癌因性疲乏相关治疗研究进展
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摘要
癌因性疲乏是临床上癌症患者最为常见的伴随症状,它不仅严重影响患者的生活质量,并可导致患者癌症治疗中断,危及患者的生命安全。CRF的病因及机制较为复杂,国外许多学者认为,CRF的发生可能与贫血、肥胖、肿瘤类型、失眠、炎性细胞因子,下丘脑-垂体-肾上腺轴等有关。针对CRF患者应采取有效措施进行干预,本文对CRF的相关治疗进展进行综述,为临床提供指导。
Cancer-related fatigue is the most common concomitant symptom in cancer patients.It not only seriously affects the quality of life of patients,but also leads to the interruption of cancer treatment and endangers the lives of patients.The etiology and mechanism of CRF are more complicated.Many foreign scholars believe that the occurrence of CRF may be related to anemia,obesity,tumor type,insomnia,inflammatory cytokines,and hypothalamus-pituitary-adrenal axis.The CRF patients should take effective measures to intervene.This article reviews the progress of CRF related treatment and provides guidance for clinical practice.
Cancer-related fatigue is the most common concomitant symptom in cancer patients.It not only seriously affects the quality of life of patients,but also leads to the interruption of cancer treatment and endangers the lives of patients.The etiology and mechanism of CRF are more complicated.Many foreign scholars believe that the occurrence of CRF may be related to anemia,obesity,tumor type,insomnia,inflammatory cytokines,and hypothalamus-pituitary-adrenal axis.The CRF patients should take effective measures to intervene.This article reviews the progress of CRF related treatment and provides guidance for clinical practice.
引文
[1]林允照,顾华,沈健.癌因性疲乏研究进展[J].浙江预防医学,2014,26(8):796-799,802.
[2]Berger AM,Mooney K,Alvarez-Perez A,et al.National comprehensive cancer network.Cancer-Related Fatigue,Version2.2015[J].J Natl Compr Canc Netw,2015,13(8):1012-1039.
[3]Grant MD,Piper M,Bohlius J,et al.Epoetin and darbepoetin for managing anemia in patients undergoing cancer treatment:comparative effectiveness update[C].Rockville(MD):Agency for Healthcare Research and Quality(US),2013.
[4]李征,米登海,温志震,等.癌因性疲乏与神经内分泌相关性的前瞻性临床对照研究[J].甘肃医药,2018,37(1):5-10.
[5]Haywood A,Good P,Khan S,et al.Corticosteroids for the management of cancer-related pain in adults[J].Cochrane Database Syst Rev,2015,4(4):CD010756.
[6]Begley S,Rose K,O'Connor M.The use of corticosteroids in reducing cancer-related fatigue:assessing the evidence for clinical practice[J].Int J Palliat Nurs,2016,22(1):5-9.
[7]Kamath J.Cancer-related fatigue,inflammation and thyrotropin-releasing hormone[J].Curr Aging Sci,2012,5(3):195-202.
[8]Minton O,Richardson A,Sharpe M,et al.A systematic review and meta-analysis of the pharmacological treatment of cancerrelated fatigue[J].J Natl Cancer Inst,2008,100(16):1155-1166.
[9]Qu D,Zhang Z,Yu X,et al.Psychotropic drugs for the management of cancer-related fatigue:a systematic review and meta-analysis[J].European Journal of Cancer Care,2016,25(6):970-979.
[10]Berger AM,Moony K,Alvarez-Perez A,et al.Cancer-Related Fatigue,Version2.2015[J].J Natl Compr Canc Netw,2015,13(8):1012-1039.
[11]Mucke M,Mochamat M,Cuhls H.Pharmacological treatments for fatigue asso-ciated with palliative care[J].Cochrane Database Syst Rev,2015,4(5):CD006788.
[12]吴锡娟.参麦注射液对癌因性疲乏患者中医症候积分的影响及机制研究[J].辽宁中医杂志,2014,41(6):1171-1173.
[13]郭慧茹,刘苓霜,孙建立,等.参芪扶正注射液治疗晚期肺癌患者癌因性疲乏的临床疗效及生活质量评价[J].川北医学院学报,2017,32(2):163-166.
[14]冯烨,王薇,张燕,等.人参养荣汤改善化疗患者疲乏70例随机对照研究[J].中国中医基础医学杂志,2014,20(6):798-800.
[15]关洁珊.正元胶囊防治癌因性疲乏的疗效及机制研究[D].广州中医药大学,2016.
[16]Eickmeyer SM,Gamble GL,Shahpar S,et al.The role and efficacy of exercise in persons with cancer[J].PM R,2012,4(11):874-881.
[17]Larkin D,Lopez V,Aromataris E.Managing cancer-related fatigue in men with prostate cancer:a systematic review of nonpharmacological interventions[J].Int J Nurs Pract,2014,20(5):549-560.
[18]Hasenoehrl T,Keilani M,Sedghi Komanadj T,et al.The effects of resistance exercise on physical performance and healthrelated quality of life in prostate cancer patients:a systematic review[J].Support Care Cancer,2015,23(8):2479-2497.
[19]Gracey JH,Watson M,Payne C,et al.Translation research:'Back on Track',a multiprofessional rehabilitation service for cancer-related fatigue[J].BMJ Support Palliat Care,2016,6(1):94-96.
