重组牛碱性成纤维细胞生长因子滴眼液与羟糖苷滴眼液治疗年龄相关性白内障患者术后干眼症的效果比较
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摘要
目的比较重组牛碱性成纤维细胞生长因子(rb-bFGF)滴眼液与羟糖苷滴眼液治疗年龄相关性白内障(ARC)患者术后干眼症的效果。方法选择2015年1月～2018年6月在安徽省铜陵市人民医院接受白内障超声乳化手术治疗的ARC患者89例进行观察。根据随机数字表法将患者分成观察组(45例)和对照组(44例)。在常规用药的基础上,对照组术后给予羟糖苷滴眼液治疗,观察组术后给予rb-bFGF滴眼液治疗,3个月后比较两组疗效、炎性因子、临床指标及不良反应发生情况。结果观察组总有效率高于对照组(P <0.05)。治疗后两组白细胞介素-1β(IL-1β)和肿瘤坏死因子-α(TNF-α)水平均较治疗前明显降低,且观察组显著低于对照组,差异有统计学意义(P <0.05)。治疗后两组的泪液分泌试验(SIt)、角膜荧光素钠染色(FL)评分及干眼症状评分均较治疗前明显降低,且观察组低于对照组,差异有统计学意义(P <0.05)。治疗后两组泪膜破裂时间(BUT)长于治疗前,且观察组长于对照组,差异有统计学意义(P <0.05)。观察组不良反应发生率低于对照组(P <0.05)。结论 rbbFGF滴眼液治疗ARC患者术后干眼症的效果更好,安全性也更佳,同时能够有效改善患者的炎症状态、泪膜损伤和角膜状况,值得临床推广。
Objective To compare the efficacy of Recombinant Bovine Basic Fibroblast Growth Factor(rb-bFGF) Eye Drops and Hydroxycarboside Eye Drops in the treatment of dry eye after age-related cataract( ARC) operation.Methods Eighty-nine patients with ARC who underwent phacoemulsification in Tongling People′s Hospital from January 2015 to June 2018 were observed. Patients were divided into observation group(45 cases) and control group(44 cases) by random number table method. On the basis of routine medication, the control group was treated with Hydroxycarboside Eye Drops after operation, while the observation group was treated with rb-bFGF Eye Drops after operation.After 3 months, the efficacy, inflammatory factor, clinical indicators and adverse reactions of the two groups were compared. Results The total effective rate of the observation group was higher than that of the control group(P < 0.05). After treatment, the levels of interleukin-1β(IL-1β) and tumor necrosis factor-α(TNF-α) in the two groups were significantly lower than those before treatment, and the observation group was significantly lower than the control group, the differences were statistically significant(P < 0.05). The Schirmer I test(SIt), fluorescein corneal staining(FL) and dry eye symptom score of the two groups were significantly lower than those before treatment, and the observation group was lower than the control group, the differences were statistically significant(P < 0.05). The tear break-up time(BUT)of the two groups after treatment was longer than that before treatment, and the observation group was longer than the control group, the differences were statistically significant(P < 0.05). The incidence of adverse reactions in the observation group was lower than that in the control group(P < 0.05). Conclusion rb-bFGF Eye Drops has better efficacy and safety in the treatment of dry eye after ARC operation, and can effectively improve inflammation, tear film injury and corneal condition. It is worthy of promotion in clinic.
Objective To compare the efficacy of Recombinant Bovine Basic Fibroblast Growth Factor(rb-bFGF) Eye Drops and Hydroxycarboside Eye Drops in the treatment of dry eye after age-related cataract( ARC) operation.Methods Eighty-nine patients with ARC who underwent phacoemulsification in Tongling People′s Hospital from January 2015 to June 2018 were observed. Patients were divided into observation group(45 cases) and control group(44 cases) by random number table method. On the basis of routine medication, the control group was treated with Hydroxycarboside Eye Drops after operation, while the observation group was treated with rb-bFGF Eye Drops after operation.After 3 months, the efficacy, inflammatory factor, clinical indicators and adverse reactions of the two groups were compared. Results The total effective rate of the observation group was higher than that of the control group(P < 0.05). After treatment, the levels of interleukin-1β(IL-1β) and tumor necrosis factor-α(TNF-α) in the two groups were significantly lower than those before treatment, and the observation group was significantly lower than the control group, the differences were statistically significant(P < 0.05). The Schirmer I test(SIt), fluorescein corneal staining(FL) and dry eye symptom score of the two groups were significantly lower than those before treatment, and the observation group was lower than the control group, the differences were statistically significant(P < 0.05). The tear break-up time(BUT)of the two groups after treatment was longer than that before treatment, and the observation group was longer than the control group, the differences were statistically significant(P < 0.05). The incidence of adverse reactions in the observation group was lower than that in the control group(P < 0.05). Conclusion rb-bFGF Eye Drops has better efficacy and safety in the treatment of dry eye after ARC operation, and can effectively improve inflammation, tear film injury and corneal condition. It is worthy of promotion in clinic.
