金钗石斛生物碱药理作用研究进展
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摘要
综述金钗石斛生物碱药理作用研究进展。金钗石斛生物碱是金钗石斛药用的主要活性成分,具有抗白内障、抗肿瘤、保护神经、降血糖、降血脂、抗氧化等药理作用。
This article is a review of the pharmacological effects of Dendrobium nobile Lindl.alkaloids( DNLA). DNLA is the main active ingredient of Dendrobium nobile Lindl.,and has pharmacological effects such as anti-cataract,anti-tumor,neuroprotection,hypoglycemic,hypolipidemic and antioxidation.
This article is a review of the pharmacological effects of Dendrobium nobile Lindl.alkaloids( DNLA). DNLA is the main active ingredient of Dendrobium nobile Lindl.,and has pharmacological effects such as anti-cataract,anti-tumor,neuroprotection,hypoglycemic,hypolipidemic and antioxidation.
引文
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[2]张晓敏,孙志蓉,陈龙,等.金钗石斛的化学成分和药理作用研究进展[J].中国现代应用药学,2014,31(7):895-899.
[3]NG T B,LIU J,WONG J H,et al.Review of research on Dendrobium,a prized folk medicine[J].Appl Microbiol Biotechnol,2012,93(5):1795-1803.
[4]陈晶.金钗石斛生物总碱研究进展[J].现代医药卫生,2016,32(5):728-730.
[5]JISANG H,SEONA L,SEONGSU H,et al.Phenanthrenes from Dendrobium nobile and their inhibition of the LPS-induced production of nitric oxide in macrophage RAW 264.7 cells[J].Bioorg Med Chem Lett,2010,20(12):3785-3787.
[6]徐云燕,王令仪,黄彬,等.不同生长期金钗石斛和铁皮石斛中总生物碱及多糖的比较[J].华西药学杂志,2014,29(3):288-291.
[7]XU J,HAN Q B,LI S L,et al.Chemistry,bioactivity and quality control of Dendrobium,a commonly used tonic herb in traditional Chinese medicine[J].Phytochem Rev,2013,12(2):341-367.
[8]何芋岐,鲁艳柳,李利生,等.基于UPLC-ESI-Orbitrap-MS技术对金钗石斛生物碱的分析[J].中国实验方剂学杂志,2017,23(20):30-35.
[9]魏小勇,龙艳.金钗石斛生物碱抗糖性白内障作用及蛋白质组学效应的实验研究[J].天然产物研究与开发,2008,20(4):617-621.
[10]龙艳,魏小勇,詹宇坚,等.金钗石斛提取物抗白内障的体外实验研究[J].广州中医药大学学报,2008,22(4):345-349.
[11]魏小勇,龙艳.金钗石斛生物碱对糖性白内障大鼠诱导型一氧化氮合酶基因的调控[J].解剖学研究,2008,30(3):177-180,205.
[12]马伟凤,徐勤.金钗石斛提取物对晶状体上皮细胞氧化损伤防护作用[J].国际眼科杂志,2010,10(4):650-652.
[13]王亚芸.石斛生物碱提取及其抑制Caco-2活性的研究[D].北京:北京林业大学,2015.
[14]安欣,任建武,李虹阳,等.金钗石斛生物碱对mcf-7细胞线粒体凋亡通路研究[J].江西农业大学学报,2015,37(5):920-926.
[15]和磊,罗婧,王亚芸,等.金钗石斛脂溶性生物碱提取物诱导人结肠癌HT-29细胞凋亡[J].食品工业科技,2017,38(3):170-174,191.
[16]LI Y,LI F,GONG Q,et al.Inhibitory effects of Dendrobium alkaloids on memory impairment induced by lipopolysaccharide in rats[J].Planta Medica,2011,77(2):117-121.
[17]巴智胜,蔡锐,尹彩霞,等.金钗石斛总生物碱改善链脲佐菌素所致大鼠海马神经元损伤[J].中国新药与临床杂志,2017,36(6):340-346.
[18]姜琳珊,李菲,聂晶,等.金钗石斛总生物碱对APP/PS1转基因小鼠学习记忆能力的影响[J].遵义医学院学报,2016,39(3):246-249.
[19]张明辉,李菲,张玮,等.金钗石斛总生物碱对Aβ-(25-35)所致大鼠海马组织Aβ含量的影响[J].遵义医学院学报,2016,39(1):18-21.
[20]李菲,黄琦,李向阳,等.金钗石斛提取物对肾上腺素所致血糖升高的影响[J].遵义医学院学报,2008,31(1):11-12.
[21]黄琦,廖鑫,吴芹,等.金钗石斛生物总碱对糖尿病大鼠血糖及肝脏组织IRS-2 mRNA,IGF-1 mRNA表达的影响[J].中国实验方剂学杂志,2014,20(19):155-158.
[22]张明辉.金钗石斛总生物碱对db/db小鼠血糖的影响及机制研究[D].遵义:遵义医学院,2016.
[23]徐云燕.金钗石斛总生物碱对小鼠糖、脂代谢的影响[D].遵义:遵义医学院,2014.
[24]何晓然.金钗石斛总碱对高糖诱导的大鼠肾系膜细胞增殖及PPAR-γ表达的影响[D].遵义:遵义医学院,2013.
[25]李向阳,杨丹莉,吴芹,等.金钗石斛生物总碱对大鼠高脂血症和肝脏脂肪变性的影响[J].中国新药与临床杂志,2011,30(7):529-532.
