冷冻治疗的研究
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摘要
冷冻治疗是一种利用冷冻引起局部组织的烧蚀反应,而可控地破坏活组织的物理治疗方法,目前主要应用于皮肤病和肿瘤的治疗。手持液氮喷雾设备主要用于皮肤疾病的治疗。氩氦刀和康博刀是自动化多探针的冷冻设备,用于全身各种实体肿瘤的治疗。目前,对冷冻治疗技术、冷冻治疗机制以及皮肤病和恶性肿瘤冷冻治疗的临床治疗效果研究已取得丰富成果。对基因层面冷冻免疫应答以及氩氦刀或康博刀联合治疗等的深入研究,对更好地认识冷冻治疗的本质,提高临床冷冻治疗效果至关重要。
Cryotherapy is a kind of physical treatment that utilizes freezing temperature to induce local tissue ablation and destroys certain live tissue controllably,which has most therapeutic applications in dermatology and oncology. Handheld nitrogen spraying equipment is mainly used in treating skin lesions while automatic multiple-probe freezing systems such as argon-helium knife and combined knife are used in treating a variety of solid tumors. Recently,researches have covered most of the mechanisms,techniques and clinical analysis of cryotherapy. However,genome-level variations in immune response to cryotherapy and combined therapy with immunological drugs still warrants further investigation to reveal the nature of cryotherapy and enhance its clinical effect.
Cryotherapy is a kind of physical treatment that utilizes freezing temperature to induce local tissue ablation and destroys certain live tissue controllably,which has most therapeutic applications in dermatology and oncology. Handheld nitrogen spraying equipment is mainly used in treating skin lesions while automatic multiple-probe freezing systems such as argon-helium knife and combined knife are used in treating a variety of solid tumors. Recently,researches have covered most of the mechanisms,techniques and clinical analysis of cryotherapy. However,genome-level variations in immune response to cryotherapy and combined therapy with immunological drugs still warrants further investigation to reveal the nature of cryotherapy and enhance its clinical effect.
引文
[1] Hu KQ. Advances in clinical application of cryoablation therapy for hepatocellular carcinoma and metastatic liver tumor[J]. J Clin Gastroenterol,2014,48(10):830-836.
[2]刘建刚.氩氦冷冻治疗肿瘤进展[J].中华实用诊断与治疗杂志,2011,25(8):733-734.
[3]猪猪钱罐.中关村发展集团科技创新成果亮相“京交会”[EB/OL].(2017-05-03)[2017-07-11]. https://baijiahao. baidu.com/s? id=1568809700118595&wfr=spider&for=pc.
[4]刘静.低温生物医学工程学原理[M].北京:科学出版社,2007:338.
[5]高雅丽.“康博刀”让肿瘤走开[N].中国科学报,2018-03-19(第6版)[2018-06-21]. http://www. cas. cn/cm/201803/t20180319_4638776. shtml.
[6] Jones SK,Darville JM. Transmission of virus by cryotherapy and multi-use caustic pencils:A problem to dermatologists?[J]. Br J Dermatol,1989,121(4):481-486.
[7] Grimmett RH. Liquid nitrogen therapy. Histologic observations[J].Arch Dermatol,1961,83:563-567.
[8] Gage AA,Baust J. Mechanisms of tissue injury in cryosurgery[J]. Cryobiology,1998,37:171-186.
[9] Farrant J,Walter CA. The cryobiological basis for cryosurgery[J].J Dermatol Surg Oncol,1977,3(4):403-407.
[10] Whittaker DK. Repeat freeze cycles in cryosurgery of oral tissues[J].Br Dent J,1975,139(12):459-465.
[11] Helpap B. Morphologic and cell kinetic investigations of the cryolesion[J]. Clin Dermatol,1990,8(1):5-29.
[12] Dawber R. Cryosurgery:Unapproved uses,dosages,or indications[J]. Clin Dermatol,2002,20(5):563-570.
[13] Forest V,Peoc'h M,Campos L,et al. Benefit of a combined treatment of cryotherapy and chemotherapy on tumour growth and late cryoinduced angiogenesis in a non-small-cell lung cancer model[J].Lung Cancer,2006,54(1):79-86.
[14] Robilotto AT,Baust JM,Van Buskirk RG,et al. Temperaturedependent activation of differential apoptotic pathways during cryoablation in a human prostate cancer model[J]. Prostate Cancer Prostatic Dis,2013,16(1):41-49.
[15] Chu KF,Dupuy DE. Thermal ablation of tumours:Biological mechanisms and advances in therapy[J]. Nat Rev Cancer,2014,14(3):199-208.
[16] Gazzaniga S,Bravo A,Goldszmid SR,et al. Inflammatory changes after cryosurgery-induced necrosis in human melanoma xenografted in nude mice[J]. J Invest Dermatol,2001,116(5):664-671.
