吡咯喹啉醌在心血管疾病中的研究进展
|
摘要
氧化应激与线粒体功能障碍是心血管疾病的两个重要发病机制,两者在发生过程中均伴随氧自由基堆积而造成氧化损伤。吡咯喹啉醌(PQQ)的独特优势在于不仅具有强的抗氧化作用,还具有水溶性和热稳定性,可在体内环境下快速进入组织和细胞,稳定、高效地清除细胞内氧自由基而避免氧化损伤。其能高效减少氧化应激造成的氧自由基堆积从而减弱心肌损伤,并具有修复线粒体功能障碍,改善心肌功能的作用。未来,应深入研究PQQ在心血管疾病中的作用,并协同中医用药经验开发出新的可运用于心血管疾病的药物。
Two important pathogenesis of cardiovascular disease: Oxidative stress and mitochondrial dysfunction,in both of which progress are accompanied by free radical accumulation and further result in oxidative damage. The unique advantage of pyrroloquinoline quinone( PQQ) is that it not only has strong anti-oxidation effect,but also has water-soluble and thermo-stable properties. It can rapidly enter tissues and cells in the body environment,as well as stably and efficiently scavenge intracellular oxygen free radicals to avoid oxidative damage. PQQ can effectively reduce the accumulation of oxygen free radicals caused by oxidative stress,thereby decreasing myocardial damage,and has the function of repairing mitochondrial dysfunction improving mitochondrial function and improving myocardial function. In the future,the role of PQQ in cardiovascular diseases should be studied in depth,and new drugs for cardiovascular diseases should be developed in collaboration with the experience of traditional Chinese medicine.
Two important pathogenesis of cardiovascular disease: Oxidative stress and mitochondrial dysfunction,in both of which progress are accompanied by free radical accumulation and further result in oxidative damage. The unique advantage of pyrroloquinoline quinone( PQQ) is that it not only has strong anti-oxidation effect,but also has water-soluble and thermo-stable properties. It can rapidly enter tissues and cells in the body environment,as well as stably and efficiently scavenge intracellular oxygen free radicals to avoid oxidative damage. PQQ can effectively reduce the accumulation of oxygen free radicals caused by oxidative stress,thereby decreasing myocardial damage,and has the function of repairing mitochondrial dysfunction improving mitochondrial function and improving myocardial function. In the future,the role of PQQ in cardiovascular diseases should be studied in depth,and new drugs for cardiovascular diseases should be developed in collaboration with the experience of traditional Chinese medicine.
引文
[1] Weiwei C, Runlin G, Lisheng L, et al. Outline of the report on cardiovascular disease in China,2014[J]. Eur Heart J Suppl,2016,18(Suppl F):F2-41.
[2]朱启明,罗娇.他汀类药物治疗心血管疾病依从性因素研究[J].中国城乡企业卫生,2018,33(1):131-132.
[3] Nezu M,Souma T, Yu L,et al. Nrf2 inactivation enhances placental angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomes[J]. Sci Signal,2017,10(479). pii:eaam5711.
[4] Henning RJ, Bourgeois M, Harbison RD. Poly(ADP-ribose)Polymerase(PARP)and PARP inhibitors:Mechanisms of action and role in cardiovascular disorders[J]. Cardiovasc Toxicol,2018,18(6):493-506.
[5] Siqueira DA,Sousa AG,Costa Junior Jde R, et al. Correlation between plaque composition as assessed by virtual histology and C-reactive protein[J]. Arq Bras Cardiol,2013,101(1):78-86.
[6] Zhu BQ,Simonis U,Cecchini G,et al. Comparison of pyrroloquinoline quinone and/or metoprolol on myocardial infarct size and mitochondrial damage in a rat model of ischemia/reperfusion injury[J].J Cardio Pha Ther,2006,11(2):119-128.
[7] Aghadavod E,Soleimani A,Hamidi G,et al. Effects of high-dose vitamin E supplementation on markers of cardiometabolic risk and oxidative stress in patients with diabetic nephropathy:A randomized double-blinded controlled trial[J]. Iran J Kidney Dis,2018,12(3):156462.
[8] Zhao Y, Wang J, Ballevre O, et al. Antihypertensive effects and mechanisms of chlorogenic acids[J]. Hypertens Res,2012,35(4):370-374.
