甲氨蝶呤与米非司酮联合治疗剖宫产术后子宫切口瘢痕妊娠的疗效观察
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摘要
目的观察剖宫产术后子宫切口瘢痕妊娠(cesarean scars pregnancy, CSP)患者应用甲氨蝶呤与米非司酮联合治疗的效果。方法选择2016年6月～2018年6月本院收治的CSP患者100例,采用随机数表法分为两组,各50例。对照组单用甲氨蝶呤,观察组联合米非司酮。比较两组康复指标、临床疗效与不良反应。结果观察组β-HCG达标时间、子宫下段信号消失时间、阴道出血消失时间、月经恢复时间均短于对照组,观察组治疗总有效率高于对照组的(P <0.05);两组不良反应发生率相比,差异无统计学意义(P> 0.05)。结论 CSP患者采用甲氨蝶呤与米非司酮联合治疗利于缩短康复时间,增强临床疗效,且不会增加不良反应发生,利于改善患者预后。
Objective To observe the effect of methotrexate combined with mifepristone in the treatment of cesarean scar pregnancy(CSP). Methods From June 2016 to June 2018, 100 patients with CSP were randomLy divided into two groups, 50 cases in each group. The control group was given methotrexate alone, and the observation group was combined with mifepristone. The rehabilitation indicators, clinical ef?cacy and adverse reactions were compared between the two groups.Results In the observation group,the time to reach the standard of beta-HCG, the time to disappear of lower uterine signal, the time to disappear of vaginal bleeding, and the time to menstrual recovery, which were shorter than those in the control group.The total effective rate of the treatment group higher than that of the control group, the difference was statistically signi?cant(P < 0.05); there was no significant difference in the incidence of adverse reactions between the two groups(P > 0.05).Conclusion The combination therapy of methotrexate and mifepristone is bene?cial to shorten the recovery time and enhance the clinical ef?cacy of CSP patients without increasing the occurrence of adverse reactions and improve the prognosis of CSP patients.
Objective To observe the effect of methotrexate combined with mifepristone in the treatment of cesarean scar pregnancy(CSP). Methods From June 2016 to June 2018, 100 patients with CSP were randomLy divided into two groups, 50 cases in each group. The control group was given methotrexate alone, and the observation group was combined with mifepristone. The rehabilitation indicators, clinical ef?cacy and adverse reactions were compared between the two groups.Results In the observation group,the time to reach the standard of beta-HCG, the time to disappear of lower uterine signal, the time to disappear of vaginal bleeding, and the time to menstrual recovery, which were shorter than those in the control group.The total effective rate of the treatment group higher than that of the control group, the difference was statistically signi?cant(P < 0.05); there was no significant difference in the incidence of adverse reactions between the two groups(P > 0.05).Conclusion The combination therapy of methotrexate and mifepristone is bene?cial to shorten the recovery time and enhance the clinical ef?cacy of CSP patients without increasing the occurrence of adverse reactions and improve the prognosis of CSP patients.
引文
[1]叶青剑,邓佩霞,沈晓婷,等.剖宫产切口瘢痕妊娠分析[J].中山大学学报(医学科学版),2017,38(04):596-600.
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[3]常立功,张娜,赵盛光.B超引导清宫术联合甲氨蝶呤与米非司酮治疗子宫瘢痕妊娠的效果观察[J].中国妇幼保健,2018,33(06):1278-1281.
[4]郑一君,彭春红,何峥,等.超声引导下经腹局部注射MTX联合米非司酮治疗孕囊型切口妊娠的临床疗效评估[J].影像诊断与介入放射学,2017,26(05):362-366.
[5]吴淑芬,黄文亮.子宫动脉栓塞术联合清宫术对剖宫产术后瘢痕妊娠的疗效分析[J].河南医学研究,2018,27(07):1316-1317.
[6]倪萍,龙玲,范幸.宫腔镜联合甲氨蝶呤,米非司酮治疗子宫切口妊娠疗效观察[J].中国计划生育和妇产科,2016,8(04):59-61.
[7]杨庆彪,张婷,陆燕,等.甲氨蝶呤联合米非司酮及宫外孕2号方加味治疗剖宫产子宫切口瘢痕妊娠疗效观察[J].现代中西医结合杂志,2018,27(02):160-162.
[8]关蓓蓓.米非司酮联合甲氨蝶呤治疗剖宫产瘢痕部位妊娠的疗效及对新生儿Apgar评分的影响[J].中国妇幼保健,2018,33(05):1120-1122.
[2]王俊岭,苏红阁.剖宫产瘢痕妊娠治疗方案选取及效果分析[J].医药论坛杂志,2017,25(02):98-100.
[3]常立功,张娜,赵盛光.B超引导清宫术联合甲氨蝶呤与米非司酮治疗子宫瘢痕妊娠的效果观察[J].中国妇幼保健,2018,33(06):1278-1281.
[4]郑一君,彭春红,何峥,等.超声引导下经腹局部注射MTX联合米非司酮治疗孕囊型切口妊娠的临床疗效评估[J].影像诊断与介入放射学,2017,26(05):362-366.
[5]吴淑芬,黄文亮.子宫动脉栓塞术联合清宫术对剖宫产术后瘢痕妊娠的疗效分析[J].河南医学研究,2018,27(07):1316-1317.
[6]倪萍,龙玲,范幸.宫腔镜联合甲氨蝶呤,米非司酮治疗子宫切口妊娠疗效观察[J].中国计划生育和妇产科,2016,8(04):59-61.
[7]杨庆彪,张婷,陆燕,等.甲氨蝶呤联合米非司酮及宫外孕2号方加味治疗剖宫产子宫切口瘢痕妊娠疗效观察[J].现代中西医结合杂志,2018,27(02):160-162.
[8]关蓓蓓.米非司酮联合甲氨蝶呤治疗剖宫产瘢痕部位妊娠的疗效及对新生儿Apgar评分的影响[J].中国妇幼保健,2018,33(05):1120-1122.