晶星900光学生物测量仪测量近视患者眼轴及中央角膜厚度的准确性评价
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摘要
目的评价晶星900光学生物测量仪测量近视患者眼轴长度(AL)及中央角膜厚度(CCT)的准确性。方法选取在广西视光中心就诊的近视患者48例(96眼),年龄18～45(26.38±6.03)岁,等效球镜-(1.0～6.75) D。采用晶星900和A超测量AL,用晶星900、A超和Pentacam测量CCT,应用配对t检验比较不同方法测量结果的差异,采用Pearson相关分析评估不同仪器测量结果的相关性,Bland-Altman分析评价不同方法测量结果的一致性。结果晶星900和A超测得的AL分别为(25.21±1.18) mm和(25.09±1.17) mm,差异有统计学意义(P<0.01),两者间呈正相关关系(r=0.982,P<0.01),95%一致性界限为(-0.31～0.10) mm。晶星900、A超和Pentacam测得的CCT分别为(532.55±24.09)μm、(530.03±23.39)μm和(537.64±23.75)μm,差异均有统计学意义(P均<0.01),Pearson相关分析显示晶星900测得的AL与A超(r=0.985,P<0.01)、Pentacam(r=0.956,P<0.01)的结果呈正相关关系,其三者测量CCT的95%界限:A超与晶星900为(-10.6～6.0)μm、晶星900与pentacam为(-14.7～8.4)μm、A超与Pentacam为(-14.8～5.2)μm。结论晶星900与A超所测AL相关性好;晶星900与A超、Pentacam所测量CCT均有明显相关性,其中晶星900与金标准的A超所测得的CCT一致性较好。晶星900可以作为近视患者AL和CCT的非接触式测量工具之一。
Objective To evaluate the accuracy of Lenstar 900 optical biometry for measurement of axial length(AL) and central corneal thickness(CCT) in myopia.Methods Forty-eight myopic patients(96 eyes) with spherical equivalent(SE) varied from -1.00～-6.75 D,aged 18～45(26.38 ± 6.03) years,were recruited from the Visual Science and Optometry center of Guangxi.AL was measured by Lenstar 900 and A-scan,and CCT was measured by Lenstar 900,A-scan and Pentacam.The paired t-test was used to compare the differences of the measured results of different instruments.Pearson correlation analysis and Bland-Altman analysis were used to evaluate the correlation and the consistency of the measured results of the different methods.Results The values of AL measured by Lenstar 900 and A-scan were(25.21 ± 1.18) and(25.09 ± 1.17) mm,respectively,with a significant difference between the two measured methods(P<0.01) and a significant correlation between them(r=0.982,P<0.01),and the 95% limit of agreement(LOA) was(-0.31 ～ 0.10) mm.The values of CCT measured by Lenstar 900,Ascan and Pentacam were(532.55 ± 24.09) μm,(530.03 ± 23.39) μm and(537.64 ± 23.75) μm respectively.There was significant difference among the three methods(all P<0.01).Pearson correlation analysis showed that the value of AL measured by Lenstar 900 was positively correlated with the results of A-scan(r=0.985,P<0.01),and the results of Pentacam(r=0.956,P<0.01).The values of 95% LOA of CCT were(-10.6 ～ 6.0) μm for A-scan versus Lenstar 900,(-14.7 ～ 8.4) μm for Lenstar 900 versus Pentacam,and(-14.8 ～ 5.2) μm for A-scan versus Pentacam,respectively.Conclusion AL measured by Lenstar 900 is significantly correlated with that measured by ultrasound A-scan.Similarly,CCT measured by Lenstar 900 shows significant correlation with that measured by ultrasound A-scan or Pentacam.CCT measured by Lenstar 900 shows satisfactory consistency with that measured by the gold standard ultrasound A-scan.Lenstar 900 can be used as one of the non-contact measurement tools for AL and CCT in myopia.
