MYC2转录因子参与植物发育调控的研究进展
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摘要
MYC转录因子是bHLH家族中的重要成员,近几年研究表明MYC2转录因子是以茉莉酸为核心的激素调控网络中的关键组分,参与调控大量植物发育过程与多种抗逆过程,例如:花青素、酚酸等次生代谢产物合成;氧化、虫害等胁迫响应;植物器官发育调控;激素互作过程,包括茉莉酸-水杨酸、茉莉酸-乙烯、茉莉酸-脱落酸等。本文对MYC2转录因子的结构、与激素的互作关系以及在植物器官发育中的调控功能的最新研究进展进行了简要综述。
MYC transcription factor is an important member of bHLH family. In recent years, studies have shown that MYC2 transcription factor is a key component of the hormone regulatory network which takes jasmonic acid(JA) as core and is involved in the regulation of a large number of plant development processes and a variety of anti-stress processes, for example: the synthesis of secondary metabolites like anthocyanin and phenolic acid; stress response like oxidation and insect pests; the development of six major organs of plants; the hormone interaction processes, including JA-salicylic acid, JA-ethylene, JA-abscisic acid, etc. In this paper, the latest research progress of the structure of MYC2 transcription factor together with its interaction with hormones and its regulatory function in plant organ development are reviewed.
MYC transcription factor is an important member of bHLH family. In recent years, studies have shown that MYC2 transcription factor is a key component of the hormone regulatory network which takes jasmonic acid(JA) as core and is involved in the regulation of a large number of plant development processes and a variety of anti-stress processes, for example: the synthesis of secondary metabolites like anthocyanin and phenolic acid; stress response like oxidation and insect pests; the development of six major organs of plants; the hormone interaction processes, including JA-salicylic acid, JA-ethylene, JA-abscisic acid, etc. In this paper, the latest research progress of the structure of MYC2 transcription factor together with its interaction with hormones and its regulatory function in plant organ development are reviewed.
引文
Aleman F,Yazaki J,Lee M,et al(2016).An ABA-increased interaction of the PYL6 ABA receptor with MYC2 transcription factor:a putative link of ABA and JA signaling.Sci Rep,6:28941
Brossa R,López-Carbonell M,Jubany-MaríT,et al(2011).Interplay between abscisic acid and jasmonic acid and its role in water-oxidative stress in wild-type,ABA-deficient,JA-deficient,and ascorbate-deficient Arabidopsis plants.J Plant Growth Regul,30(3):322-333
Chang J,Chen T,Huang T,et al(2016).Anthocyanin accumulation induced by MeJA in somatic embryo of rubber tree(Hevea brasiliensis).Genom Appl Biol,35(11):3115-3121(in Chinese with English abstract)[畅姣,陈涛,黄天带等(2016).茉莉酸诱导橡胶树体细胞胚花青素的累积,基因组学与应用生物学,35(11):3115-3121]
Chen Q,Sun J,Zhai Q,et al(2011).The basic helix-loop-helix transcription factor MYC2 directly represses PLETH-ORA expression during jasmonate-mediated modulation of the root stem cell niche in Arabidopsis.Plant Cell,23(9):3335-3352
Cheng Z,Sun L,Qi T,et al(2011).The bHLH transcription factor MYC3 interacts with the jasmonate ZIM-domain proteins to mediate jasmonate response in Arabidopsis.Mol Plant,4(2):279-288
Chini A,Boter M,Solano R(2009).Plant oxylipins:COI1/JAZs/MYC2 as the core jasmonic acid-signalling module.FEBS J,276(17):4682-4692
Dombrecht B,Xue GP,Sprague SJ,et al(2007).MYC2 differentially modulates diverse jasmonate-dependent functions in Arabidopsis.Plant Cell,19(7):2225-2245
Gagne JM,Smalle J,Gingerich DJ,et al(2004).Arabidopsis EIN3-binding F-box 1 and 2 form ubiquitin-protein ligases that repress ethylene action and promote growth by directing EIN3 degradation.Proc Natl Acad Sci USA,101(17):6803-6808
