丹参注射液联合顺铂治疗肺癌的临床效果研究
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摘要
目的:观察丹参注射液联合顺铂对肺癌的治疗效果。方法:选取2016年2月—2017年9月在医院接受治疗的肺癌患者为研究对象,根据其治疗方式分为对照组和观察组,对照组给予顺铂治疗,观察组在此基础上给予丹参注射液治疗。观察两组患者的治疗效果,比较两组治疗前后肿瘤标志物、免疫指标和生活质量的差异。结果:观察组患者治疗有效率为97.50%,明显高于对照组(χ~2=3.914,P=0.048);两组患者治疗前肿瘤标志物水平无差别,治疗后,观察组患者CYFRA21-1、NSE和CEA水平低于对照组(t=10.765、5.210、20.215,P<0.001);两组患者治疗前免疫指标无差别,治疗后,观察组患者IgG、IgA、IgM高于对照组(t=-7.994、-10.313、-3.161,P<0.001);两组患者治疗前生活质量无差别,治疗后,观察组生活质量高于对照组。结论:丹参注射液联合顺铂对肺癌患者有较好的治疗效果,可明显改善患者的免疫功能和生活质量。
Objective:To observe the effect of Salvia miltiorrhiza injection combined with cisplatin in the treatment of lung cancer. Methods:The lung cancer patients who received treatment in our hospital from February 2016 to September 2017 were selected as the subjects. According to their treatment, they were divided into control group and observation group. The control group was given cisplatin treatment, and the observation group was treated with Salvia miltiorrhiza injection on this basis. The therapeutic effects of the two groups were observed and the differences of tumor markers, immune indexes and quality of life before and after treatment were compared between the two groups. Results:The effective rate of the observation group was 97.50%, significantly higher than the control group's(χ~2 =3.914, P=0.048). There was no difference in the level of tumor markers between the two groups before treatment. After treatment, the levels of CYFRA21-1, NSE and CEA in the observation group were lower than those in the control group(t=10.765, 5.210, 20.215, P<0.001). After treatment, the IgG, IgA and IgM of the observation group were higher than those of the control group(t=-7.994,-10.313,-3.161, P<0.001) after treatment in the two groups. The quality of life of the two groups before treatment had no difference. After treatment, the quality of life in the observation group was higher than that of the control group. Conclusion: Salvia miltiorrhiza injection combined with cisplatin has good therapeutic effect on patients with lung cancer, and can obviously improve the immune function and quality of life of the patients.
Objective:To observe the effect of Salvia miltiorrhiza injection combined with cisplatin in the treatment of lung cancer. Methods:The lung cancer patients who received treatment in our hospital from February 2016 to September 2017 were selected as the subjects. According to their treatment, they were divided into control group and observation group. The control group was given cisplatin treatment, and the observation group was treated with Salvia miltiorrhiza injection on this basis. The therapeutic effects of the two groups were observed and the differences of tumor markers, immune indexes and quality of life before and after treatment were compared between the two groups. Results:The effective rate of the observation group was 97.50%, significantly higher than the control group's(χ~2 =3.914, P=0.048). There was no difference in the level of tumor markers between the two groups before treatment. After treatment, the levels of CYFRA21-1, NSE and CEA in the observation group were lower than those in the control group(t=10.765, 5.210, 20.215, P<0.001). After treatment, the IgG, IgA and IgM of the observation group were higher than those of the control group(t=-7.994,-10.313,-3.161, P<0.001) after treatment in the two groups. The quality of life of the two groups before treatment had no difference. After treatment, the quality of life in the observation group was higher than that of the control group. Conclusion: Salvia miltiorrhiza injection combined with cisplatin has good therapeutic effect on patients with lung cancer, and can obviously improve the immune function and quality of life of the patients.
引文
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[5] 丁新民,冯华松,伏婷婷,等.紫杉醇顺铂方案联合同步放疗治疗顺铂依托泊苷化疗不敏感局限期小细胞肺癌的临床疗效[J].中国老年学杂志,2016,36(2):344-346.
[6] 凡国华,徐兴祥,陈勇,等.经皮神经电刺激与穴位按压联合艾灸对减轻肺癌患者含顺铂方案化疗后胃肠道反应的对比研究[J].中华肺部疾病杂志(电子版),2016,6(1):41-45.
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[9] 师林,柯斌,黄圆圆,等.加味龟鹿二仙胶汤联合顺铂对小鼠Lewis肺癌PI3K/AKT/mTOR通路的影响[J].中成药,2017,39(10):2148-2152.
[10] 吴文琴,皮海菊,秦雪琴,等.丹参注射液辅助下治疗急性脑梗死对患者SOD的影响[J].河北医药,2017,39(10):1445-1448.
[11] 王爱岳,李强,余丹,等.丹参注射液联合尼莫地平缓释片治疗高血压出血性脑卒中的临床研究[J].中国临床药理学杂志,2017,33(8):681-683.
[12] 王玲,张建果,陈兵,等.黄芪联合丹参注射液促进异环磷酰胺治疗老年宫颈癌患者增效减毒的机制[J].中国老年学杂志,2017,37(5):1162-1164.
[13] 张玲玲,徐蔚然,梁军,等.补体活化与肿瘤免疫关系的新进展[J].中华检验医学杂志,2017,40(9):664-666.
