IgG4相关性疾病合并肺腺癌一例
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摘要
IgG4相关性疾病(IgG4-RD)是一种免疫介导的炎症伴纤维化疾病,临床上发现部分IgG4-RD可合并恶性肿瘤。本文通过回顾性分析2018年5月收治的1例病理诊断IgG4-RD合并肺腺癌患者的相关资料,探讨IgG4-RD的临床表现、病理特点、诊疗情况及与恶性肿瘤之间的联系。
IgG4-related disease(IgG4-RD) is an immune-mediated inflammation with fibrotic disease, and it is clinically found that some IgG4-RD can be combined with malignant tumors. Based on the retrospective analysis of 1 case of IgG4-RD with lung adenocarcinoma identified pathologically in May 2018, the clinical manifestation, pathological characteristics, diagnosis and treatment of IgG4-RD, and the relationship between IgG4-RD and malignant tumors were studied.
IgG4-related disease(IgG4-RD) is an immune-mediated inflammation with fibrotic disease, and it is clinically found that some IgG4-RD can be combined with malignant tumors. Based on the retrospective analysis of 1 case of IgG4-RD with lung adenocarcinoma identified pathologically in May 2018, the clinical manifestation, pathological characteristics, diagnosis and treatment of IgG4-RD, and the relationship between IgG4-RD and malignant tumors were studied.
引文
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[6]Bruhns P.Properties of mouse and human IgG receptors and their contribution to disease models[J].Blood,2012,119(24):5640-5649.doi:10.1182/blood-2012-01-380121.
[7]Joseph CG,Darrah E,Shah AA,et al.Association of the autoimmune disease scleroderma with an immunologic response to cancer[J].Science,2014,343(6167):152-157.doi:10.1126/science.1246886.
[8]Carruthers MN,Khosroshahi A,Augustin T,et al.The diagnostic utility of serum IgG4 concentrations in IgG4-related disease[J].Ann Rheum Dis,2015,74(1):14-18.doi:10.1136/annrheumdis-2013-204907.
[9]Kitada M,Matuda Y,Hayashi S,et al.IgG4-related lung disease showing high standardized uptake values on FDG-PET:report of two cases[J].J Cardiothorac Surg,2013,8:160.doi:10.1186/1749-8090-8-160.
[10]Khosroshahi A,Wallace ZS,Crowe JL,et al.International consensus guidance statement on the management and treatment of IgG4-related disease[J].Arthritis Rheumatol,2015,67(7):1688-1699.doi:10.1002/art.39132.2018-10-252019-01-11
[2]Koo BS,Koh YW,Hong S,et al.Clinicopathologic characteristics of IgG4-related retroperitoneal fibrosis among patients initially diagnosed as having idiopathic retroperitoneal fibrosis[J].Mod Rheumatol,2015,25(2):194-198.doi:10.3109/14397595.2014.931908.
[3]Umehara H,Okazaki K,Masaki Y,et al.Comprehensive diagnostic criteria for IgG4-related disease(IgG4-RD),2011[J].Mod Rheumatol,2012,22(1):21-30.doi:10.1007/s10165-011-0571-z.
[4]Wallace ZS,Wallace CJ,Lu N,et al.Association of IgG4-related disease with history of malignancy[J].Arthritis Rheumatol,2016,68(9):2283-2289.doi:10.1002/art.39773.
[5]Shimo T,Yao M,Takebe Y,et al.A case of adenoid cystic carcinoma associated with IgG4-related disease[J].Int J Surg Case Rep,2015,10:12-16.doi:10.1016/j.ijscr.2015.01.022.
[6]Bruhns P.Properties of mouse and human IgG receptors and their contribution to disease models[J].Blood,2012,119(24):5640-5649.doi:10.1182/blood-2012-01-380121.
[7]Joseph CG,Darrah E,Shah AA,et al.Association of the autoimmune disease scleroderma with an immunologic response to cancer[J].Science,2014,343(6167):152-157.doi:10.1126/science.1246886.
[8]Carruthers MN,Khosroshahi A,Augustin T,et al.The diagnostic utility of serum IgG4 concentrations in IgG4-related disease[J].Ann Rheum Dis,2015,74(1):14-18.doi:10.1136/annrheumdis-2013-204907.
[9]Kitada M,Matuda Y,Hayashi S,et al.IgG4-related lung disease showing high standardized uptake values on FDG-PET:report of two cases[J].J Cardiothorac Surg,2013,8:160.doi:10.1186/1749-8090-8-160.
[10]Khosroshahi A,Wallace ZS,Crowe JL,et al.International consensus guidance statement on the management and treatment of IgG4-related disease[J].Arthritis Rheumatol,2015,67(7):1688-1699.doi:10.1002/art.39132.2018-10-252019-01-11