补充核桃对学生记忆作用的随机双盲对照研究
|
摘要
目的:通过人群干预研究,观察核桃对学生记忆的作用。方法:采用随机对照双盲的试验设计,将120名学校、家长和学生自己均知情同意的初中生,年龄12.6～14.0岁,随机分为核桃干预组和安慰剂对照组,每日服用2罐产品(240 mL/罐),连续饮用30d。干预组学生每日补充核桃植物蛋白饮料,相当于24g核桃,对照组给予外型包装口感均与受试样品相似的安慰剂产品。试验前后分别使用中国科学院心理研究所编制的临床记忆量表检测记忆水平。结果:在干预后,干预组的指向记忆、联想学习和图像自由回忆的测验量表分及记忆商高于试验前,且均有显著性差异(P <0.01)。与对照组比较结果表明,干预组的指向记忆、联想学习、无意义图形再认和人像特点联想回忆测验量表分和记忆商均高于对照组,且均有显著性差异(P<0.01)。结论:核桃植物蛋白饮料具有辅助改善记忆功能的作用。
Objective:This study aimed to investigate the effect of Walnut supplementation on memory performance of students. Method:By a randomized,double-blind,placebo-controlled design,120 middle school students,aged from 12.6 to 14.0,were selected objectives with consensus from school,parents and students after fully informed and divided randomly into intervention group and control group. Intervention group was given 24 g Walnut through two cans(240 m L per can)of Walnut milk per day,and control group was given placebo,the similar product for 30 days. The cognitive function was evaluated by the clinical memory test before and after the intervention for each student. Results:The scores of the directed memory test,the associative learning test,the image free recall test and the memory quotient in experimental students were significantly higher than that before the intake of Walnut supplementation(P<0.01). And the scores of the directed memory test,the associative learning test,the recognition of meaningless graphics,the portrait characteristic relationship recall test and the memory quotient were significantly higher than the placebo groups(P<0.01). Conclusion:Walnut supplementation could improve the memory function.
Objective:This study aimed to investigate the effect of Walnut supplementation on memory performance of students. Method:By a randomized,double-blind,placebo-controlled design,120 middle school students,aged from 12.6 to 14.0,were selected objectives with consensus from school,parents and students after fully informed and divided randomly into intervention group and control group. Intervention group was given 24 g Walnut through two cans(240 m L per can)of Walnut milk per day,and control group was given placebo,the similar product for 30 days. The cognitive function was evaluated by the clinical memory test before and after the intervention for each student. Results:The scores of the directed memory test,the associative learning test,the image free recall test and the memory quotient in experimental students were significantly higher than that before the intake of Walnut supplementation(P<0.01). And the scores of the directed memory test,the associative learning test,the recognition of meaningless graphics,the portrait characteristic relationship recall test and the memory quotient were significantly higher than the placebo groups(P<0.01). Conclusion:Walnut supplementation could improve the memory function.
引文
[1]Roads BD.Improving human-machine cooperative classification via cognitive theories of similarity[J].Cognitive Science,2016(41):1394-1411.
[2]Ampaabeng SK.The long-term cognitive consequences of early childhood malnutrition:The case of famine in Ghana[J].Journal of Health Economics,2013(32):1013-1027.
[3]胡尧,郭启浩,岑屹,等.老年痴呆患者认知功能与维生素B12及叶酸的相关性.老年痴呆患者认知功能与维生素及叶酸的相关性[J].检验医学,2017,32(4):284-289.
[4]Debbora H,Christopher J,John N,et al.The developmental influence of primary memory capacity on working memory and academic achievement[J].Dev Psychol,2015,51(8):1131-1147.
[5]Jon DH.Food and memory[J].Annu.Rev,Annual Review of Anthropology,2006,35(35):361-378.
[6]王玉英,王福珍,王克安,等.营养强化辅食补充对甘肃贫困农村婴幼儿智力发育的影响[J].卫生研究,2006,36(6):772-774.
[7]Chen CM,Wang YY,Chang SY,et al.Effect of inhome fortification of complementary feeding on intellectual development of Chinese children[J].Biomedical and Enviromental Sciences,2010(23):83-91.
[8]Chang SY,Wang YY,Brouwer ID,et al.Iron-deficiency anemia in infancy and social emotional development in preschool-aged children[J].Pediatrics,,2011,127(4):927-933.
[9]王冰,孙静,霍军生,等.铁缺乏对学生认知能力的影响[J].职业与健康,2011,27(6):614-617.
[10]王劼,霍军生,孙静,等.铁强化酱油对铁缺乏不贫血学生注意力和学习成绩的干预效果[J].现代食品科技,2011,27(8):887-890.
