋白及晚期糖基化终末产物与2型糖尿病认知功能障碍的相关性研究[J].现代医院,2017,17(1):87-88.
[42]INGELSSON M,FUKUMOTO H,NEWELL KL,et al.Early Aβaccumulation and progressive synaptic loss,gliosis,and tangle formation in AD brain[J].Neurology,2004,62(6):925-931.
[43]CHEN X,WALKER DG,SCHMIDT AM,et al.RAGE:apotential target for Abeta-mediated cellular perturbation in Alzheimer′s disease[J].Curr Mol Med,2007,7(8):735-742.
[44]CUDABACK E,JORSTAD NL,YANG Y,et al.Therapeutic implications of the prostaglandin pathway in Alzheimer′s disease[J].Biochem Pharmacol,2014,88(4):565-572.
[45]BORG DJ,FORBES JM.Targeting advanced glycation with pharmaceutical agents:where are we now?[J].Glycoconj J,2016,33(4):653-670.
[46]KALOUSOVM,ZIMA T,TESAR V,et al.Advanced glycation end products in clinical nephrology[J].Kidney Blood Press Res,2004,27(1):18-28.
[47]BOULANGER CM,POITEVIN P,VASAN S,et al.Breakers of advanced glycation end products restore large artery properties in experimental diabetes[J].Proc Natl Acad Sci USA,1998,95(8):4630-4634.
[48]杨秀颖,杜冠华.糖基化终末产物及相关药物研究进展[J].中国药理学通报,2011,27(9):1185-1188.
[49]WANG H,WEIHRAUCH D,KERSTEN JR,et al.Alagebrium inhibits neointimal hyperplasia and restores distributions of wall shear stress by reducing downstream vascular resistance in obese and diabetic rats[J].Am J Physiol Heart Circ Physiol,2015,309(7):H1130-1140.
[50]FURLANI RE,RICHARDSON MA,PODELL BK,et al.Second generation 2-aminoimidazole based advanced glycation end product inhibitors and breakers[J].Bioorg Med Chem Lett,2015,25(21):4820-4823.
[51]HONG Y,SHEN C,YIN Q,et al.Effects of RAGE-specific inhibitor fps-zm1on amyloid-βmetabolism and ages-induced inflammation and oxidative stress in rat hippocampus[J].Neurochem Res,2016,41(5):1192-1199.
[52]YAN FL,ZHENG Y,ZHAO FD.Effects of ginkgo biloba extract EGb761on expression of RAGE and LRP-1in cerebral microvascular endothelial cells under chronic hypoxia and hypoglycemia[J].Acta Neuropathol,2008,116(5):529-535.
[53]王延江,卜先乐,向阳,等.从全身角度对阿尔茨海默病发病机制及预防与治疗初步探索[J].中国现代神经疾病杂志,2018,18(1):25-29.
[54]许良元,刘勇,张弓,等.晚期糖基化终末产物检测方法的研究[J].传感器与微系统,2008,27(10):27-29.
[55]ASHRAF JM,AHMAD S,CHOI I,et al.Recent advances in detection of AGEs:immunochemical,bioanalytical and biochemical approaches[J].IUBMB Life,2015,67(12):897-913.
[56]PITT JJ.Principles and applications of liquid chromatographymass spectrometry in clinical biochemistry[J].Clin Biochem Rev,2009,30(1):19-34.
[2]陈庆华,张凤强,李立新,等.阿尔茨海默病发病机制和诊断技术研究进展[J].中华老年心脑血管病杂志,2018,20(1):108-110.
[3]陈以丽.痴呆与轻度认知障碍的流行病学、发病机制和诊治分析[J].临床合理用药杂志,2017,10(1):172-173.
[4]International Working Group.Advancing research diagnostic criteria for Alzheimer′s disease:the IWG-2criteria[J].Lancet Neurol,2014,13(6):614-629.
[5]LI J,LIU D,SUN L,et al.Advanced glycation end products and neurodegenerative diseases:mechanisms and perspective[J].JNeurol Sci,2012,317(1/2):1-5.
[6]KO SY,KO HA,CHU KH,et al.The Possible mechanism of advanced glycation end products(AGEs)for Alzheimer′s disease[J].PLoS One,2015,10(11):e0143345.
[7]XANTHIS A,HATZITOLIOS A,KOLIAKOS G,et al.Advanced glycosylation end products and nutrition-A possible relation with diabetic atherosclerosis and how to prevent it[J].J Food Sci,2007,72(8):125-129.
[8]SENATUS LM,SCHMIDT AM.The AGE-RAGE Axis:implications for age-associated arterial diseases[J].Front Genet,2017,8:187.
[9]ASSIRI A,KAMEL H,ALREFAI A.Critical appraisal of advanced glycation end products(ages)and circulating soluble receptors for advanced glycation end products(srage)as a predictive biomarkers for cardiovascular disease in hemodialysis patients[J].Med Sci(Basel),2018,6(2):E38.
