摘要
目的:分析菖蒲郁金汤辅助治疗重症病毒性脑炎患儿对神经功能、S100B蛋白、神经元特异性烯醇化酶(NSE)的影响。方法:选取重症病毒性脑炎患者66例,根据治疗方法不同分为对照组和观察组。对照组患者采用常规对症治疗,观察组患者加用菖蒲郁金汤进行辅助治疗,分析两组患者治疗后的临床效果。结果:观察组患者头晕目眩、神识昏蒙、四肢懈怠及身热不退等中医症候消失时间短于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者S100B、NSE、β-EP水平比较,差异无统计学意义(P>0.05)。治疗3、10 d后,观察组患者S100B、NSE、β-EP水平低于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者MMSE评分比较,差异无统计学意义(P>0.05)。治疗后,观察组患者MMSE评分高于对照组,差异有统计学意义(P<0.05)。结论:菖蒲郁金汤辅助治疗重症病毒性脑炎可促进患者神经功能的恢复,降低S100B、NSE、β-EP水平,加快临床症状的消失。
Objective:To analyze the effect of Changpu Yujin Decoction on neurologic function,S100 B protein and neuron specific enolase(NSE) in children with severe viral encephalitis.Methods:Sixty-six patients with severe viral encephalitis were divided into control group and observation group according to different treatment methods. The patients in the control group were treated with routine symptomatic therapy, and those in the observation group were treated with Changpu Yujin Decoction. The clinical effects of the two groups were analyzed.Results:The time of disappearance of TCM symptoms in the observation group was shorter than that in the control group(P<0.05). Before treatment, there was no significant difference in NSE or β-EP levels between the two groups(P>0.05). After 3 days treatment, the levels of S100 B,NSE and β-EP in the observation group were significantly lower than those in the control group(P<0.05). Before treatment, there was no significant difference in MMSE score between the two groups(P>0.05). After treatment, the MMSE scores of the patients in the observation group were higher than those in the control group. The difference was statistically significant(P<0.05). Conclusion:The adjuvant treatment of severe viral encephalitis with Changpu Yujin Decoction can promote the recovery of nervous function, decrease the levels of NSE and β-EP and accelerate the disappearance of clinical symptoms in patients with severe viral encephalitis.
引文
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