[9] Ruiz-Gines JA, Lopez-Ongil S, Gonzalez-Rubio MR, et al.Reactive oxygen species induce proliferation of bouine aortic endothelial cells[J]. J Cardio Phar,2000,35(1):109-413.
[10]刘艳丽,刘奔,屈扬扬,等.氧化应激和钙/钙调蛋白依赖性蛋白激酶Ⅱ参与β肾上腺素受体持久激动引起的大鼠心肌肥厚[J].生理学报,2013,65(1):1-7.
[11] Lishmanov YB, Naryzhnaya NV, Maslov LN,et al. Functional state of myocardial mitochondria in ischemia reperfusion of the heart in rats adapted to hypoxia[J]. Bull Exp Biol Med,2014, 156(5):645-648.
[12] Yin J,Kwon Y,Kim D,et al. Cyanine-based fluorescent probe for highly selective detection of glutathione in cell cultures and live mouse tissues[J]. J Am Chem Soc,2014,136(14):5351-5358.
[13] Anthony C,Zatman LJ. The microbial oxidation of methanol,the prosthetic group of the alcohol dehydrogenase of Pseudomonas sp.M27:A new oxidoreductase prosthetic group[J]. Biochem J,1967,104(3):960-969.
[14] Salisbury SA,Forrest HS, Curse WB,et al. A novel coenzyme from bacterial primary alcohol dehydrogenases[J]. Nature,1979,280(5725):843-844.
[15] Westerling J, Frank J, Duine JA. The prosthetic group of methanol dehydrogenase from Hyphomicrobium X:Electron spin resonance evidence for a quinone structure[J]. Biochem Biophys Res Commun, 1979,87(3):719-724.
[16] Duine JA, Frank J, Vermell PE. Structure and activity of the prosthetic group of methanol dehydrogenase[J]. Eur J Biochem,1980,108(1):187492.
[17] Smidt CR, Bean-Knudsen D,Kirsch D,et al. Does the intestinal microflora synthesize pyrroloquinoline quinone?[J]. Biofactors1991,3(1):53-59.
[18] Huang Y,Chen N,Miao D. Radioprotective effects of pyrroloquinoline quinone on parotid glands in C57BL/6J mice[J]. Exp Ther Med,2016,12(6):3685-3693.
[19] Zhang LI, Liu J, Cheng C, et al. The neuroprotective effect of pyrroloquinoline quinone on traumatic brain injury[J]. J Neurotrauma,2012,29(5):851-864.
[20]赵芹,张海军,武书庚,等.吡咯喹啉醌对脂肪肝胆肌肝损伤的保护作用机制[J].动物营养学报,2014,26(3):651-658.
[21] Steinberg F,Stites TE,Anderson P,et al. Pyrroloquinoline quinone improves growth and reproductive performance in mice fed chemically defined diets[J]. Exp Biol Med,2003,228(2):160-166.
[22]杜阳.吡咯喹啉醌(PQQ)对几种水生生物影响的研究[D].大连:大连海洋大学,2014.
[23] Urakami T, Yoshida C, Akaike T, et al. Synthesis of monsters of pyrroloquinoline quinone and imidazopyrroloquinoline, and radical scavenging activities using electron spin resonance in vitro and pharmacological activity in vivo[J]. J Nutr Sci Vitaminol,1997,43(1):19-33.
[24] Tao R,Karliner JS,Simonis U, et al. Pyrroloquinoline quinone preserves mitochondrial function and prevents oxidative injury in adult rat cardiac myocytes[J]. Biochem Biophys Res Commun,2007,363(2):257-362.
[25] Rajpurohit YS,Gopalakrishnan R,Misra HS. Involvement of a protein kinase activity inducer in DNA double strand break repair and radio resistance of Deinococcus radiodurans[J]. J Bacteriol,2008,190(11):3948-3954.
[26] Ohwada K,Takeda H,Yamasaki M,et al. Pyrroloquinoline quinone(PQQ)prevents cognitive deficit caused by oxidative stress in rats[J]. J Clin Biochem Nutr,2008,42(1):29-34.
[27]邱秀芹,刘春亮,徐岚,等.吡咯喹啉醌对γ射线照射后AGS细胞抗氧化力的影响[J].江苏大学学报(医学版),2009,19(4):293-295,301.