Gao C,Qi S,Liu K,et al(2016).MYC2,MYC3,and MYC4function redundantly in seed storage protein accumulation in Arabidopsis.Plant Physiol Biochem,108:63-70
Gasperini D,Chételat A,Acosta IF,et al(2015).Multilayered organization of jasmonate signalling in the regulation of root growth.PLoS Genet,11(6):e1005300
He YM,Liu SF,Lei SQ(2018).The dynamic changes in jasmonate levels and expression of its pathway-related genes in anthers before dehiscence in rice.Acta Agr Univ Jiangxiensis,40(3):429-434(in Chinese with English abstract)[何永明,刘遂飞,雷抒情(2018).水稻花药开裂前茉莉酸水平及信号途径相关基因表达的动态变化.江西农业大学学报,40(3):429-434]
Helfer A,Nusinow DA,Chow BY,et al(2011).LUX AR-RHYTHMO encodes a night time repressor of circadian gene expression in the Arabidopsis core clock.Curr Biol,21(2):126-133
Hills MJ(2004).Control of storage-product synthesis in seeds.Curr Opin Plant Biol,7(3):302-308
Hiruma K,Nishiuchi T,Kato T,et al(2011).Arabidopsis ENHANCED DISEASE RESISTANCE 1 is required for pathogen-induced expression of plant defensins in nonhost resistance,and acts through interference of MYC2-mediated repressor function.Plant J,67(6):980-992
Hou X,Lee LYC,Xia K,et al(2010).DELLAs modulate jasmonate signaling via competitive binding to JAZs.Dev Cell,19(6):884-894
Huang CF,Yu CP,Wu YH,et al(2017).Elevated auxin biosynthesis and transport underlie high vein density in C4leaves.Proc Natl Acad Sci USA,114(33):E6884-E6891
Jeong JS,Jung C,Seo JS,et al(2017).The deubiquitinating enzymes UBP12 and UBP13 positively regulate MYC2levels in jasmonate responses.Plant Cell,29(6):1406-1424
Jung C,Zhao P,Seo JS,et al(2015).PLANT U-BOX PRO-TEIN10 regulates MYC2 stability in Arabidopsis.Plant Cell,27(7):2016-2031
Li T,Xu Y,Zhang L,et al(2017).The jasmonate-activated transcription factor MdMYC2 regulates ETHYLENERESPONSE FACTOR and ethylene biosynthetic genes to promote ethylene biosynthesis during apple fruit ripening.Plant Cell,29(6):1316-1334
Lian TF,Xu YP,Li LF,et al(2017).Crystal structure of tetrameric Arabidopsis MYC2 reveals the mechanism of enhanced interaction with DNA.Cell Rep,19(7):1334-1342
Liu XY,Wang WS,Fu BY,et al(2011).Research progress of plant bHLH transcription factor family.Curr Biotechnol,1(6):391-397(in Chinese with English abstract)[刘晓月,王文生,傅彬英等(2011).植物bHLH转录因子家族的功能研究进展.生物技术进展,1(6):391-397]
Lorenzo O,Chico JM,Sánchez-Serrano JJ,et al(2004).JAS-MONATE-INSENSITIVE1 encodes a MYC transcription factor essential to discriminate between different jasmonate-regulated defense responses in Arabidopsis.Plant Cell,16(7):1938-1950
Maksymiec W,Wianowska D,Dawidowicz AL,et al(2005).The level of jasmonic acid in Arabidopsis thaliana and Phaseolus coccineus plants under heavy metal stress.Plant Physiol,162(12):1338-1346
Pech JC,LatchéA,Bouzayen M(2010).Ethylene biosynthesis.In:Davies PJ(ed).Plant Hormones.Biosynthesis,Signal Transduction,Action!Dordrecht:Springer,115-136
Qi T,Huang H,Song S,et al(2015).Regulation of jasmonate-mediated stamen development and seed production by a bHLH-MYB complex in Arabidopsis.Plant Cell,27(6):1620-1633
Qi T,Wang J,Huang H,et al(2015).Regulation of jasmonate-induced leaf senescence by antagonism between bHLHsubgroup IIIe and IIId factors in Arabidopsis.Plant Cell,27(6):1634-1649
Qiao H,Shen Z,Huang SC,et al(2012).Processing and subcellular trafficking of ER-tethered EIN2 control response to ethylene gas.Science,338(6105):390-393