[11]Aburto N,Abudou M,Candeias V,et al.Effect and safety of salt iodization to prevent iodine deficiency disorders:a systematic review with meta-analyses.WHO e-Library of Evidence for Nutrition Actions(e-LENA).Geneva:WHO,2014:1-32.
[12]Gómez-Pinilla F.Brain foods:The effects of nutrients on brain function[J].Nature Reviews Neuroscience,2008(9):568-578.
[13]Molteni R,Barnard R J,Gómez-Pinilla F,et al.A highfat,refined sugar diet reduces hippocampal brain-derived neurotrophic factor,neuronal plasticity,and learning[J].Neuroscience,2001,112(4):803-814.
[14]琚腊红,于冬梅,许晓丽,等.中国居民2010-2012年坚果摄入状况及不同年份变化趋势[J].中国公共卫生,2017,33(6):916-918.
[15]Willis L M,Shukitthale B,Cheng V,et al.Dose-dependent effects of walnuts on motor and cognitive function in aged rats[J].British Journal of Nutrition,2009,101(8):1140-1144.
[16]王鸿飞,徐超,周明亮,等.山核桃油改善小鼠记忆功能的研究[J].中国粮油学报,,2012,27(7):63-66.
[17]樊永波,陶兴无,马琳,等.核桃饼粕对大鼠学习、记忆和抗氧化功能的影响[J].食品科学,2013,34(17):323-326.
[18]付艾妮,朱书秀,艾永循,等.核桃仁提取物对阿尔茨海默病模型大鼠学习记忆能力和海马区神经元的保护作用[J].医药导报,2015,34(6):723-725.
[19]陈亮,王丽梅,郭艳芬,等.核桃油、紫苏油、α-亚麻酸、亚油酸对大鼠学习记忆的影响[J].中国油脂,2011,36(10):33-37.
[20]王杰,王丽梅,赵秀举,等.不同油脂对大鼠空间学习记忆的影响及与ASICs亚型受体的关系[J].油脂化学,2015,40(2):40-45.
[21]虞立霞,王伟光,洪燕.核桃乳改善学习记忆的实验研究[J].饮料工业,2015,18(2):17-19.
[22]Arab L,Ang A.A cross sectional study of the association琶洲新馆网址:www.cfaa.cn展出时间:2018年11八主办单位:中国食品添加剂和配料协会北京中食添会展中心秋季全国FIC-Autu展出地点:广州中国进between walnut consumption and cognitive function among adult US populations represented in NHANES[J].J Nutr Health Aging,2015,19(3):284-290.
[23]田粟,冯冬颖,姚奎章,等.核桃植物蛋白饮料改善记忆人群试食试验研究[J].中国食品学报,2016,16(3):36-41.
[24]曹卉娟,陈薇,韩梅,等.比较效果研究常用方法之一:实用型随机对照试验设计[J].现代中医临床,2015,22(2):32-35.
[25]刘风奎,刘贵建.临床常用检验与诊断速查[M].北京:北京科学技术出版社,2010:67.
[26]张双庆,崔雅娟,张彦,等.保健食品检验与评价技术指南[M].北京:北京科技出版社,2017:512.
[27]张津津,逯志杰,高艳杰,等.临床记忆量表的应用[J].医学理论与实践,2017,30(17):2543-2546.
[28]王丽梅,叶诚,郭艳芬,等.DHA油与其他4种油脂对大鼠空间学习记忆、脂质过氧化及其血脂水平的影响[J].中国油脂,2013,38(3):34-38.
[29]张清安,李建科,范学辉.核桃油对小鼠学习记忆能力的影响[J].陕西师范大学学报(自然科学版),2006,34(4):89-91.
[30]Shi DD,Chen CY,Zhao SL,et al.Effects of walnut polyphenol on learning and memory functions in hypercholesterolemia Mice[J].Journal of Food and Nutrition Research,2014,2(8):450-456.电话:010-5979583311月8日~10日会《中国食品添加剂》杂志社有限公司umn 2018进出口商品交易会展馆
[2]Ampaabeng SK.The long-term cognitive consequences of early childhood malnutrition:The case of famine in Ghana[J].Journal of Health Economics,2013(32):1013-1027.
[3]胡尧,郭启浩,岑屹,等.老年痴呆患者认知功能与维生素B12及叶酸的相关性.老年痴呆患者认知功能与维生素及叶酸的相关性[J].检验医学,2017,32(4):284-289.
[4]Debbora H,Christopher J,John N,et al.The developmental influence of primary memory capacity on working memory and academic achievement[J].Dev Psychol,2015,51(8):1131-1147.
[5]Jon DH.Food and memory[J].Annu.Rev,Annual Review of Anthropology,2006,35(35):361-378.
[6]王玉英,王福珍,王克安,等.营养强化辅食补充对甘肃贫困农村婴幼儿智力发育的影响[J].卫生研究,2006,36(6):772-774.
