银翘麻杏石甘汤联合肺康复疗法治疗慢性阻塞性肺疾病急性加重期的临床疗效
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摘要
目的:研究银翘麻杏石甘汤联合肺康复疗法治疗慢性阻塞性肺疾病急性加重期(AECOPD)的临床疗效。方法:选取2016年1月—2017年6月期间在本院接受诊治的138例慢性阻塞性肺疾病急性加重期患者作为研究对象,根据随机数表法分为对照组、研究组,各69例。对照组患者采用肺康复疗法治疗,研究组患者采用银翘麻杏石甘汤联合肺康复疗法治疗。比较两组患者临床症状及体征缓解时间及治疗前后动脉血气指标、肺功能变化。结果:研究组患者喘鸣音消失时间、喘息缓解时间、湿啰音消失时间、咳嗽消失时间均低于对照组,差异有统计学意义(P<0.05);治疗后两组患者的PO_2水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);治疗后两组患者的PCO_2水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);治疗后两组患者的FVC、FEV_1、FEV_1/FVC水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05)。结论:银翘麻杏石甘汤联合肺康复疗法治疗AECOPD的临床疗效显著,能有效缓解或消除临床症状及体征,改善患者肺功能,值得临床推广。
Objective:To study the clinical efficacy of Yinqiao Maxing Shigan Decoction combined with pulmonary rehabilitation therapy in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:A total of 138 cases of patients with acute exacerbation of chronic obstructive pulmonary disease treated in our hospital from January 2016 to June 2017 were selected as the subjects of this study.All the patients were divided into a control group and a study group according to the random number table method,with 69 cases in each group.The patients in the control group were treated with pulmonary rehabilitation therapy,and those in the study group were treated with Yinqiao Maxing Shigan Decoction combined with pulmonary rehabilitation therapy.The clinical symptoms and signs of remission time and the changes of arterial blood gas and lung function before and after treatment were compared between the two groups.Results:The disappearance time of wheezing sound,the time of wheezing remission,the disappearance time of wet rales and the disappearance time of cough were lower in the study group than those in the control group(P<0.05).After treatment,the PO_2 levels of the two groups were higher than those before treatment,and the study group′s was higher than the control group′s(P<0.05).After treatment,the PCO_2 level of the two groups was lower than that before treatment,and the study group′s was lower than that of the control group(P<0.05).The levels of FVC,FEV_1 and FVC/FEV_1 in the two groups were higher than those before treatment,and the study group′s was higher than that of the control group(P<0.05).Conclusion:Yinqiao Maxing Shigan Decoction combined with pulmonary rehabilitation therapy has a significant clinical effect on AECOPD.It can effectively alleviate or eliminate clinical symptoms and signs and improve lung function.It is worthy of clinical promotion.
Objective:To study the clinical efficacy of Yinqiao Maxing Shigan Decoction combined with pulmonary rehabilitation therapy in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:A total of 138 cases of patients with acute exacerbation of chronic obstructive pulmonary disease treated in our hospital from January 2016 to June 2017 were selected as the subjects of this study.All the patients were divided into a control group and a study group according to the random number table method,with 69 cases in each group.The patients in the control group were treated with pulmonary rehabilitation therapy,and those in the study group were treated with Yinqiao Maxing Shigan Decoction combined with pulmonary rehabilitation therapy.The clinical symptoms and signs of remission time and the changes of arterial blood gas and lung function before and after treatment were compared between the two groups.Results:The disappearance time of wheezing sound,the time of wheezing remission,the disappearance time of wet rales and the disappearance time of cough were lower in the study group than those in the control group(P<0.05).After treatment,the PO_2 levels of the two groups were higher than those before treatment,and the study group′s was higher than the control group′s(P<0.05).After treatment,the PCO_2 level of the two groups was lower than that before treatment,and the study group′s was lower than that of the control group(P<0.05).The levels of FVC,FEV_1 and FVC/FEV_1 in the two groups were higher than those before treatment,and the study group′s was higher than that of the control group(P<0.05).Conclusion:Yinqiao Maxing Shigan Decoction combined with pulmonary rehabilitation therapy has a significant clinical effect on AECOPD.It can effectively alleviate or eliminate clinical symptoms and signs and improve lung function.It is worthy of clinical promotion.
引文
[1] 汪颖,王迪芬,刘颖,等.AECOPD与ARDS患者动脉血气特点及短期疗效比较[J].贵州医科大学学报,2017,42(8):919-923.
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[6] 陈锦平.肺康复疗法对慢性阻塞性肺疾病急性加重期肺功能及血清 IL-10、TNF-α、CRP的影响[J].广西医学,2014,36(7):964-965,974.
[7] 许斐,刘彦辉,刘晓芳.左西孟旦联合西地那非治疗慢性心力衰竭伴肺动脉高压的疗效观察[J].中西医结合心血管病电子杂志,2015,3(12):27,29.
[8] 杨菊芳.分析麻杏石甘汤与银翘散联合加减治疗支气管肺炎患儿的临床疗效及安全性[J].中外医疗,2017,36(26):154-155.
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[10] 董胜莲,汪凤兰,邢凤梅,等.自我效能系统干预对慢性阻塞性肺疾病患者生存质量的影响[J].现代预防医学,2014,41(18):3357-3359.
[11] 郑灵春.布地奈德联合肺康复疗法雾化吸入治疗COPD急性加重期患者的疗效观察[J].医药前沿,2017,7(23):44-45.
[12]张丹凤,罗彩凤.赋能呼吸康复训练对慢性阻塞性肺疾病患者自我效能的影响[J].广东医学,2014,35(24):3932-3933.
[13]曹利花.舒适护理对老年慢性阻塞性肺疾病患者临床症状治疗依从性及生活自理能力的影响[J].中国药物与临床,2017,17(5):770-772.
