食管炎合剂治疗反流性食管炎的临床效果
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摘要
目的探讨陕西中医药大学第二附属医院脾胃病科自拟方——食管炎合剂治疗反流性食管炎(RE)瘀血阻络证的临床效果。方法选取2017年10月至2018年9月陕西中医药大学第二附属医院门诊及住院部收治的RE瘀血内阻证患者63例为研究对象,按就诊顺序使用随机数字表法将患者分为治疗组(31例)和对照组(32例)。治疗组给予口服食管炎合剂,对照组给予泮托拉唑胶囊治疗。比较两组患者治疗前、后中医症状总积分、具体症状积分及远期疗效。结果治疗前,两组中医症状总积分比较,差异无统计学意义(P>0.05);治疗后,两组中医症状总积分均降低,且治疗组低于对照组,差异具有统计学意义(P<0.05)。治疗前,两组具体症状积分比较,差异无统计学意义(P>0.05);治疗后,两组具体症状积分均降低,且治疗组低于对照组,差异具有统计学意义(P<0.05)。治疗组的复发率显著低于对照组,差异具有统计学意义(P<0.05)。结论食管炎合剂治疗RE瘀血内阻证的效果显著,值得临床应用推广。
Objective To explore the clinical effect of esophagitis mixture, a self-made prescription of spleen and stomach diseases department in the Second Affiliated Hospital of Shaanxi University of Chinese Medicine, in treating reflux esophagitis(RE) with syndrome of blood stasis and obstruction of collaterals. Methods From October 2017 to September2018, 63 RE patients with syndrome of blood stasis and obstruction of collaterals admitted in the outpatient and inpatient department of the Second Affiliated Hospital of Shaanxi University of Chinese Medicine were selected as the research objects. According to the order of visiting, the patients were divided into treatment group(31 cases) and control group(32 cases) by random number table method. The treatment group was treated with oral esophagitis mixture, while the control group was treated with pantoprazole capsule. The total scores of TCM symptoms, specific symptoms scores before and after treatment and long-term efficacy of the two groups were compared. Results Before treatment, there was no significant difference in the total score of TCM symptoms between the two groups(P>0.05); after treatment, the total scores of TCM symptoms in both groups decreased, and that in the treatment group was lower than the control group, and the differences were statistically significant(P <0.05). Before treatment, there were no significant differences in the scores of specific symptoms between the two groups(P>0.05); after treatment, the scores of specific symptoms in the two groups decreased,and those in the treatment group were lower than the control group, and the differences were statistically significant(P<0.05). The recurrence rate of the treatment group was significantly lower than that of the control group, and the difference was statistically significant(P <0.05). Conclusion Esophagitis mixture has a remarkable effect on RE with syndrome of blood stasis and obstruction of collaterals, which is worthy of clinical application and promotion.
Objective To explore the clinical effect of esophagitis mixture, a self-made prescription of spleen and stomach diseases department in the Second Affiliated Hospital of Shaanxi University of Chinese Medicine, in treating reflux esophagitis(RE) with syndrome of blood stasis and obstruction of collaterals. Methods From October 2017 to September2018, 63 RE patients with syndrome of blood stasis and obstruction of collaterals admitted in the outpatient and inpatient department of the Second Affiliated Hospital of Shaanxi University of Chinese Medicine were selected as the research objects. According to the order of visiting, the patients were divided into treatment group(31 cases) and control group(32 cases) by random number table method. The treatment group was treated with oral esophagitis mixture, while the control group was treated with pantoprazole capsule. The total scores of TCM symptoms, specific symptoms scores before and after treatment and long-term efficacy of the two groups were compared. Results Before treatment, there was no significant difference in the total score of TCM symptoms between the two groups(P>0.05); after treatment, the total scores of TCM symptoms in both groups decreased, and that in the treatment group was lower than the control group, and the differences were statistically significant(P <0.05). Before treatment, there were no significant differences in the scores of specific symptoms between the two groups(P>0.05); after treatment, the scores of specific symptoms in the two groups decreased,and those in the treatment group were lower than the control group, and the differences were statistically significant(P<0.05). The recurrence rate of the treatment group was significantly lower than that of the control group, and the difference was statistically significant(P <0.05). Conclusion Esophagitis mixture has a remarkable effect on RE with syndrome of blood stasis and obstruction of collaterals, which is worthy of clinical application and promotion.
引文
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[2]张声生,朱生樑,王宏伟,等.胃食管反流病中医诊疗专家共识意见(2017)[J].中国中西医结合消化杂志,2017,25(5):321-326.
[3]郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:383-385.
[4]朱志强,郑颖颖,李贵,等.针药结合治疗肝胃郁热型反流性食管炎46例临床观察[J].中医杂志,2017,58(1):46-49.
[5]国家技术监督局.中医临床诊疗术语疾病部分[J].成都中医药大学学报,2003,26(1):62-63.
[6]潘鸿鹄.中医药治疗炎症学[M].北京:军事医学科学出版社,2000:13-14.