[7]Chen CM,Wang YY,Chang SY,et al.Effect of inhome fortification of complementary feeding on intellectual development of Chinese children[J].Biomedical and Enviromental Sciences,2010(23):83-91.
[8]Chang SY,Wang YY,Brouwer ID,et al.Iron-deficiency anemia in infancy and social emotional development in preschool-aged children[J].Pediatrics,,2011,127(4):927-933.
[9]王冰,孙静,霍军生,等.铁缺乏对学生认知能力的影响[J].职业与健康,2011,27(6):614-617.
[10]王劼,霍军生,孙静,等.铁强化酱油对铁缺乏不贫血学生注意力和学习成绩的干预效果[J].现代食品科技,2011,27(8):887-890.
[11]Aburto N,Abudou M,Candeias V,et al.Effect and safety of salt iodization to prevent iodine deficiency disorders:a systematic review with meta-analyses.WHO e-Library of Evidence for Nutrition Actions(e-LENA).Geneva:WHO,2014:1-32.
[12]Gómez-Pinilla F.Brain foods:The effects of nutrients on brain function[J].Nature Reviews Neuroscience,2008(9):568-578.
[13]Molteni R,Barnard R J,Gómez-Pinilla F,et al.A highfat,refined sugar diet reduces hippocampal brain-derived neurotrophic factor,neuronal plasticity,and learning[J].Neuroscience,2001,112(4):803-814.
[14]琚腊红,于冬梅,许晓丽,等.中国居民2010-2012年坚果摄入状况及不同年份变化趋势[J].中国公共卫生,2017,33(6):916-918.
[15]Willis L M,Shukitthale B,Cheng V,et al.Dose-dependent effects of walnuts on motor and cognitive function in aged rats[J].British Journal of Nutrition,2009,101(8):1140-1144.
[16]王鸿飞,徐超,周明亮,等.山核桃油改善小鼠记忆功能的研究[J].中国粮油学报,,2012,27(7):63-66.
[17]樊永波,陶兴无,马琳,等.核桃饼粕对大鼠学习、记忆和抗氧化功能的影响[J].食品科学,2013,34(17):323-326.
[18]付艾妮,朱书秀,艾永循,等.核桃仁提取物对阿尔茨海默病模型大鼠学习记忆能力和海马区神经元的保护作用[J].医药导报,2015,34(6):723-725.
[19]陈亮,王丽梅,郭艳芬,等.核桃油、紫苏油、α-亚麻酸、亚油酸对大鼠学习记忆的影响[J].中国油脂,2011,36(10):33-37.
[20]王杰,王丽梅,赵秀举,等.不同油脂对大鼠空间学习记忆的影响及与ASICs亚型受体的关系[J].油脂化学,2015,40(2):40-45.
[21]虞立霞,王伟光,洪燕.核桃乳改善学习记忆的实验研究[J].饮料工业,2015,18(2):17-19.
[22]Arab L,Ang A.A cross sectional study of the association琶洲新馆网址:www.cfaa.cn展出时间:2018年11八主办单位:中国食品添加剂和配料协会北京中食添会展中心秋季全国FIC-Autu展出地点:广州中国进between walnut consumption and cognitive function among adult US populations represented in NHANES[J].J Nutr Health Aging,2015,19(3):284-290.
[23]田粟,冯冬颖,姚奎章,等.核桃植物蛋白饮料改善记忆人群试食试验研究[J].中国食品学报,2016,16(3):36-41.
[24]曹卉娟,陈薇,韩梅,等.比较效果研究常用方法之一:实用型随机对照试验设计[J].现代中医临床,2015,22(2):32-35.
[25]刘风奎,刘贵建.临床常用检验与诊断速查[M].北京:北京科学技术出版社,2010:67.
[26]张双庆,崔雅娟,张彦,等.保健食品检验与评价技术指南[M].北京:北京科技出版社,2017:512.
[27]张津津,逯志杰,高艳杰,等.临床记忆量表的应用[J].医学理论与实践,2017,30(17):2543-2546.
[28]王丽梅,叶诚,郭艳芬,等.DHA油与其他4种油脂对大鼠空间学习记忆、脂质过氧化及其血脂水平的影响[J].中国油脂,2013,38(3):34-38.
[29]张清安,李建科,范学辉.核桃油对小鼠学习记忆能力的影响[J].陕西师范大学学报(自然科学版),2006,34(4):89-91.
[30]Shi DD,Chen CY,Zhao SL,et al.Effects of walnut polyphenol on learning and memory functions in hypercholesterolemia Mice[J].Journal of Food and Nutrition Research,2014,2(8):450-456.电话:010-5979583311月8日~10日会《中国食品添加剂》杂志社有限公司umn 2018进出口商品交易会展馆