[17] Schacht V,Becker K,Szeimies RM,et al. Apoptosis and leucocyte-endothelium interactions contribute to the delayed effects of cryotherapy on tumors in vivo[J]. Arch Dermatol Res,2002,294(8):341-348.
[18] Mc Kenna JK,Florell SR,Goldman GD,et al. Lentigo maligna/lentigo maligna melanoma:Current state of diagnosis and treatment[J]. Dermatol Surg,2006,32(4):493-504.
[19] Kuflik EG. Cryosurgery for skin cancer:30-year experience and cure rates[J]. Dermatol Surg,2004,30(2 Pt 2):297-300.
[20] Nordin P,Stenquist B. Five-year results of curettage cryosurgery for 100 consecutive auricular non-melanoma skin cancers[J].J Laryngol Otol,2002,116(11):893-898.
[21] Shi J,Li Y,Liang S,et al. Circulating tumour cells as biomarkers for evaluating cryosurgery on unresectable hepatocellular carcinoma[J].Oncol Rep,2016,36(4):1845-1851.
[22] Baust JG,Gage AA,Bjerklund Johansen TE,et al. Mechanisms of cryoablation:Clinical consequences on malignant tumors[J].Cryobiology,2014,68(1):1-11.
[23] Kumar A,Kumar S,Katiyar VK,et al. Phase change heat transfer during cryosurgery of lung cancer using hyperbolic heat conduction model[J]. Comput Biol Med,2017,84:20-29.
[24]伏婷婷,张宝和,徐洪涛,等.经皮肺穿刺氩氦刀靶向治疗老年原发性肺部恶性肿瘤的临床观察[J].中国医学装备,2017,14(6):69-73.
[25] Kongnyuy M,Halpern DM,Kosinski KE,et al. Cryosurgery,an alternative treatment option for organ-confined prostate cancer:Current beliefs and practice patterns of urologists[J]. Int Urol Nephrol,2017,49(1):43-48.
[26] Kim HK,Pyun JH,Cho S,et al. Tumor-specific immunity induced by cryoablation in a murine renal cell carcinoma model[J]. Korean J Urol,2014,55(12):834-840.
[27]雷斌,刘会侠,李文鹏,等.氩氦刀低温冷冻治疗肛管直肠癌的临床分析[J].临床医学研究与实践,2017,2(13):75-76.
[28]李鹏,李文良,孙增峰,等.氩氦刀冷冻消融治疗脑胶质瘤的现状与展望[J].中国肿瘤临床,2014,41(5):345-348.
[29] He XZ,Wang QF,Han S,et al. Cryo-ablation improves anti-tumor immunity through recovering tumor educated dendritic cells in tumor-draining lymph nodes[J]. Drug Des Devel Ther,2015,9:1449-1458.
[30]黄立群,齐隽.冷冻消融治疗小肾癌的疗效及其影响因素的研究进展[J].现代泌尿外科杂志,2015,20(2):133-137.
[31]赵朝阳,邓少杰,叶军,等. CT引导下经皮穿刺氩氦刀冷冻技术对转移性骨肿瘤的临床疗效观察与研究[J].白求恩医学杂志,2016,14(4):424-426.
[32] Kudo-Saito C,Fuwa T,Kawakami Y. Targeting ALCAM in the cryo-treated tumour microenvironment successfully induces systemic anti-tumour immunity[J]. Eur J Cancer,2016,62:54-61.
[33] He K,Liu P,Xu LX. The cryo-thermal therapy eradicated melanoma in mice by eliciting CD4+T-cell-mediated antitumor memory immune response[J]. Cell Death Dis,2017,8(3):e2703.
[34] Veenstra JJ,Gibson HM,Littrup PJ,et al. Cryotherapy with concurrent CpG oligonucleotide treatment controls local tumor recurrence and modulates HER2/neu immunity[J]. Cancer Res,2014,74(19):5409-5420.
[35] Luo XM,Niu LZ,Chen JB,et al. Advances in cryoablation for pancreatic cancer[J]. World J Gastroenterol,2016,22(2):790-800.
[36] Susa M,Kikuta K,Nakayama R,et al. CT guided cryoablation for locally recurrent or metastatic bone and soft tissue tumor:Initial experience[J]. BMC Cancer,2016,16(1):798.
[37] Gage AA,Baust JG. Cryosurgery for tumors[J]. J Am Coll Surg,2007,205(2):342-356.
[38]人民网.中国教授徐克成当选世界冷冻治疗学会主席[EB/OL].(2013-12-18).[2014-10-15]. http://tv. people. com. cn/n/2013/1218/c39805-23871696. html.