引文
[1]岑羽捷,王薇.年龄相关性白内障患者术后视觉满意度的影响因素[J].国际眼科纵览,2018,42(1):60-64.
[2]余永贵,黄晓红,何华,等.年龄相关性白内障超声乳化摘除联合人工晶体植入手术的健康教育与护理[J].实用临床护理学电子杂志,2018,3(18):80-83.
[3]罗斌,张彤,陈萌,等.曲安奈德对年龄相关性白内障患者房水TNF-α、IL-1β、IL-6的影响[J].现代生物医学进展,2018,18(4):721-724.
[4]刘院斌,武忠华,郭俊儿,等.重组牛碱性成纤维细胞生长因子对白内障超声乳化联合IOL植入术后干眼的治疗[J].中华实验眼科杂志,2016,34(2):175-180.
[5]郭胜.玻璃体切除联合硅油填充术后并发性白内障患者与年龄相关性白内障患者房水中细胞因子的表达差异分析[J].中国实用医刊,2017,44(19):114-116.
[6]曹贺,阎启昌.白内障诊疗指南———第42届日本白内障学会制定[J].日本医学介绍,2004,25(10):467-469.
[7]蒋伟蓉,陈瑶,谭浅,等.年龄相关性白内障的高阶像差及光学质量[J].中华眼视光学与视觉科学杂志,2018,20(3):150-155.
[8]王坤,金靖宇.重组牛碱性成纤维细胞生长因子滴眼液治疗膜性结膜炎的临床效果分析[J].中国处方药,2017,15(5):75-76.
[9]张佳楠,李海丽,晏晓明,等.两种干眼症状问卷评分与干眼临床检查的关联性研究[J].中华实验眼科杂志,2012,30(4):362-366.
[10]汪枫桦,孙晓东.规范和优化临床诊疗实践,提高老年性黄斑变性治疗水平:英国皇家眼科学院老年性黄斑变性临床指南解读[J].中华眼底病杂志,2012,28(5):436-440.
[11]付浩祥,周金长,蔡多贤,等.术前治疗睑板腺功能障碍对年龄相关性白内障术后泪膜变化影响的研究[J].数理医药学杂志,2018,31(1):35-36.
[12]王素雅.重组牛碱性成纤维细胞生长因子滴眼液联合妥布霉素地塞米松滴眼液治疗白内障超声乳化术后角膜水肿的应用效果分析[J].山西医药杂志,2018,47(17):2054-2056.
[13]刘锦魁,唐健青.重组牛碱性成纤维细胞生长因子眼用凝胶在睑板腺异常相关干眼患者中的临床应用[J].海南医学,2017,28(4):658-659.
[14]凌宇,彭子春,唐琪,等.rb-bFGF滴眼液与羟糖苷滴眼液对年龄相关性白内障术后泪膜稳定性及干眼症状的影响[J].国际眼科杂志,2018,18(1):104-107.
[15]林丽敏,黄锐升,李庆南,等.溴芬酸钠滴眼液联合重组牛碱性成纤维细胞生长因子滴眼液对白内障超声乳化术后泪膜稳定性的影响[J].饮食保健,2017,4(16):43-44.
[16]牛洁.飞秒激光辅助超声乳化术对年龄相关性白内障患者角膜散光和SIA值的影响[J].国际眼科杂志,2018,18(10):1838-1842.
[17] Shen J,Lu XG,Jin JJ,et al. Combination of a 2940 nm Er:YAG laser with recombinant bovine basic fibroblast growth factor(rb-bFGF)and light-emitting diode-red light(LED-RL)for the treatment of striae alba:A pilot study[J]. J Cosmet Dermatol,2018,17(2):176-183.
[18]惠娜,韩春娟,张健,等.超声乳化联合人工晶体植入术治疗年龄相关性白内障合并干眼症的临床效果[J].临床医学研究与实践,2018,3(26):91-92.
[19]冯江虹.重组牛碱性成纤维细胞生长因子对老年糖尿病性白内障超声乳化术患者临床症状及视觉恢复的影响[J].中国药物与临床,2017,17(6):810-813.
[20]陈静.b FGF滴眼液与羟糖甘滴眼液对年龄相关性白内障术后泪膜稳定性及干眼症状的影响[J].国际眼科杂志,2017,17(10):1841-1844.