[20]Bennell KL,Nelligan R,Dobson F,et al.Effectiveness of an internet-delivered exercise and pain-coping skills training intervention for persons with chronic knee pain:a randomized trial[J].Ann Intern Med,2017,166(7):453-462.
[21]Ferguson RJ,Sigmon ST,Pritchard AJ,et al.A randomized trial of videoconference-delivered cognitive behavioral therapy for survivors of breast cancer with self-reported cognitive dysfunction[J].Cancer,2016,122(11):1782-1791.
[22]覃霄燕,刘展华.复背温灸法治疗晚期癌症患者癌因性疲乏的临床研究[J].中医学报,2012,27(3):273-274.
[23]Molassiotis A,Bardy J,Finneganjohn J,et al.Acupuncture for cancer-related fatigue in patients with breast cancer:a pragmatic randomized controlled trail[J].J Clin Oncol,2012,30(36):4470-4476.
[2]Berger AM,Mooney K,Alvarez-Perez A,et al.National comprehensive cancer network.Cancer-Related Fatigue,Version2.2015[J].J Natl Compr Canc Netw,2015,13(8):1012-1039.
[3]Grant MD,Piper M,Bohlius J,et al.Epoetin and darbepoetin for managing anemia in patients undergoing cancer treatment:comparative effectiveness update[C].Rockville(MD):Agency for Healthcare Research and Quality(US),2013.
[4]李征,米登海,温志震,等.癌因性疲乏与神经内分泌相关性的前瞻性临床对照研究[J].甘肃医药,2018,37(1):5-10.
[5]Haywood A,Good P,Khan S,et al.Corticosteroids for the management of cancer-related pain in adults[J].Cochrane Database Syst Rev,2015,4(4):CD010756.
[6]Begley S,Rose K,O'Connor M.The use of corticosteroids in reducing cancer-related fatigue:assessing the evidence for clinical practice[J].Int J Palliat Nurs,2016,22(1):5-9.
[7]Kamath J.Cancer-related fatigue,inflammation and thyrotropin-releasing hormone[J].Curr Aging Sci,2012,5(3):195-202.
[8]Minton O,Richardson A,Sharpe M,et al.A systematic review and meta-analysis of the pharmacological treatment of cancerrelated fatigue[J].J Natl Cancer Inst,2008,100(16):1155-1166.
[9]Qu D,Zhang Z,Yu X,et al.Psychotropic drugs for the management of cancer-related fatigue:a systematic review and meta-analysis[J].European Journal of Cancer Care,2016,25(6):970-979.
[10]Berger AM,Moony K,Alvarez-Perez A,et al.Cancer-Related Fatigue,Version2.2015[J].J Natl Compr Canc Netw,2015,13(8):1012-1039.
[11]Mucke M,Mochamat M,Cuhls H.Pharmacological treatments for fatigue asso-ciated with palliative care[J].Cochrane Database Syst Rev,2015,4(5):CD006788.
[12]吴锡娟.参麦注射液对癌因性疲乏患者中医症候积分的影响及机制研究[J].辽宁中医杂志,2014,41(6):1171-1173.
[13]郭慧茹,刘苓霜,孙建立,等.参芪扶正注射液治疗晚期肺癌患者癌因性疲乏的临床疗效及生活质量评价[J].川北医学院学报,2017,32(2):163-166.
[14]冯烨,王薇,张燕,等.人参养荣汤改善化疗患者疲乏70例随机对照研究[J].中国中医基础医学杂志,2014,20(6):798-800.
[15]关洁珊.正元胶囊防治癌因性疲乏的疗效及机制研究[D].广州中医药大学,2016.
[16]Eickmeyer SM,Gamble GL,Shahpar S,et al.The role and efficacy of exercise in persons with cancer[J].PM R,2012,4(11):874-881.
[17]Larkin D,Lopez V,Aromataris E.Managing cancer-related fatigue in men with prostate cancer:a systematic review of nonpharmacological interventions[J].Int J Nurs Pract,2014,20(5):549-560.
[18]Hasenoehrl T,Keilani M,Sedghi Komanadj T,et al.The effects of resistance exercise on physical performance and healthrelated quality of life in prostate cancer patients:a systematic review[J].Support Care Cancer,2015,23(8):2479-2497.
[19]Gracey JH,Watson M,Payne C,et al.Translation research:'Back on Track',a multiprofessional rehabilitation service for cancer-related fatigue[J].BMJ Support Palliat Care,2016,6(1):94-96.
[20]Bennell KL,Nelligan R,Dobson F,et al.Effectiveness of an internet-delivered exercise and pain-coping skills training intervention for persons with chronic knee pain:a randomized trial[J].Ann Intern Med,2017,166(7):453-462.
[21]Ferguson RJ,Sigmon ST,Pritchard AJ,et al.A randomized trial of videoconference-delivered cognitive behavioral therapy for survivors of breast cancer with self-reported cognitive dysfunction[J].Cancer,2016,122(11):1782-1791.
[22]覃霄燕,刘展华.复背温灸法治疗晚期癌症患者癌因性疲乏的临床研究[J].中医学报,2012,27(3):273-274.
[23]Molassiotis A,Bardy J,Finneganjohn J,et al.Acupuncture for cancer-related fatigue in patients with breast cancer:a pragmatic randomized controlled trail[J].J Clin Oncol,2012,30(36):4470-4476.