生长激素对年轻卵巢储备功能减退患者体外受精—胚胎移植结局的影响
摘要
目的探讨生长激素(GH)对卵巢储备功能减退的年轻患者(<35岁)在体外受精—胚胎移植(IVF-ET)结局的影响。方法将82例使用短方案进行IVF-ET的卵巢储备功能减退的年轻患者随机分成两组:观察组(应用GH) 40例,对照组(未用GH) 42例,比较各组的IVF-ET结局。结果两组患者的一般情况差异无统计学意义(P>0. 05),观察组的优胚数、可用胚胎数、优胚率显著高于对照组(P<0. 05);观察组临床妊娠率(59. 3%)亦显著高于对照组(26. 1%)(P<0. 05)。结论 GH可以提高卵巢储备功能减退的年轻患者的临床结局,GH适用于此类患者。
引文
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[9]Weall BM,Al-Samerria S,Conceicao J,et al. A direct action for GH in improvement of oocyte quality in poor-responder patients[J].Reproduction,2015,149(2):147-154.
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[12]Eftekhar M, Aflatoonian A, Mohammadian F, et al. Adjuvant growth hormone therapy in antagonist protocol in poor responders undergoing assisted reproductive technology. Arch Gynecol Obstet,2013,287(5):1017-21.
[13]Keane KN,Yovich JL,Hamidi A,et al. Single-centre retrospective analysis of growth hormone supplement-ation in IVF patients classified as poor-prognosis[J]. BMJ Open,2017,7(10):e018107.
[14]Gerkowicz SA,Henriquez S,Sanchez YN,et al. Growth hormone improves cycle outcome in patients with low ovarian reserve undergoing in vitro fertilization:a cost-effectiveness analysis[J]. Fertil Steril,2015,104(3):e329-e329.
[2]Sills ES,Alper MM,Walsh AP. Ovarian reserve screening in infertility:practical applications and theoretical directions for research[J]. Eur J Obstet Gynecol Reprod Biol,2009,146(1):30-36.
[3]朱洁茹,欧建平.生长激素对卵巢功能影响的研究进展[J].生殖与避孕,2016,8(6):489-494.
[4]Bachelot A,Monget P,Imbert-BolloréP,et al. Growth hormone is required for ovarian follicular growth[J]. Endocrinology, 2002,143(10):4104.
[5]Zaczek D,Hammond J,Suen L,et al. Impact of growth hormone resistance on female reproductive function:new in sights from growth hormone receptor knockout mice[J]. Biol Reprod, 2002, 67(4):1115-24.
[6]Practice Committee of the American Society for Reproductive Medicine. Testing and interpreting measures of ovarian reserve:a committee opinion[J]. Fertil Steri,2015,103:e9-e17.
[7]Fisch JD,Sher G,Adamowicz M,et al. The graduated embryo score predicts the outcome of assisted reproductive technologies better than a single day 3 evaluation and achieves results associated with blastocyst transfer from day 3 embryo transfer[J]. Fertil Steril,2003,80(6):1352-1358.
[8]韩莹,张云山.卵巢储备功能下降相关因素的logistic回归分析[J].现代妇产科进展,2015,27(2):109-111.
[9]Weall BM,Al-Samerria S,Conceicao J,et al. A direct action for GH in improvement of oocyte quality in poor-responder patients[J].Reproduction,2015,149(2):147-154.
[10]Yu X,Ruan J,He LP,et al. Efficacy of growth hormone supplementation with gonadotrophins in vitro fertilization for poor ovarian responders:an updated meta-analysis[J]. Int J Clin Exp Med,2015,8(4):4954-4967.
[11]Lattes K,Brassesco M,Gomez M,et al. Low-dose growth hormone supplementation increases clinical pregnancy rate in poor responders undergoing in vitro fertilisation. Gynecol Endocrinol,2015,31(7):565-468.
[12]Eftekhar M, Aflatoonian A, Mohammadian F, et al. Adjuvant growth hormone therapy in antagonist protocol in poor responders undergoing assisted reproductive technology. Arch Gynecol Obstet,2013,287(5):1017-21.
[13]Keane KN,Yovich JL,Hamidi A,et al. Single-centre retrospective analysis of growth hormone supplement-ation in IVF patients classified as poor-prognosis[J]. BMJ Open,2017,7(10):e018107.
[14]Gerkowicz SA,Henriquez S,Sanchez YN,et al. Growth hormone improves cycle outcome in patients with low ovarian reserve undergoing in vitro fertilization:a cost-effectiveness analysis[J]. Fertil Steril,2015,104(3):e329-e329.