吸入镇静在重症医学科的应用
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摘要
重症医学科(ICU)镇静治疗已成为一项基本的治疗措施。最近文献报道ICU应用吸入镇静在唤醒时间、简单遵医嘱动作时间上要短于持续静脉注射镇静,而且有心脏、大脑等器官功能保护作用。目前国内ICU尚未见吸入镇静报道,本文将对吸入镇静在ICU中的应用做一综述。
Sedation has become one of the basic treatment in intensive care unit(ICU). Existing studies have demonstrated inhalation sedation might reduce the time to wake-up, time to follow the order,and has a protection for heart and brain. In this review, we summarized the advantages of using inhalation sedation in intensive care unit.
Sedation has become one of the basic treatment in intensive care unit(ICU). Existing studies have demonstrated inhalation sedation might reduce the time to wake-up, time to follow the order,and has a protection for heart and brain. In this review, we summarized the advantages of using inhalation sedation in intensive care unit.
引文
1中华医学会重症医学分会.中国重症加强治疗病房患者镇痛和镇静治疗指导意见(2006)[J].中华外科杂志,2006,44(17):1158-1166.
2 Barr J,Fraser GL,Puntillo K,et al.Clinical practice guidelines for the management of pain,agitation,and delirium in adult patients in the intensive care unit[J].Crit Care Med,2013,41(1):263-306.
3 Barr J,Fraser GL,Puntillo K,et al.Clinical practice guidelines for the management of pain,agitation,and delirium in adult patients in the Intensive Care Unit:executive summary[J].Am J Health Syst Pharm,2013,70(1):53-8.
4 Martin J,Heymann A,B?sell K,et al.Evidence and consensus-based German guidelines for the management of analgesia,sedation and delirium in intensive care--short version[J].Ger Med Sci,2010,8:Doc02.
5 Shafer A.Complications of sedation with midazolam in the intensive care unit and a comparison with other sedative regimens[J].Crit Care Med,1998,26(5):947-956.
6 Smuszkiewicz P,Wiczling P,Przyby?owski K,et al.T h e pharmacokinetics of propofol in ICUpatients undergoing long-term sedation[J].Biopharm Drug Dispos,2016,37(8):456-466.
7 Page VJ,McAuley DF.Sedation/drugs used in intensive care sedation[J].Curr Opin Anaesthesiol,2015,28(2):139-144.
8 Sakai EM,Connolly LA,Klauck JA.Inhalation anesthesiology and volatile liquid anesthetics:focus on isoflurane,desflurane,and sevoflurane[J].Pharmacotherapy,2005,25(12):1773-1788.
9 Misra S,Koshy T.A review of the practice of sedation with inhalational anaesthetics in the intensive care unit with the AnaConDa(?)device[J].Indian J Anaesth,2012,56(6):518-523.
10 Sackey PV,Martling CR,Granath F,et al.Prolonged isoflurane sedation of intensive care unit patients with the Anesthetic Conserving Device[J].Crit Care Med,2004,32(11):2241-2246.
11 Mesnil M,Capdevila X,Bringuier S,et al.Long-term sedation in intensive care unit:a randomized comparison between inhaled sevoflurane and intravenous propofol or midazolam[J].Intensive Care Med,2011,37(6):933-941.
12 Hellstr?m J,?wall A,Sackey PV.Wake-up times following sedation with sevoflurane versus propofol after cardiac surgery[J].Scand Cardiovasc J,2012,46(5):262-268.
13 R?hm KD,Wolf MW,Sch?llhorn T,et al.Short-term sevoflurane sedation using the Anaesthetic Conserving Device after cardiothoracic surgery[J].Intensive Care Med,2008,34(9):1683-1689.
14 L′her E,Dy L,Pili R,et al.Feasibility and potential cost/benefit of routine isoflurane sedation using an anesthetic-conserving device:a prospective observational study[J].Respir Care,2008,53(10):1295-1303.
15 B?sel J,Purrucker JC,Nowak F,et al.Volatile isoflurane sedation in cerebrovascular intensive care patients using AnaConDa(?):effects on cerebral oxygenation,circulation,and pressure[J].Intensive Care Med,2012,38(12):1955-1964.
16 Villa F,Iacca C,Molinari AF,et al.Inhalation versus endovenous sedation in subarachnoid hemorrhage patients:effects on regional cerebral blood flow[J].Crit Care Med,2012,40(10):2797-2804.
17 Steurer MP,Steurer MA,Baulig W,et al.Late pharmacologic conditioning with volatile anesthetics after cardiac surgery[J].Crit Care,2012,16(5):R191.