[10]DEN DEKKER MA,ZWIERS M,VAN DEN HEUVEL ER,et al.Skin autofluorescence,a non-invasive marker for AGE accumulation,is associated with the degree of atherosclerosis[J].PLoS One,2013,8(12):e83084.
[11]付文萍.晚期糖基化终末产物与2型糖尿病患者骨代谢及骨密度的相关性研究[J].中国全科医学,2013,16(2):154-157.
[12]SEBEKOVK,SOMOZA V.Dietary advanced glycation endproducts(AGEs)and their health effects-PRO[J].Mol Nutr Food Res,2007,51(9):1079-1084.
[13]SREY C,HULL GLJ,CONNOLLY L,et al.Effect of inhibitor compounds on Nε-(carboxymethyl)lysine(CML)and Nε-(carboxyethyl)lysine(CEL)formation in model foods[J].J Agric Food Chem,2010,58(22):12036-12041.
[14]汪佳琦,姜文月,张琳,等.胡芦巴中皂苷、黄酮和多糖组分不同配伍对1型糖尿病大鼠的降血糖作用[J].吉林大学学报(医学版),2016,42(6):1081-1086..
[15]NAU JY.100years later,what to know about Maillard reaction and French fries toxicity?[J].Rev Med Suisse,2014,10(424):772-773.
[16]URIBARRI J,TUTTLE KR.Advanced glycation end products and nephrotoxicity of high-protein diets[J].Clin J Am Soc Nephrol,2006,1(6):1293-1299.
[17]HEROLD K,MOSER B,CHEN Y,et al.Receptor for advanced glycation end products(RAGE)in a dash to the rescue:inflammatory signals gone away in the primal response to stress[J].J Leukoc Biol,2007,82(2):204-212.
[18]YAMAGISHI S,MATSUI TK,NAKAMURA K.Possible involvement of tobacco-derived advanced glycation end products(AGEs)in an increased risk for developing cancers and cardiovascular disease in former smokers[J].Med Hypotheses,2008,71(2):259-261.
[19]郭宏伟,张武昌,杨金凤,等.晚期糖基化终末产物在阿尔茨海默病患者中的变化及影响因素的分析[J].中风与神经疾病,2012,29(9):808-811.
[20]薛金山,林勇.阻塞性睡眠呼吸暂停低通气综合征患者血清糖基化终末产物的变化[J].中华结核和呼吸杂志,2007,30(2):155-156.
[21]DICKSON DW,SINICROPI S,YEN SH,et al.Glycation and microglial reaction in lesions of Alzheimer′s disease[J].Neurobiol Aging,1996,17(5):733-743.
[22]URIBARRI J,WOODRUFF S,GOODMAN S,et al.Advanced glycation end products in foods and a practical guide to their reduction in the diet[J].J Am Diet Assoc,2010,110(6):911-916.
[23]VLASSARA H.Advanced glycation in health and disease:role of the modern environment[J].Ann N Y Acad Sci,2005,1043:452-460.
[24]KRAUTWALD M,MNCH G.Advanced glycation end products as biomarkers and gerontotoxins-A basis to explore methylglyoxal-lowering agents for Alzheimer′s disease?[J].Exp Gerontol,2010,45(10):744-751.
[25]DEANE R,BELL RD,SAGARE A,et al.Clearance of amyloidbeta peptide across the blood-brain barrier:implication for therapies in Alzheimer′s disease[J].CNS Neurol Disord Drug Targets,2009,8(1):16-30.
[26]DEANE RJ.Is RAGE still a therapeutic target for Alzheime′s disease?[J].Future Med Chem,2012,4(7):915-925.
[27]LTH HJ,OGUNLADE V,KUHLA B,et al.Age-and stage-dependent accumulation of advanced glycation end products in intracellular deposits in normal and Alzheimer′s disease brains[J].Cereb Cortex,2005,15(2):211-220.
[28]赵方圆.关于晚期糖基化终末产物的研究进展[J].山东医学高等专科学校学报,2013,35(5):394-396.
[29]HORIE K,MIYATA T,YASUDA T,et al.Immunohistochemical localization of advanced glycation end products,pentosidine,and carboxymethyllysine in lipofuscin pigments of Alzheimer′s disease and aged neurons[J].Biochem Biophys Res Commun,1997,236(2):327-332.
[30]KUDO T,IMAIZUMI K,TANIMUKAI H,et al.Are cerebrovascular factors involved in Alzheimer′s disease?[J].Neurobiol Aging,2000,21(2):215-224.
[31]LI XH,LV BL,XIE JZ,et al.AGEs induce Alzheimer-like tau pathology and memory deficit via RAGE-mediated GSK-3activation[J].Neurobiol Aging,2012,33(7):1400-1410.
[32]TAKEUCHI M,YAMAGISHI S.Possible involvement of advanced glycation endproducts(AGEs)in the pathogenesis of Alzheimer′s disease[J].Curr Pharm Des,2008,14(10):973-978.
[33]PIPERI C,ADAMOPOULOS C,PAPAVASSILIOU AG.Potential of glycative stress targeting for cancer prevention[J].Cancer Lett,2017,390:153-159.
