影响育龄期妇女复发性流产的相关危险因素logistic回归分析
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摘要
目的探讨育龄期妇女发生复发性流产(RSA)的相关危险因素,为早期防治提供依据。方法选取120例确诊的育龄期RSA患者为病例组,同期随机选取120例正常妊娠的孕妇为对照组,采用病例对照的研究方法,进行单因素比较法和多因素logistic回归法来筛选RSA的相关危险因素。结果多因素logistic回归分析结果显示,引起育龄期RSA患者发病的危险因素包括不良生活方式(OR=4.358)、不良心理因素(OR=2.826)、自身免疫疾病(OR=3.518)、生殖系统感染(OR=3.666)、获得性子宫异常(OR=5.038)及配偶精子质量差(OR=1.996)。结论引起育龄期妇女发生RSA的高危因素包括不良生活方式、心理因素、免疫性疾病、生殖道感染、子宫异常及男性因素等;应针对以上高危因素,早期采取防治措施,降低育龄期妇女的RSA发生率。
Objective To explore the correlated risk factors of recurrent spontaneous abortion(RSA)among women of childbearing age,so as to provide a basis for preventing and treating RSA.Methods 120 cases of RSA were chosen as case group,and the other 120 cases of normal pregnancy women were chosen as the control group in the meanwhile.With Case-Control study method,the correlated risk factors of RSA were screened by a single comparison method and multiple factors logistic regression method,respectively.Results Multiple factors logistic regression methods showed that the risk factors of RSA among women of childbearing age included bad lifestyle(OR=4.358),adverse psychological factors(OR=2.826),autoimmune disease(OR=3.518),reproductive system infection(OR=3.666),acquired uterine abnormalities(OR=5.038)and poor sperm quality of spouses(OR=1.996).Conclusion The high-risk factors of RSA among women of childbearing age contain bad lifestyle,psychological factor,immune disease,reproductive system infection,abnormality of uterus and male factors.In view of the above high-risk factors,early preventive measures should be taken to reduce the incidence of RSA among women of childbearing age.
Objective To explore the correlated risk factors of recurrent spontaneous abortion(RSA)among women of childbearing age,so as to provide a basis for preventing and treating RSA.Methods 120 cases of RSA were chosen as case group,and the other 120 cases of normal pregnancy women were chosen as the control group in the meanwhile.With Case-Control study method,the correlated risk factors of RSA were screened by a single comparison method and multiple factors logistic regression method,respectively.Results Multiple factors logistic regression methods showed that the risk factors of RSA among women of childbearing age included bad lifestyle(OR=4.358),adverse psychological factors(OR=2.826),autoimmune disease(OR=3.518),reproductive system infection(OR=3.666),acquired uterine abnormalities(OR=5.038)and poor sperm quality of spouses(OR=1.996).Conclusion The high-risk factors of RSA among women of childbearing age contain bad lifestyle,psychological factor,immune disease,reproductive system infection,abnormality of uterus and male factors.In view of the above high-risk factors,early preventive measures should be taken to reduce the incidence of RSA among women of childbearing age.
引文
[1] 李艳芳,李相宜,罗颂平.复发性流产患者成功妊娠后妊娠结局研究[J].广州中医药大学学报,2015,32(6):979-983.
[2] 李仁燕,杨学妞,廖会姝,等.影响不明原因复发性流产的相关因素及治疗新进展[J].中国生育健康杂志,2016,27(3):279-282,292.
[3] 谷晔,高鸣燕,李娴彧.胚胎停止发育危险因素logistic回归分析[J].中国卫生统计,2015,32(5):820-822.
[4] 徐子衿,薛晴.不明原因复发性流产的治疗进展[J].中国计划生育学杂志,2018,26(3):233-238.
[5] 方锦川,周燕妮,李丽萍,等.复发性流产患病危险因素的Logistic回归分析[J].中国医师杂志,2015,17(11):1709-1711.
[6] 张红,张觇宇.心理应激对复发性流产患者母儿的影响及作用机制探讨[J].重庆医学,2017,46(11):1562-1564.
[7] Francisco MF,Mattar R,Boroletti FF.Sexuality and depression among pregnant women with recurrent spontaneous abortion[J].Revista Brasileira de Ginecologia e Obstetricia,2014,36(4):152-156.
[8] Fichna J,Janecka A,Costentin J,et al.The endomorphin system and its evolving neurophysiological role[J].Pharmacological Reviews,2007,59(1):88-123.
[9] 毛姝雯(综述),夏天(审校).复发性流产的免疫性因素研究新进展[J].河北医科大学学报,2015,36(1):117-119.
[10] 贾新转,郭丽娜,张娜,等.原发不孕及复发性流产女性血清泌乳素与NK细胞相关性分析[J].现代预防医学,2017,44(16):2960-2962,2971.
[11] 陈赛兰,张丹丹,高琴,等.生殖道沙眼衣原体感染、淋球菌感染与复发性自然流产的关系[J].中国妇幼保健,2018,33(6):1360-1362.
[12] 乌守恒,林卫.复发性流产与生殖道感染[J].实用妇产科杂志,2016,32(2):85-86.
[13] 李豫峰.子宫因素与复发性流产[J].实用妇产科杂志,2016,32(2):87-89.
[14] 金保方.复发性流产的男方因素与对策[J].中华男科学杂志,2017,23(10):867-872.
[2] 李仁燕,杨学妞,廖会姝,等.影响不明原因复发性流产的相关因素及治疗新进展[J].中国生育健康杂志,2016,27(3):279-282,292.
[3] 谷晔,高鸣燕,李娴彧.胚胎停止发育危险因素logistic回归分析[J].中国卫生统计,2015,32(5):820-822.
[4] 徐子衿,薛晴.不明原因复发性流产的治疗进展[J].中国计划生育学杂志,2018,26(3):233-238.
[5] 方锦川,周燕妮,李丽萍,等.复发性流产患病危险因素的Logistic回归分析[J].中国医师杂志,2015,17(11):1709-1711.
[6] 张红,张觇宇.心理应激对复发性流产患者母儿的影响及作用机制探讨[J].重庆医学,2017,46(11):1562-1564.
[7] Francisco MF,Mattar R,Boroletti FF.Sexuality and depression among pregnant women with recurrent spontaneous abortion[J].Revista Brasileira de Ginecologia e Obstetricia,2014,36(4):152-156.
[8] Fichna J,Janecka A,Costentin J,et al.The endomorphin system and its evolving neurophysiological role[J].Pharmacological Reviews,2007,59(1):88-123.
[9] 毛姝雯(综述),夏天(审校).复发性流产的免疫性因素研究新进展[J].河北医科大学学报,2015,36(1):117-119.
[10] 贾新转,郭丽娜,张娜,等.原发不孕及复发性流产女性血清泌乳素与NK细胞相关性分析[J].现代预防医学,2017,44(16):2960-2962,2971.
[11] 陈赛兰,张丹丹,高琴,等.生殖道沙眼衣原体感染、淋球菌感染与复发性自然流产的关系[J].中国妇幼保健,2018,33(6):1360-1362.
[12] 乌守恒,林卫.复发性流产与生殖道感染[J].实用妇产科杂志,2016,32(2):85-86.
[13] 李豫峰.子宫因素与复发性流产[J].实用妇产科杂志,2016,32(2):87-89.
[14] 金保方.复发性流产的男方因素与对策[J].中华男科学杂志,2017,23(10):867-872.