APP/PS1双转基因小鼠自主活动的节律性
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摘要
目的探讨5个月龄APP/PS1双转基因小鼠自主活动的生物节律变化。方法采用小鼠自主活动测试仪对5个月龄APP/PS1双转基因小鼠和空白背景小鼠的活动度进行连续72 h的监测。结果在12D/12L光暗影响下,5个月龄空白背景小鼠在黑暗相的活动度(自主活动时间、自主活动次数)均明显比光照相多(P<0.01);而5个月龄APP/PS1双转基因小鼠在光照及黑暗条件下的活动度(自主活动时间、自主活动次数)无显著差异(P>0.05)。结论 5个月龄APP/PS1双转基因阿尔茨海默病小鼠的自主活动近日节律紊乱。
Objective To discuss biological rhythms change in the autonomic activities in five months APP/PS1 double transgenic mice.Methods The autonomic activities were measured of 5 months APP/PS1 double transgenic mice and blank background mice for continuous monitoring of 72 h.Results In 12D/12 L under the influence of the light from the darkness,the activity( autonomic activity time,autonomic activity times) of 5 months blank background mice in the dark phase was significantly more than that in light phase( P<0.01). The activity( autonomic activity time,autonomic activity times) degree of five months APP/PS1 double transgenic mice of light and dark conditions had no significant difference( P>0.05).Conclusions The autonomic activities rhythm of 5 months APP/PS1 double transgenic Alzheimer disease model mice is in one day disorders.
Objective To discuss biological rhythms change in the autonomic activities in five months APP/PS1 double transgenic mice.Methods The autonomic activities were measured of 5 months APP/PS1 double transgenic mice and blank background mice for continuous monitoring of 72 h.Results In 12D/12 L under the influence of the light from the darkness,the activity( autonomic activity time,autonomic activity times) of 5 months blank background mice in the dark phase was significantly more than that in light phase( P<0.01). The activity( autonomic activity time,autonomic activity times) degree of five months APP/PS1 double transgenic mice of light and dark conditions had no significant difference( P>0.05).Conclusions The autonomic activities rhythm of 5 months APP/PS1 double transgenic Alzheimer disease model mice is in one day disorders.
引文
1 Khachiyants N,Trinkle D,Son SJ,et al.Sundown syndrome in persons with dementia:an update[J].Psychiatry Investig,2011;8(4):275-87.
2 Satlin A,Volicer L,Stopa EG,et al.Circadian locomot or activity and core body temperature rhythms in Alzheimer's disease[J].Neurobiol Aging,1995;16(5):765-71.
3 Harper DG,Stopa EG,Mc Kee AC,et al.Dementia severity and Lewy bodies affect circadian rhythms in Alzheimer disease[J].Neurobiol Aging,2004;25(6):771-81.
4 张景行,章功良.睡眠-觉醒机制研究概况[J].中国现代神经疾病杂志,2006;6(1):11-6.
5 Zhou JN,Liu RY,Kamphorst W,et al.Early neuropathological Alzheimer's changes in aged individuals are accompanied by decreased cerebrospinal fluid melatonin levels[J].J Pineal Res,2003;35:125-30.
6 李胜吾,薛红,吴佳,等.荷乳腺癌小鼠自发性活动节律变化特征及不同时相点电针对其效应的研究[J].成都中医药大学学报,2012;35(1):9-13.
7 关俊文,刘衍宇,方凌燕,等.阿尔茨海默病小鼠自发性活动分析[J].四川生理科学杂志,2011;33(3):102-4.
8 Gorman MR,Yellon S.Lifespan daily locomotor activity rhythms in a mouse model of amyloid-induced neuropathology[J].Chronobiol Int,2010;27(6):1159-77.
2 Satlin A,Volicer L,Stopa EG,et al.Circadian locomot or activity and core body temperature rhythms in Alzheimer's disease[J].Neurobiol Aging,1995;16(5):765-71.
3 Harper DG,Stopa EG,Mc Kee AC,et al.Dementia severity and Lewy bodies affect circadian rhythms in Alzheimer disease[J].Neurobiol Aging,2004;25(6):771-81.
4 张景行,章功良.睡眠-觉醒机制研究概况[J].中国现代神经疾病杂志,2006;6(1):11-6.
5 Zhou JN,Liu RY,Kamphorst W,et al.Early neuropathological Alzheimer's changes in aged individuals are accompanied by decreased cerebrospinal fluid melatonin levels[J].J Pineal Res,2003;35:125-30.
6 李胜吾,薛红,吴佳,等.荷乳腺癌小鼠自发性活动节律变化特征及不同时相点电针对其效应的研究[J].成都中医药大学学报,2012;35(1):9-13.
7 关俊文,刘衍宇,方凌燕,等.阿尔茨海默病小鼠自发性活动分析[J].四川生理科学杂志,2011;33(3):102-4.
8 Gorman MR,Yellon S.Lifespan daily locomotor activity rhythms in a mouse model of amyloid-induced neuropathology[J].Chronobiol Int,2010;27(6):1159-77.