复方杏香兔耳风胶囊联合克拉霉素治疗慢性宫颈炎的临床研究
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摘要
目的探讨复方杏香兔耳风胶囊联合克拉霉素治疗慢性宫颈炎的临床疗效。方法选取2016年8月—2017年8月在河北省第七人民医院就诊的130例患者。随机分为对照组和治疗组,每组各65例。对照组口服克拉霉素片,1片/次,2次/d;治疗组在对照组治疗基础上口服杏香兔耳风胶囊,4粒/次,3次/d。所有患者均连续用药2周。观察两组的临床疗效,比较两组糜烂创面愈合时间、VAS评分、SF-36评分及血清学指标的变化情况。随访6个月,比较两组的复发率。结果治疗后,对照组和治疗组的总有效率分别是83.08%、95.38%,两组比较差异具有统计学意义(P<0.05)。治疗后,治疗组患者糜烂创面愈合时间要明显短于对照组,两组比较差异有统计学意义(P<0.05);治疗后,两组VAS评分较治疗前显著降低,SF-36评分显著升高,同组治疗前后比较差异均有统计学意义(P<0.05);治疗后,治疗组VAS评分低于对照组,SF-36评分高于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组血清肿瘤坏死因子-α(TNF-α)较治疗前均显著降低,而白细胞介素-10(IL-10)、血管内皮生长因子(VEGF)水平显著升高,同组治疗前后比较差异均有统计学意义(P<0.05);治疗后,治疗组TNF-α低于对照组,而IL-10、VEGF水平高于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,对照组和治疗组的不良反应发生率分别是13.85%、3.08%,两组复发率分别是13.85%、3.08%,两组比较差异具有统计学意义(P<0.05)。结论复方杏香兔耳风胶囊联合克拉霉素治疗慢性宫颈炎具有较好的临床疗效,可加速宫颈糜烂的修复,降低复发率,具有一定的临床推广应用价值。
Objective To investigate the clinical effect of Compound Xingxiang Tuerfeng Capsules combined with clarithromycin in treatment of chronic cervicitis. Methods 130 Patients with chronic cervicitis in the Seventh People's Hospital of Hebei Province from August 2016 to August 2017 were randomly divided into control(65 cases) and treatment(65 cases) groups. Patients in the control group were po administered with Clarithromycin Tablets, 1 tablet/time, twice daily. Patients in the treatment group were po administered with Xingxiang Tuerfeng Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacy was evaluated, and the changes of erosion wound healing time, VAS score, SF-36 score, and serological indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment group were 83.08% and 95.38%, and there were differences between two groups(P < 0.05). After treatment, erosion wound healing time in the treatment group was shorter than that in the control group, and there were differences between two groups(P < 0.05). After treatment, VAS score in the two groups was significantly decreased, but SF-36 score was significantly increased, and there were differences in the same group(P < 0.05). After treatment, VAS score in the treatment group was lower than that in the control group, but SF-36 score was higher than that in the control group, and there were differences between two groups(P < 0.05). After treatment, TNF-α in the two groups was significantly decreased, but IL-10 and VEGF were significantly increased, and there were differences in the same group(P < 0.05). After treatment, TNF-α in the treatment group was lower than that in the control group, but IL-10 and VEGF were higher than those in the control group, and there were differences between two groups(P < 0.05). Conclusion Compound Xingxiang Tuerfeng Capsules combined with clarithromycin has significant clinical effect in treatment of chronic cervicitis, and can accelerate the repair of cervical erosion, and also can reduce the recurrence rate, which has a certain clinical application value.
Objective To investigate the clinical effect of Compound Xingxiang Tuerfeng Capsules combined with clarithromycin in treatment of chronic cervicitis. Methods 130 Patients with chronic cervicitis in the Seventh People's Hospital of Hebei Province from August 2016 to August 2017 were randomly divided into control(65 cases) and treatment(65 cases) groups. Patients in the control group were po administered with Clarithromycin Tablets, 1 tablet/time, twice daily. Patients in the treatment group were po administered with Xingxiang Tuerfeng Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacy was evaluated, and the changes of erosion wound healing time, VAS score, SF-36 score, and serological indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment group were 83.08% and 95.38%, and there were differences between two groups(P < 0.05). After treatment, erosion wound healing time in the treatment group was shorter than that in the control group, and there were differences between two groups(P < 0.05). After treatment, VAS score in the two groups was significantly decreased, but SF-36 score was significantly increased, and there were differences in the same group(P < 0.05). After treatment, VAS score in the treatment group was lower than that in the control group, but SF-36 score was higher than that in the control group, and there were differences between two groups(P < 0.05). After treatment, TNF-α in the two groups was significantly decreased, but IL-10 and VEGF were significantly increased, and there were differences in the same group(P < 0.05). After treatment, TNF-α in the treatment group was lower than that in the control group, but IL-10 and VEGF were higher than those in the control group, and there were differences between two groups(P < 0.05). Conclusion Compound Xingxiang Tuerfeng Capsules combined with clarithromycin has significant clinical effect in treatment of chronic cervicitis, and can accelerate the repair of cervical erosion, and also can reduce the recurrence rate, which has a certain clinical application value.
引文
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[13]王彦敏.血管生成因子VEGF研究进展[J].河北医药,2010,32(11):1456-1458.
[2]韦日葵.慢性宫颈炎病因和治疗方法的研究[J].中国医药科学,2012,2(10):40-42.
[3]邹达亮,张佳,糜志远.克拉霉素制剂研究应用进展[J].中国医院药学杂志,2016,36(24):2222-2225.
[4]崔雪靖,张橡楠,康文艺.复方杏香兔耳风研究进展[J].河南大学学报:医学版,2014,33(1):68-71.
[5]谢幸,苟文丽.妇产科学[M].第8版.北京:人民卫生出版社,2013:255-257.
[6]孙传兴,张学庸,李焕章,等.临床疾病诊断治愈好转标准[M].北京:人民军医出版社,1998:530-531.
[7]严广斌.视觉模拟评分法[J].中华关节外科杂志:电子版,2014,8(2):34.
[8]李鲁,王红妹,沈毅.SF-36健康调查量表中文版的研制及其性能测试[J].中华预防医学杂志,2002,36(2):109-113.
[9]黎瑞英.慢性宫颈炎的诊断治疗研究进展[J].北方药学,2011,8(3):36-38.
[10]王晓燕.克拉霉素临床应用进展[J].中国社区医师,2007,23(15):20.
[11]Sawada M,Otsuki K,Mitsukawa K,et al.下生殖道感染孕妇宫颈黏液中的宫颈炎症细胞因子及其他炎症标志物[J].世界核心医学期刊文摘:妇产科学分册,2006,2(5):56.
[12]朱平,杜小萍,鞠吉雨.IL-10与疾病关系的研究进展[J].国际免疫学杂志,2012,35(1):14-17.
[13]王彦敏.血管生成因子VEGF研究进展[J].河北医药,2010,32(11):1456-1458.