Objective To evaluate the accuracy of Lenstar 900 optical biometry for measurement of axial length(AL) and central corneal thickness(CCT) in myopia.Methods Forty-eight myopic patients(96 eyes) with spherical equivalent(SE) varied from -1.00～-6.75 D,aged 18～45(26.38 ± 6.03) years,were recruited from the Visual Science and Optometry center of Guangxi.AL was measured by Lenstar 900 and A-scan,and CCT was measured by Lenstar 900,A-scan and Pentacam.The paired t-test was used to compare the differences of the measured results of different instruments.Pearson correlation analysis and Bland-Altman analysis were used to evaluate the correlation and the consistency of the measured results of the different methods.Results The values of AL measured by Lenstar 900 and A-scan were(25.21 ± 1.18) and(25.09 ± 1.17) mm,respectively,with a significant difference between the two measured methods(P<0.01) and a significant correlation between them(r=0.982,P<0.01),and the 95% limit of agreement(LOA) was(-0.31 ～ 0.10) mm.The values of CCT measured by Lenstar 900,Ascan and Pentacam were(532.55 ± 24.09) μm,(530.03 ± 23.39) μm and(537.64 ± 23.75) μm respectively.There was significant difference among the three methods(all P<0.01).Pearson correlation analysis showed that the value of AL measured by Lenstar 900 was positively correlated with the results of A-scan(r=0.985,P<0.01),and the results of Pentacam(r=0.956,P<0.01).The values of 95% LOA of CCT were(-10.6 ～ 6.0) μm for A-scan versus Lenstar 900,(-14.7 ～ 8.4) μm for Lenstar 900 versus Pentacam,and(-14.8 ～ 5.2) μm for A-scan versus Pentacam,respectively.Conclusion AL measured by Lenstar 900 is significantly correlated with that measured by ultrasound A-scan.Similarly,CCT measured by Lenstar 900 shows significant correlation with that measured by ultrasound A-scan or Pentacam.CCT measured by Lenstar 900 shows satisfactory consistency with that measured by the gold standard ultrasound A-scan.Lenstar 900 can be used as one of the non-contact measurement tools for AL and CCT in myopia.
引文
1李莉,蓝倩倩,王璐.非球面散光型人工晶状体植入治疗合并角膜散光白内障患者的临床研究[J].中国临床新医学,2016,9(1):1-5.
2 Hoffer KJ,Shammas HJ,Savini G.Comparison of 2 laser instruments for measuring axial length[J].J Cataract Refracl Surg,2010,36(4):644-648.
3解蕊,原文新,芦利娟,等.晶星900与A超生物测量对比研究[J].中国实用眼科杂志,2014,32(11):1306-1308.
4 O'Donnell C,Hartwig A,Radhakrishnan H.Correlations between refractive error and biometric parameters in human eyes using the LenStar 900[J].Cont Lens Anterior Eye,2011,34(1):26-31.
5王峥,郑帆,吴文凌,等.Lenstar LS900、IOLMaster与A超测量白内障患者人工晶状体度数的对比研究[J].福建医药杂志,2012,34(2):115-117.
6王乐,张广斌,叶向彧,等.Lenstar LS900与A超测算白内障患者人工晶状体度数对比研究[J].中国实用眼科杂志,2012,30(3):263-265.
7于广委,张琰,李筱荣.光相干生物测量仪与接触式A型超声测量特发性黄斑裂孔患者眼轴长度的比较[J].中华眼底病杂志,2013,29(5):465-469.
8沈政伟,尹禾,薛林平,等.白内障患者Lenstar与A型超声或角膜曲率计眼部生物学参数测量结果的比较[J].中华实验眼科杂志,2012,30(12):1114-1117.
9 Tappeiner C,Rohrer K,Frueh BE,et al.Clinical comparison of biometry using the non-contact optical low coherence refleetometer(Lenstar LS 900)and contact ultrasound biometer(Tomey AL-3000)in cataract eyes[J].Br J Ophthalmol,2010,94(5):666-667.
10黄锦海,李坚,杨欣,等.新型眼球生物测量仪Lenstar的原理及其临床应用[J].中华眼视光学与视觉科学杂志,2013,15(5):314-317.
11 Tai LY,Khaw KW,Nq CM,et al.Central corneal thickness measurements with different imaging devices and ultrasound pachymetry[J].Cornea,2013,32(6):766-771.
12张鸿蹈,蒋华.三种角膜测厚仪测量近视患者中央角膜厚度的对比[J].国际眼科杂志,2013,13(9):1801-1804.
13王顺清,孙成淑,张小兰,等.Lenstar LS 900与角膜超声测厚仪测量角膜中央厚度的对比观察[J].临床眼科杂志,2012,20(4):307-309.
14 Koktekir BE,Gcdik S,Bakbak B.Comparison of central corneal thickness measurements with optical low-coherence reflectometry and ultrasound pachymetry and reproducibility of both devices[J].Cornea,2012,31(11):1278-1281.
