水产动物及其制品中苯并(a)芘的研究进展和标准化现状
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摘要
近些年来,由于人类的生产和生活导致了海洋资源的破坏和海洋环境的持续恶化,已引起了国内学术界的高度重视和密切关注。因此迅速、有效地监测海洋中生物变化,及时督促海洋污染的治理,将损失降至最低,显得尤为重要。苯并(a)芘(Benzo(a)pyrene,B(a)P)是一种具有明显致癌作用的多环芳烃类化合物。随着海洋环境污染事件频发,水产动物及其制品中苯并(a)芘的残留日益受到人们的重视。就苯并(a)芘的危害、来源、预处理技术、检测方法、标准化以及存在的问题等进行阐述,并展望今后研究的重点和方向。旨在加强我国水产动物及其制品中的苯并(a)芘监测,为制定相关标准提供技术参考。
In recent years,the production and life of human lead to the destruction of marine resources and the marine environment,which have attracted much attention in the relevant domestic academic fields. Thus,monitoring the changes of the organisms in the sea timely and effectively,guiding the improvement of the marine environment and minimizing the damage become more and more important. Benzo(a)pyrene(B(a)P)is a kind of polycyclic aromatic compounds which has strong carcinogenic. The benzo(a)pyrene residue in aquatic animals and their products has attracted increasing attention with the frequent marine environmental pollution incidents.This article reviewed the harmful effects,sources,pretreatment techniques,detecting methods,standardization status and existing problems of benzo(a)pyrene. Then it proposed the emphasis and direction of the future research. In order to strengthen the benzo(a)pyrene monitoring in China in aquatic animals and their products,provide technical reference for the relevant standards.
In recent years,the production and life of human lead to the destruction of marine resources and the marine environment,which have attracted much attention in the relevant domestic academic fields. Thus,monitoring the changes of the organisms in the sea timely and effectively,guiding the improvement of the marine environment and minimizing the damage become more and more important. Benzo(a)pyrene(B(a)P)is a kind of polycyclic aromatic compounds which has strong carcinogenic. The benzo(a)pyrene residue in aquatic animals and their products has attracted increasing attention with the frequent marine environmental pollution incidents.This article reviewed the harmful effects,sources,pretreatment techniques,detecting methods,standardization status and existing problems of benzo(a)pyrene. Then it proposed the emphasis and direction of the future research. In order to strengthen the benzo(a)pyrene monitoring in China in aquatic animals and their products,provide technical reference for the relevant standards.
引文
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[12]王欣,周智慧,赵晓联.苯并(a)芘危害性及其检测技术[J].粮食与油脂,2011(3):48-49
