硒多糖药理作用的研究进展
|
摘要
硒多糖是一种有机硒化合物,兼具硒和多糖的活性且具有相当高的药用价值。除此之外,硒多糖还具有良好的抗氧化,抗肿瘤,提高机体免疫力等生物作用,已成为近年来的研究热点。目前已知的富含硒多糖的产品有酵母硒多糖、海藻硒多糖、灵芝硒多糖等,其中大部分已被广泛应用于临床。因为目前对硒多糖的药理作用机制尚不完全清楚,有待进一步研究,因此本文就现已发现的硒多糖的药理作用综述如下,旨在为以后硒多糖的进一步研究提供参考和理论依据。
Selenium polysaccharide is a kind of organic selenium compounds,which has both the activities of selenium and polysaccharide and has quite high medicinal value.In addition,selenium–polysaccharide also has good biological activities such as good anti-oxidation,anti-tumor and enhance the body's immunity,which has become a research hotspot in recent years.At present,selenium-rich products are known as yeast seleniumpolysaccharide,seaweed selenium-polysaccharide and ganoderma selenium-polysaccharide,most of which have been widely applied in clinical.The pharmacological mechanisms of selenium-polysaccharide are not completely clear and need to be further studied.Therefore,In order to provide reference and theoretical basis for further study of selenium-polysaccharide in the futher,the pharmacological actions of selenium polysaccharide are summarized as follows.
Selenium polysaccharide is a kind of organic selenium compounds,which has both the activities of selenium and polysaccharide and has quite high medicinal value.In addition,selenium–polysaccharide also has good biological activities such as good anti-oxidation,anti-tumor and enhance the body's immunity,which has become a research hotspot in recent years.At present,selenium-rich products are known as yeast seleniumpolysaccharide,seaweed selenium-polysaccharide and ganoderma selenium-polysaccharide,most of which have been widely applied in clinical.The pharmacological mechanisms of selenium-polysaccharide are not completely clear and need to be further studied.Therefore,In order to provide reference and theoretical basis for further study of selenium-polysaccharide in the futher,the pharmacological actions of selenium polysaccharide are summarized as follows.
引文
[1]Kieliszek M,Blazejak S.Current knowledge on the importance of selenium in food for living organisms:a review[J].Molecules,2016,21(5):609.
[2]Xu X M,Carlson B A,Grimm T A,et al.Rhesus monkey simian immunod-eficiency virus infection as a model for assessing the role of selenium in AIDS[J].Acquired Immune Defic Syndr,2006,31(5):453-463.
[3]林海鸣,刘艳丽,孙晓飞,等.多糖的药理活性研究概况[J].亚太传统医药,2008,4(2):63-67.
[4]Sun Q,Dong M,Wang Z,et al.Selenium-enriched polysaccharides from Pyracantha(Se-PFPs)inhibit the growth and invasive potential of ovarian cancer cells through inhibitingβ-catenin signaling[J].Oncotarget,2016,7(19):28369-28383.
[5]齐睿婷,颜炳祥,潘道东,等.乳酸乳球菌富硒及其硒多糖抗氧化活性研究[J].食品工业科技,2012,33(11):67-70.
[6]李华为,赵素云,刘晓波,等.硒多糖的抗氧化活性及与过氧化氢酶协同作用的研究[J].分析化学,2010,38(9):1256-1260.
[7]岳丽红,王玉俊,李静,等.黑木耳硒多糖体外抗氧化作用的研究[J].畜牧与饲料科学,2016,37(8):18-19.
[8]Jiang J,Mai H,Xie B,et al.Optimization of Se-rich culture conditions and antioxidant activities of polysaccharides from Morchella esculenta mycelium[J].Food and Fermentation Industries,2016,47(9):120-125.
[9]张越峰,李福艳,吴瑛.红枣多糖及红枣硒多糖抗氧化活性的比较研究[J].食品研究与开发,2015,36(3):4-9.
[10]谷娜,侯艳秋,郑晓凤,等.山药多糖及其硒多糖抗氧化性的比较研究[J].微量元素与健康研究,2016,33(5):41-43.
[11]付欣.灵芝硒多糖诱导乳腺癌MCF-7细胞凋亡过程中的抗氧化作用[D].辽宁:辽宁师范大学,2011.
[12]朱黎霞,周竹音,潘丽媛.黑木耳硒多糖抗肿瘤作用的研究[J].中国中医药科技,2011,18(5):454.
[13]Zhao Y,Xu C,Liang S,et al.Preparation and antioxidation activity of selened lycium barbarum polysaccharides sulfate and its inhibitory effect on Hela cell growth in vitro[J].Chinese pharmacy journal,2012,47(6):423.
[14]邹修文.灵芝硒多糖的合成及抗肿瘤活性研究[D].南宁:广西师范学院,2015.
[15]路则庆.Enterobacter cloacae Z0206富硒多糖对动物生长性能和免疫功能的影响及其作用机制研究[D].杭州:浙江大学,2014.
