不同类型淋巴瘤中TNF-α的表达情况及临床价值分析
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摘要
目的探讨不同类型淋巴瘤中血浆TNF-的表达情况及其在临床价值。方法选取淋巴瘤患者100例作为病例组,从同期健康体检者中选50例健康体检者作为对照组,比较两组患者血浆TNF-的表达情况,分析血浆TNF-水平与淋巴瘤临床病理特征间的关系。结果与对照组比,HL、DLBCL、FL、PTL患者血浆TNF-水平显著上升(P <0. 05),MCL患者血浆TNF-水平显著降低(P <0. 05),MALT、NK/TCL患者差异不显著(P> 0. 05)。Ann ArborⅢ～Ⅳ期淋巴瘤患者血浆TNF-水平显著高于Ⅰ～Ⅱ期(P <0. 05),有全身症状淋巴瘤患者血浆TNF-水平显著高于无全身症状患者(P <0. 05),IPI评分中高危组淋巴瘤患者血浆TNF-水平显著高于低危组(P <0. 05),血浆TNF-的表达在不同性别、年龄、组间无显著性差异(P>0. 05)。结论血浆TNF-水平能够反映淋巴瘤患者体内肿瘤细胞增殖活性及负荷,为临床诊断及预后提供一定的参考价值。
Objective To explore the expression of plasma TNF-in different types of lymphoma and its clinical value.Methods Selected 100 patients with lymphoma treated as the case group. From the same period of healthy physical examination,50 healthy checkers were selected as the control group. The expression of plasma TNF-was compared between the two groups. The relationship between plasma TNF-levels and clinicopathological features of lymphoma was analyzed. Results Compared with the control group,plasma TNF-levels were significantly increased in patients with HL,DLBCL,FL,and PTL( P < 0. 05). Plasma TNF-levels were significantly lower in MCL and patients( P < 0. 05). There was no significant difference between MALT and NK/TCL patients( P > 0. 05). The plasma levels of TNF-in patients with Ann Arbor Ⅲ ～ Ⅳ lymphoma were significantly higher than those in Ⅰ ～ Ⅱ( P < 0. 05). Plasma levels of TNF-in patients with systemic lymphoma were significantly higher than those without systemic symptoms( P < 0. 05). Plasma TNF-levels in high-risk group lymphoma patients with IPI score were significantly higher than those in low-risk group( P < 0. 05). There was no significant difference in plasma TNF-expression between genders,ages,and groups( P > 0. 05). Conclusion Plasma TNF-levels can reflect the tumor cell proliferation activity and load in lymphoma patients,providing a certain reference value for clinical diagnosis and prognosis.
Objective To explore the expression of plasma TNF-in different types of lymphoma and its clinical value.Methods Selected 100 patients with lymphoma treated as the case group. From the same period of healthy physical examination,50 healthy checkers were selected as the control group. The expression of plasma TNF-was compared between the two groups. The relationship between plasma TNF-levels and clinicopathological features of lymphoma was analyzed. Results Compared with the control group,plasma TNF-levels were significantly increased in patients with HL,DLBCL,FL,and PTL( P < 0. 05). Plasma TNF-levels were significantly lower in MCL and patients( P < 0. 05). There was no significant difference between MALT and NK/TCL patients( P > 0. 05). The plasma levels of TNF-in patients with Ann Arbor Ⅲ ～ Ⅳ lymphoma were significantly higher than those in Ⅰ ～ Ⅱ( P < 0. 05). Plasma levels of TNF-in patients with systemic lymphoma were significantly higher than those without systemic symptoms( P < 0. 05). Plasma TNF-levels in high-risk group lymphoma patients with IPI score were significantly higher than those in low-risk group( P < 0. 05). There was no significant difference in plasma TNF-expression between genders,ages,and groups( P > 0. 05). Conclusion Plasma TNF-levels can reflect the tumor cell proliferation activity and load in lymphoma patients,providing a certain reference value for clinical diagnosis and prognosis.
引文
[1]Lech-Maranda E,Bienvenu J,Broussais-Guillaumot F,et al.Plasma TNF-αand IL-10 Level-Based Prognostic Model Predicts Outcome of Patients with Diffuse Large B-Cell Lymphoma in Different Risk Groups Defined by the International Prognostic Index[J].Archivum Immunologiae Et Therapiae Experimentalis,2010,58(2):131-141.
[2]陈海霞,吴文华,顾霞,等.TNF-α、TNF-β和NF-κBp50在不同类型淋巴瘤的表达及其意义[J].新疆医科大学学报,2012,35(1):37-43.
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[4]樊璠,徐笑红,陈文虎.非霍奇金淋巴瘤患者血清TNF-α、CA125、β_2-MG、LDH水平及临床意义[J].肿瘤学杂志,2012,18(10):780-783.
