肺腺癌GGNs的多排螺旋CT诊断在判定微浸润中的价值研究
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摘要
目的对肺腺癌GGNs的多排螺旋CT诊断在判定微浸润中的价值进行系统评估,为患者早期防治方案的个性化制定提供参考依据。方法以肺腺癌患者作为研究对象,在征得患者及其家属同意的前提下对所有入选的患者行多排螺旋CT检查,并收集所有入选患者的基本资料,采用ROC受试者特征曲线初步评估肺腺癌GGNs的多排螺旋CT诊断在判定微浸润中的诊断中的敏感性和特异性。结果本研究有效观察对象128例;多排螺旋CT对肺腺癌GGNs的诊断结果与患者原始诊断结果的差异没有统计学意义(χ~2=2. 218,P> 0. 05);多排螺旋CT结果对肺腺癌GGNs检测结果ROC曲线下面积为0. 783(95%CI:0. 636～0. 905);影响患者多排螺旋CT结果对肺腺癌GGNs诊断结果的相关因素包括患者年龄、是否患有呼吸系统慢性炎症、是否新发、吸烟年限(P均<0. 05)。结论肺腺癌GGNs的多排螺旋CT诊断在判定微浸润中具有较优质的诊断价值,但多排螺旋CT定性结果可能会受到患者自身因素的影响,在作出诊断时需结合相关资料进一步分析。
Objective To evaluate the value of multi-slice spiral CT in the diagnosis of GGNs in the diagnosis of microinvasion,and to provide a reference for the individuation of early prevention and treatment of lung adenocarcinoma. Methods Lung adenocarcinoma patients treated in department of respiratory medicine of a grade 3 A hospital were selected as study subjects. All patients were examined with multi-slice spiral CT with the consent of patients and their families. The basic data of all the patients were collected and the diagnostic value of multi-slice spiral CT( MSCT) in the diagnosis of pulmonary adenocarcinoma( GGNs) was preliminarily evaluated by using the characteristic curve of ROC subjects in the diagnosis of microinfiltration. Sensitivity and specificity. Results 128 cases were observed effectively. There was no significant difference between the results of multislice spiral CT and that of the original diagnosis of lung adenocarcinoma( P > 0. 05),and the area under the ROC curve of multislice spiral CT for pulmonary adenocarcinoma was 0. 783/95 CI: 0. 636/0. 905,which affected the results of multi-slice spiral CT in patients with lung adenocarcinoma. The factors associated with GGNs diagnosis of lung adenocarcinoma include age. Whether you have chronic inflammation of the respiratory system,whether it was new,and the number of years of smoking( Pall < 0. 05).0. 05. Conclusion Multi-slice spiral CT diagnosis of lung adenocarcinoma GGNs is valuable in the diagnosis of microinvasion,but the qualitative results of multi-slice spiral CT may be affected by the patient's own factors.
Objective To evaluate the value of multi-slice spiral CT in the diagnosis of GGNs in the diagnosis of microinvasion,and to provide a reference for the individuation of early prevention and treatment of lung adenocarcinoma. Methods Lung adenocarcinoma patients treated in department of respiratory medicine of a grade 3 A hospital were selected as study subjects. All patients were examined with multi-slice spiral CT with the consent of patients and their families. The basic data of all the patients were collected and the diagnostic value of multi-slice spiral CT( MSCT) in the diagnosis of pulmonary adenocarcinoma( GGNs) was preliminarily evaluated by using the characteristic curve of ROC subjects in the diagnosis of microinfiltration. Sensitivity and specificity. Results 128 cases were observed effectively. There was no significant difference between the results of multislice spiral CT and that of the original diagnosis of lung adenocarcinoma( P > 0. 05),and the area under the ROC curve of multislice spiral CT for pulmonary adenocarcinoma was 0. 783/95 CI: 0. 636/0. 905,which affected the results of multi-slice spiral CT in patients with lung adenocarcinoma. The factors associated with GGNs diagnosis of lung adenocarcinoma include age. Whether you have chronic inflammation of the respiratory system,whether it was new,and the number of years of smoking( Pall < 0. 05).0. 05. Conclusion Multi-slice spiral CT diagnosis of lung adenocarcinoma GGNs is valuable in the diagnosis of microinvasion,but the qualitative results of multi-slice spiral CT may be affected by the patient's own factors.
引文
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[9]温玉婷,杨巧.热休克蛋白90-β过表达作为肺腺癌患者不良预后标志物的探讨[J].现代医学,2016,44(11):1531-1536.
[10]刘剑,吉浩明,刘春桂,等.血清CEA、LDH对肺腺癌靶向治疗的临床疗效及预后的预测价值[J].实用癌症杂志,2017,32(2):178-180.
[11]郝艳萍,吴俊,艾风波.CA19-9、CA125、CEA和CY-FRA21-1检测对肺腺癌患者骨转移的诊断价值分析[J].标记免疫分析与临床,2016,23(12):1372-1374,1398.
[12]童天夫.血清CEA和CYFRA21-1检测对ⅢB、Ⅳ期非小细胞肺癌患者化疗疗效的评估[J].国际检验医学杂志,2018,39(3):361-363.
[2]樊兴海,杨欢欢,许秀春,等.3 cm以下纯磨玻璃结节肺腺癌的组织学与CT扫描值的相关性研究[J].中国临床医生杂志,2018,46(3):307-310.
[3]戈霞晖,管雯斌,韩锋锋,等.表现为肺部磨玻璃结节的浸润前病变和浸润性腺癌的CT及病理对比研究[J].中国呼吸与危重监护杂志,2017,16(6):561-566.
[4]闫如意,刘军华,王艳茹,等.肺部亚厘米磨玻璃结节的螺旋CT与病理对照分析[J].局解手术学杂志,2018,27(4):275-279.
[5]苗润丰,陶玉坚.持续存在的肺磨玻璃结节临床研究进展[J].医学综述,2018,24(7):1378-1382.
[6]韩丽珠,叶兆祥,李绪斌,等.CT定量参数预测评估肺混合磨玻璃结节侵袭性的临床价值[J].中国肿瘤临床,2018,45(6):286-290.
[7]左玉强,孟庆春,田云霞,等.纯磨玻璃密度浸润前病变与浸润性肺腺癌的临床及CT鉴别[J].重庆医学,2017,46(13):1782-1785.
[8]陈昕,陈小岩,陈前顺,等.表现为磨玻璃样结节非鳞屑样浸润性肺腺癌的临床病理学特征及其预后[J].福建医药杂志,2017,39(6):35-37.
[9]温玉婷,杨巧.热休克蛋白90-β过表达作为肺腺癌患者不良预后标志物的探讨[J].现代医学,2016,44(11):1531-1536.
[10]刘剑,吉浩明,刘春桂,等.血清CEA、LDH对肺腺癌靶向治疗的临床疗效及预后的预测价值[J].实用癌症杂志,2017,32(2):178-180.
[11]郝艳萍,吴俊,艾风波.CA19-9、CA125、CEA和CY-FRA21-1检测对肺腺癌患者骨转移的诊断价值分析[J].标记免疫分析与临床,2016,23(12):1372-1374,1398.
[12]童天夫.血清CEA和CYFRA21-1检测对ⅢB、Ⅳ期非小细胞肺癌患者化疗疗效的评估[J].国际检验医学杂志,2018,39(3):361-363.