膳食营养与帕金森病的关系
摘要
帕金森病是一种常见的中枢神经系统退行性疾病,除具有典型的运动症状外还伴多种非运动症状,严重的功能障碍显著影响患者的身心健康以及生活质量。目前发现膳食营养干预在帕金森病防治过程中起重要作用。本文从茶多酚、多不饱和脂肪酸、维生素、膳食模式等方面综述近年来膳食营养对帕金森病防治的研究进展。
引文
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[23]ALCALAY R N,GU Y,MEJIA-SANTANA H,et al.The association between Mediterranean diet adherence and Parkinson's disease[J].Mov Disord,2012,27(6):771.
[24]GAO X,CHEN H,FUNG T T,et al.Prospective study of dietary pattern and risk of Parkinson disease[J].Am J Clin Nutr,2007,86(5):1486.
[25]OKUBO H,MIYAKE Y,SASAKI S,et al.Dietary patterns and risk of Parkinson’s disease:a casecontrol study in Japan[J].Eur J Neurol,2012,19(5):681-688.
[2]ZOU Y M,LIU J,TIAN Z Y,et al.Systematic review of the prevalence and incidence of Parkinson’s disease in the People’s Republic of China[J].Neuropsychiatr Dis Treat,2015(11):1467-1472.
[3]GABA A.Recent studies on nutrition and Parkinson’s disease prevention:a systematic review[J].Open JPrevent Med,2015,5(5):197-205.
[4]SINGH N A,MANDAL A K A,KHAN Z A.Potential neuroprotective properties of epigallocatechin-3-gallate(EGCG)[J].Nutr J,2015,15(1):1-17.
[5]HAE-SUK K,QUON M J,JEONG-A K.New insights into the mechanisms of polyphenols beyond antioxidant properties;lessons from the green tea polyphenol,epigallocatechin 3-gallate[J].Redox Biol,2014(2):187.
[6]赵保路.茶多酚保护脑神经防止帕金森病损伤作用及其分子机理[J].生物化学与生物物理进展,2008,35(7):735-743.
[7]陈宏伟,于兰,陈敏,等.茶多酚对帕金森病猴多巴胺能神经元保护作用的研究[J].首都医科大学学报,2015,36(5):689-693.
[8]CHEN M,WANG T,YUE F,et al.Tea polyphenols alleviate motor impairments,dopaminergic neuronal injury,and cerebralα-synuclein aggregation in MPTP-intoxicated parkinsonian monkeys[J].Neuroscience,2015,286:383-392.
[9]HENNEBELLE M,CHAMPEIL P G,LAVIALLEM,et al.Omega-3 polyunsaturated fatty acids and chronic stress-induced modulations of glutamatergic neurotransmission in the hippocampus[J].Nutr Rev,2014,72(2):99-112.
[10]BOUSQUET M,SAINTPIERRE M,JULIEN C,et al.Beneficial effects of dietary omega-3polyunsaturated fatty acid on toxin-induced neuronal degeneration in an animal model of Parkinson’s disease[J].Faseb J,2008,22(4):1213-1225.
[11]BOUSQUET M,GUE K,EMOND V,et al.Transgenic conversion of omega-6 into omega-3 fatty acids in a mouse model of Parkinson's disease[J].JLipid Res,2011,52(2):263-271.
[12]OZSOY O,SEVALCELIK Y,HACIOGLU G,et al.The influence and the mechanism of docosahexaenoic acid on a mouse model of Parkinson's disease[J].Neurochem Int,2011,59(5):664.
[13]KAMEL F,GOLDMAN S M,UMBACH D M,et al.Dietary fat intake,pesticide use,and Parkinson's disease[J].Parkinsonism Disord,2014,20(1):82-87.
[14]DONG J,BEARD J D,UMBACH D M,et al.Dietary fat intake and risk for Parkinson’s disease[J].Mov Disord Off J Mov Disord Soc,2014,29(13):1623-1630.
[15]王乐,毕胜,范晓雪,等.维生素D及其受体在帕金森病中的作用[J].现代生物医学进展,2015,15(3):594-597.(下转封三)
[16]NISSOU M F,BROCARD J,EL A M,et al.The transcriptomic response of mixed neuron-glial cell cultures to 1,25-dihydroxyvitamin d3 includes genes limiting the progression of neurodegenerative diseases[J].J Alzheimers Dis,2013,35(3):553.
[17]PETERSON A L,MURCHISON C,ZABETIAN C,et al.Memory,mood,and vitamin D in persons with Parkinson's disease[J].J Parkinsons Dis,2013,3(4):547-555.
[18]MOGHADDASI M,MAMARABADI M,AGHAII M.Serum 25-hydroxyvitamin D3 concentration in Iranian patients with Parkinson's disease[J].Iran J Neurol,2013,12(2):56.
[19]ZHU D,LIU G Y,LV Z,et al.Inverse associations of outdoor activity and vitamin D intake with the risk of Parkinson’s disease[J].J Zhejiang Univ Sci B,2014,15(10):923-927.
[20]YANG F,WOLK A,HKANSSON N,et al.Dietary antioxidants and risk of Parkinson's disease in two population-based cohorts[J].Mov Disord,2017,32(11):1631-1636.
[21]HUGHES K C,GAO X,KIM I Y,et al.Intake of antioxidant vitamins and risk of Parkinson's disease[J].Mov Disord,2016,31(12):1909-1914.
[22]杨溢,何悦,陈思远,等.维生素E对帕金森病模型细胞的抗凋亡作用及其机制[J].江苏大学学报(医学版),2017,27(1):27-30.
[23]ALCALAY R N,GU Y,MEJIA-SANTANA H,et al.The association between Mediterranean diet adherence and Parkinson's disease[J].Mov Disord,2012,27(6):771.
[24]GAO X,CHEN H,FUNG T T,et al.Prospective study of dietary pattern and risk of Parkinson disease[J].Am J Clin Nutr,2007,86(5):1486.
[25]OKUBO H,MIYAKE Y,SASAKI S,et al.Dietary patterns and risk of Parkinson’s disease:a casecontrol study in Japan[J].Eur J Neurol,2012,19(5):681-688.