啮齿动物热量限制的注意事项
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摘要
热量限制在延缓衰老、抗癌、治疗糖尿病等慢性代谢疾病的作用显著,目前热量限制的方案并没有统一的标准,具有明显争议。限食的时间长短、组份、喂养的时间段不同,动物的种类等都可能影响实验的结果,本文就热量限制过程中的相关影响因素进行综述。
Calorie restriction has a significant role in delaying aging, anti-cancer, and treating chronic metabolic diseases such as diabetes. Currently, there is no uniform standard scheme for calorie restriction programs, which is obviously controversial. The length of time, the composition of food, the feeding time and the type of animal may affect the results of the experiment. This paper reviews the relevant influence factors in the process of calorie restriction.
Calorie restriction has a significant role in delaying aging, anti-cancer, and treating chronic metabolic diseases such as diabetes. Currently, there is no uniform standard scheme for calorie restriction programs, which is obviously controversial. The length of time, the composition of food, the feeding time and the type of animal may affect the results of the experiment. This paper reviews the relevant influence factors in the process of calorie restriction.
引文
[1]Most J,Tosti V,Redman LM,et al.Calorie restriction in humans:an update[J].Ageing Res Rev,2017,39:36-45.
[2]陈国芳,刘超.对限食疗法的新认识[J].中华内分泌代谢杂志,2013,29(4):269-272.
[3]李春睿,徐书杭,蔡可英,等.限食疗法对2型糖尿病的预防和治疗作用[J].国际内分泌代谢杂志,2014,34(2):123-126.
[4]Robertson LT,Mitchell JR.Benefits of short-term dietary restriction in mammals[J].Exp Gerontol,2013,48(10):1043-1048.
[5]Park S,Komatsu T,Hayashi H,et al.Calorie restriction initiated at middle age improved glucose tolerance without affecting age-related impairments of insulin signaling in rat skeletal muscle[J].Exp Gerontol,2006,41(9):837-845.
[6]Sarker MR,Franks S,Sumien N,et al.Curcumin mimics the neurocognitive and anti-inflammatory effects of caloric restriction in a mouse model of midlife obesity[J].PLo SOne,2015,10(10):e0140431.
[7]Dhurandhar EJ,Allison DB,Van GT,et al.Hunger in the absence of caloric restriction improves cognition and attenuates Alzheimer′s disease pathology in a mouse model[J]PLo S One,2013,8(4):e60437.
[8]Tikoo K,Tripathi DN,Kabra DG,et al.Intermittent fasting prevents the progression of typeⅠdiabetic nephropathy in rats and changes the expression of Sir2 and p53[J].Febs Letters,2007,581(5):1071-1078.
[9]Marie C,Bralet AM,Gueldry S,et al.Fasting prior to transient cerebral ischemia reduces delayed neuronal necrosis[J]Metab Brain Dis,1990,5(2):65-75.
[10]Chiba T,Ezaki O.Dietary restriction suppresses inflammation and delays the onset of stroke in stroke-prone spontaneously hypertensive rats[J].Biochem Biophys Res Commun,2010,399(1):98-103.
[11]Longo VD,Panda S.Fasting,circadian rhythms,and timerestricted feeding in healthy lifespan[J].Cell Metab,2016,23(6):1048-1059.
[12]Perry RJ,Peng L,Cline GW,et al.Mechanisms by which a very-low-calorie diet reverses hyperglycemia in a rat model of type 2 diabetes[J].Cell Metab,2017,27(1):210.
[13]Liao CY,Rikke BA,Johnson TE,et al.Fat maintenance is a predictor of the murine lifespan response to dietary restriction[J].Aging Cell,2011,10(4):629-639.
[14]Mitchell SJ,Matute JM,Scheibyeknudsen M,et al.Effects of sex,strain,and energy intake on hallmarks of aging in mice[J].Cell Metab,2016,23(6):1093-1112.
[15]Wan R,Camandola S,Mattson MP.Intermittent fasting and dietary supplementation with 2-deoxy-D-glucose improve functional and metabolic cardiovascular risk factors in rats[J].Faseb J,2003,17(9):1133-1134.
[16]Tikoo K,Tripathi DN,Kabra DG,et al.Intermittent fasting prevents the progression of type I diabetic nephropathy in rats and changes the expression of Sir2 and p53[J].Febs Lett,2007,581(5):1071-1078.
[17]Belkacemi L,Selseletattou G,Hupkens E,et al.Intermittent fasting modulation of the diabetic syndrome in streptozotocin-injected rats[J].Int J Endocrinol,2011,2012(2):962012.
