红细胞免疫及血清炎性因子水平与轮状病毒肠炎患儿脱水程度的关系
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摘要
目的研究红细胞免疫及血清炎性因子水平与轮状病毒肠炎患儿脱水程度的关系。方法回顾性分析2015年2月～2018年2月阜新矿业(集团)有限责任公司总医院收治的82例轮状病毒肠炎患儿的临床资料,将其按照脱水程度不同分为轻度脱水组(25例)、中度脱水组(27例)、重度脱水组(30例)。另取同期进行体检的健康儿童30名为对照组。分别对比各组各项红细胞免疫指标与血清炎性因子水平,并作相关性分析。结果对照组、轻度脱水组、中度脱水组、重度脱水组免疫黏附促进因子(RFER)、红细胞促中性粒细胞吞噬率(ERPN)、红细胞C3b受体花环率(RBC-C3bR)水平均逐渐降低,而免疫黏附抑制因子(FEIR)与免疫复合物花环率(RBC-ICR)水平逐渐上升,差异均有统计学意义(P <0.05)。对照组、轻度脱水组、中度脱水组、重度脱水组肿瘤坏死因子α(TNF-α)、降钙素原(PCT)以及超敏C反应蛋白(hs-CRP)水平均逐渐升高,差异均有统计学意义(P <0.05)。经Spearman相关性分析可得:TNF-α、PCT、hs-CRP与RFER、ERPN、RBC-C3bR均呈负相关(P <0.05),而与FEIR、RBC-ICR均呈正相关(P <0.05)。结论红细胞免疫及血清炎性因子水平与轮状病毒肠炎患儿的脱水程度密切相关,可为轮状病毒肠炎患儿疾病诊断和严重程度评估提供依据。
Objective To study the relationship between erythrocyte immunity, level of serum inflammatory factors and the degree of dehydration in children with rotavirus enteritis. Methods From February 2015 to February 2018, in General Hospital of Fuxin Mining Industry(Group) Company with Limited Liability, the clinical data of 82 children with rotavirus enteritis were retrospectively analyzed, according to the degree of dehydration, they were divided into mild dehydration group(25 cases), moderate dehydration group(27 cases), and severe dehydration group(30 cases), another 30 healthy children had physical examination were selected as control group. The level of erythrocyte immune indexes and serum inflammatory factors in each group was compared, and correlation analysis was made. Results The level of immune adherence enhance factor(RFER), enhancing rosette rate of phygocytosis of red cells on neutrophils(ERPN)and erythrocyte C3b receptor rosette rate(RBC-C3bR) in the control group, mild dehydration group, moderate dehydration group and severe dehydration group decreased gradually, the level of immune adherence inhibitor factor(RFIR)and immunocomplex receptor chaplet rate(RBC-ICR) increased gradually, the differences were statistically significant(P < 0.05). The level of tumor necrosis factor-α(TNF-α), procalcitonin(PCT) and high-sensitivity C-reactive protein(hs-CRP) in the control group, mild dehydration group, moderate dehydration group and severe dehydration group increased gradually, the differences were statistically significant(P < 0.05). Spearman correlation analysis showed that TNF-α, PCT, hs-CRP were negatively correlated with RFER, ERPN, RBC-C3bR(P < 0.05),they were positively correlated with FEIR and RBC-ICR(P < 0.05). Conclusion The level of erythrocyte immunity and serum inflammatory factors are closely related to the degree of dehydration in children with rotavirus enteritis, it can provide basis for disease diagnosis and severity assessment of children with rotavirus enteritis.
