中西医结合治疗自身免疫性肝炎疗效的Meta分析
摘要
<正>自身免疫性肝炎(autoimmune hepatitis,AIH)是一种由自身免疫反应介导的慢性进行性肝脏炎症性疾病,以血清转氨酶增高、自身抗体阳性、高免疫球蛋白G血症、肝组织学表现为淋巴细胞、浆细胞浸润为主的界面性肝炎等为主要特点[1]。AIH在全球分布较
引文
[1]Czaja AJ.Diagnosis and Management of Autoimmune Hepatitis:Current Status and Future Directions[J].Gut&Liver,2016,10(2):177-203.
[2]Wang QX,Yan L,Ma X.Autoimmune Hepatitis in the AsiaPacific Area[J].Journal of Clinical&Translational Hepatology,2018,6(1):48-56.
[3]Yang F,Wang Q,Jia J,et al.Autoimmune Hepatitis:East Meets West[J].Journal of Gastroenterology&Hepatology,2015,30(8):1230-1236.
[4]Roberts SK,Kemp W.Salvage Therapies for Autoimmune Hepatitis:A Critical Review[J].Seminars in Liver Disease,2017,37(4):343-362.
[5]European Association for the Study of the Liver.EASL Clinical Practice Guidelines:Autoimmune hepatitis[J].Journal of Hepatology,2015,63(4):971-1004.
[6]Liwinski T,Schramm C.Autoimmune hepatitis-update on clinical management in 2017[J].Clinics&Research in Hepatology&Gastroenterology,2017,41(6):617-625.
[7]Purnak T,Efe C,Kav T,et al.Treatment Response and Outcome with Two Different Prednisolone Regimens in Autoimmune Hepatitis[J].Digestive Diseases&Sciences,2017,62(10):2900-2907.
[8]Liberal R,De Boer YS,Andrade RJ,et al.International Autoimmune Hepatitis Group(IAIHG).Expert clinical management of autoimmune hepatitis in the real world[J].Alimentary Pharmacology&Therapeutics,2017,45(5):723-732.
[9]Hartl J,Ehlken H,Weilernormann C,et al.Patient selection based on treatment duration and liver biochemistry increases success rates after treatment withdrawal in autoimmune hepatitis[J].Journal of Hepatology,2015,62(3):642-646.
[10]Van Gerven NM,Verwer BJ,Witte BI,et al.Relapse is almost universal after withdrawal of immunosuppressive medication in patients with autoimmune hepatitis in remission[J].Journal of Hepatology,2013,58(1):141-147.
[11]Chen J,Eslick GD,Weltman M.Systematic review with meta-analysis:clinical manifestations and management of autoimmune hepatitis in the elderly[J].Alimentary Pharmacology&Therapeutics,2014,39(2):117-124.
[12]Czaja AJ.Review article:the prevention and reversal of hepatic fibrosis in autoimmune hepatitis[J].Alimentary Pharmacology&Therapeutics,2014,39(4):385-406.
[13]Peiseler M,Liebscher T,Sebode M,et al.Efficacy and Limitations of Budesonide as a Second-line Treatment for Patients With Autoimmune Hepatitis[J].Clinical Gastroenterology&Hepatology,2018,16(2):260-267.
[14]Efe C,Hagstrm H,Ytting H,et al.Efficacy and Safety of Mycophenolate Mofetil and Tacrolimus as Second-line Therapy for Patients with Autoimmune Hepatitis[J].Clinical Gastroenterology&Hepatology,2017,15(12):1950-1956.
[15]陈成伟,陈晓宇,成军,等.自身免疫性肝炎诊断和治疗共识(2015)[J].国际消化病杂志,2016,21(1):165-178.
[16]胡青海.中西医结合治疗自身免疫性肝炎的临床效果观察[J].中国医药指南,2016,14(11):189-190.
[17]张红星,刘旭东.中西医结合治疗自身免疫性肝炎30例观察[J].实用中医药杂志,2016,32(6):555-556.
[18]甘霞,赵新芳,杨百京.小柴胡汤加减治疗肝郁脾虚型自身免疫性肝炎的临床疗效分析[J].中国医药指南,2016,14(21):198-199.
[19]杨福奎.自身免疫性肝病临床特征及治疗效果观察[J].医学信息,2015,(38):402-403.
[20]万琦兵,陈礼荣.疏肝祛风清血法联合泼尼松治疗自身免疫性肝炎30例[J].中西医结合肝病杂志,2015,25(4):249-250.
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[22]黄晶晶,黄鸿娜,潘哲,等.柔肝化纤颗粒治疗自身免疫性肝炎临床观察[J].新中医,2014,(3):68-70.
[23]冯晶远.中西医结合治疗自身免疫性肝炎20例[J].中国中医药现代远程教育,2008,6(11):50.
[24]施伯安,邵凤珍,张俊富,等.滋肾柔肝方治疗自身免疫性肝炎30例临床观察[J].长春中医药大学学报,2008,24(3):271-272.
[25]陈静.六味地黄汤治疗自身免疫性肝炎的临床观察[J].中成药,2001,23(3):188-190.