[39] Niu LZ,Li JL,Zeng JY,et al. Combination treatment with comprehensive cryoablation and immunotherapy in metastatic hepatocellular cancer[J]. World J Gastroenterol,2013,19(22):3473-3480.
[40] Abdo J,Cornell DL,Mittal SK,et al. Immunotherapy Plus Cryotherapy:Potential Augmented Abscopal Effect for Advanced Cancers[J]. Front Oncol,2018,8:85.
[41]刘冰,张元昊.磁共振导引下氩氦刀冷冻消融联合免疫生物治疗肠癌肝转移的效果研究[J].中国当代医药,2016,23(19):140-143.
[42] Liang S,Niu L,Xu K,et al. Tumor cryoablation in combination with natural killer cells therapy and herceptin in patients with HER2-overexpressing recurrent breast cancer[J]. Mol Immunol,2017,92:45-53.
[43]北京日报客户端.有效发明专利突破8万件中关村跻身全球科技创新中心行列[EB/OL].(2018-7-11)[2018-7-12].https://baijiahao. baidu. com/s? id=1605771144722695628&wfr=spider&for=pc.
[2]刘建刚.氩氦冷冻治疗肿瘤进展[J].中华实用诊断与治疗杂志,2011,25(8):733-734.
[3]猪猪钱罐.中关村发展集团科技创新成果亮相“京交会”[EB/OL].(2017-05-03)[2017-07-11]. https://baijiahao. baidu.com/s? id=1568809700118595&wfr=spider&for=pc.
[4]刘静.低温生物医学工程学原理[M].北京:科学出版社,2007:338.
[5]高雅丽.“康博刀”让肿瘤走开[N].中国科学报,2018-03-19(第6版)[2018-06-21]. http://www. cas. cn/cm/201803/t20180319_4638776. shtml.
[6] Jones SK,Darville JM. Transmission of virus by cryotherapy and multi-use caustic pencils:A problem to dermatologists?[J]. Br J Dermatol,1989,121(4):481-486.
[7] Grimmett RH. Liquid nitrogen therapy. Histologic observations[J].Arch Dermatol,1961,83:563-567.
[8] Gage AA,Baust J. Mechanisms of tissue injury in cryosurgery[J]. Cryobiology,1998,37:171-186.
[9] Farrant J,Walter CA. The cryobiological basis for cryosurgery[J].J Dermatol Surg Oncol,1977,3(4):403-407.
[10] Whittaker DK. Repeat freeze cycles in cryosurgery of oral tissues[J].Br Dent J,1975,139(12):459-465.
[11] Helpap B. Morphologic and cell kinetic investigations of the cryolesion[J]. Clin Dermatol,1990,8(1):5-29.
[12] Dawber R. Cryosurgery:Unapproved uses,dosages,or indications[J]. Clin Dermatol,2002,20(5):563-570.
[13] Forest V,Peoc'h M,Campos L,et al. Benefit of a combined treatment of cryotherapy and chemotherapy on tumour growth and late cryoinduced angiogenesis in a non-small-cell lung cancer model[J].Lung Cancer,2006,54(1):79-86.
[14] Robilotto AT,Baust JM,Van Buskirk RG,et al. Temperaturedependent activation of differential apoptotic pathways during cryoablation in a human prostate cancer model[J]. Prostate Cancer Prostatic Dis,2013,16(1):41-49.
[15] Chu KF,Dupuy DE. Thermal ablation of tumours:Biological mechanisms and advances in therapy[J]. Nat Rev Cancer,2014,14(3):199-208.
[16] Gazzaniga S,Bravo A,Goldszmid SR,et al. Inflammatory changes after cryosurgery-induced necrosis in human melanoma xenografted in nude mice[J]. J Invest Dermatol,2001,116(5):664-671.
[17] Schacht V,Becker K,Szeimies RM,et al. Apoptosis and leucocyte-endothelium interactions contribute to the delayed effects of cryotherapy on tumors in vivo[J]. Arch Dermatol Res,2002,294(8):341-348.
[18] Mc Kenna JK,Florell SR,Goldman GD,et al. Lentigo maligna/lentigo maligna melanoma:Current state of diagnosis and treatment[J]. Dermatol Surg,2006,32(4):493-504.
[19] Kuflik EG. Cryosurgery for skin cancer:30-year experience and cure rates[J]. Dermatol Surg,2004,30(2 Pt 2):297-300.
[20] Nordin P,Stenquist B. Five-year results of curettage cryosurgery for 100 consecutive auricular non-melanoma skin cancers[J].J Laryngol Otol,2002,116(11):893-898.
[21] Shi J,Li Y,Liang S,et al. Circulating tumour cells as biomarkers for evaluating cryosurgery on unresectable hepatocellular carcinoma[J].Oncol Rep,2016,36(4):1845-1851.