[28] Smith RA, Hartley RC, Cocheme HM,et al. Mitochondrial pharmacology[J]. Trends Pharmacol Sci,2012,33(6):341-352.
[29] Stites TE, Storms D, Barely K, et al. Pyrroloquinoline quinone modulates mitochondrial quantity and function in mice[J].J Nutr,2006,136(2):390-396.
[30] Rucker R, Chowanadisai W, Nakano M. Potential physiological importance of pyrroloquinoline quinone[J]. Alter Med Rev,2009,14(3):268-277.
[31] Zhu BQ, Zhou HZ, Teerlink JR, et al. Pyrroloquinoline quinone(PQQ)decreases myocardial infarct size and improves cardiac function in rat models of ischemia and ischemia/reperfusion[J].Cardiovase Drugs Ther,2004,18(6):421-431.
[32] Xu F, Kim SQ, Vincent et al. Pyrroloquinoline quinone acts with flavin reductase to reduce ferryl myoglobin in vitro and protects isolated heart from re-oxygenation injury[J]. Biochem Biophys Res Commun,1993,193(1):434-439.
[33] Mis HS,Khairnar NP,Barik A,et al. Pyrroloquinoline quinone:A reactive oxygen species scavenger in bacteria[J]. FEBS lett,2004,578(1/2):26-30.
[34] Singh AK, Pandey SK, Saha G, et al. Pyrroloquinoline quinone(PQQ)producing Escherichia coli Nissle 1917(EcN)alleviates age associated oxidative stress and hyperlipidemia, and improves mitochondrial function in ageing rats[J]. Exp Gerontol,2015,66:1-9.
[35] Gong D,Geng C,Jiang L,et al. Effect of pyrroloquinoline quinone on neuropathic pain following chronic constriction injury of the sciatic nerve in rats[J]. Eur J Pharmacol,2012,697(1/3):53-58.
[36] Xu F,Yu HX, Liu JY, et al. Pyrroloquinoline quinone inhibits oxygen/glucose deprivation-induced apoptosis by activating the PI3K/AKT pathway in cardiomyocytes[J]. Mol Cell Biochem,2014,386(1/2):107415.
[37] Callera GE,Tostes RC, Yogi A,et al. Endothelia-1-induced oxidative stress in DOCA-salt hypertension involves NADPH-oxidaseindependent mechanisms[J]. Clin Sci,2006,110(2):243-353.
[38] Nehra S,Bhardwaj V,Bansal A,et al. Nanocurcumin-pyrroloquinoline formulation prevents hypertrophy-induced pathological damage by relieving mitochondrial stress in cardiomyocytes under hypoxic conditions[J]. Exp Mol Med,2017,49(12):e404.
[39] Dargel R. The lipid infiltration theory of atherosclerosis[J].Z Med Lab Diagn, 1989,30(5):251-255.
[40] Mercer JR,Chem KK,Figg N,et al. DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome[J]. Circ Res,2012,107(8):1021-1031.
[41]王全伟,凡文博,王智昊,等.氧化应激与心血管疾病关系的研究进展[J].中国老年学杂志,2014,34(1):270-273.
[42] Perrelli MG,Pagliaro P,Penna C. Ischemia/reperfusion injury and cardioprotective mechanisms:Role of mitochondria and reactive oxygen species[J]. World J Cardiol,2011,3(6):186-200.
[43] Perrelli MG,Pagliaro P,Penna C. Mitochondrial pathways,permeability transition pore and redox signaling in cardioprotection:Therapeutic implications[J]. Antioxid Redox Signal,2013,18(5):556-599.
[44] Heusch G. Cardioprotection:Chances and callenges of its translation to the clinic[J]. Lancet,2013,381(9861):166-175.
[45] Carpi A, Menaba R,Kaludercic N,et al. The cardioprotective effects elicited by p66(Shc)ablation demonstrate the crucial role of mitochondrial ROS formation in ischemia/reperfusion injury[J].Biochim Biophys Acta,2009,1787(7):774-780.
[46] Saint DA. The role of the persistent Na~+current during cardiac ischemia and hypoxia[J]. J Cardiovasc Electrophysiol,2006, 17Suppl 1:S96-403.