[14] Daver N,Kantarjian H.Malignancy-assoiated haemophagocytic lymphohistiocytosis in adults[J].Lancet Oncol,2017,18(2):169-171.
[15] 李汝芳,张剑青,王旭明,等.α-烯醇化酶联合CYFRA21-1、CA125在恶性胸腔积液诊断中的应用[J].实用医学杂志,2017,33(18):3114-3118.
[16] 杨银忠,张建英,程文霞,等.血液HSP90α、CEA、NSE、CYFRA21-1及SCCA联合检测对肺癌的诊断价值研究[J].中国现代医学杂志,2017,27(12):60-64.
[17] 王强,陈传艳,王东生,等.血清HE4、CEA、NSE和Cyfra21-1联合检测在肺癌中的诊断价值[J].重庆医学,2017,46(26):3721-3722,3729.
[18] Kikuchi M,Nakajima M,Muroi H,et al.Significance of expression of complement C4d in esophageal squamous cell carcinoma[J].Anticancer Res,2016,36(9):4553-4557.
[19] 田莹莹,张银铃,李新,等.CEA、CYFRA21-1、NSE联合检测对于肺癌早期诊断的临床价值[J].癌症进展,2017,15(10):1206-1208.
[20] 曾慧婷,宿树兰,沙秀秀,等.丹参茎叶提取物抗氧化活性物质基础与量效关系研究[J].中草药,2017,48(22):4688-4694.
[2] 刘玲,钟世寿,李国苗,等.复方苦参注射液联合顺铂治疗恶性胸腔积液疗效及不良反应观察[J].现代肿瘤医学,2017,25(2):230-233.
[3] 韩海英,张培彤,王耀焓,等.川芎嗪联合丹参酮ⅡA对人肺巨细胞癌PG-BE1、PG-LH7细胞增殖、黏附及侵袭的影响[J].中国肿瘤,2016,25(9):728-733.
[4] 王启鸣.精准医学背景下肺癌化疗的新角度和新思考[J].医学研究生学报,2017,30(11):1151-1154.
[5] 丁新民,冯华松,伏婷婷,等.紫杉醇顺铂方案联合同步放疗治疗顺铂依托泊苷化疗不敏感局限期小细胞肺癌的临床疗效[J].中国老年学杂志,2016,36(2):344-346.
[6] 凡国华,徐兴祥,陈勇,等.经皮神经电刺激与穴位按压联合艾灸对减轻肺癌患者含顺铂方案化疗后胃肠道反应的对比研究[J].中华肺部疾病杂志(电子版),2016,6(1):41-45.
[7] 李琛,杨晓光,钱海红,等.IP、EP方案治疗广泛期小细胞肺癌的临床对比观察[J].山东医药,2017,57(32):70-72.
[8] 安改丽,陈小龙,郭维,等.吉西他滨联合顺铂治疗晚期肺鳞癌的疗效及生存情况分析[J].癌症进展,2017,15(12):1433-1435,1452.
[9] 师林,柯斌,黄圆圆,等.加味龟鹿二仙胶汤联合顺铂对小鼠Lewis肺癌PI3K/AKT/mTOR通路的影响[J].中成药,2017,39(10):2148-2152.
[10] 吴文琴,皮海菊,秦雪琴,等.丹参注射液辅助下治疗急性脑梗死对患者SOD的影响[J].河北医药,2017,39(10):1445-1448.
[11] 王爱岳,李强,余丹,等.丹参注射液联合尼莫地平缓释片治疗高血压出血性脑卒中的临床研究[J].中国临床药理学杂志,2017,33(8):681-683.
[12] 王玲,张建果,陈兵,等.黄芪联合丹参注射液促进异环磷酰胺治疗老年宫颈癌患者增效减毒的机制[J].中国老年学杂志,2017,37(5):1162-1164.
[13] 张玲玲,徐蔚然,梁军,等.补体活化与肿瘤免疫关系的新进展[J].中华检验医学杂志,2017,40(9):664-666.
[14] Daver N,Kantarjian H.Malignancy-assoiated haemophagocytic lymphohistiocytosis in adults[J].Lancet Oncol,2017,18(2):169-171.
[15] 李汝芳,张剑青,王旭明,等.α-烯醇化酶联合CYFRA21-1、CA125在恶性胸腔积液诊断中的应用[J].实用医学杂志,2017,33(18):3114-3118.
[16] 杨银忠,张建英,程文霞,等.血液HSP90α、CEA、NSE、CYFRA21-1及SCCA联合检测对肺癌的诊断价值研究[J].中国现代医学杂志,2017,27(12):60-64.
[17] 王强,陈传艳,王东生,等.血清HE4、CEA、NSE和Cyfra21-1联合检测在肺癌中的诊断价值[J].重庆医学,2017,46(26):3721-3722,3729.
[18] Kikuchi M,Nakajima M,Muroi H,et al.Significance of expression of complement C4d in esophageal squamous cell carcinoma[J].Anticancer Res,2016,36(9):4553-4557.
[19] 田莹莹,张银铃,李新,等.CEA、CYFRA21-1、NSE联合检测对于肺癌早期诊断的临床价值[J].癌症进展,2017,15(10):1206-1208.
[20] 曾慧婷,宿树兰,沙秀秀,等.丹参茎叶提取物抗氧化活性物质基础与量效关系研究[J].中草药,2017,48(22):4688-4694.