~(125)I粒子植入治疗非小细胞肺癌放化疗后复发的疗效观察
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摘要
目的探讨~(125)I粒子植入治疗非小细胞肺癌放化疗后复发的临床疗效。方法对14例非小细胞肺癌放化疗后复发患者进行~(125)I粒子植入治疗,术后观察手术并发症,术后2月开始进行影像学评估疗效。结果 14例患者均一次性完成~(125)I粒子植入,术后并发症主要为穿刺道出血、气胸等,给予对症处理痊愈。术后2月、4月、6月、12月评估,治疗有效率分别为7.1%、42.9%、64.3%、78.6%;1年生存率为85.7%。结论 ~(125)I粒子植入治疗非小细胞肺癌放化疗后复发是安全、有效,值得临床推广。
Objective To investigate the clinical efficacy of ~(125)I seed implantation in the treatment of recurrent non-small cell lung cancer after radiation and chemotherapy. Methods 14 patients of recurrent non-small cell lung cancer after radiation and chemotherapy were treated with ~(125)I seed implantation, postoperative complications were observed, and 2 months ~(125)I seed implantation, the effect was evaluated by CT imaging. Results All the 14 patients completed the implantation at one time, and postoperative complications mainly included puncture bleeding, pneumothorax and so on. The effective rate of treatment was 7.1%, 42.9%, 64.3% and 78.6%, respectively. On the second month, 4 th month, 6 th month and 12 th month after implantation, the 1-year survival rate was 85.7%. Conclusion ~(125)I seed implantation is safe and effective in the treatment of recurrent non-small cell lung cancer after radiation and chemotherapy, which is worthy of clinical promotion.
Objective To investigate the clinical efficacy of ~(125)I seed implantation in the treatment of recurrent non-small cell lung cancer after radiation and chemotherapy. Methods 14 patients of recurrent non-small cell lung cancer after radiation and chemotherapy were treated with ~(125)I seed implantation, postoperative complications were observed, and 2 months ~(125)I seed implantation, the effect was evaluated by CT imaging. Results All the 14 patients completed the implantation at one time, and postoperative complications mainly included puncture bleeding, pneumothorax and so on. The effective rate of treatment was 7.1%, 42.9%, 64.3% and 78.6%, respectively. On the second month, 4 th month, 6 th month and 12 th month after implantation, the 1-year survival rate was 85.7%. Conclusion ~(125)I seed implantation is safe and effective in the treatment of recurrent non-small cell lung cancer after radiation and chemotherapy, which is worthy of clinical promotion.
引文
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[2] 蔡进中,苏伟珠,何凡,等. 125I粒子联合氩氦刀冷冻消融术治疗中晚期肺癌的临床疗效研究[J].临床放射学杂志,2015,34(7):1136-1139.
[3] 贺克武,高斌,秦汉林,等. CT导引下125I粒子组织间植入联合支气管动脉灌注化疗治疗肺癌[J].临床放射学实践,2012,31(7):1018-1021
[4] 王俊杰.放射性粒子治疗肿瘤临床应用规范[M].北京:北京大学医学出版社,2011.33.
[5] 刘金平,尤传文,陈建章,等. 放疗后复发肺癌适形放疗的疗效分析[J].实用癌症杂志,2015,30(2):208-210.
[6] 张千仕.肺癌放疗后复发患者应用适形放疗的疗效观察[J].西部医学,2013,25(9):1339-1341.
[7] 陈玉峰,邱若光,陈崇光,等. 体内γ-刀在肺癌治疗中的临床应用[J].医学影像学杂志,2013,23(8):1319-1321.
[8] 林永,陈建萍,于平,等.CT导向125I植入联合支气管动脉灌注治疗中晚期中心型肺癌的临床分析[J].医学影像学杂志,2015,25(8):1381-1383.