Sanchez SE,Kay SA(2016).The plant circadian clock:from a simple timekeeper to a complex developmental manager.Cold Spring Harb Perspect Biol,8(12):a027748
Song S,Huang H,Gao H,et al(2014).Interaction between MYC2 and ETHYLENE INSENSITIVE3 modulates antagonism between jasmonate and ethylene signaling in Arabidopsis.Plant Cell,26:263-279
Sun J,Xu Y,Ye S,et al(2009).Arabidopsis ASA1 is important for jasmonate-mediated regulation of auxin biosynthesis and transport during lateral root formation.Plant Cell,21(5):1495-1511
Wang H,Li Y,Pan J,et al(2017).The bHLH transcription factors MYC2,MYC3,and MYC4 are required for jasmonate-mediated inhibition of flowering in Arabidopsis.Mol Plant,10(11):1461-1464
Wen X,Zhang C,Ji Y,et al(2012).Activation of ethylene signaling is mediated by nuclear translocation of the cleaved EIN2 carboxyl terminus.Cell Res,22(11):1613-1616
Wild M,Davière JM,Cheminant S,et al(2012).The Arabidopsis DELLA RGA-LIKE3 is a direct target of MYC2and modulates jasmonate signaling responses.Plant Cell,24(8):3307-3319
Wu JM,Huang X,Qiu LH,et al(2016).The progress of DEL-LA protein in plants.J Agr Biotechnol,24(8):1207-1215[吴建明,黄杏,丘立杭等(2016).DELLA蛋白在植物中的研究进展.农业生物技术学报,24(8):1207-1215]
Wu XY,Kuai BK,Jia JZ,et al(2012).Regulation of leaf senescence and crop genetic improvement.Integr Plant Biol,54(12):936-952
Yadav V,Mallappa C,Gangappa SN,et al(2005).A basic helix-loop-helix transcription factor in Arabidopsis,MYC2,acts as a repressor of blue light-mediated photomorphogenic growth.Plant Cell,17(7):1953-1966
Yang DL,Yao J,Mei CS,et al(2012).Plant hormone jasmonate prioritizes defense over growth by interfering with gibberellin signaling cascade.Proc Natl Acad Sci USA,109(19):E1192-E1200
Yi WK,Wang J,Yang H,et al(2012).Abscisic acid receptors:abscisic acid signaling transduction pathways in plants.Chin Bull Bot,47(5):515-524(in Chinese with English abstract)[易文凯,王佳,杨辉等(2012)植物ABA受体及其介导的信号转导通路.植物学报,47(5):515-524]
Yu J,Zhang Y,Di C,et al(2016).JAZ7 negatively regulates dark-induced leaf senescence in Arabidopsis.J Exp Bot,67(3):751-762
Zhang Y,Wang Y,Wei H,et al(2018).Circadian evening complex represses jasmonate-induced leaf senescence in Arabidopsis.Mol Plant,11(2):326-337
Zhao Y,Dong W,Zhang N,et al(2014).A wheat allene oxide cyclase gene enhances salinity tolerance via jasmonate signaling.Plant Physiol,164(2):1068-1076
Zhu C,Gan L,Shen Z,et al(2006).Interactions between jasmonates and ethylene in the regulation of root hair development in Arabidopsis.J Exp Bot,57(6):1299-1308
Zhu Z,An F,Feng Y,et al(2011).Derepression of ethylene-stabilized transcription factors(EIN3/EIL1)mediates jasmonate and ethylene signaling synergy in Arabidopsis.Proc Natl Acad Sci USA,108(30):12539-12544
Zhu Z,Lee B(2015).Friends or foes:new insights in jasmonate and ethylene co-actions.Plant Cell Physiol,56(3):414-420
Brossa R,López-Carbonell M,Jubany-MaríT,et al(2011).Interplay between abscisic acid and jasmonic acid and its role in water-oxidative stress in wild-type,ABA-deficient,JA-deficient,and ascorbate-deficient Arabidopsis plants.J Plant Growth Regul,30(3):322-333
Chang J,Chen T,Huang T,et al(2016).Anthocyanin accumulation induced by MeJA in somatic embryo of rubber tree(Hevea brasiliensis).Genom Appl Biol,35(11):3115-3121(in Chinese with English abstract)[畅姣,陈涛,黄天带等(2016).茉莉酸诱导橡胶树体细胞胚花青素的累积,基因组学与应用生物学,35(11):3115-3121]
Chen Q,Sun J,Zhai Q,et al(2011).The basic helix-loop-helix transcription factor MYC2 directly represses PLETH-ORA expression during jasmonate-mediated modulation of the root stem cell niche in Arabidopsis.Plant Cell,23(9):3335-3352
