同型半胱氨酸在冠心病发病机制中的研究进展
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摘要
同型半胱氨酸(Hcy)作为冠心病(CHD)的独立危险因素,已经得到了广泛的临床重视。Hcy在CHD中的相关研究不断在进展,但是Hcy引起CHD的发病机制还有待进一步研究。本文就当前Hcy在CHD发病机制中的研究进展做一综述,旨在探讨Hcy在CHD发病过程中的作用以及相关影响。
Homocysteine(Hcy),as an independent risk factor for coronary heart disease(CHD),has received extensive clinical attention.The related research on Hcy in CHD is progressing,but the pathogenesis of CHD caused by Hcy remains to be further studied.This article reviews the current research progress of Hcy in the pathogenesis of CHD,and aims to explore the role of Hcy in the pathogenesis of CHD and its related effects.
Homocysteine(Hcy),as an independent risk factor for coronary heart disease(CHD),has received extensive clinical attention.The related research on Hcy in CHD is progressing,but the pathogenesis of CHD caused by Hcy remains to be further studied.This article reviews the current research progress of Hcy in the pathogenesis of CHD,and aims to explore the role of Hcy in the pathogenesis of CHD and its related effects.
引文
[1]刘玉薇,万楠.血清同型半胱氨酸水平与冠心病相关性研究[J].国际检验医学杂志,2018,39(19):2373-2375.
[2]张贞,宁兴旺,匡敏,等.冠状动脉粥样硬化性心脏病患者血浆同型半胱氨酸水平检测研究的进展[J].中华检验医学杂志,2016,39(9):726-728.
[3]MATSUZAWA Y,LERMAN A.Endothelial dysfunction and coronary artery disease:assessment,prognosis,and treatment[J].Coron Artery Dis,2014,25(8):713-714.
[4]LIU C,YANG Y,PENG D,et al.Hyperhomocysteinemia as a metabolic disorder parameter is independently associated with the severity of coronary heart disease[J].Saudi Med J,2015,36(7):839-846.
[5]QIN X,QIN L,LUO J,et al.Correlation analysis between25-hydroxyvitamin D3,vitamin B12and vitamin C and endothelial function of patients with CHD[J].Exp ther med,2019,17(1):418-422.
[6]YANG F,QI X,GAO Z,et al.Homocysteine injures vascular endothelial cells by inhibiting mitochondrial activity.[J].Exp Ther Med,2016,12(4):2247-2252.
[7]WU X,ZHANG L,MIAO Y,et al.Homocysteine causes vascular endothelial dysfunction by disrupting endoplasmic reticulum redox homeostasis[J].Redox biol,2019,20(3):46-59.
[8]黄宁江,黄海,姜卓,等.同型半胱氨酸硫内酯-内质网应激途径促进HUVECs黏附[J].基础医学与临床,2018,38(9):1274-1279.
[9]ZHANG Z,WEI C,ZHOU Y,et al.Homocysteine Induces Apoptosis of Human Umbilical Vein Endothelial Cells via Mitochondrial Dysfunction and Endoplasmic Reticulum Stress[J].Oxid Med Cell Longev,2017,2017(1):5736506.
[10]YANG F,QI X,GAO Z,et al.Homocysteine injures vascular endothelial cells by inhibiting mitochondrial activity.[J].Exp Ther Med,2016,12(4):2247-2252.
[11]LI F,CHEN Q,SONG X,et al.MiR-30bIs Involved in the Homocysteine-Induced Apoptosis in Human Coronary Artery Endothelial Cells by Regulating the Expression of Caspase 3.[J].Inter J Mol Sci,2015,16(8):17682.
[12]MA Y,PENG D,LIU C,et al.Serum high concentrations of homocysteine and low levels of folic acid and vitamin B12,are significantly correlated with the categories of coronary artery diseases[J].Bmc Cardiovasc Disord,2017,17(1):37.
[13]李萱,羊梅,刘敦芳,等.血清尿酸和同型半胱氨酸与冠心病严重程度的相关性分析[J].临床合理用药杂志.2017.10(36):13-14.
[14]DAVI G,DI M G,COPPOLA A,et al.Oxidative stress and platelet activation in homozygous homocystinuria.[J].Circulation,2001,104(10):1124.
[15]HAN X B,ZHANG H P,CAO C J,et al.Aberrant DNAmethylation of the PDGF gene in homocysteine mediated VSMC proliferation and its underlying mechanism[J].Mol Med Rep,2014,10(2):947.
[16]杨晓玲,郭凤英,马胜超,等.miRNA-143在同型半胱氨酸致血管平滑肌细胞增殖中作用的研究[J].中国药理学通报,2016,32(8):1097-1101.