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[15]谢君红,姚祖江,冯辉.食品中苯并芘的来源和危害及其预防[J].中外食品,2014(1):51-53
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[17]朱小玲.烹饪过程中多环芳烃的产生及控制[J].四川烹饪高等专科学校学报,2012(5):22-25
[18]王珍.食用油中苯并(a)芘检测的前处理及其GC/MS分析[D].南宁:广西大学,2013
[19]胡浩军,侯逸众,黄方取,等.固相萃取-气相色谱-质谱法测定植物油中苯并(a)芘和苯并(e)芘[J].中国卫生检验杂志,2014,24(11):1570-1572
[20]杨水艳,邵志凌.食用油中苯并(a)芘分析方法的最新研究进展[J].粮油加工(电子版),2014(2):43-46
[21]李进伟,王兴国,金青哲.食用油中苯并(a)芘的来源、检测和控制[J].中国油脂,2011,36(6):7-11
[22]俞晔,金青哲,刘海珍,等.食用油脂中多环芳烃检测的前处理技术研究进展[J].中国油脂,2011,36(7):1-4
[23]彭志兵,莫逆,杨学文.食用油中苯并(a)芘分析方法研究进展[J].粮油食品科技,2013,21(1):46-49
[24]程春梅,董刘敏,彭进.超高效液相色谱法检测食用植物油中的苯并(a)芘[J].中国油脂,2011,36(2):77-79
[25]俸金梅,张学忠,冯雷,等.高效液相色谱-荧光法快速测定植物油中的苯并(a)芘[J].农业机械,2012(24):56-58
[26]杜京霖.油茶籽油中苯并(a)芘的产生与控制技术研究[D].宁波:宁波大学,2014
[27]杨燕.济南市食用油中苯并芘、酸价及过氧化值的调查分析[D].济南:山东大学,2012
[28]王浩,杨红梅,郭启雷,等.高效液相色谱-串联质谱法同时测定植物油中苯并芘与黄曲霉毒素B1,B2,G1,G2[J].分析测试学报,2014,33(8):911-916
[29]刘艳琴,王浩,杨红梅.凝胶渗透色谱-高效液相色谱法测定植物油中苯并芘[J].食品科技,2013,38(1):327-329
[30]陈洪涛,王力清,甄成,等.食用油脂多环芳烃污染研究进展[J].粮食与油脂,2011(6):37-39
[31]肖海波.利用新型核壳纳米粒子作为SERS基底检测苯并(a)芘[D].福建:集美大学,2012
[32]无锡市金坤生物工程有限公司.苯并芘金标检测试纸及其制备方法以及检测试纸盒:201110022123.1[P].2011-09-07
[33]Scientific Committee on Food(SCF).Opinion of the Scientific Committee on Food on the risks to human health of Polycyclic Aromatic Hydrocarbons in food(expressed on 4 December 2002)[EB/OL].(2002-11-04).http://ec.europa.eu/food/fs/sc/scf/out153_en.pdf
[34]Joint FAO/WHO Expert Committee on Food Additives(JECFA).Summary and conclusions of the sixty-fourth meeting of the Joint FAO/WHO Expert Committee on Food Additives(JECFA)[EB/OL].(2005-02-17).http://www.fda.gov/downloads/Food/Foodborne Illness Contaminants/Chemical Contaminants/UCM194526.pdf
[35]范波.城市污水处理中颗粒物对多环芳烃的吸附去除特性研究[D].西安:西安建筑科技大学,2011
[36]中华人民共和国国家卫生和计划生育委员会.国家卫生计生委办公厅关于征求《食品安全国家标准饮用天然矿泉水检验方法》等11项食品安全国家标准(征求意见稿)意见的函[EB/OL].(2015-08-04).http://www.nhfpc.gov.cn/zhuzhan/zqyj/201508/077b818189e9436bbf5179a000b2146c.shtml
[2]中国海洋信息网.中国海洋环境状况公报[EB/OL].(2016-04-14).http://www.coi.gov.cn/gongbao/huanjing/201604/t20160414_33875.html.
[3]段小丽,陶澍,徐东群,等.多环芳烃污染的人体暴露和健康风险评价方法[M].北京:中国环境科学出版社,2011:9,48
[4]秦晓蕾.PAHs多途径暴露的健康风险评估和生物标志物的研究[D].天津:天津医科大学,2013
[5]王秋兰,朱建坤,韩涛.苯并(a)芘诱发小鼠实体瘤及其对机体IL-2、IL-6的影响[J].实用预防医学,2015,22(3):296-298
[6]连立芬.苯并芘的生殖毒性机制研究进展[J].国际生殖健康/计划生育杂志,2013,32(6):450-453
[7]贾鸿宁,戴红.多环芳烃的致癌性及其机制研究进展[J].大连医科大学学报,2009,31(5):604-607
[8]贾国力,冉华中,季亢挺,等.3,4苯并芘对内皮祖细胞生物学功能的影响[J].中华细胞与干细胞杂志,2013,3(3):137