Cheng Z,Sun L,Qi T,et al(2011).The bHLH transcription factor MYC3 interacts with the jasmonate ZIM-domain proteins to mediate jasmonate response in Arabidopsis.Mol Plant,4(2):279-288
Chini A,Boter M,Solano R(2009).Plant oxylipins:COI1/JAZs/MYC2 as the core jasmonic acid-signalling module.FEBS J,276(17):4682-4692
Dombrecht B,Xue GP,Sprague SJ,et al(2007).MYC2 differentially modulates diverse jasmonate-dependent functions in Arabidopsis.Plant Cell,19(7):2225-2245
Gagne JM,Smalle J,Gingerich DJ,et al(2004).Arabidopsis EIN3-binding F-box 1 and 2 form ubiquitin-protein ligases that repress ethylene action and promote growth by directing EIN3 degradation.Proc Natl Acad Sci USA,101(17):6803-6808
Gao C,Qi S,Liu K,et al(2016).MYC2,MYC3,and MYC4function redundantly in seed storage protein accumulation in Arabidopsis.Plant Physiol Biochem,108:63-70
Gasperini D,Chételat A,Acosta IF,et al(2015).Multilayered organization of jasmonate signalling in the regulation of root growth.PLoS Genet,11(6):e1005300
He YM,Liu SF,Lei SQ(2018).The dynamic changes in jasmonate levels and expression of its pathway-related genes in anthers before dehiscence in rice.Acta Agr Univ Jiangxiensis,40(3):429-434(in Chinese with English abstract)[何永明,刘遂飞,雷抒情(2018).水稻花药开裂前茉莉酸水平及信号途径相关基因表达的动态变化.江西农业大学学报,40(3):429-434]
Helfer A,Nusinow DA,Chow BY,et al(2011).LUX AR-RHYTHMO encodes a night time repressor of circadian gene expression in the Arabidopsis core clock.Curr Biol,21(2):126-133
Hills MJ(2004).Control of storage-product synthesis in seeds.Curr Opin Plant Biol,7(3):302-308
Hiruma K,Nishiuchi T,Kato T,et al(2011).Arabidopsis ENHANCED DISEASE RESISTANCE 1 is required for pathogen-induced expression of plant defensins in nonhost resistance,and acts through interference of MYC2-mediated repressor function.Plant J,67(6):980-992
Hou X,Lee LYC,Xia K,et al(2010).DELLAs modulate jasmonate signaling via competitive binding to JAZs.Dev Cell,19(6):884-894
Huang CF,Yu CP,Wu YH,et al(2017).Elevated auxin biosynthesis and transport underlie high vein density in C4leaves.Proc Natl Acad Sci USA,114(33):E6884-E6891
Jeong JS,Jung C,Seo JS,et al(2017).The deubiquitinating enzymes UBP12 and UBP13 positively regulate MYC2levels in jasmonate responses.Plant Cell,29(6):1406-1424
Jung C,Zhao P,Seo JS,et al(2015).PLANT U-BOX PRO-TEIN10 regulates MYC2 stability in Arabidopsis.Plant Cell,27(7):2016-2031
Li T,Xu Y,Zhang L,et al(2017).The jasmonate-activated transcription factor MdMYC2 regulates ETHYLENERESPONSE FACTOR and ethylene biosynthetic genes to promote ethylene biosynthesis during apple fruit ripening.Plant Cell,29(6):1316-1334
Lian TF,Xu YP,Li LF,et al(2017).Crystal structure of tetrameric Arabidopsis MYC2 reveals the mechanism of enhanced interaction with DNA.Cell Rep,19(7):1334-1342
Liu XY,Wang WS,Fu BY,et al(2011).Research progress of plant bHLH transcription factor family.Curr Biotechnol,1(6):391-397(in Chinese with English abstract)[刘晓月,王文生,傅彬英等(2011).植物bHLH转录因子家族的功能研究进展.生物技术进展,1(6):391-397]
Lorenzo O,Chico JM,Sánchez-Serrano JJ,et al(2004).JAS-MONATE-INSENSITIVE1 encodes a MYC transcription factor essential to discriminate between different jasmonate-regulated defense responses in Arabidopsis.Plant Cell,16(7):1938-1950
Maksymiec W,Wianowska D,Dawidowicz AL,et al(2005).The level of jasmonic acid in Arabidopsis thaliana and Phaseolus coccineus plants under heavy metal stress.Plant Physiol,162(12):1338-1346
