茶叶对口腔疾病的预防功效与机理
摘要
口腔是承担人们日常饮食和语言交流的重要器官,一旦发生口腔疾病,有可能严重影响人体健康和正常生活。许多研究表明,饮茶有助于维护人体口腔健康,对于口腔龋病、牙周病、口腔黏膜病、口腔癌等病症都有一定的防治功效。研究表明,茶叶中的茶多酚、儿茶素、茶色素等成分,能够抑制口腔中的多种致龋菌、牙周致病菌、α唾液淀粉水解酶等活性,可以清除自由基、抑制氧化应激反应、调节肿瘤细胞周期、阻止癌细胞的增殖等,在预防口腔疾病方面表现出良好的功能作用。
引文
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[15]Gennaro G,Claudino M,Cestari TM,et al.Green tea modulates cytokine expression in the periodontium and attenuates alveolar bone resorption in type 1 diabetic rats[J].PLoS ONE,2015,10(8):e0134784.
[16]刘洁,逯宜,王珍珍,等.表没食子儿茶素没食子酸酯对人牙周膜细胞增殖及成骨分化的影响[J].中华口腔医学杂志,2016,(12):758-764.
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[21]Masuda J,Hiroshi M,Joji F.Deodorization by used tealeaves[J].Seikatsu Eisei,2004,48:92-96.
[22]张微云.茶多酚与维生素C联合应用抑制口腔产臭细菌发生挥发性硫化物的体外研究[J].中国临床医师杂志,2011,5(18):5462-5464.
[23]Yang Z,Jie G,Dong F,et al.Radical-scavenging abilities and antioxidant properties of theaflavins and their gallate esters in H2O2-mediated oxidative damage system in the HPF-1 cells[J].Toxicol in Vitro,2008,22(5):1250-1256.
[24]杜俊兰,王林娟,张纲,等.益口含漱液治疗复发性口腔溃疡的疗效观察[J].第三军医大学学报,2004,26(8):709,713.
[25]Sitheeque MA,Panagoda GJ,Yau J,et al.Antifungal activity of black tea polyphenols(catechins and theaflavins)against Candida species[J].Chemotherapy,2009,55(3):189-196.
[26]Dsouza S,ddepalli V.Preventive measures in oral cancer:An overview[J].Biomedicine&Pharmacotherapy,2018,107:72-80.
[27]倪成励,张晨,陶冶.儿茶素EGCG对口腔癌细胞体外增殖的抑制作用及相关机制研究[J].宜春学院学报,2017,39(3):70-72.
[28]李宁,孙正,刘立军,等.茶对口腔癌前病变的干预试验研究[J].卫生研究,2002,31(6):428-430.
[29]Halder A,Raychowdhury R,Ghosh A,et al.Black tea(Camellia sinensis)as a chemopreventive agent in oral precancerous lesions[J].J Environ Pathol Toxicol Oncol,2005,24(2):141-144.
[30]Pal D,Sur S,Mandal S,et al.Regular black tea habit could reduce tobacco associated ROS generation and DNA damage in oral mucosa of normal population[J].Food Chem Toxicol,2012,50(9):2996-3003.
[31]安舟,周建英.茶多酚抑制口腔上皮癌细胞增殖机理研究[J].浙江预防医学,2006,18(11):3-4,12.
[32]Morita T,Kourembanas S.Endothelial cell expression of vasoconstrictors and growth factors is regulated by smooth muscle cell-derived carbon monoxide[J].J Clin Invest,1995,96:2676.
[2]吴慧敏,杨江帆.茶叶功能性成分与口腔疾病治疗研究进展[J].武夷学院学报,2015,34(9):18-21.
[3]雅子.中国人七大口腔健康问题[J].大家健康,2012(9):72-73.
[4]樊明文.牙体牙髓病学[M].4版.北京:人民卫生出版社,2012:17-26.
