青紫合剂治疗儿童热毒血瘀型过敏性紫癜的临床疗效观察
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摘要
目的:观察青紫合剂治疗儿童热毒血瘀型过敏性紫癜临床疗效及可行性。方法:采用随机数字表法将180例热毒血瘀型过敏性紫癜患儿随机分为治疗组(青紫合剂联合常规西医治疗)和对照组(常规西医治疗),每组90例,两组疗程均14d。比较两组患儿临床疗效、实验室指标、药物不良反应发生率、复发率。结果:治疗组和对照组的临床总有效率为96.67%和82.22%,差异有统计学意义(P<0.05);治疗组各临床症状消失时间、住院时间、WBC、ESR、CRP、不良反应发生率及复发率均显著降低对照组(P<0.05,P<0.01)。结论:青紫合剂联合西药治疗儿童热毒血瘀型过敏性紫癜恢复时间短,复发率低,疗效确切。
Objective: To observe the clinical efficacy and feasibility of Qingzi Mixture treating Henoch-Schonlein purpura children with heat-toxicity and blood stasis syndrome. Methods: A total of 180 Henoch-Schonlein purpura children with heat-toxicity and blood stasis syndrome were randomly divided into treatment group by random number table method(implementation of Qingzi Mixture combined with conventional western medicine treatment) and control group(routine western medicine treatment), 90 cases in each group, both groups were treated for 14 days. The clinical efficacy, laboratory indexes,incidence of adverse drug reactions and recurrence rate were compared between the two groups. Results: The total effective rate of the treatment group and the control group was 96.67% and 82.22%, the difference was statistically significant(P<0.05). Time of disappearance of clinical symptoms hospitalization time, WBC, ESR, CRP, the incidence of adverse reaction and recurrence rate in treatment group were significantly better than that of the control group(P<0.05, P<0.01). Conclusion: Qingzi Mixture combined with western medicine for children with Henoch-Schonlein purpura(heat-toxicity and blood stasis syndrome) has a short recovery time, low recurrence rate andexact curative effect.
Objective: To observe the clinical efficacy and feasibility of Qingzi Mixture treating Henoch-Schonlein purpura children with heat-toxicity and blood stasis syndrome. Methods: A total of 180 Henoch-Schonlein purpura children with heat-toxicity and blood stasis syndrome were randomly divided into treatment group by random number table method(implementation of Qingzi Mixture combined with conventional western medicine treatment) and control group(routine western medicine treatment), 90 cases in each group, both groups were treated for 14 days. The clinical efficacy, laboratory indexes,incidence of adverse drug reactions and recurrence rate were compared between the two groups. Results: The total effective rate of the treatment group and the control group was 96.67% and 82.22%, the difference was statistically significant(P<0.05). Time of disappearance of clinical symptoms hospitalization time, WBC, ESR, CRP, the incidence of adverse reaction and recurrence rate in treatment group were significantly better than that of the control group(P<0.05, P<0.01). Conclusion: Qingzi Mixture combined with western medicine for children with Henoch-Schonlein purpura(heat-toxicity and blood stasis syndrome) has a short recovery time, low recurrence rate andexact curative effect.
引文
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[14]胡荣,李祖伦,杨露,等.白芷提取物欧前胡素对急性胸膜炎大鼠抗炎作用研究.中国中医急症,2012,21(4):576-577
[15]郑辉,王德才.白芷的药理作用与临床应用研究进展.医药导报,2009,28(1):83-84
[16]刘光颖,李峥.丹参现代药理研究概述.实用中医内科杂志,2013,27(10):156-157
[17]魏晓,朱德增,张敏,等.大剂量赤芍治疗重症急性胰腺炎疗效观察.中国中西医结合消化杂志,2007,15(1):32-34
[18]Hamdan J M,Barqawi M A.Henoch-Schonlein purpura in children:Influence of age on the incidence of nephritis and arthritis.Saudi Med J,2008,29(4):549-552
[19]Kawasaki Y,Suzuki J,Sakai N,et al.Clinical and pathological features of children with Henoch-Schnlein purpura nephritisrisk factors associated with prognosis.Clin Nephrol,2003,60(3):153-160
[20]杨燕,盛燕,张克青,等.清热利湿活血解毒中药联合西药治疗腹型过敏性紫癜湿毒内蕴证75例临床观察.中医杂志,2016,57(9):763-766
[2]Chen J Y,Mao J H.Henoch-Sch?nlein purpura nephritis in children:Incidence,pathogenesis and management.World J Pediatr,2015,11(1):29-34
[3]王林浅.肝素联合丙种球蛋白治疗过敏性紫癜的临床研究.临床和实验医学杂志,2010,9(15):1167-1168
[4]杨皓.中西医结合治疗小儿过敏性紫癜疗效观察.临床和实验医学杂志,2010,9(15):1180-1181
[5]胡亚美,江载芳.诸福棠实用儿科学.7版.北京:人民卫生出版社,2002:688-690
[6]国家中医药管理局.中医病证诊断疗效标准.南京:南京大学出版社,1994:12
[7]苗德光,袁泉,李玲,等.陈权从风毒论治过敏性紫癜经验.中华中医药杂志,2016,31(1):129-131
[8]车颖,单新军,陈楠楠,等.黄世林从湿热论治过敏性紫癜经验.中华中医药杂志,2018,33(2):572-573
[9]李鲜明,宗士群,李桐,等.青黛颗粒对溃疡性结肠炎实验大鼠血清白细胞介素6和10水平的影响.中西医结合消化杂志,2011,19(2):81-83
[10]吴可人,叶志鹏,李宁,等.大黄素对实验性自身免疫性甲状腺炎小鼠辅助型T细胞亚群的影响.中国临床药理学与治疗学,2017,22(6):633-639
[11]吴媛媛,蒋桂华,马逾英,等.白芷的药理作用研究进展.时珍国医国药,2009,20(3):625-627
[12]周学寻.壮医药线点灸联合白芷固肠汤治疗腹泻型肠易激综合征疗效观察.广西中医药,2013,36(3):51-52
[13]李永超,宋杨,齐云.白芷的药理作用研究进展.国外医药:植物药分册,2007,22(4):161-162
[14]胡荣,李祖伦,杨露,等.白芷提取物欧前胡素对急性胸膜炎大鼠抗炎作用研究.中国中医急症,2012,21(4):576-577
[15]郑辉,王德才.白芷的药理作用与临床应用研究进展.医药导报,2009,28(1):83-84
[16]刘光颖,李峥.丹参现代药理研究概述.实用中医内科杂志,2013,27(10):156-157
[17]魏晓,朱德增,张敏,等.大剂量赤芍治疗重症急性胰腺炎疗效观察.中国中西医结合消化杂志,2007,15(1):32-34
[18]Hamdan J M,Barqawi M A.Henoch-Schonlein purpura in children:Influence of age on the incidence of nephritis and arthritis.Saudi Med J,2008,29(4):549-552
[19]Kawasaki Y,Suzuki J,Sakai N,et al.Clinical and pathological features of children with Henoch-Schnlein purpura nephritisrisk factors associated with prognosis.Clin Nephrol,2003,60(3):153-160
[20]杨燕,盛燕,张克青,等.清热利湿活血解毒中药联合西药治疗腹型过敏性紫癜湿毒内蕴证75例临床观察.中医杂志,2016,57(9):763-766