藏药仁青常觉临床安全性评价
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摘要
目的:观察藏药仁青常觉的临床安全性。方法:患者服药15d,于服药前、服药15d和停药15d分别收集血样、尿样、粪便,检测血常规、尿常规、肝肾功能,以及血尿便中铅、砷、汞的含量。结果:与服药前比较,服药15d总蛋白、白蛋白水平显著降低(P<0.05),血肌酐水平、尿液pH值显著升高(P<0.05,P<0.01),血、尿、便的汞、铅、砷含量显著升高(P<0.01);与服药15d比较,停药15d总蛋白、白蛋白、球蛋白和总胆红素水平显著升高(P<0.05),尿素氮水平、尿液pH值显著降低(P<0.05),血汞、血铅、血砷、尿砷、便汞和便砷含量显著降低(P<0.01)。结论:按藏医理论服用仁青常觉,短期内对肝脏和肾脏部分指标有一定影响,但停药后均有恢复趋势,显示仁青常觉临床用药的安全性。
Objective: To observe the clinical safety of Tibetan medicine Renqingchangjue(RQCJ). Methods: The cases of taking the medicine for 15 days, at the time of before, 15 th days of taking the medicine, and 15 th days after taking the medicine, collect blood, urine and faeces to test blood routine, liver and kidney function, urines routine and the content of mercury, plumbum and arsenic in the blood, urine and faeces sample. Results: At the time of 15 th days of taking RQCJ,compared to the before period, the level of total protein and albumin decreased significantly(P<0.05), blood creatinine level,urine pH significantly increased(P<0.05, P<0.01), the content of mercury, plumbum and arsenic in the blood, urine and faeces sample all increased significantly(P<0.01); Compared to the 15 th days of taking RQCJ, at the 15 th days of stop taking RQCJ,the levels of total protein, albumin, globulin, and total bilirubin were significantly increased(P<0.05), urea nitrogen level,urine pH value significantly reduced(P<0.05), blood mercury, blood plumbum, blood arsenic, urine arsenic, fecal mercury and fecal arsenic content significantly decreased(P<0.01). Conclusion: According to the Tibetan theory to take RQCJ have effect on the liver and kidney function index, but they all could recover to the level of before period, these showed the safety of RQCJ clinical medication.
Objective: To observe the clinical safety of Tibetan medicine Renqingchangjue(RQCJ). Methods: The cases of taking the medicine for 15 days, at the time of before, 15 th days of taking the medicine, and 15 th days after taking the medicine, collect blood, urine and faeces to test blood routine, liver and kidney function, urines routine and the content of mercury, plumbum and arsenic in the blood, urine and faeces sample. Results: At the time of 15 th days of taking RQCJ,compared to the before period, the level of total protein and albumin decreased significantly(P<0.05), blood creatinine level,urine pH significantly increased(P<0.05, P<0.01), the content of mercury, plumbum and arsenic in the blood, urine and faeces sample all increased significantly(P<0.01); Compared to the 15 th days of taking RQCJ, at the 15 th days of stop taking RQCJ,the levels of total protein, albumin, globulin, and total bilirubin were significantly increased(P<0.05), urea nitrogen level,urine pH value significantly reduced(P<0.05), blood mercury, blood plumbum, blood arsenic, urine arsenic, fecal mercury and fecal arsenic content significantly decreased(P<0.01). Conclusion: According to the Tibetan theory to take RQCJ have effect on the liver and kidney function index, but they all could recover to the level of before period, these showed the safety of RQCJ clinical medication.
引文
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[12]朱旭明,郁昊达,张健,等.血肌酐、尿素氮及白细胞计数在原发性高血压中的意义.国际检验医学杂志,2011,32(15):1749-1750
[13]黄晓玲,高云华.急性肾衰时血肌酐、尿素氮与肾血流参数变化关系的实验研究.中国超声医学杂志,2000,16(8):564-567
[14]石凯峰,张宁,柳诗意,等.补肾活血方通过调节Bcl-2/Bax凋亡相关蛋白对慢性肾脏病大鼠血管钙化的影响.中华中医药杂志,2017,32(5):2188-2193
[15]李光,冉鹏,杨旭希,等.尿p H值与慢性肾脏疾病患者对比剂肾病的关系.岭南心血管病杂志,2014,20(6):744-747
[16]李士梅.临床肾脏病学.上海:上海科学技术出版社,1986:66
[2]马文俊,孙雪梅,李宝文,等.藏药仁青常觉的毒理学实验研究.亚太传统医药,2013,9(2):15-17
[3]陈乐.仁青常觉安全性评价以及相伴毒代动力学研究.成都:成都中医药大学,2011
[4]吴洪革,邵成雷,付素心.藏药仁青常觉联合环磷酰胺治疗白血病的实验研究.中国民族民间医药,2014,23(15):21-22
[5]斗周才让,才让卓玛,杨忠措,等.藏药仁青常觉治疗慢性萎缩性胃炎30例.中国民族医药杂志,2010,16(11):4-5
[6]李向阳,冯伟力,马祁生,等.藏药佐太中的汞在大鼠体内吸收和排泄的初步研究.时珍国医国药,2010,21(2):290
[7]久美彭措.藏药中重金属毒性的实验研究.成都:全国藏医药学术研讨会,1999:199
[8]杨宝寿,江吉村,降拥,等.藏药“佐塔”中汞的作用特点和安全性评价研究.西藏研究,2004(1):74-80
[9]李晶.血清总蛋白测定方法及临床意义.中国现代药物应用,2012,6(9):28-29
[10]张英霞,张云.血清白蛋白的功能及应用.海南大学学报自然科学版,2007,25(3):315-320
[11]张宏,王旭昀,刘美奇,等.血肌酐升高的病因病机分析及中医药治疗.吉林中医药,2014,34(12):1195-1197
[12]朱旭明,郁昊达,张健,等.血肌酐、尿素氮及白细胞计数在原发性高血压中的意义.国际检验医学杂志,2011,32(15):1749-1750
[13]黄晓玲,高云华.急性肾衰时血肌酐、尿素氮与肾血流参数变化关系的实验研究.中国超声医学杂志,2000,16(8):564-567
[14]石凯峰,张宁,柳诗意,等.补肾活血方通过调节Bcl-2/Bax凋亡相关蛋白对慢性肾脏病大鼠血管钙化的影响.中华中医药杂志,2017,32(5):2188-2193
[15]李光,冉鹏,杨旭希,等.尿p H值与慢性肾脏疾病患者对比剂肾病的关系.岭南心血管病杂志,2014,20(6):744-747
[16]李士梅.临床肾脏病学.上海:上海科学技术出版社,1986:66