[21] Nanu RV,Ungureanu E,Istrate SL,et al. Investigation of importance of the structural parameters of the eyeball and of the technical parameters of cataract surgery on corneal endothelial changes[J]. Rom J Ophthalmol,2018,62(3):203-211.
[2]余永贵,黄晓红,何华,等.年龄相关性白内障超声乳化摘除联合人工晶体植入手术的健康教育与护理[J].实用临床护理学电子杂志,2018,3(18):80-83.
[3]罗斌,张彤,陈萌,等.曲安奈德对年龄相关性白内障患者房水TNF-α、IL-1β、IL-6的影响[J].现代生物医学进展,2018,18(4):721-724.
[4]刘院斌,武忠华,郭俊儿,等.重组牛碱性成纤维细胞生长因子对白内障超声乳化联合IOL植入术后干眼的治疗[J].中华实验眼科杂志,2016,34(2):175-180.
[5]郭胜.玻璃体切除联合硅油填充术后并发性白内障患者与年龄相关性白内障患者房水中细胞因子的表达差异分析[J].中国实用医刊,2017,44(19):114-116.
[6]曹贺,阎启昌.白内障诊疗指南———第42届日本白内障学会制定[J].日本医学介绍,2004,25(10):467-469.
[7]蒋伟蓉,陈瑶,谭浅,等.年龄相关性白内障的高阶像差及光学质量[J].中华眼视光学与视觉科学杂志,2018,20(3):150-155.
[8]王坤,金靖宇.重组牛碱性成纤维细胞生长因子滴眼液治疗膜性结膜炎的临床效果分析[J].中国处方药,2017,15(5):75-76.
[9]张佳楠,李海丽,晏晓明,等.两种干眼症状问卷评分与干眼临床检查的关联性研究[J].中华实验眼科杂志,2012,30(4):362-366.
[10]汪枫桦,孙晓东.规范和优化临床诊疗实践,提高老年性黄斑变性治疗水平:英国皇家眼科学院老年性黄斑变性临床指南解读[J].中华眼底病杂志,2012,28(5):436-440.
[11]付浩祥,周金长,蔡多贤,等.术前治疗睑板腺功能障碍对年龄相关性白内障术后泪膜变化影响的研究[J].数理医药学杂志,2018,31(1):35-36.
[12]王素雅.重组牛碱性成纤维细胞生长因子滴眼液联合妥布霉素地塞米松滴眼液治疗白内障超声乳化术后角膜水肿的应用效果分析[J].山西医药杂志,2018,47(17):2054-2056.
[13]刘锦魁,唐健青.重组牛碱性成纤维细胞生长因子眼用凝胶在睑板腺异常相关干眼患者中的临床应用[J].海南医学,2017,28(4):658-659.
[14]凌宇,彭子春,唐琪,等.rb-bFGF滴眼液与羟糖苷滴眼液对年龄相关性白内障术后泪膜稳定性及干眼症状的影响[J].国际眼科杂志,2018,18(1):104-107.
[15]林丽敏,黄锐升,李庆南,等.溴芬酸钠滴眼液联合重组牛碱性成纤维细胞生长因子滴眼液对白内障超声乳化术后泪膜稳定性的影响[J].饮食保健,2017,4(16):43-44.
[16]牛洁.飞秒激光辅助超声乳化术对年龄相关性白内障患者角膜散光和SIA值的影响[J].国际眼科杂志,2018,18(10):1838-1842.
[17] Shen J,Lu XG,Jin JJ,et al. Combination of a 2940 nm Er:YAG laser with recombinant bovine basic fibroblast growth factor(rb-bFGF)and light-emitting diode-red light(LED-RL)for the treatment of striae alba:A pilot study[J]. J Cosmet Dermatol,2018,17(2):176-183.
[18]惠娜,韩春娟,张健,等.超声乳化联合人工晶体植入术治疗年龄相关性白内障合并干眼症的临床效果[J].临床医学研究与实践,2018,3(26):91-92.
[19]冯江虹.重组牛碱性成纤维细胞生长因子对老年糖尿病性白内障超声乳化术患者临床症状及视觉恢复的影响[J].中国药物与临床,2017,17(6):810-813.
[20]陈静.b FGF滴眼液与羟糖甘滴眼液对年龄相关性白内障术后泪膜稳定性及干眼症状的影响[J].国际眼科杂志,2017,17(10):1841-1844.
[21] Nanu RV,Ungureanu E,Istrate SL,et al. Investigation of importance of the structural parameters of the eyeball and of the technical parameters of cataract surgery on corneal endothelial changes[J]. Rom J Ophthalmol,2018,62(3):203-211.