丹红注射液对比复方丹参注射液治疗冠心病心绞痛有效性及安全性的Meta分析
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摘要
目的应用Meta分析的方法比较丹红与复方丹参注射液治疗冠心病心绞痛的有效性及安全性。方法通过计算机检索Cochrane试验资料库(2018年第1期)、Embase(1966年至2018年3月)、Pubmed(1966年至2018年3月)、中国学术文献总库(CNKI)(1979年至2018年3月)、中文科技期刊数据库(1989年至2018年3月)、万方数字期刊库(1981年至2018年3月),由2名评价员分别独立的筛选文献、并对文献进行质量评估,从文献中获取相关数据,应用RevMan 5.3软件对提取的数据进行Meta分析。结果初步检索出187篇文献,纳入符合标准者11篇。从症状疗效来分析:χ2=9.73,df=10,P=0.46,合并OR=3.23,95%CI[2.17,4.80],Z=5.80 (P <0.00001);从心电图疗效来分析:χ2=8.55,df=10,P=0.58,合并OR=2.27,95%CI[1.68,3.05],Z=5.38(P <0.00001)。结论丹红注射液较复方丹参注射液治疗冠心病心绞痛在缓解症状及改善心电图方面效果更好,两药均未发现明显不良反应。
Objective: To compare the efficacy and safety of Danhong Injection and Compound Danshen Injection on coronary angina pectoris by Meta-analysis. Methods: Computer was used to search Cochrane trial database,Embase,Pubmed,CNKI,Chinese Science and Technology Journal Database and Wan Fang. Two evaluators independently screened articles and evaluated the quality of the articles. RevMan 5.3 software was used to analyze the extracted data. Results: 187 documents were initially retrieved,11 of which met the inclusion criteria.Analysis from the effect of symptoms: χ2=9.73,df=10,P = 0.46,combined OR=3.23,95%CI [2.17,4.80],Z = 5.80(P < 0.00001);analysis from the effect of electrocardiogram: χ2=8.55,df=10,P = 0.58,combined OR=2.27,95%CI[1.68,3.05],Z = 5.38(P < 0.00001). Conclusion: Danhong Injection is better than Compound Danshen Injection in relieving symptoms and improving electrocardiogram on angina pectoris of coronary heart disease. No obvious adverse reactions were found in both drugs.
Objective: To compare the efficacy and safety of Danhong Injection and Compound Danshen Injection on coronary angina pectoris by Meta-analysis. Methods: Computer was used to search Cochrane trial database,Embase,Pubmed,CNKI,Chinese Science and Technology Journal Database and Wan Fang. Two evaluators independently screened articles and evaluated the quality of the articles. RevMan 5.3 software was used to analyze the extracted data. Results: 187 documents were initially retrieved,11 of which met the inclusion criteria.Analysis from the effect of symptoms: χ2=9.73,df=10,P = 0.46,combined OR=3.23,95%CI [2.17,4.80],Z = 5.80(P < 0.00001);analysis from the effect of electrocardiogram: χ2=8.55,df=10,P = 0.58,combined OR=2.27,95%CI[1.68,3.05],Z = 5.38(P < 0.00001). Conclusion: Danhong Injection is better than Compound Danshen Injection in relieving symptoms and improving electrocardiogram on angina pectoris of coronary heart disease. No obvious adverse reactions were found in both drugs.
引文
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[23]Derrick A Bennett,Nancy K Latham,Caroline Stretton,et al.Anderson capture-recapture is a potentially useful method for assessing publication bias[J].Journal of Clinical Epidemiology,2004,57:349-357.
[2]高润霖.急性心肌梗死诊断和治疗指南[J].中华心血管痛杂志,2001,29(12):710-725.
[3]付长庚,刘龙涛,王跃飞,等.丹红注射液临床应用中国专家共识[J].中国中西医结合杂志,2018,38(4):389-397.
[4]范红晶,李敏,万海同,等.丹红注射液抗血栓药理作用的研究进展[J].中国中医急症,2015,24(12):2160-2164.
[3]Li Q,Wu JH,Guo DJ,et al.Suppression of diet-induced hyper-cholesterolemia by scutellarin in rats[J].Planta Med,2009,75(11):1203-1208.
[4]He M,Xue ZM,Li J,et al.Breviscapine inhibits high glucoseinduced proliferation and migration of cultured vascular smooth muscle cells of rats via suppressing the ERK1/2MAPK signaling pathway[J].Acta Pharmacol Sin,2012,33(5):606-614.
[5]贺运河,陈镜合.中药抗心肌缺血-再灌注损伤作用的机制研究现状[J].中西医结合心脑血管病杂志,2004,2(3):165-167.
[6]1980年全国内科学术会议关于冠状动脉心脏病命名及诊断标准[J].中华内科杂志,1981,20(4):253-255.
[7]中华人民共和国卫生部医政司.中国常见心脑血管疾病诊治指南[M].北京:北京科学技术出版社,2000:59-60.
[8]Sackett DL,Clarke M,Oxman AD,et a1.Cochrane Reviewers,Handbook 4.2,In Renew Manager[M].Versions 4.2.Oxford,England:The cochrane collaboration,2002:13-36.
[9]Jadad AR,Moore A,Carroll D,et al.Assessing the quality of reports of randomized clinical trials:is blinding necessary[J].Control Clin Trials,1996,17(1):1-12.
[10]董惠文,魏大东.丹红注射液治疗冠心病心绞痛及心肌缺血的疗效观察[J].内蒙古医学杂志,2012,44(S5):1-2.
[11]叶晓林.丹红注射液治疗不稳定性心绞痛60例[J].中国民间疗法,2011,19(6):42.
[12]刁鸿英,宋春莉.丹红注射液治疗冠心病心绞痛及心肌缺血的疗效观察[J].中国实用医药,2011,6(1):143-144.
[13]庄玉红.丹红注射液治疗不稳定心绞痛的临床疗效观察[J].中国实用医药,2010,5(5):117-118.
[14]刘华玲,安慧.丹红注射液治疗不稳定性心绞痛临床疗效观察[J].中国误诊学杂志,2009,9(3):547-548.
[15]戴慧,张延林,戴琴.丹红注射液治疗心绞痛112例效果观察[J].卫生职业教育,2009,27(3):137-138.
[16]杨虹,黄苏英.丹红与复方丹参注射液治疗稳定性心绞痛疗效观察[J].兵团医学,2009,20(2):20-21.
[17]张晶,孙萍.丹红注射液治疗冠心病心绞痛临床观察[J].辽宁中医杂志,2008,51(8):1208.
[18]庄玉红.丹红注射液治疗冠心病临床疗效观察[J].吉林医学,2008,51(15):1291-1292.
[19]赵书平.丹红注射液治疗不稳定型心绞痛临床观察[J].甘肃医药,2008,27(5):75-76.
[20]金海欧.丹红注射液治疗不稳定型心绞痛效果观察[J].交通医学,2007,4(4):397-398.
[21]Tonelli MR.The limits of evidence based medicine[J].Respir Care,2001,46(12):1435-1440.
[22]Matthias Egger,George Davey Smith,Martin Schneider,et al.Bias in Meta-analysis detected by a simple,graphical test[J].British Medical Journal,1998,315:629-634.
[23]Derrick A Bennett,Nancy K Latham,Caroline Stretton,et al.Anderson capture-recapture is a potentially useful method for assessing publication bias[J].Journal of Clinical Epidemiology,2004,57:349-357.