[18]Mattson MP.Lifelong brain health is a lifelong challenge:from evolutionary principles to empirical evidence[J].Ageing Research Reviews,2015,20:37-45.
[19]Brandhorst S,Choi IY,Wei M,et al.A periodic diet that mimics fasting promotes multi-system regeneration,enhanced cognitive performance,and healthspan[J].Cell Metab,2015,22(1):86.
[20]Duncan MJ,Smith JT,Narbaiza J,et al.Restricting feeding to the active phase in middle-aged mice attenuates adverse metabolic effects of a high-fat diet[J].Physiol Behav,2016,167:1-9.
[21]Belkacemi L,Selselet-Attou G,Louchami K,et al.Intermittent fasting modulation of the diabetic syndrome in sand rats.II.In vivo investigations[J].Int J Mol Med,2010,26(5):759-765.
[22]Hatori M,Vollmers C,Zarrinpar A,et al.Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet[J].Cell Metab,2012,15(6):848-860.
[23]Hattori S,Park JH,Agata U,et al.Food restriction causes low bone strength and microarchitectural deterioration in exercised growing male rats[J].J Nutr Sci Vitaminol(Tokyo),2014,60(1):35-42.
[24]Haraguchi A,Aoki N,Ohtsu T,et al.Controlling access time to a high-fat diet during the inactive period protects against obesity in mice[J].Chronobiol Int,2014,31(8):935-944.
[25]Halade GV,Rahman MM,Bhattacharya A,et al.Docosahexaenoic acid-enriched fish oil attenuates kidney disease and prolongs median and maximal life span of autoimmune lupus-prone mice[J].J Immunol,184(9),5280-5286.
[26]Tsuduki T,Honma T,Nakagawa K,et al.Long-term intake of fish oil increases oxidative stress and decreases lifespan in senescence-accelerated mice[J].Nutrition,2011,27(3):334-337.
[27]Cerqueira FM,Kowaltowski AJ.Commonly adopted caloric restriction protocols often involve malnutrition[J].Ageing Res Rev,2010,9(4):424-430.
[28]Couteur DGL,Solonbiet S,Wahl D,et al.New Horizons:Dietary protein,ageing and the Okinawan ratio[J].Age Ageing,2016,45(4):443-447.
[29]Ayala V,NaudíA,Sanz A,et al.Dietary protein restriction decreases oxidative protein damage,peroxidizability index,and mitochondrial complex I content in rat liver[J].J Gerontol A Biol Sci Med Sci,2007,62(4):352-360.
[30]Sanz A,Caro P,Ayala V,et al.Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins[J].Faseb J,2006,20(8):1064-1073.
[31]Speakman JR,Mitchell SE,Mazidi M.Calories or Protein?The effect of dietary restriction on lifespan in rodents is explained by calories alone[J].Exp Gerontol,2016,86:28-38.
[2]陈国芳,刘超.对限食疗法的新认识[J].中华内分泌代谢杂志,2013,29(4):269-272.
[3]李春睿,徐书杭,蔡可英,等.限食疗法对2型糖尿病的预防和治疗作用[J].国际内分泌代谢杂志,2014,34(2):123-126.
[4]Robertson LT,Mitchell JR.Benefits of short-term dietary restriction in mammals[J].Exp Gerontol,2013,48(10):1043-1048.
[5]Park S,Komatsu T,Hayashi H,et al.Calorie restriction initiated at middle age improved glucose tolerance without affecting age-related impairments of insulin signaling in rat skeletal muscle[J].Exp Gerontol,2006,41(9):837-845.
[6]Sarker MR,Franks S,Sumien N,et al.Curcumin mimics the neurocognitive and anti-inflammatory effects of caloric restriction in a mouse model of midlife obesity[J].PLo SOne,2015,10(10):e0140431.
[7]Dhurandhar EJ,Allison DB,Van GT,et al.Hunger in the absence of caloric restriction improves cognition and attenuates Alzheimer′s disease pathology in a mouse model[J]PLo S One,2013,8(4):e60437.
[8]Tikoo K,Tripathi DN,Kabra DG,et al.Intermittent fasting prevents the progression of typeⅠdiabetic nephropathy in rats and changes the expression of Sir2 and p53[J].Febs Letters,2007,581(5):1071-1078.
[9]Marie C,Bralet AM,Gueldry S,et al.Fasting prior to transient cerebral ischemia reduces delayed neuronal necrosis[J]Metab Brain Dis,1990,5(2):65-75.