Objective To study the relationship between erythrocyte immunity, level of serum inflammatory factors and the degree of dehydration in children with rotavirus enteritis. Methods From February 2015 to February 2018, in General Hospital of Fuxin Mining Industry(Group) Company with Limited Liability, the clinical data of 82 children with rotavirus enteritis were retrospectively analyzed, according to the degree of dehydration, they were divided into mild dehydration group(25 cases), moderate dehydration group(27 cases), and severe dehydration group(30 cases), another 30 healthy children had physical examination were selected as control group. The level of erythrocyte immune indexes and serum inflammatory factors in each group was compared, and correlation analysis was made. Results The level of immune adherence enhance factor(RFER), enhancing rosette rate of phygocytosis of red cells on neutrophils(ERPN)and erythrocyte C3b receptor rosette rate(RBC-C3bR) in the control group, mild dehydration group, moderate dehydration group and severe dehydration group decreased gradually, the level of immune adherence inhibitor factor(RFIR)and immunocomplex receptor chaplet rate(RBC-ICR) increased gradually, the differences were statistically significant(P < 0.05). The level of tumor necrosis factor-α(TNF-α), procalcitonin(PCT) and high-sensitivity C-reactive protein(hs-CRP) in the control group, mild dehydration group, moderate dehydration group and severe dehydration group increased gradually, the differences were statistically significant(P < 0.05). Spearman correlation analysis showed that TNF-α, PCT, hs-CRP were negatively correlated with RFER, ERPN, RBC-C3bR(P < 0.05),they were positively correlated with FEIR and RBC-ICR(P < 0.05). Conclusion The level of erythrocyte immunity and serum inflammatory factors are closely related to the degree of dehydration in children with rotavirus enteritis, it can provide basis for disease diagnosis and severity assessment of children with rotavirus enteritis.
引文
[1]蒋丽芳,魏洪平,吴莉萍,等.七味白术散治疗轮状病毒肠炎疗效及对血清肿瘤坏死因子-α和白介素-6水平的影响[J].浙江中西医结合杂志,2015,25(7):656-657.
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[7]李志,张广超,赵保玲,等.布拉酵母菌散治疗儿童轮状病毒性肠炎的疗效及对患儿血清和粪便IL-6、TNF-α和IFN-γ水平的影响[J].临床心身疾病杂志,2018,24(3):18-20.
[8]蔡东黎,戚那那,高敏都,等.消旋卡多曲颗粒联合蒙脱石散对婴幼儿轮状病毒肠炎的疗效及对心肌酶谱的影响[J].中国生化药物杂志,2016,36(11):65-67.
[9]杨璐,陈又华,董玲,等.中药灌肠治疗小儿轮状病毒肠炎疗效及对炎症因子影响的观察[J].中国中医急症,2016,25(2):295-297.
[10]龙彪,曾冬梅,罗莉,等.热毒宁注射液辅助治疗小儿轮状病毒肠炎及对血清炎症因子水平的影响[J].中药材,2017,40(7):1738-1740.
[11]曹玉琳.分析血清细胞因子和红细胞免疫指标与轮状病毒腹泻的关系[J].中国卫生标准管理,2017,8(1):94-95.
[12]宋翠领,曹锦芬,张晓,等.布拉氏酵母菌联合瑞安吉口服液对轮状病毒肠炎患儿细胞免疫功能的影响[J].海南医学院学报,2017,23(23):3275-3277.
[13]陈思如.PCT、CRP、hs-CRP在急性轮状病毒肠炎伴心肌损害中的表达[J].现代临床医学,2017,43(3):185-186.
[14]来蔓丽.葡萄糖酸锌对轮状病毒肠炎患儿心肌损伤、免疫功能及血清炎性因子的影响[J].中国医药导刊,2015,32(6):583-585.
[15]李佩琼,张岚.小儿轮状病毒肠炎患者红细胞免疫及血清炎性因子水平变化研究[J].成都医学院学报,2014,9(4):389-391.
[16]郝雯颖,夏萍,王红,等.轮状病毒肠炎患儿血清免疫球蛋白、补体及抗炎/促炎因子的动态变化及意义[J].中国现代医生,2017,55(24):71-74.
[17]贵仁伍,任静,赵润,等.喜炎平注射液联合阿奇霉素对儿童肺炎患儿炎症细胞因子、淋巴细胞亚群、红细胞免疫指标及免疫球蛋白的影响[J].中国妇幼保健,2017,32(20):5010-5013.
[18]Hu Y,Gui L,Chang J,et al.The incidence of infants with rotavirus enteritis combined with lactose intolerance[J].Pak J Pharm Sci,2016,29(1):321-323.
[19]朱晓华,王建成,苏建荣.婴幼儿腹泻的轮状病毒检测分析及其流行病学特征[J].临床和实验医学杂志,2016,15(21):2170-2172.