[16]邱树磊.硒化大蒜多糖和硒化枸杞多糖的增强免疫和抗氧化活性研究[D].江苏:南京农业大学,2014.
[17]李岩,霍娇,吕晓华,等.硒多糖对小鼠免疫功能的影响[J].四川大学学报(医学版),2014,45(3):512-514.
[18]秦韬,胡元亮,王德云,等.硒化修饰能提高当归多糖的免疫增强活性[C].许剑琴.中国畜牧兽医学会会议论文集,2013:221-225.
[19]王宇飞,东方,季宇彬.硒多糖的研究进展[J].赣南医学院学报,2013,33(4):635-637.
[20]张百岩,张天扬,王栗,等.富硒木耳栽培硒多糖提取及抗铅抗汞的研究[J].农业环境保护,2002,21(4):309-313.
[21]聂木海,张全新,柳杨,等.硒多糖对镉中毒大鼠肾保护作用的研究[J].实用预防医学,2005,12(6):1311-1312.
[22]Das K,Jacob V,Bouquegneau J M.White-sided dolphinmetallothioneins:Purification,characterisation and poten-tial role[J].Comp Biochem Physiol Part C,2002,131(3):245-251.
[23]李锦金,盛家荣,邹修文,等.硒多糖的研究进展[J].广西师范学院学报(自然科学版),2014,31(1):41-45.
[24]门晓媛,王一飞,郑文杰,等.纳米硒化裙带菜多糖的制备及其体外抗CVB3病毒作用研究[J].中国卫生检验杂志,2005,15(10):1152-1155.
[25]魏战勇,崔保安,黄克和,等.硒对猪细小病毒体外增殖抑制作用的研究[J].中国病毒学,2005,12(6):1311-1312.
[26]Ning G.Status quo and prospect of prevention and control of diabetes in China[J].Scientia Sinica(Vitae),2018,48(8):810-811.
[27]黄春林,方敏,李邦良,等.甲壳低聚糖-硒对2型糖尿病大鼠血中糖、脂和胰岛素水平的影响[J].中国生化药物杂志,2008,29(5):299-301.
[28]李洁,黄春林.COS-Se对2型糖尿病大鼠血糖的影响[J].微量元素与健康研究,2018,35(5):3-4.
[29]任志生,徐能义,杜晓红,等.硒对多种疾病的影响[J].基层医学论坛,2012,16(28):3772-3774.
[30]黄见.魔芋硒多糖胶囊治疗高脂血症的临床疗效观察[J].中国医药指南,2013,11(4):298-299.
[31]高玉洁,吕海涛.浒苔多糖和硒化浒苔多糖抑菌作用研究[J].食品科技,2013,38(1):195-198,205.
[32]Zhang H,Zeng H,Yang H,et al.Research Bacteriostasis of the Selenium Polysaccharide of Ampelopsis grossedentata in vitro[J].Studies of Trace Elements and Health,2009,26(2):12-14.
[33]Li Z,Liu J,Wang J,et al.Study on the continuous chemical synthesis process of polyporus selenium-polysaccharide and its bacteriostasis[J].Food&Machinery,2013,29(1):31-35.
[34]许伟,潘丽媛,朱黎霞,等.猴头蘑硒多糖的抗脂质过氧化作用[J].航空航天医学杂志,2010,21(5):658-660.
[35]田丽,董维兵,张晓娟.植物硒多糖的研究与应用[J].广州化工,2014,42(7):14-16.
[36]梁欢,黄进,王丽,等.药用植物硒多糖的研究进展[J].中国中药杂志,2018,43(15):3080-3092.
[2]Xu X M,Carlson B A,Grimm T A,et al.Rhesus monkey simian immunod-eficiency virus infection as a model for assessing the role of selenium in AIDS[J].Acquired Immune Defic Syndr,2006,31(5):453-463.
[3]林海鸣,刘艳丽,孙晓飞,等.多糖的药理活性研究概况[J].亚太传统医药,2008,4(2):63-67.
[4]Sun Q,Dong M,Wang Z,et al.Selenium-enriched polysaccharides from Pyracantha(Se-PFPs)inhibit the growth and invasive potential of ovarian cancer cells through inhibitingβ-catenin signaling[J].Oncotarget,2016,7(19):28369-28383.
[5]齐睿婷,颜炳祥,潘道东,等.乳酸乳球菌富硒及其硒多糖抗氧化活性研究[J].食品工业科技,2012,33(11):67-70.
[6]李华为,赵素云,刘晓波,等.硒多糖的抗氧化活性及与过氧化氢酶协同作用的研究[J].分析化学,2010,38(9):1256-1260.
[7]岳丽红,王玉俊,李静,等.黑木耳硒多糖体外抗氧化作用的研究[J].畜牧与饲料科学,2016,37(8):18-19.
