ER、p63、PTEN在子宫内膜息肉中的研究现状
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摘要
子宫内膜息肉是引起异常子宫出血的常见妇科疾病,患病率为24%～25%,复发率高,其病因学及分子生物学发病机制尚未明确,目前认为可能与受体表达水平的改变、内膜细胞的增殖/凋亡活性失衡等方面相关。有研究表明子宫内膜息肉患者血清雌激素在正常水平,内膜息肉局部雌激素受体含量增高;在子宫内膜息肉中,由于p63的表达增高,PTEN蛋白表达下降,细胞正常增殖、凋亡失衡,诱发子宫内膜息肉的形成。现就ER、p63、PTEN在子宫内膜息肉发生中可能的作用作一综述。
Endometrial polyp is a common gynecological diseases causing abnormal uterine bleeding, the morbidity is24% to 25%, and the recurrence rate is high. The etiology and molecular biology pathogenesis remain still unclear.Currently, it is believed that endometrial polyp is associated with changes in receptor expression levels, imbalances of proliferation/apoptotic activity of endometrial cells. Studies show that serum estrogen level in patients with endometrial polyps is normal, but its local estrogen receptor levels increase. The formation of endometrial polyps may be related to increased expression of p63 and decreased expression of PTEN protein expression, which lead to the imbalance of proliferation and apoptosis in normal cells, inducing the formation of endometrial polyps. The possible roles of ER, p63,and PTEN in the development of endometrial polyps are reviewed.
Endometrial polyp is a common gynecological diseases causing abnormal uterine bleeding, the morbidity is24% to 25%, and the recurrence rate is high. The etiology and molecular biology pathogenesis remain still unclear.Currently, it is believed that endometrial polyp is associated with changes in receptor expression levels, imbalances of proliferation/apoptotic activity of endometrial cells. Studies show that serum estrogen level in patients with endometrial polyps is normal, but its local estrogen receptor levels increase. The formation of endometrial polyps may be related to increased expression of p63 and decreased expression of PTEN protein expression, which lead to the imbalance of proliferation and apoptosis in normal cells, inducing the formation of endometrial polyps. The possible roles of ER, p63,and PTEN in the development of endometrial polyps are reviewed.
引文
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[4]Lieng M,Istre O,Qvigstad E.Treatment of endometrial polyps:a systematic review[J].Acta Obstet Gynecol Scand,2010,89(8):992-1002.
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[14]Reis Filho JS,Schmitt FC.Taking advantage of basic research p63 is a reliable myoepithelial and stem cell marker[J].Adv Anat Pathol,2002,9(5):280-289.
[15]Nogueira AA,Sant′Ana de Almeida EC,Poli Neto OB,et al.Immunohistochemical expression of p63 in endometrial polys:evidence that a basal cell immunophenotype is maintained[J].Menopause,2006,13(5):826-830.
[16]郝国荣,白凤楼.P63及PTEN在子宫内膜息肉中的表达及意义[J].河北医药,2016,38(3):376-378.
[17]苏婷婷,隋龙.P63蛋白、芳香酶P450及类固醇生成因子1在子宫内膜息肉中的表达及意义[J].中华妇产科杂志,2014,49(8):604-608.
[18]Tantbirojn P,Triratanachat S.Detection of PTEN immunoreactivity in endometrial hyperplasia and adenocarcinoma[J].J Med Assoc Thai,2008,91(8):1161-1165.
[19]程佳,杨晓龙,寻志杰,等.卵巢上皮性癌中p-AKT、PI3K和PTEN蛋白的表达及意义[J].河北医药,2014,36(4):501-504.
[20]Salina L,Carracedo A,Pandolfi PP.Tenets of PTEN tumor suppression[J].Cell,2008,133(3):403-414.
[21]覃丽渊,孙燕.PTEN、PI3K、AKT蛋白在子宫内膜息肉中的表达及意义[J].广东医学,2018,39(9):1639-1671.
[22]钟长晔,蒋凤艳.PTEN蛋白在子宫内膜息肉中的表达研究[J].广西医科大学学报,2015,32(2):254-256.
[23]赵桂凤,张艳红.PTEN和C-erbB-2蛋白在子宫内膜癌的表达及临床意义[J].中国优生与遗传杂志,2013,21(6):39-40.
[24]侯国胜,冯晨.PTEN在60例子宫内膜癌中的表达及意义[J].农垦医学,2012,34(1):26-28.