15 Huang J,Pesudovs K,Wen D,et al.Comparison of anterior segment measurements with rotating Scheimpflug photography and partial coherence reflectometry[J].Cataract Refract Surg,2011,37(2):341-348.
16 O'Donnell C,Hartwig A,Radhakrishnan H.Comparison of Central Corneal Thickness and Anterior Chamber Depth Measured Using LenStar LS900 Pentacam and Visante AS-OCT[J].Cornea,2012,31(9):983-988.
17洪华丽,王英,肖信,等.护理干预对角膜屈光手术后遵医行为及视觉满意度的影响[J].中国临床新医学,2015,8(4):364-367.
18 Bjelos RM,Busic M,Cima I,et al.Intraobserver and interobserver repeatability of ocular components measurement in cataract eyes using a new optical low coherence reflectometer[J].Graefes Arch Clin Exp Ophthalmol,2011,249(1):83-87.
2 Hoffer KJ,Shammas HJ,Savini G.Comparison of 2 laser instruments for measuring axial length[J].J Cataract Refracl Surg,2010,36(4):644-648.
3解蕊,原文新,芦利娟,等.晶星900与A超生物测量对比研究[J].中国实用眼科杂志,2014,32(11):1306-1308.
4 O'Donnell C,Hartwig A,Radhakrishnan H.Correlations between refractive error and biometric parameters in human eyes using the LenStar 900[J].Cont Lens Anterior Eye,2011,34(1):26-31.
5王峥,郑帆,吴文凌,等.Lenstar LS900、IOLMaster与A超测量白内障患者人工晶状体度数的对比研究[J].福建医药杂志,2012,34(2):115-117.
6王乐,张广斌,叶向彧,等.Lenstar LS900与A超测算白内障患者人工晶状体度数对比研究[J].中国实用眼科杂志,2012,30(3):263-265.
7于广委,张琰,李筱荣.光相干生物测量仪与接触式A型超声测量特发性黄斑裂孔患者眼轴长度的比较[J].中华眼底病杂志,2013,29(5):465-469.
8沈政伟,尹禾,薛林平,等.白内障患者Lenstar与A型超声或角膜曲率计眼部生物学参数测量结果的比较[J].中华实验眼科杂志,2012,30(12):1114-1117.
9 Tappeiner C,Rohrer K,Frueh BE,et al.Clinical comparison of biometry using the non-contact optical low coherence refleetometer(Lenstar LS 900)and contact ultrasound biometer(Tomey AL-3000)in cataract eyes[J].Br J Ophthalmol,2010,94(5):666-667.
10黄锦海,李坚,杨欣,等.新型眼球生物测量仪Lenstar的原理及其临床应用[J].中华眼视光学与视觉科学杂志,2013,15(5):314-317.
11 Tai LY,Khaw KW,Nq CM,et al.Central corneal thickness measurements with different imaging devices and ultrasound pachymetry[J].Cornea,2013,32(6):766-771.
12张鸿蹈,蒋华.三种角膜测厚仪测量近视患者中央角膜厚度的对比[J].国际眼科杂志,2013,13(9):1801-1804.
13王顺清,孙成淑,张小兰,等.Lenstar LS 900与角膜超声测厚仪测量角膜中央厚度的对比观察[J].临床眼科杂志,2012,20(4):307-309.
14 Koktekir BE,Gcdik S,Bakbak B.Comparison of central corneal thickness measurements with optical low-coherence reflectometry and ultrasound pachymetry and reproducibility of both devices[J].Cornea,2012,31(11):1278-1281.
15 Huang J,Pesudovs K,Wen D,et al.Comparison of anterior segment measurements with rotating Scheimpflug photography and partial coherence reflectometry[J].Cataract Refract Surg,2011,37(2):341-348.
16 O'Donnell C,Hartwig A,Radhakrishnan H.Comparison of Central Corneal Thickness and Anterior Chamber Depth Measured Using LenStar LS900 Pentacam and Visante AS-OCT[J].Cornea,2012,31(9):983-988.
17洪华丽,王英,肖信,等.护理干预对角膜屈光手术后遵医行为及视觉满意度的影响[J].中国临床新医学,2015,8(4):364-367.
18 Bjelos RM,Busic M,Cima I,et al.Intraobserver and interobserver repeatability of ocular components measurement in cataract eyes using a new optical low coherence reflectometer[J].Graefes Arch Clin Exp Ophthalmol,2011,249(1):83-87.