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[7]He B,Chadburn A,Jou E,et al.Lymphoma B cells evade apoptosis through the TNF family members BAFF/BLy Sand APRIL[J].Journal of Immunology,2004,172(5):3268-3279.
[8]哈力达·亚森,郭新红,阿丽亚·热哈提,等.淋巴瘤患者血浆TNF-α和TNF-β水平及其临床意义[J].中华血液学杂志,2011,32(10):695-697.
[9]Seki Y,Koike T,Yano M,et al.Bone marrow necrosis with dyspnea in a patient with malignant lymphoma and plasma levels of thrombomodulin,tumor necrosis factor-alpha,and D-dimer[J].American Journal of Hematology,2002,70(3):250-253.
[10]沈艳,顾霞,富玲,等.TNF-α和IL-10基因多态性及其血浆浓度与弥漫大B细胞淋巴瘤的关系[J].临床与实验病理学杂志,2017,33(7):715-719.
[11]孟伟,顾霞,王富强.TNF-α、TNF-β在弥漫性大B细胞淋巴瘤中的表达及其意义[J].新疆医科大学学报,2010,33(4):346-349.
[12]张瑞丽,张景萍,张静,等.NHL患者血清TNF-α、LDH水平及与血沉的相关性研究[J].实用肿瘤学杂志,2006,20(1):9-11.
[13]叶琇锦,林茂芳,孟筱坚.恶性淋巴瘤患者血清可溶性肿瘤坏死因子受体水平及临床意义[J].实用肿瘤杂志,2001,16(6):385-387.
[14]王思力,方志鸿,黄耘,等.肿瘤坏死因子α在不同类型淋巴瘤患者中的表达及其临床预后意义[J].中华血液学杂志,2014,35(12):1107-1110.
[2]陈海霞,吴文华,顾霞,等.TNF-α、TNF-β和NF-κBp50在不同类型淋巴瘤的表达及其意义[J].新疆医科大学学报,2012,35(1):37-43.
[3]张倩,张红宇,钟凤鸾,等.非霍奇金淋巴瘤患者外周血Treg细胞及IL-6、TNF-α水平的研究[J].临床血液学杂志,2014,25(1):32-34.
[4]樊璠,徐笑红,陈文虎.非霍奇金淋巴瘤患者血清TNF-α、CA125、β_2-MG、LDH水平及临床意义[J].肿瘤学杂志,2012,18(10):780-783.
[5]Bentley S.WHO Classification of Tumours:Pathology and Genetics.Tumours of Haematopoietic and Lymphoid Tissues[J].International Journal of Laboratory Hematology,2003,25(3):201-201.
[6]阿丽亚·热哈提,哈力达·亚森,顾霞,等.不同类型淋巴瘤患者血浆TNF-α测定及其临床意义[J].新疆医科大学学报,2011,34(8):843-846.
[7]He B,Chadburn A,Jou E,et al.Lymphoma B cells evade apoptosis through the TNF family members BAFF/BLy Sand APRIL[J].Journal of Immunology,2004,172(5):3268-3279.
[8]哈力达·亚森,郭新红,阿丽亚·热哈提,等.淋巴瘤患者血浆TNF-α和TNF-β水平及其临床意义[J].中华血液学杂志,2011,32(10):695-697.
[9]Seki Y,Koike T,Yano M,et al.Bone marrow necrosis with dyspnea in a patient with malignant lymphoma and plasma levels of thrombomodulin,tumor necrosis factor-alpha,and D-dimer[J].American Journal of Hematology,2002,70(3):250-253.
[10]沈艳,顾霞,富玲,等.TNF-α和IL-10基因多态性及其血浆浓度与弥漫大B细胞淋巴瘤的关系[J].临床与实验病理学杂志,2017,33(7):715-719.
[11]孟伟,顾霞,王富强.TNF-α、TNF-β在弥漫性大B细胞淋巴瘤中的表达及其意义[J].新疆医科大学学报,2010,33(4):346-349.
[12]张瑞丽,张景萍,张静,等.NHL患者血清TNF-α、LDH水平及与血沉的相关性研究[J].实用肿瘤学杂志,2006,20(1):9-11.
[13]叶琇锦,林茂芳,孟筱坚.恶性淋巴瘤患者血清可溶性肿瘤坏死因子受体水平及临床意义[J].实用肿瘤杂志,2001,16(6):385-387.
[14]王思力,方志鸿,黄耘,等.肿瘤坏死因子α在不同类型淋巴瘤患者中的表达及其临床预后意义[J].中华血液学杂志,2014,35(12):1107-1110.