[47] Gonzalez-Montero J,Brito R,Gajardo AI,et al. Myocardial reperfusion injury and oxidative stress:Therapeutic opportunities[J].World J Cardiol,2018,10(9):74-86.
[48] Nattel S. From guidelines to bench:Implications of unresolved clinical issues for basic investigations of atrial fibrillation mechanisms[J]. Can J CardiolL,2011,27(1):19-26.
[49] Tsutsui H, Kinugawa S,Matsushima S. Mitochondrial oxidative stress and dysfunction in myocardial remodelling[J]. Cardio Res,2009,81(3):449-456.
[50]张春丽,邹阳,林金德,等.吡咯喹啉醌对UVA诱导人皮肤成纤维细胞衰老的保护作用及机制研究[J].南京医科大学学报(自然科学版),2013,33(3):337-341.
[51] Zhang P, Ye Y, Qian Y, et al. The effect of pyrroloquinoline quinone on apoptosis and autophagy in traumatic brain injury[J].CNS Neurol Disord Drug Targetss,2017,16(6):724-736.
[52] Min Z, Wang L, Jin J, et al. Pyrroloquinoline quinone induces cancer cell apoptosis via mitochondrial-dependent pathway and down-regulating cellular Bcl-2 protein expression[J]. J Cancer,2014,5(7):609-624.
[2]朱启明,罗娇.他汀类药物治疗心血管疾病依从性因素研究[J].中国城乡企业卫生,2018,33(1):131-132.
[3] Nezu M,Souma T, Yu L,et al. Nrf2 inactivation enhances placental angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomes[J]. Sci Signal,2017,10(479). pii:eaam5711.
[4] Henning RJ, Bourgeois M, Harbison RD. Poly(ADP-ribose)Polymerase(PARP)and PARP inhibitors:Mechanisms of action and role in cardiovascular disorders[J]. Cardiovasc Toxicol,2018,18(6):493-506.
[5] Siqueira DA,Sousa AG,Costa Junior Jde R, et al. Correlation between plaque composition as assessed by virtual histology and C-reactive protein[J]. Arq Bras Cardiol,2013,101(1):78-86.
[6] Zhu BQ,Simonis U,Cecchini G,et al. Comparison of pyrroloquinoline quinone and/or metoprolol on myocardial infarct size and mitochondrial damage in a rat model of ischemia/reperfusion injury[J].J Cardio Pha Ther,2006,11(2):119-128.
[7] Aghadavod E,Soleimani A,Hamidi G,et al. Effects of high-dose vitamin E supplementation on markers of cardiometabolic risk and oxidative stress in patients with diabetic nephropathy:A randomized double-blinded controlled trial[J]. Iran J Kidney Dis,2018,12(3):156462.
[8] Zhao Y, Wang J, Ballevre O, et al. Antihypertensive effects and mechanisms of chlorogenic acids[J]. Hypertens Res,2012,35(4):370-374.
[9] Ruiz-Gines JA, Lopez-Ongil S, Gonzalez-Rubio MR, et al.Reactive oxygen species induce proliferation of bouine aortic endothelial cells[J]. J Cardio Phar,2000,35(1):109-413.
[10]刘艳丽,刘奔,屈扬扬,等.氧化应激和钙/钙调蛋白依赖性蛋白激酶Ⅱ参与β肾上腺素受体持久激动引起的大鼠心肌肥厚[J].生理学报,2013,65(1):1-7.
[11] Lishmanov YB, Naryzhnaya NV, Maslov LN,et al. Functional state of myocardial mitochondria in ischemia reperfusion of the heart in rats adapted to hypoxia[J]. Bull Exp Biol Med,2014, 156(5):645-648.
[12] Yin J,Kwon Y,Kim D,et al. Cyanine-based fluorescent probe for highly selective detection of glutathione in cell cultures and live mouse tissues[J]. J Am Chem Soc,2014,136(14):5351-5358.
[13] Anthony C,Zatman LJ. The microbial oxidation of methanol,the prosthetic group of the alcohol dehydrogenase of Pseudomonas sp.M27:A new oxidoreductase prosthetic group[J]. Biochem J,1967,104(3):960-969.
