PG、PGR与胃息肉病理类型的相关性研究
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摘要
目的对血清胃蛋白酶原Ⅰ、胃蛋白酶原Ⅱ(PGⅠ、PGⅡ)含量及其比值(PGR)与胃息肉病理类型的相关性研究。方法应用化学发光法,检测82例接受内镜下检查治疗的胃息肉患者及31例正常对照组的空腹血清PGⅠ及PGⅡ水平并计算PGR,统计分析PGⅠ、PGⅡ、PGR与胃息肉病理分型及临床病理参数的关系。结果各病理类型息肉组中PGⅠ、PGR明显低于正常对照组(P<0.05),以腺瘤性息肉组为著,其表达低于错构瘤性、增生性息肉组,差异具有统计学意义(P<0.05),临床病理参数分析显示PGⅠ、PGⅡ、PGR与息肉大小、位置密切相关。而PGⅡ在以上各分组的表达则无明显统计学意义(P>0.05)。结论血清PG浓度是判断胃息肉病理分型的一个重要参考指标。
Objective To investigate the pepsinogen(PG)I,pepsinogen(PG)II and theirs ratio in the diagnosis of gastric polyps.Methods Chemoluminescence assay was used to detect theserum levels of PG I and PG II and the PGR was calculated in 82 patients with gastric polyps and 33 healthy controls,and the results were analyzed statistically.Results The serum level of PGI and PGR were significantly lower in patients with gastric polyps than those in normal controls,especially in cases of adenomatous polyp,the serum level was significantly lower in patients with adenomatous polyps than that of Hyperplastic polyp and inflammation polyp.Analysis on clintcopathological parameters showed that the serum level of PG I、PG Ⅱand PGR were significantly corrected with the size and location of polyps.Conclusion The level of serum PG is an important reference indication for the pathology diagnosis of gastric polyp.
Objective To investigate the pepsinogen(PG)I,pepsinogen(PG)II and theirs ratio in the diagnosis of gastric polyps.Methods Chemoluminescence assay was used to detect theserum levels of PG I and PG II and the PGR was calculated in 82 patients with gastric polyps and 33 healthy controls,and the results were analyzed statistically.Results The serum level of PGI and PGR were significantly lower in patients with gastric polyps than those in normal controls,especially in cases of adenomatous polyp,the serum level was significantly lower in patients with adenomatous polyps than that of Hyperplastic polyp and inflammation polyp.Analysis on clintcopathological parameters showed that the serum level of PG I、PG Ⅱand PGR were significantly corrected with the size and location of polyps.Conclusion The level of serum PG is an important reference indication for the pathology diagnosis of gastric polyp.
引文
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[8]叶玲,刘霆,冷爱民,等.胃息肉的临床特征分析与治疗决策[J].中国现代医学杂志,2011,21(5):659-661.
[9]Zhang X M,L i J X,Zhang G Y,et al.The value of serum pepsinogen levels for the diagnosis of gastric diseases in Chinese Han people in midsouth China[J].BMC Gastroenterol,2014,1 4(1):9006.
[10]Shafaghi A,Mansour-Ghanaei F,Joukar F,et al.Serum gastrin and the pepsinogen I/II ratio as markers for diagnosis of premalignant gastric lesions[J].Asian Pac J Cancer Prev,2013,14(6):3931-3936.
[11]Kitahara F,Kobayashi K,Sato T,et al.Accuracy of screening for gastric cancer using serum pepsinogen concentrations[J].Gut,1999,44(5):693-697.
[12]袁媛,张联.胃癌高发现场高危人群综合防治研究[J].中国肿瘤,2001,10(3):139-142.
[13]Cao H,Wang B,Zhang Z,et al.Distribution trends of gastric polyps:an endoscopy database analysis of 24 121northern Chinese patients[J].J Gastroenterol Hepatol,2012,27(7):1175-1180.
[2]Kwak M S,Kim N,Lee H S,et al.Predictive power of serum pepsinogen tests for the development of gastric cancer in comparison to the histologic risk index[J].Dig Dis Sci,2010,55(8):2275-2282.
[3]Choi C W,Kang D H,Kim H W,et al.Endoscopic submucosal dissection as a treatment for gastric adenomatous polyps:predictive factors for early gastric cancer[J].Scand J Gastroenterol,2012,47(10):1218-1225.
[4]Imura J,Hayashi S,Ichikawa K,et al.Malignant transformation of hyperplastic gastric polyps:An immunohistochemical and pathological study of the changes of neoplastic phenotype[J].Oncol Lett,2014,7(5):1459-1463.
[5]Sung H Y,Cheung D Y,Cho S H,et al.Polyps in the gastrointestinal tract:discrepancy between endoscopic forceps biopsies and resected specimens[J].Eur J Gastroenterol Hepatol,2009,21(2):190-195.
[6]Ahn J Y,Son D H,Choi K D,et al.Neoplasms arising in large gastric hyperplastic polyps:endoscopic and pathologic features[J].Gastrointest Endosc,2014,80(6):1005-1013.
[7]Liapunova V N,Nikiforov P A,Brekhov E I,et al.Results of dynamic observation of patients with polyps in the stomach[J].Eksp Klin Gastroenterol,2013(12):33-38.
[8]叶玲,刘霆,冷爱民,等.胃息肉的临床特征分析与治疗决策[J].中国现代医学杂志,2011,21(5):659-661.
[9]Zhang X M,L i J X,Zhang G Y,et al.The value of serum pepsinogen levels for the diagnosis of gastric diseases in Chinese Han people in midsouth China[J].BMC Gastroenterol,2014,1 4(1):9006.
[10]Shafaghi A,Mansour-Ghanaei F,Joukar F,et al.Serum gastrin and the pepsinogen I/II ratio as markers for diagnosis of premalignant gastric lesions[J].Asian Pac J Cancer Prev,2013,14(6):3931-3936.
[11]Kitahara F,Kobayashi K,Sato T,et al.Accuracy of screening for gastric cancer using serum pepsinogen concentrations[J].Gut,1999,44(5):693-697.
[12]袁媛,张联.胃癌高发现场高危人群综合防治研究[J].中国肿瘤,2001,10(3):139-142.
[13]Cao H,Wang B,Zhang Z,et al.Distribution trends of gastric polyps:an endoscopy database analysis of 24 121northern Chinese patients[J].J Gastroenterol Hepatol,2012,27(7):1175-1180.