Pech JC,LatchéA,Bouzayen M(2010).Ethylene biosynthesis.In:Davies PJ(ed).Plant Hormones.Biosynthesis,Signal Transduction,Action!Dordrecht:Springer,115-136
Qi T,Huang H,Song S,et al(2015).Regulation of jasmonate-mediated stamen development and seed production by a bHLH-MYB complex in Arabidopsis.Plant Cell,27(6):1620-1633
Qi T,Wang J,Huang H,et al(2015).Regulation of jasmonate-induced leaf senescence by antagonism between bHLHsubgroup IIIe and IIId factors in Arabidopsis.Plant Cell,27(6):1634-1649
Qiao H,Shen Z,Huang SC,et al(2012).Processing and subcellular trafficking of ER-tethered EIN2 control response to ethylene gas.Science,338(6105):390-393
Sanchez SE,Kay SA(2016).The plant circadian clock:from a simple timekeeper to a complex developmental manager.Cold Spring Harb Perspect Biol,8(12):a027748
Song S,Huang H,Gao H,et al(2014).Interaction between MYC2 and ETHYLENE INSENSITIVE3 modulates antagonism between jasmonate and ethylene signaling in Arabidopsis.Plant Cell,26:263-279
Sun J,Xu Y,Ye S,et al(2009).Arabidopsis ASA1 is important for jasmonate-mediated regulation of auxin biosynthesis and transport during lateral root formation.Plant Cell,21(5):1495-1511
Wang H,Li Y,Pan J,et al(2017).The bHLH transcription factors MYC2,MYC3,and MYC4 are required for jasmonate-mediated inhibition of flowering in Arabidopsis.Mol Plant,10(11):1461-1464
Wen X,Zhang C,Ji Y,et al(2012).Activation of ethylene signaling is mediated by nuclear translocation of the cleaved EIN2 carboxyl terminus.Cell Res,22(11):1613-1616
Wild M,Davière JM,Cheminant S,et al(2012).The Arabidopsis DELLA RGA-LIKE3 is a direct target of MYC2and modulates jasmonate signaling responses.Plant Cell,24(8):3307-3319
Wu JM,Huang X,Qiu LH,et al(2016).The progress of DEL-LA protein in plants.J Agr Biotechnol,24(8):1207-1215[吴建明,黄杏,丘立杭等(2016).DELLA蛋白在植物中的研究进展.农业生物技术学报,24(8):1207-1215]
Wu XY,Kuai BK,Jia JZ,et al(2012).Regulation of leaf senescence and crop genetic improvement.Integr Plant Biol,54(12):936-952
Yadav V,Mallappa C,Gangappa SN,et al(2005).A basic helix-loop-helix transcription factor in Arabidopsis,MYC2,acts as a repressor of blue light-mediated photomorphogenic growth.Plant Cell,17(7):1953-1966
Yang DL,Yao J,Mei CS,et al(2012).Plant hormone jasmonate prioritizes defense over growth by interfering with gibberellin signaling cascade.Proc Natl Acad Sci USA,109(19):E1192-E1200
Yi WK,Wang J,Yang H,et al(2012).Abscisic acid receptors:abscisic acid signaling transduction pathways in plants.Chin Bull Bot,47(5):515-524(in Chinese with English abstract)[易文凯,王佳,杨辉等(2012)植物ABA受体及其介导的信号转导通路.植物学报,47(5):515-524]
Yu J,Zhang Y,Di C,et al(2016).JAZ7 negatively regulates dark-induced leaf senescence in Arabidopsis.J Exp Bot,67(3):751-762
Zhang Y,Wang Y,Wei H,et al(2018).Circadian evening complex represses jasmonate-induced leaf senescence in Arabidopsis.Mol Plant,11(2):326-337
Zhao Y,Dong W,Zhang N,et al(2014).A wheat allene oxide cyclase gene enhances salinity tolerance via jasmonate signaling.Plant Physiol,164(2):1068-1076
Zhu C,Gan L,Shen Z,et al(2006).Interactions between jasmonates and ethylene in the regulation of root hair development in Arabidopsis.J Exp Bot,57(6):1299-1308
Zhu Z,An F,Feng Y,et al(2011).Derepression of ethylene-stabilized transcription factors(EIN3/EIL1)mediates jasmonate and ethylene signaling synergy in Arabidopsis.Proc Natl Acad Sci USA,108(30):12539-12544
Zhu Z,Lee B(2015).Friends or foes:new insights in jasmonate and ethylene co-actions.Plant Cell Physiol,56(3):414-420