[14] Salisbury SA,Forrest HS, Curse WB,et al. A novel coenzyme from bacterial primary alcohol dehydrogenases[J]. Nature,1979,280(5725):843-844.
[15] Westerling J, Frank J, Duine JA. The prosthetic group of methanol dehydrogenase from Hyphomicrobium X:Electron spin resonance evidence for a quinone structure[J]. Biochem Biophys Res Commun, 1979,87(3):719-724.
[16] Duine JA, Frank J, Vermell PE. Structure and activity of the prosthetic group of methanol dehydrogenase[J]. Eur J Biochem,1980,108(1):187492.
[17] Smidt CR, Bean-Knudsen D,Kirsch D,et al. Does the intestinal microflora synthesize pyrroloquinoline quinone?[J]. Biofactors1991,3(1):53-59.
[18] Huang Y,Chen N,Miao D. Radioprotective effects of pyrroloquinoline quinone on parotid glands in C57BL/6J mice[J]. Exp Ther Med,2016,12(6):3685-3693.
[19] Zhang LI, Liu J, Cheng C, et al. The neuroprotective effect of pyrroloquinoline quinone on traumatic brain injury[J]. J Neurotrauma,2012,29(5):851-864.
[20]赵芹,张海军,武书庚,等.吡咯喹啉醌对脂肪肝胆肌肝损伤的保护作用机制[J].动物营养学报,2014,26(3):651-658.
[21] Steinberg F,Stites TE,Anderson P,et al. Pyrroloquinoline quinone improves growth and reproductive performance in mice fed chemically defined diets[J]. Exp Biol Med,2003,228(2):160-166.
[22]杜阳.吡咯喹啉醌(PQQ)对几种水生生物影响的研究[D].大连:大连海洋大学,2014.
[23] Urakami T, Yoshida C, Akaike T, et al. Synthesis of monsters of pyrroloquinoline quinone and imidazopyrroloquinoline, and radical scavenging activities using electron spin resonance in vitro and pharmacological activity in vivo[J]. J Nutr Sci Vitaminol,1997,43(1):19-33.
[24] Tao R,Karliner JS,Simonis U, et al. Pyrroloquinoline quinone preserves mitochondrial function and prevents oxidative injury in adult rat cardiac myocytes[J]. Biochem Biophys Res Commun,2007,363(2):257-362.
[25] Rajpurohit YS,Gopalakrishnan R,Misra HS. Involvement of a protein kinase activity inducer in DNA double strand break repair and radio resistance of Deinococcus radiodurans[J]. J Bacteriol,2008,190(11):3948-3954.
[26] Ohwada K,Takeda H,Yamasaki M,et al. Pyrroloquinoline quinone(PQQ)prevents cognitive deficit caused by oxidative stress in rats[J]. J Clin Biochem Nutr,2008,42(1):29-34.
[27]邱秀芹,刘春亮,徐岚,等.吡咯喹啉醌对γ射线照射后AGS细胞抗氧化力的影响[J].江苏大学学报(医学版),2009,19(4):293-295,301.
[28] Smith RA, Hartley RC, Cocheme HM,et al. Mitochondrial pharmacology[J]. Trends Pharmacol Sci,2012,33(6):341-352.
[29] Stites TE, Storms D, Barely K, et al. Pyrroloquinoline quinone modulates mitochondrial quantity and function in mice[J].J Nutr,2006,136(2):390-396.
[30] Rucker R, Chowanadisai W, Nakano M. Potential physiological importance of pyrroloquinoline quinone[J]. Alter Med Rev,2009,14(3):268-277.
[31] Zhu BQ, Zhou HZ, Teerlink JR, et al. Pyrroloquinoline quinone(PQQ)decreases myocardial infarct size and improves cardiac function in rat models of ischemia and ischemia/reperfusion[J].Cardiovase Drugs Ther,2004,18(6):421-431.
[32] Xu F, Kim SQ, Vincent et al. Pyrroloquinoline quinone acts with flavin reductase to reduce ferryl myoglobin in vitro and protects isolated heart from re-oxygenation injury[J]. Biochem Biophys Res Commun,1993,193(1):434-439.
[33] Mis HS,Khairnar NP,Barik A,et al. Pyrroloquinoline quinone:A reactive oxygen species scavenger in bacteria[J]. FEBS lett,2004,578(1/2):26-30.