[17]MA S C,CAO J C,ZHANG H P,et al.Aberrant promoter methylation of multiple genes in VSMC proliferation induced by Hcy[J].Mol Med Rep,2017,16(5):7775-7783.
[18]CHERNYAVSKIY I,VEERANKI S,SEN U,et al.Atherogenesis:hyperhomocysteinemia interactions with LDL,macrophage function,paraoxonase 1,and exercise[J].Ann N Y Acad Sci,2016,1363(1):138-154.
[19]MOMIN M,JIA J,FAN F,et al.Relationship between plasma homocysteine level and lipid profiles in a community-based Chinese population[J].Lipids Health Dis,2017,16(1):54.
[20]郭伟,马胜超,张辉,等.脂肪酸结合蛋白4在Hcy致泡沫细胞胆固醇聚积中的作用[J].中国动脉硬化杂志,2016,24(8):757-762.
[21]SCHAFFER A,VERDOIA M,CASSETTI E,et al.Relationship between homocysteine and coronary artery disease.Results from a large prospective cohort study[J].Thromb res,2014,134(2):288-293.
[22]张秦风,秦卫伟,李虹,等.冠心病患者中HCY与HDL对氧磷酶抗氧化功能的相关性研究[J/CD].中西医结合心血管病电子杂志,2018,6(2):98-100.
[23]李莉,高胜利,翟晓娟,等.冠心病患者Hcy和SAH与外周血淋巴细胞基因组甲基化相关性研究[J].临床医药实践,2017,26(12):899-903
[24]张辉,郭伟,高婷婷,等.血清SAM/SAH在Hcy引起动脉粥样硬化基因组DNA甲基化中的作用[J].中国动脉硬化杂志,2017,25(2):129-133.
[25]ZHOU S,ZHANG Z,XU G.Notable epigenetic role of hyperhomocysteinemia in atherogenesis[J].Lipids Health Dis,2014,13(1):1-8.
[26]YANG X L,TIAN J,LIANG Y,et al.Homocysteine induces blood vessel global hypomethylation mediated by LOX-1[J].Gen Mol Res Gmr,2014,13(2):3787.
[27]WEI G,LIU H,JIE Y,et al.Exosomes derived from mature dendritic cells increase endothelial inflammation and atherosclerosis via membrane TNF-αmediated NF-κBpathway[J].J Cell Mol Med,2016,20(12):2318-2327.
[28]代佩,高奋,高宏伟,等.同型半胱氨酸通过诱导miR-33激活NF-κB途径上调RAW264.7源性泡沫细胞TNF-α、IL-6的表达[J].中国动脉硬化杂志,2018,25(12):1239-1244.
[29]WANG R,WANG Y,MU N,et al.Activation of NLRP3inflammasomes contributes to hyperhomocysteinemia-aggravated inflammation and atherosclerosis in apoE-deficient mice[J].Lab Inv,2017,97(8):922-934.
[2]张贞,宁兴旺,匡敏,等.冠状动脉粥样硬化性心脏病患者血浆同型半胱氨酸水平检测研究的进展[J].中华检验医学杂志,2016,39(9):726-728.
[3]MATSUZAWA Y,LERMAN A.Endothelial dysfunction and coronary artery disease:assessment,prognosis,and treatment[J].Coron Artery Dis,2014,25(8):713-714.
[4]LIU C,YANG Y,PENG D,et al.Hyperhomocysteinemia as a metabolic disorder parameter is independently associated with the severity of coronary heart disease[J].Saudi Med J,2015,36(7):839-846.
[5]QIN X,QIN L,LUO J,et al.Correlation analysis between25-hydroxyvitamin D3,vitamin B12and vitamin C and endothelial function of patients with CHD[J].Exp ther med,2019,17(1):418-422.
[6]YANG F,QI X,GAO Z,et al.Homocysteine injures vascular endothelial cells by inhibiting mitochondrial activity.[J].Exp Ther Med,2016,12(4):2247-2252.
[7]WU X,ZHANG L,MIAO Y,et al.Homocysteine causes vascular endothelial dysfunction by disrupting endoplasmic reticulum redox homeostasis[J].Redox biol,2019,20(3):46-59.
[8]黄宁江,黄海,姜卓,等.同型半胱氨酸硫内酯-内质网应激途径促进HUVECs黏附[J].基础医学与临床,2018,38(9):1274-1279.