[34]HOU X,HU Z,XU H,et al.Advanced glycation endproducts trigger autophagy in cadiomyocyte via RAGE/PI3K/AKT/mTOR pathway[J].Cardiovasc Diabetol,2014,13:78.
[35]GUGLIELMOTTO M,ARAGNO M,TONOGNO E,et al.AGEs/RAGE complex upregulates BACE1via NF-κB pathway activation[J].Neurobiol Aging,2012,33(1):196.
[36]孔卫娜,安胜军,柴锡庆.晚期糖基化终产物受体与β-淀粉样蛋白的相互作用促进阿尔茨海默病的发展[J].中国药理学通报,2009,25(4):424-428.
[37]CHO HJ,SON SM,JIN SM,et al.RAGE regulates BACE1and Abeta generation via NFAT1activation in Alzheimer′s disease animal model[J].FASEB J,2009,23(8):2639-2649.
[38]GHAZALEH K,MAHSA D,FARZANEH R,et al.Role of p38/MAPKs in Alzheimer′s disease:implications for amyloid beta toxicity targeted therapy[J].Neurosciences,2018:1-22.
[39]WEI Y,HAN C,WANG Y,et al.Ribosylation triggering Alzheimer′s disease-like Tau hyperphosphorylation via activation of CaMKII[J].Aging Cell,2015,14(5):754-763.
[40]RIVERA-CERVANTES MC,CASTAEDA-ARELLANO R,CASTRO-TORRES RD,et al.P38 MAPK inhibition protects against glutamate neurotoxicity and modifies nmda and ampa receptor subunit expression[J].J Mol Neurosci,2015,55(3):596-608.
[41]朱金林,陈信良.血清β-淀粉样蛋白及晚期糖基化终末产物与2型糖尿病认知功能障碍的相关性研究[J].现代医院,2017,17(1):87-88.
[42]INGELSSON M,FUKUMOTO H,NEWELL KL,et al.Early Aβaccumulation and progressive synaptic loss,gliosis,and tangle formation in AD brain[J].Neurology,2004,62(6):925-931.
[43]CHEN X,WALKER DG,SCHMIDT AM,et al.RAGE:apotential target for Abeta-mediated cellular perturbation in Alzheimer′s disease[J].Curr Mol Med,2007,7(8):735-742.
[44]CUDABACK E,JORSTAD NL,YANG Y,et al.Therapeutic implications of the prostaglandin pathway in Alzheimer′s disease[J].Biochem Pharmacol,2014,88(4):565-572.
[45]BORG DJ,FORBES JM.Targeting advanced glycation with pharmaceutical agents:where are we now?[J].Glycoconj J,2016,33(4):653-670.
[46]KALOUSOVM,ZIMA T,TESAR V,et al.Advanced glycation end products in clinical nephrology[J].Kidney Blood Press Res,2004,27(1):18-28.
[47]BOULANGER CM,POITEVIN P,VASAN S,et al.Breakers of advanced glycation end products restore large artery properties in experimental diabetes[J].Proc Natl Acad Sci USA,1998,95(8):4630-4634.
[48]杨秀颖,杜冠华.糖基化终末产物及相关药物研究进展[J].中国药理学通报,2011,27(9):1185-1188.
[49]WANG H,WEIHRAUCH D,KERSTEN JR,et al.Alagebrium inhibits neointimal hyperplasia and restores distributions of wall shear stress by reducing downstream vascular resistance in obese and diabetic rats[J].Am J Physiol Heart Circ Physiol,2015,309(7):H1130-1140.
[50]FURLANI RE,RICHARDSON MA,PODELL BK,et al.Second generation 2-aminoimidazole based advanced glycation end product inhibitors and breakers[J].Bioorg Med Chem Lett,2015,25(21):4820-4823.
[51]HONG Y,SHEN C,YIN Q,et al.Effects of RAGE-specific inhibitor fps-zm1on amyloid-βmetabolism and ages-induced inflammation and oxidative stress in rat hippocampus[J].Neurochem Res,2016,41(5):1192-1199.
[52]YAN FL,ZHENG Y,ZHAO FD.Effects of ginkgo biloba extract EGb761on expression of RAGE and LRP-1in cerebral microvascular endothelial cells under chronic hypoxia and hypoglycemia[J].Acta Neuropathol,2008,116(5):529-535.
[53]王延江,卜先乐,向阳,等.从全身角度对阿尔茨海默病发病机制及预防与治疗初步探索[J].中国现代神经疾病杂志,2018,18(1):25-29.
[54]许良元,刘勇,张弓,等.晚期糖基化终末产物检测方法的研究[J].传感器与微系统,2008,27(10):27-29.
[55]ASHRAF JM,AHMAD S,CHOI I,et al.Recent advances in detection of AGEs:immunochemical,bioanalytical and biochemical approaches[J].IUBMB Life,2015,67(12):897-913.
[56]PITT JJ.Principles and applications of liquid chromatographymass spectrometry in clinical biochemistry[J].Clin Biochem Rev,2009,30(1):19-34.