[34] Singh AK, Pandey SK, Saha G, et al. Pyrroloquinoline quinone(PQQ)producing Escherichia coli Nissle 1917(EcN)alleviates age associated oxidative stress and hyperlipidemia, and improves mitochondrial function in ageing rats[J]. Exp Gerontol,2015,66:1-9.
[35] Gong D,Geng C,Jiang L,et al. Effect of pyrroloquinoline quinone on neuropathic pain following chronic constriction injury of the sciatic nerve in rats[J]. Eur J Pharmacol,2012,697(1/3):53-58.
[36] Xu F,Yu HX, Liu JY, et al. Pyrroloquinoline quinone inhibits oxygen/glucose deprivation-induced apoptosis by activating the PI3K/AKT pathway in cardiomyocytes[J]. Mol Cell Biochem,2014,386(1/2):107415.
[37] Callera GE,Tostes RC, Yogi A,et al. Endothelia-1-induced oxidative stress in DOCA-salt hypertension involves NADPH-oxidaseindependent mechanisms[J]. Clin Sci,2006,110(2):243-353.
[38] Nehra S,Bhardwaj V,Bansal A,et al. Nanocurcumin-pyrroloquinoline formulation prevents hypertrophy-induced pathological damage by relieving mitochondrial stress in cardiomyocytes under hypoxic conditions[J]. Exp Mol Med,2017,49(12):e404.
[39] Dargel R. The lipid infiltration theory of atherosclerosis[J].Z Med Lab Diagn, 1989,30(5):251-255.
[40] Mercer JR,Chem KK,Figg N,et al. DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome[J]. Circ Res,2012,107(8):1021-1031.
[41]王全伟,凡文博,王智昊,等.氧化应激与心血管疾病关系的研究进展[J].中国老年学杂志,2014,34(1):270-273.
[42] Perrelli MG,Pagliaro P,Penna C. Ischemia/reperfusion injury and cardioprotective mechanisms:Role of mitochondria and reactive oxygen species[J]. World J Cardiol,2011,3(6):186-200.
[43] Perrelli MG,Pagliaro P,Penna C. Mitochondrial pathways,permeability transition pore and redox signaling in cardioprotection:Therapeutic implications[J]. Antioxid Redox Signal,2013,18(5):556-599.
[44] Heusch G. Cardioprotection:Chances and callenges of its translation to the clinic[J]. Lancet,2013,381(9861):166-175.
[45] Carpi A, Menaba R,Kaludercic N,et al. The cardioprotective effects elicited by p66(Shc)ablation demonstrate the crucial role of mitochondrial ROS formation in ischemia/reperfusion injury[J].Biochim Biophys Acta,2009,1787(7):774-780.
[46] Saint DA. The role of the persistent Na~+current during cardiac ischemia and hypoxia[J]. J Cardiovasc Electrophysiol,2006, 17Suppl 1:S96-403.
[47] Gonzalez-Montero J,Brito R,Gajardo AI,et al. Myocardial reperfusion injury and oxidative stress:Therapeutic opportunities[J].World J Cardiol,2018,10(9):74-86.
[48] Nattel S. From guidelines to bench:Implications of unresolved clinical issues for basic investigations of atrial fibrillation mechanisms[J]. Can J CardiolL,2011,27(1):19-26.
[49] Tsutsui H, Kinugawa S,Matsushima S. Mitochondrial oxidative stress and dysfunction in myocardial remodelling[J]. Cardio Res,2009,81(3):449-456.
[50]张春丽,邹阳,林金德,等.吡咯喹啉醌对UVA诱导人皮肤成纤维细胞衰老的保护作用及机制研究[J].南京医科大学学报(自然科学版),2013,33(3):337-341.
[51] Zhang P, Ye Y, Qian Y, et al. The effect of pyrroloquinoline quinone on apoptosis and autophagy in traumatic brain injury[J].CNS Neurol Disord Drug Targetss,2017,16(6):724-736.
[52] Min Z, Wang L, Jin J, et al. Pyrroloquinoline quinone induces cancer cell apoptosis via mitochondrial-dependent pathway and down-regulating cellular Bcl-2 protein expression[J]. J Cancer,2014,5(7):609-624.