[14]徐洪建.肺康复疗法联合α-糜蛋白酶雾化吸入治疗COPD急性加重期患者的疗效[J].中国处方药,2016,14(5):59-60.
[15]冼少静,石湘淋,黄奕江.慢性阻塞性肺疾病伴呼吸衰竭患者两种通气模式应用比较研究[J].湖南师范大学学报:医学版,2016,13(3):80-82.
[16]刘晓燕,冯国和,吴立燕.无创正压通气治疗老年慢性阻塞性肺疾病合并重症Ⅱ型呼吸衰竭疗效分析及护理体会[J].浙江医学,2014,36(7):624-628.
[17]李飞燕,吴绍萍,杨光静,等.慢性阻塞性肺疾病急性加重期护理现状及研究进展[J].国际护理学杂志,2016,35(8):1009-1012.
[18]吕绍翔,霍敏琴.肺康复疗法支气管肺泡灌洗对慢性阻塞性肺疾病合并肺部感染的疗效[J].广东医学,2016,37(2):228-229.
[19]黄穗华,蒋玲,邓杰方.无创呼吸机联合纳洛酮治疗老年慢性阻塞性肺疾病并发呼吸衰竭的临床疗效分析[J].中国实用医药,2015,10(6):59-60.
[20]景璇,郭洁,张嘉,等.加味麻杏石甘汤配合穴位贴敷治疗老年慢性阻塞性肺病急性加重期患者的效果及对肺功能和肿瘤坏死因子-α、白细胞介素-8表达的影响[J].中国老年学杂志,2017,37(1):132-133.
[2] Mao T,Chen H,Hong L,et al.Pigment epithelium-derived factor inhibits high glucose-induced JAK/STAT signalling pathway activation in human glomerular mesangial cells[J].Saudi Medical Journal,2013,12(34):3213-3215.
[3] 李慧丽,焦凤梅,田昭涛,等.氧驱雾化吸入肺康复疗法治疗COPD急性加重期患者的临床疗效观察[J].湖南师范大学学报:医学版,2016,13(3):133-135.
[4] 林金鱼,陈亚红.不同剂量肺康复疗法治疗慢性阻塞性肺疾病急性加重期老年患者的疗效比较[J].中国医药,2014,9(8):1120-1124.
[5] 高静珍,陈宝元.肺康复疗法不同持续使用时间对慢性阻塞性肺疾病急性加重期的治疗效果[J].中华老年医学杂志,2014,33(3):294-296.
[6] 陈锦平.肺康复疗法对慢性阻塞性肺疾病急性加重期肺功能及血清 IL-10、TNF-α、CRP的影响[J].广西医学,2014,36(7):964-965,974.
[7] 许斐,刘彦辉,刘晓芳.左西孟旦联合西地那非治疗慢性心力衰竭伴肺动脉高压的疗效观察[J].中西医结合心血管病电子杂志,2015,3(12):27,29.
[8] 杨菊芳.分析麻杏石甘汤与银翘散联合加减治疗支气管肺炎患儿的临床疗效及安全性[J].中外医疗,2017,36(26):154-155.
[9] Yohannes A M,Willgoss T G,Baldwin R C,et al.Depression and anxiety in chronic heart failure and chronic obstructive pulmonary disease:prevalence,relevance,clinical implications and management principles[J].Int J Geriatr Psychiatry,2014,25(12):1209-1221.
[10] 董胜莲,汪凤兰,邢凤梅,等.自我效能系统干预对慢性阻塞性肺疾病患者生存质量的影响[J].现代预防医学,2014,41(18):3357-3359.
[11] 郑灵春.布地奈德联合肺康复疗法雾化吸入治疗COPD急性加重期患者的疗效观察[J].医药前沿,2017,7(23):44-45.
[12]张丹凤,罗彩凤.赋能呼吸康复训练对慢性阻塞性肺疾病患者自我效能的影响[J].广东医学,2014,35(24):3932-3933.
[13]曹利花.舒适护理对老年慢性阻塞性肺疾病患者临床症状治疗依从性及生活自理能力的影响[J].中国药物与临床,2017,17(5):770-772.
[14]徐洪建.肺康复疗法联合α-糜蛋白酶雾化吸入治疗COPD急性加重期患者的疗效[J].中国处方药,2016,14(5):59-60.
[15]冼少静,石湘淋,黄奕江.慢性阻塞性肺疾病伴呼吸衰竭患者两种通气模式应用比较研究[J].湖南师范大学学报:医学版,2016,13(3):80-82.
[16]刘晓燕,冯国和,吴立燕.无创正压通气治疗老年慢性阻塞性肺疾病合并重症Ⅱ型呼吸衰竭疗效分析及护理体会[J].浙江医学,2014,36(7):624-628.
[17]李飞燕,吴绍萍,杨光静,等.慢性阻塞性肺疾病急性加重期护理现状及研究进展[J].国际护理学杂志,2016,35(8):1009-1012.
[18]吕绍翔,霍敏琴.肺康复疗法支气管肺泡灌洗对慢性阻塞性肺疾病合并肺部感染的疗效[J].广东医学,2016,37(2):228-229.
[19]黄穗华,蒋玲,邓杰方.无创呼吸机联合纳洛酮治疗老年慢性阻塞性肺疾病并发呼吸衰竭的临床疗效分析[J].中国实用医药,2015,10(6):59-60.
[20]景璇,郭洁,张嘉,等.加味麻杏石甘汤配合穴位贴敷治疗老年慢性阻塞性肺病急性加重期患者的效果及对肺功能和肿瘤坏死因子-α、白细胞介素-8表达的影响[J].中国老年学杂志,2017,37(1):132-133.