[22] Baust JG,Gage AA,Bjerklund Johansen TE,et al. Mechanisms of cryoablation:Clinical consequences on malignant tumors[J].Cryobiology,2014,68(1):1-11.
[23] Kumar A,Kumar S,Katiyar VK,et al. Phase change heat transfer during cryosurgery of lung cancer using hyperbolic heat conduction model[J]. Comput Biol Med,2017,84:20-29.
[24]伏婷婷,张宝和,徐洪涛,等.经皮肺穿刺氩氦刀靶向治疗老年原发性肺部恶性肿瘤的临床观察[J].中国医学装备,2017,14(6):69-73.
[25] Kongnyuy M,Halpern DM,Kosinski KE,et al. Cryosurgery,an alternative treatment option for organ-confined prostate cancer:Current beliefs and practice patterns of urologists[J]. Int Urol Nephrol,2017,49(1):43-48.
[26] Kim HK,Pyun JH,Cho S,et al. Tumor-specific immunity induced by cryoablation in a murine renal cell carcinoma model[J]. Korean J Urol,2014,55(12):834-840.
[27]雷斌,刘会侠,李文鹏,等.氩氦刀低温冷冻治疗肛管直肠癌的临床分析[J].临床医学研究与实践,2017,2(13):75-76.
[28]李鹏,李文良,孙增峰,等.氩氦刀冷冻消融治疗脑胶质瘤的现状与展望[J].中国肿瘤临床,2014,41(5):345-348.
[29] He XZ,Wang QF,Han S,et al. Cryo-ablation improves anti-tumor immunity through recovering tumor educated dendritic cells in tumor-draining lymph nodes[J]. Drug Des Devel Ther,2015,9:1449-1458.
[30]黄立群,齐隽.冷冻消融治疗小肾癌的疗效及其影响因素的研究进展[J].现代泌尿外科杂志,2015,20(2):133-137.
[31]赵朝阳,邓少杰,叶军,等. CT引导下经皮穿刺氩氦刀冷冻技术对转移性骨肿瘤的临床疗效观察与研究[J].白求恩医学杂志,2016,14(4):424-426.
[32] Kudo-Saito C,Fuwa T,Kawakami Y. Targeting ALCAM in the cryo-treated tumour microenvironment successfully induces systemic anti-tumour immunity[J]. Eur J Cancer,2016,62:54-61.
[33] He K,Liu P,Xu LX. The cryo-thermal therapy eradicated melanoma in mice by eliciting CD4+T-cell-mediated antitumor memory immune response[J]. Cell Death Dis,2017,8(3):e2703.
[34] Veenstra JJ,Gibson HM,Littrup PJ,et al. Cryotherapy with concurrent CpG oligonucleotide treatment controls local tumor recurrence and modulates HER2/neu immunity[J]. Cancer Res,2014,74(19):5409-5420.
[35] Luo XM,Niu LZ,Chen JB,et al. Advances in cryoablation for pancreatic cancer[J]. World J Gastroenterol,2016,22(2):790-800.
[36] Susa M,Kikuta K,Nakayama R,et al. CT guided cryoablation for locally recurrent or metastatic bone and soft tissue tumor:Initial experience[J]. BMC Cancer,2016,16(1):798.
[37] Gage AA,Baust JG. Cryosurgery for tumors[J]. J Am Coll Surg,2007,205(2):342-356.
[38]人民网.中国教授徐克成当选世界冷冻治疗学会主席[EB/OL].(2013-12-18).[2014-10-15]. http://tv. people. com. cn/n/2013/1218/c39805-23871696. html.
[39] Niu LZ,Li JL,Zeng JY,et al. Combination treatment with comprehensive cryoablation and immunotherapy in metastatic hepatocellular cancer[J]. World J Gastroenterol,2013,19(22):3473-3480.
[40] Abdo J,Cornell DL,Mittal SK,et al. Immunotherapy Plus Cryotherapy:Potential Augmented Abscopal Effect for Advanced Cancers[J]. Front Oncol,2018,8:85.
[41]刘冰,张元昊.磁共振导引下氩氦刀冷冻消融联合免疫生物治疗肠癌肝转移的效果研究[J].中国当代医药,2016,23(19):140-143.
[42] Liang S,Niu L,Xu K,et al. Tumor cryoablation in combination with natural killer cells therapy and herceptin in patients with HER2-overexpressing recurrent breast cancer[J]. Mol Immunol,2017,92:45-53.
[43]北京日报客户端.有效发明专利突破8万件中关村跻身全球科技创新中心行列[EB/OL].(2018-7-11)[2018-7-12].https://baijiahao. baidu. com/s? id=1605771144722695628&wfr=spider&for=pc.