[26]LI R,LIU T,LIU M,et al.Anti-influenza A Virus Activity of Dendrobine and Its Mechanism of Action[J].J Agr Food Chem,2017,65(18):3665-3674.
[27]XU Y Y,XU Y S,WANG Y,et al.Dendrobium nobile Lindl.alkaloids regulate metabolism gene expression in livers of mice[J].J Pharm Pharmacol,2017,69(10):1409-1417.
[2]张晓敏,孙志蓉,陈龙,等.金钗石斛的化学成分和药理作用研究进展[J].中国现代应用药学,2014,31(7):895-899.
[3]NG T B,LIU J,WONG J H,et al.Review of research on Dendrobium,a prized folk medicine[J].Appl Microbiol Biotechnol,2012,93(5):1795-1803.
[4]陈晶.金钗石斛生物总碱研究进展[J].现代医药卫生,2016,32(5):728-730.
[5]JISANG H,SEONA L,SEONGSU H,et al.Phenanthrenes from Dendrobium nobile and their inhibition of the LPS-induced production of nitric oxide in macrophage RAW 264.7 cells[J].Bioorg Med Chem Lett,2010,20(12):3785-3787.
[6]徐云燕,王令仪,黄彬,等.不同生长期金钗石斛和铁皮石斛中总生物碱及多糖的比较[J].华西药学杂志,2014,29(3):288-291.
[7]XU J,HAN Q B,LI S L,et al.Chemistry,bioactivity and quality control of Dendrobium,a commonly used tonic herb in traditional Chinese medicine[J].Phytochem Rev,2013,12(2):341-367.
[8]何芋岐,鲁艳柳,李利生,等.基于UPLC-ESI-Orbitrap-MS技术对金钗石斛生物碱的分析[J].中国实验方剂学杂志,2017,23(20):30-35.
[9]魏小勇,龙艳.金钗石斛生物碱抗糖性白内障作用及蛋白质组学效应的实验研究[J].天然产物研究与开发,2008,20(4):617-621.
[10]龙艳,魏小勇,詹宇坚,等.金钗石斛提取物抗白内障的体外实验研究[J].广州中医药大学学报,2008,22(4):345-349.
[11]魏小勇,龙艳.金钗石斛生物碱对糖性白内障大鼠诱导型一氧化氮合酶基因的调控[J].解剖学研究,2008,30(3):177-180,205.
[12]马伟凤,徐勤.金钗石斛提取物对晶状体上皮细胞氧化损伤防护作用[J].国际眼科杂志,2010,10(4):650-652.
[13]王亚芸.石斛生物碱提取及其抑制Caco-2活性的研究[D].北京:北京林业大学,2015.
[14]安欣,任建武,李虹阳,等.金钗石斛生物碱对mcf-7细胞线粒体凋亡通路研究[J].江西农业大学学报,2015,37(5):920-926.
[15]和磊,罗婧,王亚芸,等.金钗石斛脂溶性生物碱提取物诱导人结肠癌HT-29细胞凋亡[J].食品工业科技,2017,38(3):170-174,191.
[16]LI Y,LI F,GONG Q,et al.Inhibitory effects of Dendrobium alkaloids on memory impairment induced by lipopolysaccharide in rats[J].Planta Medica,2011,77(2):117-121.
[17]巴智胜,蔡锐,尹彩霞,等.金钗石斛总生物碱改善链脲佐菌素所致大鼠海马神经元损伤[J].中国新药与临床杂志,2017,36(6):340-346.
[18]姜琳珊,李菲,聂晶,等.金钗石斛总生物碱对APP/PS1转基因小鼠学习记忆能力的影响[J].遵义医学院学报,2016,39(3):246-249.
[19]张明辉,李菲,张玮,等.金钗石斛总生物碱对Aβ-(25-35)所致大鼠海马组织Aβ含量的影响[J].遵义医学院学报,2016,39(1):18-21.
[20]李菲,黄琦,李向阳,等.金钗石斛提取物对肾上腺素所致血糖升高的影响[J].遵义医学院学报,2008,31(1):11-12.
[21]黄琦,廖鑫,吴芹,等.金钗石斛生物总碱对糖尿病大鼠血糖及肝脏组织IRS-2 mRNA,IGF-1 mRNA表达的影响[J].中国实验方剂学杂志,2014,20(19):155-158.
[22]张明辉.金钗石斛总生物碱对db/db小鼠血糖的影响及机制研究[D].遵义:遵义医学院,2016.
[23]徐云燕.金钗石斛总生物碱对小鼠糖、脂代谢的影响[D].遵义:遵义医学院,2014.
[24]何晓然.金钗石斛总碱对高糖诱导的大鼠肾系膜细胞增殖及PPAR-γ表达的影响[D].遵义:遵义医学院,2013.
[25]李向阳,杨丹莉,吴芹,等.金钗石斛生物总碱对大鼠高脂血症和肝脏脂肪变性的影响[J].中国新药与临床杂志,2011,30(7):529-532.
[26]LI R,LIU T,LIU M,et al.Anti-influenza A Virus Activity of Dendrobine and Its Mechanism of Action[J].J Agr Food Chem,2017,65(18):3665-3674.
[27]XU Y Y,XU Y S,WANG Y,et al.Dendrobium nobile Lindl.alkaloids regulate metabolism gene expression in livers of mice[J].J Pharm Pharmacol,2017,69(10):1409-1417.