中药穴位贴敷治疗慢性阻塞性肺疾病稳定期的疗效
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摘要
目的:研究中药穴位贴敷治疗慢性阻塞性肺疾病(COPD)稳定期的疗效及对患者血清炎症因子、免疫功能的影响。方法:选取我院2014年2月—2015年6月收治的COPD患者114例,按随机数字表法分为对照组和研究组,各57例。对照组给予舒利迭(1吸/次,bid)治疗,研究组在对照组的基础上给予自制穴位贴敷中药方[分别贴于天突、中府(双侧)、定喘(双侧)、肺俞(双侧),每次贴敷8～12 h,qw]治疗。比较两组治疗效果、血清炎症因子及免疫功能指标水平。结果:研究组治疗总有效率为96.49%,高于对照组的77.19%,差异有统计学意义(P <0.05);治疗后两组干扰素(IFN)-γ、肿瘤坏死因子(TNF)-α水平较治疗前明显下降,且研究组明显低于对照组,差异有统计学意义(P <0.05);治疗后研究组T淋巴细胞亚群CD4~+、CD8~+及CD4~+/CD8~+明显高于对照组,差异有统计学意义(P <0.05)。结论:中药穴位贴敷治疗COPD稳定期疗效确切,可有效调节患者免疫功能,改善炎症状态,值得临床推广。
Objective: To study the therapeutic effect of acupoint application of traditional Chinese medicine on stable phase of chronic obstructive pulmonary disease(COPD) and its effect on serum in?ammatory factors and immune functions in the patients. Methods: 114 patients with COPD admitted to our hospital from February 2014 to June 2015 were selected and randomly divided into a control group and a study group, 57 cases each. The patients in the control group were treated with seretide(1 inhalation/time, bid), and the patients in the study group were treated with the acupoint application of self-made Chinese medicine on the basis of the control group [application on Tiantu,Zhongfu(bilateral), Dingchuan(bilaterally), Feishu(bilateral), application once for 8～12 h, qw]. The therapeutic effect and the levels of serum in?ammatory factors and immune function indexes were compared between the two groups. Results: The total effective rate in the study group was 96.49%, which was higher than 77.19% in the control group, and the difference was statistically signi?cant(P<0.05). The levels of interferon(IFN)-γ and tumor necrosis factor(TNF)-α in the two groups after treatment were signi?cantly lower than those before treatment, and the levels in the study group were signi?cantly lower than those in the control group, with statistically signi?cant differences(P<0.05). After treatment, the levels of T lymphocyte subsets CD4~+, CD8~+ and CD4~+/CD8~+ in the study group were signi?cantly higher than those in the control group, and the differences were statistically signi?cant(P<0.05).Conclusion: The acupoint application of traditional Chinese medicine is effective in the treatment of stable phase of COPD, which can effectively regulate the immune functions of patients and improve in?ammatory state, and is worthy of clinical promotion.
Objective: To study the therapeutic effect of acupoint application of traditional Chinese medicine on stable phase of chronic obstructive pulmonary disease(COPD) and its effect on serum in?ammatory factors and immune functions in the patients. Methods: 114 patients with COPD admitted to our hospital from February 2014 to June 2015 were selected and randomly divided into a control group and a study group, 57 cases each. The patients in the control group were treated with seretide(1 inhalation/time, bid), and the patients in the study group were treated with the acupoint application of self-made Chinese medicine on the basis of the control group [application on Tiantu,Zhongfu(bilateral), Dingchuan(bilaterally), Feishu(bilateral), application once for 8～12 h, qw]. The therapeutic effect and the levels of serum in?ammatory factors and immune function indexes were compared between the two groups. Results: The total effective rate in the study group was 96.49%, which was higher than 77.19% in the control group, and the difference was statistically signi?cant(P<0.05). The levels of interferon(IFN)-γ and tumor necrosis factor(TNF)-α in the two groups after treatment were signi?cantly lower than those before treatment, and the levels in the study group were signi?cantly lower than those in the control group, with statistically signi?cant differences(P<0.05). After treatment, the levels of T lymphocyte subsets CD4~+, CD8~+ and CD4~+/CD8~+ in the study group were signi?cantly higher than those in the control group, and the differences were statistically signi?cant(P<0.05).Conclusion: The acupoint application of traditional Chinese medicine is effective in the treatment of stable phase of COPD, which can effectively regulate the immune functions of patients and improve in?ammatory state, and is worthy of clinical promotion.
引文
[1]李风森,同立宏,荆晶,等.穴位贴敷治疗慢性阻塞性肺疾病稳定期选穴及用药规律研究[J].中国中医药信息杂志,2012,19(6):24-27.
[2]中华医学会呼吸病学分会慢性阻塞性肺疾病学组.慢性阻塞性肺疾病诊治指南[J].中华内科杂志,2002,41(9):640-646.
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[4]李竹英,田春燕,高风丽.中药穴位贴敷治疗慢性阻塞性肺疾病稳定期60例临床观察[J].中华中医药杂志,2015,30(11):4186-4188.
[5]武翠梅,张美超,代佳,等.慢性阻塞性肺疾病的临床治疗进展[J].吉林医药学院学报, 2016,37(4):294-297.
[6]张会娜,刘卫红,李萍.中药穴位贴敷法防治呼吸系统常见疾病应用概况[J].中华中医药杂志,2009,24(6):771-773.
[7]田怡,王蕾,刘瑞华,等.冬病夏治消喘膏穴位贴敷对稳定期慢性阻塞性肺病患者炎症因子的影响[J].中医杂志,2013,54(10):843-845.
[8]邢筱华.冬病夏治穴位贴敷对慢性阻塞性肺疾病稳定期患者免疫因子的影响[J].陕西中医,2014,35(8):949-951.
[2]中华医学会呼吸病学分会慢性阻塞性肺疾病学组.慢性阻塞性肺疾病诊治指南[J].中华内科杂志,2002,41(9):640-646.
[3]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002,113-115.
[4]李竹英,田春燕,高风丽.中药穴位贴敷治疗慢性阻塞性肺疾病稳定期60例临床观察[J].中华中医药杂志,2015,30(11):4186-4188.
[5]武翠梅,张美超,代佳,等.慢性阻塞性肺疾病的临床治疗进展[J].吉林医药学院学报, 2016,37(4):294-297.
[6]张会娜,刘卫红,李萍.中药穴位贴敷法防治呼吸系统常见疾病应用概况[J].中华中医药杂志,2009,24(6):771-773.
[7]田怡,王蕾,刘瑞华,等.冬病夏治消喘膏穴位贴敷对稳定期慢性阻塞性肺病患者炎症因子的影响[J].中医杂志,2013,54(10):843-845.
[8]邢筱华.冬病夏治穴位贴敷对慢性阻塞性肺疾病稳定期患者免疫因子的影响[J].陕西中医,2014,35(8):949-951.