[26]浦仕彪,王伽伯,王睿林,等.中医和中西医结合治疗自身免疫性肝炎的优势与挑战[J].中国实验方剂学杂志,2016,(23):197-202.
[2]Wang QX,Yan L,Ma X.Autoimmune Hepatitis in the AsiaPacific Area[J].Journal of Clinical&Translational Hepatology,2018,6(1):48-56.
[3]Yang F,Wang Q,Jia J,et al.Autoimmune Hepatitis:East Meets West[J].Journal of Gastroenterology&Hepatology,2015,30(8):1230-1236.
[4]Roberts SK,Kemp W.Salvage Therapies for Autoimmune Hepatitis:A Critical Review[J].Seminars in Liver Disease,2017,37(4):343-362.
[5]European Association for the Study of the Liver.EASL Clinical Practice Guidelines:Autoimmune hepatitis[J].Journal of Hepatology,2015,63(4):971-1004.
[6]Liwinski T,Schramm C.Autoimmune hepatitis-update on clinical management in 2017[J].Clinics&Research in Hepatology&Gastroenterology,2017,41(6):617-625.
[7]Purnak T,Efe C,Kav T,et al.Treatment Response and Outcome with Two Different Prednisolone Regimens in Autoimmune Hepatitis[J].Digestive Diseases&Sciences,2017,62(10):2900-2907.
[8]Liberal R,De Boer YS,Andrade RJ,et al.International Autoimmune Hepatitis Group(IAIHG).Expert clinical management of autoimmune hepatitis in the real world[J].Alimentary Pharmacology&Therapeutics,2017,45(5):723-732.
[9]Hartl J,Ehlken H,Weilernormann C,et al.Patient selection based on treatment duration and liver biochemistry increases success rates after treatment withdrawal in autoimmune hepatitis[J].Journal of Hepatology,2015,62(3):642-646.
[10]Van Gerven NM,Verwer BJ,Witte BI,et al.Relapse is almost universal after withdrawal of immunosuppressive medication in patients with autoimmune hepatitis in remission[J].Journal of Hepatology,2013,58(1):141-147.
[11]Chen J,Eslick GD,Weltman M.Systematic review with meta-analysis:clinical manifestations and management of autoimmune hepatitis in the elderly[J].Alimentary Pharmacology&Therapeutics,2014,39(2):117-124.
[12]Czaja AJ.Review article:the prevention and reversal of hepatic fibrosis in autoimmune hepatitis[J].Alimentary Pharmacology&Therapeutics,2014,39(4):385-406.
[13]Peiseler M,Liebscher T,Sebode M,et al.Efficacy and Limitations of Budesonide as a Second-line Treatment for Patients With Autoimmune Hepatitis[J].Clinical Gastroenterology&Hepatology,2018,16(2):260-267.
[14]Efe C,Hagstrm H,Ytting H,et al.Efficacy and Safety of Mycophenolate Mofetil and Tacrolimus as Second-line Therapy for Patients with Autoimmune Hepatitis[J].Clinical Gastroenterology&Hepatology,2017,15(12):1950-1956.
[15]陈成伟,陈晓宇,成军,等.自身免疫性肝炎诊断和治疗共识(2015)[J].国际消化病杂志,2016,21(1):165-178.
[16]胡青海.中西医结合治疗自身免疫性肝炎的临床效果观察[J].中国医药指南,2016,14(11):189-190.
[17]张红星,刘旭东.中西医结合治疗自身免疫性肝炎30例观察[J].实用中医药杂志,2016,32(6):555-556.
[18]甘霞,赵新芳,杨百京.小柴胡汤加减治疗肝郁脾虚型自身免疫性肝炎的临床疗效分析[J].中国医药指南,2016,14(21):198-199.
[19]杨福奎.自身免疫性肝病临床特征及治疗效果观察[J].医学信息,2015,(38):402-403.
[20]万琦兵,陈礼荣.疏肝祛风清血法联合泼尼松治疗自身免疫性肝炎30例[J].中西医结合肝病杂志,2015,25(4):249-250.
[21]侯丽娟.探讨糖皮质激素联合苦参素方案在自身免疫性肝炎患者治疗中的价值[D].新乡医学院,2015.
[22]黄晶晶,黄鸿娜,潘哲,等.柔肝化纤颗粒治疗自身免疫性肝炎临床观察[J].新中医,2014,(3):68-70.
[23]冯晶远.中西医结合治疗自身免疫性肝炎20例[J].中国中医药现代远程教育,2008,6(11):50.
[24]施伯安,邵凤珍,张俊富,等.滋肾柔肝方治疗自身免疫性肝炎30例临床观察[J].长春中医药大学学报,2008,24(3):271-272.
[25]陈静.六味地黄汤治疗自身免疫性肝炎的临床观察[J].中成药,2001,23(3):188-190.
[26]浦仕彪,王伽伯,王睿林,等.中医和中西医结合治疗自身免疫性肝炎的优势与挑战[J].中国实验方剂学杂志,2016,(23):197-202.