18 Baron R,Binder A,Biniek R,et al.Evidence and consensus based guideline for the management of delirium,analgesia,and sedation in intensive care medicine.Revision 2015(DAS-Guideline 2015)-short version[J].Ger Med Sci,2015,13:Doc19.
19 Geisser W,Schreiber M,Hofbauer H,et al.Sevoflurane versus isoflurane--anaesthesia for lower abdominal surgery.Effects on perioperative glucose metabolism[J].Acta Anaesthesiol Scand,2003,47(2):174-179.
2 Barr J,Fraser GL,Puntillo K,et al.Clinical practice guidelines for the management of pain,agitation,and delirium in adult patients in the intensive care unit[J].Crit Care Med,2013,41(1):263-306.
3 Barr J,Fraser GL,Puntillo K,et al.Clinical practice guidelines for the management of pain,agitation,and delirium in adult patients in the Intensive Care Unit:executive summary[J].Am J Health Syst Pharm,2013,70(1):53-8.
4 Martin J,Heymann A,B?sell K,et al.Evidence and consensus-based German guidelines for the management of analgesia,sedation and delirium in intensive care--short version[J].Ger Med Sci,2010,8:Doc02.
5 Shafer A.Complications of sedation with midazolam in the intensive care unit and a comparison with other sedative regimens[J].Crit Care Med,1998,26(5):947-956.
6 Smuszkiewicz P,Wiczling P,Przyby?owski K,et al.T h e pharmacokinetics of propofol in ICUpatients undergoing long-term sedation[J].Biopharm Drug Dispos,2016,37(8):456-466.
7 Page VJ,McAuley DF.Sedation/drugs used in intensive care sedation[J].Curr Opin Anaesthesiol,2015,28(2):139-144.
8 Sakai EM,Connolly LA,Klauck JA.Inhalation anesthesiology and volatile liquid anesthetics:focus on isoflurane,desflurane,and sevoflurane[J].Pharmacotherapy,2005,25(12):1773-1788.
9 Misra S,Koshy T.A review of the practice of sedation with inhalational anaesthetics in the intensive care unit with the AnaConDa(?)device[J].Indian J Anaesth,2012,56(6):518-523.
10 Sackey PV,Martling CR,Granath F,et al.Prolonged isoflurane sedation of intensive care unit patients with the Anesthetic Conserving Device[J].Crit Care Med,2004,32(11):2241-2246.
11 Mesnil M,Capdevila X,Bringuier S,et al.Long-term sedation in intensive care unit:a randomized comparison between inhaled sevoflurane and intravenous propofol or midazolam[J].Intensive Care Med,2011,37(6):933-941.
12 Hellstr?m J,?wall A,Sackey PV.Wake-up times following sedation with sevoflurane versus propofol after cardiac surgery[J].Scand Cardiovasc J,2012,46(5):262-268.
13 R?hm KD,Wolf MW,Sch?llhorn T,et al.Short-term sevoflurane sedation using the Anaesthetic Conserving Device after cardiothoracic surgery[J].Intensive Care Med,2008,34(9):1683-1689.
14 L′her E,Dy L,Pili R,et al.Feasibility and potential cost/benefit of routine isoflurane sedation using an anesthetic-conserving device:a prospective observational study[J].Respir Care,2008,53(10):1295-1303.
15 B?sel J,Purrucker JC,Nowak F,et al.Volatile isoflurane sedation in cerebrovascular intensive care patients using AnaConDa(?):effects on cerebral oxygenation,circulation,and pressure[J].Intensive Care Med,2012,38(12):1955-1964.
16 Villa F,Iacca C,Molinari AF,et al.Inhalation versus endovenous sedation in subarachnoid hemorrhage patients:effects on regional cerebral blood flow[J].Crit Care Med,2012,40(10):2797-2804.
17 Steurer MP,Steurer MA,Baulig W,et al.Late pharmacologic conditioning with volatile anesthetics after cardiac surgery[J].Crit Care,2012,16(5):R191.
18 Baron R,Binder A,Biniek R,et al.Evidence and consensus based guideline for the management of delirium,analgesia,and sedation in intensive care medicine.Revision 2015(DAS-Guideline 2015)-short version[J].Ger Med Sci,2015,13:Doc19.
19 Geisser W,Schreiber M,Hofbauer H,et al.Sevoflurane versus isoflurane--anaesthesia for lower abdominal surgery.Effects on perioperative glucose metabolism[J].Acta Anaesthesiol Scand,2003,47(2):174-179.