[10]Chiba T,Ezaki O.Dietary restriction suppresses inflammation and delays the onset of stroke in stroke-prone spontaneously hypertensive rats[J].Biochem Biophys Res Commun,2010,399(1):98-103.
[11]Longo VD,Panda S.Fasting,circadian rhythms,and timerestricted feeding in healthy lifespan[J].Cell Metab,2016,23(6):1048-1059.
[12]Perry RJ,Peng L,Cline GW,et al.Mechanisms by which a very-low-calorie diet reverses hyperglycemia in a rat model of type 2 diabetes[J].Cell Metab,2017,27(1):210.
[13]Liao CY,Rikke BA,Johnson TE,et al.Fat maintenance is a predictor of the murine lifespan response to dietary restriction[J].Aging Cell,2011,10(4):629-639.
[14]Mitchell SJ,Matute JM,Scheibyeknudsen M,et al.Effects of sex,strain,and energy intake on hallmarks of aging in mice[J].Cell Metab,2016,23(6):1093-1112.
[15]Wan R,Camandola S,Mattson MP.Intermittent fasting and dietary supplementation with 2-deoxy-D-glucose improve functional and metabolic cardiovascular risk factors in rats[J].Faseb J,2003,17(9):1133-1134.
[16]Tikoo K,Tripathi DN,Kabra DG,et al.Intermittent fasting prevents the progression of type I diabetic nephropathy in rats and changes the expression of Sir2 and p53[J].Febs Lett,2007,581(5):1071-1078.
[17]Belkacemi L,Selseletattou G,Hupkens E,et al.Intermittent fasting modulation of the diabetic syndrome in streptozotocin-injected rats[J].Int J Endocrinol,2011,2012(2):962012.
[18]Mattson MP.Lifelong brain health is a lifelong challenge:from evolutionary principles to empirical evidence[J].Ageing Research Reviews,2015,20:37-45.
[19]Brandhorst S,Choi IY,Wei M,et al.A periodic diet that mimics fasting promotes multi-system regeneration,enhanced cognitive performance,and healthspan[J].Cell Metab,2015,22(1):86.
[20]Duncan MJ,Smith JT,Narbaiza J,et al.Restricting feeding to the active phase in middle-aged mice attenuates adverse metabolic effects of a high-fat diet[J].Physiol Behav,2016,167:1-9.
[21]Belkacemi L,Selselet-Attou G,Louchami K,et al.Intermittent fasting modulation of the diabetic syndrome in sand rats.II.In vivo investigations[J].Int J Mol Med,2010,26(5):759-765.
[22]Hatori M,Vollmers C,Zarrinpar A,et al.Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet[J].Cell Metab,2012,15(6):848-860.
[23]Hattori S,Park JH,Agata U,et al.Food restriction causes low bone strength and microarchitectural deterioration in exercised growing male rats[J].J Nutr Sci Vitaminol(Tokyo),2014,60(1):35-42.
[24]Haraguchi A,Aoki N,Ohtsu T,et al.Controlling access time to a high-fat diet during the inactive period protects against obesity in mice[J].Chronobiol Int,2014,31(8):935-944.
[25]Halade GV,Rahman MM,Bhattacharya A,et al.Docosahexaenoic acid-enriched fish oil attenuates kidney disease and prolongs median and maximal life span of autoimmune lupus-prone mice[J].J Immunol,184(9),5280-5286.
[26]Tsuduki T,Honma T,Nakagawa K,et al.Long-term intake of fish oil increases oxidative stress and decreases lifespan in senescence-accelerated mice[J].Nutrition,2011,27(3):334-337.
[27]Cerqueira FM,Kowaltowski AJ.Commonly adopted caloric restriction protocols often involve malnutrition[J].Ageing Res Rev,2010,9(4):424-430.
[28]Couteur DGL,Solonbiet S,Wahl D,et al.New Horizons:Dietary protein,ageing and the Okinawan ratio[J].Age Ageing,2016,45(4):443-447.
[29]Ayala V,NaudíA,Sanz A,et al.Dietary protein restriction decreases oxidative protein damage,peroxidizability index,and mitochondrial complex I content in rat liver[J].J Gerontol A Biol Sci Med Sci,2007,62(4):352-360.
[30]Sanz A,Caro P,Ayala V,et al.Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins[J].Faseb J,2006,20(8):1064-1073.
[31]Speakman JR,Mitchell SE,Mazidi M.Calories or Protein?The effect of dietary restriction on lifespan in rodents is explained by calories alone[J].Exp Gerontol,2016,86:28-38.