[8]Jiang J,Mai H,Xie B,et al.Optimization of Se-rich culture conditions and antioxidant activities of polysaccharides from Morchella esculenta mycelium[J].Food and Fermentation Industries,2016,47(9):120-125.
[9]张越峰,李福艳,吴瑛.红枣多糖及红枣硒多糖抗氧化活性的比较研究[J].食品研究与开发,2015,36(3):4-9.
[10]谷娜,侯艳秋,郑晓凤,等.山药多糖及其硒多糖抗氧化性的比较研究[J].微量元素与健康研究,2016,33(5):41-43.
[11]付欣.灵芝硒多糖诱导乳腺癌MCF-7细胞凋亡过程中的抗氧化作用[D].辽宁:辽宁师范大学,2011.
[12]朱黎霞,周竹音,潘丽媛.黑木耳硒多糖抗肿瘤作用的研究[J].中国中医药科技,2011,18(5):454.
[13]Zhao Y,Xu C,Liang S,et al.Preparation and antioxidation activity of selened lycium barbarum polysaccharides sulfate and its inhibitory effect on Hela cell growth in vitro[J].Chinese pharmacy journal,2012,47(6):423.
[14]邹修文.灵芝硒多糖的合成及抗肿瘤活性研究[D].南宁:广西师范学院,2015.
[15]路则庆.Enterobacter cloacae Z0206富硒多糖对动物生长性能和免疫功能的影响及其作用机制研究[D].杭州:浙江大学,2014.
[16]邱树磊.硒化大蒜多糖和硒化枸杞多糖的增强免疫和抗氧化活性研究[D].江苏:南京农业大学,2014.
[17]李岩,霍娇,吕晓华,等.硒多糖对小鼠免疫功能的影响[J].四川大学学报(医学版),2014,45(3):512-514.
[18]秦韬,胡元亮,王德云,等.硒化修饰能提高当归多糖的免疫增强活性[C].许剑琴.中国畜牧兽医学会会议论文集,2013:221-225.
[19]王宇飞,东方,季宇彬.硒多糖的研究进展[J].赣南医学院学报,2013,33(4):635-637.
[20]张百岩,张天扬,王栗,等.富硒木耳栽培硒多糖提取及抗铅抗汞的研究[J].农业环境保护,2002,21(4):309-313.
[21]聂木海,张全新,柳杨,等.硒多糖对镉中毒大鼠肾保护作用的研究[J].实用预防医学,2005,12(6):1311-1312.
[22]Das K,Jacob V,Bouquegneau J M.White-sided dolphinmetallothioneins:Purification,characterisation and poten-tial role[J].Comp Biochem Physiol Part C,2002,131(3):245-251.
[23]李锦金,盛家荣,邹修文,等.硒多糖的研究进展[J].广西师范学院学报(自然科学版),2014,31(1):41-45.
[24]门晓媛,王一飞,郑文杰,等.纳米硒化裙带菜多糖的制备及其体外抗CVB3病毒作用研究[J].中国卫生检验杂志,2005,15(10):1152-1155.
[25]魏战勇,崔保安,黄克和,等.硒对猪细小病毒体外增殖抑制作用的研究[J].中国病毒学,2005,12(6):1311-1312.
[26]Ning G.Status quo and prospect of prevention and control of diabetes in China[J].Scientia Sinica(Vitae),2018,48(8):810-811.
[27]黄春林,方敏,李邦良,等.甲壳低聚糖-硒对2型糖尿病大鼠血中糖、脂和胰岛素水平的影响[J].中国生化药物杂志,2008,29(5):299-301.
[28]李洁,黄春林.COS-Se对2型糖尿病大鼠血糖的影响[J].微量元素与健康研究,2018,35(5):3-4.
[29]任志生,徐能义,杜晓红,等.硒对多种疾病的影响[J].基层医学论坛,2012,16(28):3772-3774.
[30]黄见.魔芋硒多糖胶囊治疗高脂血症的临床疗效观察[J].中国医药指南,2013,11(4):298-299.
[31]高玉洁,吕海涛.浒苔多糖和硒化浒苔多糖抑菌作用研究[J].食品科技,2013,38(1):195-198,205.
[32]Zhang H,Zeng H,Yang H,et al.Research Bacteriostasis of the Selenium Polysaccharide of Ampelopsis grossedentata in vitro[J].Studies of Trace Elements and Health,2009,26(2):12-14.
[33]Li Z,Liu J,Wang J,et al.Study on the continuous chemical synthesis process of polyporus selenium-polysaccharide and its bacteriostasis[J].Food&Machinery,2013,29(1):31-35.
[34]许伟,潘丽媛,朱黎霞,等.猴头蘑硒多糖的抗脂质过氧化作用[J].航空航天医学杂志,2010,21(5):658-660.
[35]田丽,董维兵,张晓娟.植物硒多糖的研究与应用[J].广州化工,2014,42(7):14-16.
[36]梁欢,黄进,王丽,等.药用植物硒多糖的研究进展[J].中国中药杂志,2018,43(15):3080-3092.