[9]ZHANG Z,WEI C,ZHOU Y,et al.Homocysteine Induces Apoptosis of Human Umbilical Vein Endothelial Cells via Mitochondrial Dysfunction and Endoplasmic Reticulum Stress[J].Oxid Med Cell Longev,2017,2017(1):5736506.
[10]YANG F,QI X,GAO Z,et al.Homocysteine injures vascular endothelial cells by inhibiting mitochondrial activity.[J].Exp Ther Med,2016,12(4):2247-2252.
[11]LI F,CHEN Q,SONG X,et al.MiR-30bIs Involved in the Homocysteine-Induced Apoptosis in Human Coronary Artery Endothelial Cells by Regulating the Expression of Caspase 3.[J].Inter J Mol Sci,2015,16(8):17682.
[12]MA Y,PENG D,LIU C,et al.Serum high concentrations of homocysteine and low levels of folic acid and vitamin B12,are significantly correlated with the categories of coronary artery diseases[J].Bmc Cardiovasc Disord,2017,17(1):37.
[13]李萱,羊梅,刘敦芳,等.血清尿酸和同型半胱氨酸与冠心病严重程度的相关性分析[J].临床合理用药杂志.2017.10(36):13-14.
[14]DAVI G,DI M G,COPPOLA A,et al.Oxidative stress and platelet activation in homozygous homocystinuria.[J].Circulation,2001,104(10):1124.
[15]HAN X B,ZHANG H P,CAO C J,et al.Aberrant DNAmethylation of the PDGF gene in homocysteine mediated VSMC proliferation and its underlying mechanism[J].Mol Med Rep,2014,10(2):947.
[16]杨晓玲,郭凤英,马胜超,等.miRNA-143在同型半胱氨酸致血管平滑肌细胞增殖中作用的研究[J].中国药理学通报,2016,32(8):1097-1101.
[17]MA S C,CAO J C,ZHANG H P,et al.Aberrant promoter methylation of multiple genes in VSMC proliferation induced by Hcy[J].Mol Med Rep,2017,16(5):7775-7783.
[18]CHERNYAVSKIY I,VEERANKI S,SEN U,et al.Atherogenesis:hyperhomocysteinemia interactions with LDL,macrophage function,paraoxonase 1,and exercise[J].Ann N Y Acad Sci,2016,1363(1):138-154.
[19]MOMIN M,JIA J,FAN F,et al.Relationship between plasma homocysteine level and lipid profiles in a community-based Chinese population[J].Lipids Health Dis,2017,16(1):54.
[20]郭伟,马胜超,张辉,等.脂肪酸结合蛋白4在Hcy致泡沫细胞胆固醇聚积中的作用[J].中国动脉硬化杂志,2016,24(8):757-762.
[21]SCHAFFER A,VERDOIA M,CASSETTI E,et al.Relationship between homocysteine and coronary artery disease.Results from a large prospective cohort study[J].Thromb res,2014,134(2):288-293.
[22]张秦风,秦卫伟,李虹,等.冠心病患者中HCY与HDL对氧磷酶抗氧化功能的相关性研究[J/CD].中西医结合心血管病电子杂志,2018,6(2):98-100.
[23]李莉,高胜利,翟晓娟,等.冠心病患者Hcy和SAH与外周血淋巴细胞基因组甲基化相关性研究[J].临床医药实践,2017,26(12):899-903
[24]张辉,郭伟,高婷婷,等.血清SAM/SAH在Hcy引起动脉粥样硬化基因组DNA甲基化中的作用[J].中国动脉硬化杂志,2017,25(2):129-133.
[25]ZHOU S,ZHANG Z,XU G.Notable epigenetic role of hyperhomocysteinemia in atherogenesis[J].Lipids Health Dis,2014,13(1):1-8.
[26]YANG X L,TIAN J,LIANG Y,et al.Homocysteine induces blood vessel global hypomethylation mediated by LOX-1[J].Gen Mol Res Gmr,2014,13(2):3787.
[27]WEI G,LIU H,JIE Y,et al.Exosomes derived from mature dendritic cells increase endothelial inflammation and atherosclerosis via membrane TNF-αmediated NF-κBpathway[J].J Cell Mol Med,2016,20(12):2318-2327.
[28]代佩,高奋,高宏伟,等.同型半胱氨酸通过诱导miR-33激活NF-κB途径上调RAW264.7源性泡沫细胞TNF-α、IL-6的表达[J].中国动脉硬化杂志,2018,25(12):1239-1244.
[29]WANG R,WANG Y,MU N,et al.Activation of NLRP3inflammasomes contributes to hyperhomocysteinemia-aggravated inflammation and atherosclerosis in apoE-deficient mice[J].Lab Inv,2017,97(8):922-934.