[20]辛秀锦.热毒宁注射液对小儿轮状病毒肠炎的辅助性治疗作用及对血清炎性因子的影响[J].齐齐哈尔医学院学报,2017,38(24):2907-2909.
[2]Amodio E,Tabacchi G,Cracchiolo M,et al.Hospitalisation of children aged 0-59 months with rotavirus gastro-enteritis before the introduction of routine vaccination(Sicily2003-2012)[J].Paediatr Int Child Health,2015,35(4):319-323.
[3]陈莉莉,李司鹏.布拉氏酵母菌散对轮状病毒肠炎患儿血清白介素-6和肿瘤坏死因子-α水平的影响及疗效观察[J].中国微生态学杂志,2014,26(2):181-183.
[4]林宏超,邝德豪,周伟光,等.哮喘患者红细胞免疫功能与外周血相关细胞炎症因子水平相关性研究[J].中国实用医药,2017,12(8):78-79.
[5]胡亚美,江载芳.诸福棠实用儿科学[M].7版.北京:人民卫生出版社:2003,270-277.
[6]陆作洁,农少云,黄翠波,等.轮状病毒肠炎患儿异型淋巴细胞和免疫球蛋白水平的变化分析[J].检验医学与临床,2014,32(1):62-63.
[7]李志,张广超,赵保玲,等.布拉酵母菌散治疗儿童轮状病毒性肠炎的疗效及对患儿血清和粪便IL-6、TNF-α和IFN-γ水平的影响[J].临床心身疾病杂志,2018,24(3):18-20.
[8]蔡东黎,戚那那,高敏都,等.消旋卡多曲颗粒联合蒙脱石散对婴幼儿轮状病毒肠炎的疗效及对心肌酶谱的影响[J].中国生化药物杂志,2016,36(11):65-67.
[9]杨璐,陈又华,董玲,等.中药灌肠治疗小儿轮状病毒肠炎疗效及对炎症因子影响的观察[J].中国中医急症,2016,25(2):295-297.
[10]龙彪,曾冬梅,罗莉,等.热毒宁注射液辅助治疗小儿轮状病毒肠炎及对血清炎症因子水平的影响[J].中药材,2017,40(7):1738-1740.
[11]曹玉琳.分析血清细胞因子和红细胞免疫指标与轮状病毒腹泻的关系[J].中国卫生标准管理,2017,8(1):94-95.
[12]宋翠领,曹锦芬,张晓,等.布拉氏酵母菌联合瑞安吉口服液对轮状病毒肠炎患儿细胞免疫功能的影响[J].海南医学院学报,2017,23(23):3275-3277.
[13]陈思如.PCT、CRP、hs-CRP在急性轮状病毒肠炎伴心肌损害中的表达[J].现代临床医学,2017,43(3):185-186.
[14]来蔓丽.葡萄糖酸锌对轮状病毒肠炎患儿心肌损伤、免疫功能及血清炎性因子的影响[J].中国医药导刊,2015,32(6):583-585.
[15]李佩琼,张岚.小儿轮状病毒肠炎患者红细胞免疫及血清炎性因子水平变化研究[J].成都医学院学报,2014,9(4):389-391.
[16]郝雯颖,夏萍,王红,等.轮状病毒肠炎患儿血清免疫球蛋白、补体及抗炎/促炎因子的动态变化及意义[J].中国现代医生,2017,55(24):71-74.
[17]贵仁伍,任静,赵润,等.喜炎平注射液联合阿奇霉素对儿童肺炎患儿炎症细胞因子、淋巴细胞亚群、红细胞免疫指标及免疫球蛋白的影响[J].中国妇幼保健,2017,32(20):5010-5013.
[18]Hu Y,Gui L,Chang J,et al.The incidence of infants with rotavirus enteritis combined with lactose intolerance[J].Pak J Pharm Sci,2016,29(1):321-323.
[19]朱晓华,王建成,苏建荣.婴幼儿腹泻的轮状病毒检测分析及其流行病学特征[J].临床和实验医学杂志,2016,15(21):2170-2172.
[20]辛秀锦.热毒宁注射液对小儿轮状病毒肠炎的辅助性治疗作用及对血清炎性因子的影响[J].齐齐哈尔医学院学报,2017,38(24):2907-2909.