[2]Dal Cin P,Timmerman D,Van den Berghe l,et al.Genomic changes in endometrial polyps associated with tamoxifen show no evidence for its action as an external carcinogen[J].Cancer Res,1998,58(11):2278-2281.
[3]Savelli L,De laco P,Santini D,et al.Histopathologic feature and risk factors for benignity.hyperplasia,and cancer in endometrial polyps[J].Am J Obstet Gynecol,2003,188(4):927-931.
[4]Lieng M,Istre O,Qvigstad E.Treatment of endometrial polyps:a systematic review[J].Acta Obstet Gynecol Scand,2010,89(8):992-1002.
[5]Baskin GB,Smith SM,Marx PA.Endometrial hyperplasia,polyps,and adenomyosis associated with unopposed estrogen in rhesus monkeys(Macaca mulatta)[J].Vet Pathol,2002,39(5):572-575.
[6]Perez-Medina T,Bajo-Arenas J,Haya J,et al.Tibolone and risk of endometrial polys:a prospective,comparative study with hormone therapy[J].Menopause,2003,10(6):534-537.
[7]彭雪冰,夏恩兰.子宫内膜息肉中雌激素受体和孕激素受体的表达特点及意义[J].首都医科大学学报,2006,27(1):117-119.
[8]Sant Ana de Almeida EC,Nogueira AA,Candido dos Reis FJ,et al.Immunohistochemical expression of estrogen and progesterone receptors in endometrial polyps and adjacent endometrium in postmenopausal women[J].Maturitas,2004,49(3):229-233.
[9]Lopes RG,Baracat EC,de Albuquerque Neto LC,et al.Analysis of estrogen-and progesterone-receptor expression in endometrial polyps[J].J Minim Invasive Gynecol,2007,14(3):300-303.
[10]孙传海,韩壮,王敏,等.p53基因家族的新成员p73和p63[J].中国肿瘤,2001,10(7):403-406.
[11]Mangiulli M,Valletti A,Caratozzolo MF,et al.Identification and functional characterization of two new transcriptional variants of the human p63 gene[J].Nucleiec Acids Res,2009,37(18):6092-6104.
[12]Weber A,Langhanki L,Schutz A,et al.Expression profiles of p53,p63,and p73 in benign salivary gland tumors[J].Virchows Arch,2002,441(5):428-436.
[13]O′Connell JT,Mutter GL,Cviko A,et a1.Identification of a basal/reserve cellimmunophenotype in benign and neoplastic endometrium:a study with the p53 homologue p63[J].Gynecol Oncol,2001,80(1):30-36
[14]Reis Filho JS,Schmitt FC.Taking advantage of basic research p63 is a reliable myoepithelial and stem cell marker[J].Adv Anat Pathol,2002,9(5):280-289.
[15]Nogueira AA,Sant′Ana de Almeida EC,Poli Neto OB,et al.Immunohistochemical expression of p63 in endometrial polys:evidence that a basal cell immunophenotype is maintained[J].Menopause,2006,13(5):826-830.
[16]郝国荣,白凤楼.P63及PTEN在子宫内膜息肉中的表达及意义[J].河北医药,2016,38(3):376-378.
[17]苏婷婷,隋龙.P63蛋白、芳香酶P450及类固醇生成因子1在子宫内膜息肉中的表达及意义[J].中华妇产科杂志,2014,49(8):604-608.
[18]Tantbirojn P,Triratanachat S.Detection of PTEN immunoreactivity in endometrial hyperplasia and adenocarcinoma[J].J Med Assoc Thai,2008,91(8):1161-1165.
[19]程佳,杨晓龙,寻志杰,等.卵巢上皮性癌中p-AKT、PI3K和PTEN蛋白的表达及意义[J].河北医药,2014,36(4):501-504.
[20]Salina L,Carracedo A,Pandolfi PP.Tenets of PTEN tumor suppression[J].Cell,2008,133(3):403-414.
[21]覃丽渊,孙燕.PTEN、PI3K、AKT蛋白在子宫内膜息肉中的表达及意义[J].广东医学,2018,39(9):1639-1671.
[22]钟长晔,蒋凤艳.PTEN蛋白在子宫内膜息肉中的表达研究[J].广西医科大学学报,2015,32(2):254-256.
[23]赵桂凤,张艳红.PTEN和C-erbB-2蛋白在子宫内膜癌的表达及临床意义[J].中国优生与遗传杂志,2013,21(6):39-40.
[24]侯国胜,冯晨.PTEN在60例子宫内膜癌中的表达及意义[J].农垦医学,2012,34(1):26-28.