[9]杨瑾,陈文涛,范燕峰,等.苯并(a)芘染毒致人支气管上皮细胞的周期改变及BPDE-DNA加合物形成[J].癌变·畸变·突变,2015,27(2):87
[10]邓南圣,吴峰.环境中的内分泌干扰物[M].北京:化学工业出版社,2004:6-10,193-206
[11]袁海艳.苯并(a)芘神经毒性及其在脑组织中分布的研究[D].重庆:重庆医科大学,2009
[12]王欣,周智慧,赵晓联.苯并(a)芘危害性及其检测技术[J].粮食与油脂,2011(3):48-49
[13]IARC Monographs on the Evaluation of Carcinogenic Risks to Humans.Some Non-heterocyclic Polycyclic Aromatic Hydrocarbons and Some Related Exposures[EB/OL].(2005-10-18).http://monographs.iarc.fr/ENG/Monographs/vol92/index.php
[14]宿书芳,刘艳明,薛霞,等.植物油中苯并(a)芘的来源分析[J].农业机械,2013(20):58-59
[15]谢君红,姚祖江,冯辉.食品中苯并芘的来源和危害及其预防[J].中外食品,2014(1):51-53
[16]譒IMKO P.Determination of polycyclic armatic hydrocarbons in smoked meat products and smoke flavouring food additives[J].Journal of Chromatography B,2002,770(1):3-18
[17]朱小玲.烹饪过程中多环芳烃的产生及控制[J].四川烹饪高等专科学校学报,2012(5):22-25
[18]王珍.食用油中苯并(a)芘检测的前处理及其GC/MS分析[D].南宁:广西大学,2013
[19]胡浩军,侯逸众,黄方取,等.固相萃取-气相色谱-质谱法测定植物油中苯并(a)芘和苯并(e)芘[J].中国卫生检验杂志,2014,24(11):1570-1572
[20]杨水艳,邵志凌.食用油中苯并(a)芘分析方法的最新研究进展[J].粮油加工(电子版),2014(2):43-46
[21]李进伟,王兴国,金青哲.食用油中苯并(a)芘的来源、检测和控制[J].中国油脂,2011,36(6):7-11
[22]俞晔,金青哲,刘海珍,等.食用油脂中多环芳烃检测的前处理技术研究进展[J].中国油脂,2011,36(7):1-4
[23]彭志兵,莫逆,杨学文.食用油中苯并(a)芘分析方法研究进展[J].粮油食品科技,2013,21(1):46-49
[24]程春梅,董刘敏,彭进.超高效液相色谱法检测食用植物油中的苯并(a)芘[J].中国油脂,2011,36(2):77-79
[25]俸金梅,张学忠,冯雷,等.高效液相色谱-荧光法快速测定植物油中的苯并(a)芘[J].农业机械,2012(24):56-58
[26]杜京霖.油茶籽油中苯并(a)芘的产生与控制技术研究[D].宁波:宁波大学,2014
[27]杨燕.济南市食用油中苯并芘、酸价及过氧化值的调查分析[D].济南:山东大学,2012
[28]王浩,杨红梅,郭启雷,等.高效液相色谱-串联质谱法同时测定植物油中苯并芘与黄曲霉毒素B1,B2,G1,G2[J].分析测试学报,2014,33(8):911-916
[29]刘艳琴,王浩,杨红梅.凝胶渗透色谱-高效液相色谱法测定植物油中苯并芘[J].食品科技,2013,38(1):327-329
[30]陈洪涛,王力清,甄成,等.食用油脂多环芳烃污染研究进展[J].粮食与油脂,2011(6):37-39
[31]肖海波.利用新型核壳纳米粒子作为SERS基底检测苯并(a)芘[D].福建:集美大学,2012
[32]无锡市金坤生物工程有限公司.苯并芘金标检测试纸及其制备方法以及检测试纸盒:201110022123.1[P].2011-09-07
[33]Scientific Committee on Food(SCF).Opinion of the Scientific Committee on Food on the risks to human health of Polycyclic Aromatic Hydrocarbons in food(expressed on 4 December 2002)[EB/OL].(2002-11-04).http://ec.europa.eu/food/fs/sc/scf/out153_en.pdf
[34]Joint FAO/WHO Expert Committee on Food Additives(JECFA).Summary and conclusions of the sixty-fourth meeting of the Joint FAO/WHO Expert Committee on Food Additives(JECFA)[EB/OL].(2005-02-17).http://www.fda.gov/downloads/Food/Foodborne Illness Contaminants/Chemical Contaminants/UCM194526.pdf
[35]范波.城市污水处理中颗粒物对多环芳烃的吸附去除特性研究[D].西安:西安建筑科技大学,2011
[36]中华人民共和国国家卫生和计划生育委员会.国家卫生计生委办公厅关于征求《食品安全国家标准饮用天然矿泉水检验方法》等11项食品安全国家标准(征求意见稿)意见的函[EB/OL].(2015-08-04).http://www.nhfpc.gov.cn/zhuzhan/zqyj/201508/077b818189e9436bbf5179a000b2146c.shtml