[5]肖悦,刘天佳,黄正蔚,等.茶多酚对口腔细菌致龋力影响的实验研究[J].广东牙病防治,2002,10(1):4-6.
[6]Ooshima T,Minami T,Matsumoto M,et al.Comparison of the cariostatic effects between regimens to administer Oolong tea polyphenols in SPF rats[J].Caries Res,1998,32:75.
[7]Lu M,Xuan S,Wang Z.Oral microbiota:A new view of body health[J].Food Sci Hum Wellness,2019.https://doi.org/10.1016/j.fshw.2018.12.001.
[8]Zhang J,Kashket S.Inhibition of salivary amylase by black and green teas and their effects on the intraoral hydrolysis of starch[J].Caries Res,1998,32(3):233-238.
[9]金恩惠,吴媛媛,屠幼英.茶黄素抑菌作用的研究[J].中国食品学报,2011,11(6):108-112.
[10]成杪莹,梁丹,唐智群,等.牙周炎与全身系统性疾病关系的研究现状[J].口腔疾病防治,2018,26(9):606-612.
[11]Lombardo Bedran TB,Morin MP,Spolidorio DP,et al.Black tea extract and its theaflavin derivatives inhibit the growth of periodontopathogens and modulate interleukin-8 andβ-defensin secretion in oral epithelial cells[J].PLoS ONE,2015,10(11):e0143158.
[12]Wei GX,Wu CD.Black tea extract and polyphenols inhibi growth and virulence factors of periodontal pathogens[J].J Dent Res,2001,80(s):73.
[13]游古莲,汪志德,周正贵,等.复方茶多酚漱口液治疗牙周病的临床应用[J].第三军医大学学报,1999,21(12):932.
[14]范芹,夏长普,王春风,等.0.4%茶多酚液治疗慢性牙周炎的疗效[J].广东医学,2012,33(16):2484-2486.
[15]Gennaro G,Claudino M,Cestari TM,et al.Green tea modulates cytokine expression in the periodontium and attenuates alveolar bone resorption in type 1 diabetic rats[J].PLoS ONE,2015,10(8):e0134784.
[16]刘洁,逯宜,王珍珍,等.表没食子儿茶素没食子酸酯对人牙周膜细胞增殖及成骨分化的影响[J].中华口腔医学杂志,2016,(12):758-764.
[17]Hosokawa Y,Hosokawa I,Ozaki K,et al.Tea polyphenols inhibit IL-6 production in tumor necrosis factor superfamily 14-stimulated human gingival fibroblasts[J].Mol Nutr Food Res,2010,54(S2):S151-S158.
[18]Lin SJ,Chen YL,Kuo MY,et al.Measurement of gp130 cytokines oncostatin M and IL-6 in gingival crevicular fluid of patients with chronic periodontitis[J].Cytokine,2005,30(4):160-167.
[19]Hosokawa Y,Hosokawa I,Shindo S,et al.Black tea polyphenol inhibits CXCL10 production in oncostatin M-stimulated human gingival fibroblasts[J].Int Immunopharmacol,2011,11(6):670-674.
[20]龚雨顺,黄建安,刘仲华,等.茶叶功能成份对甲硫醇的去除效果[J].茶叶科学,2008,28(2):111-114.
[21]Masuda J,Hiroshi M,Joji F.Deodorization by used tealeaves[J].Seikatsu Eisei,2004,48:92-96.
[22]张微云.茶多酚与维生素C联合应用抑制口腔产臭细菌发生挥发性硫化物的体外研究[J].中国临床医师杂志,2011,5(18):5462-5464.
[23]Yang Z,Jie G,Dong F,et al.Radical-scavenging abilities and antioxidant properties of theaflavins and their gallate esters in H2O2-mediated oxidative damage system in the HPF-1 cells[J].Toxicol in Vitro,2008,22(5):1250-1256.
[24]杜俊兰,王林娟,张纲,等.益口含漱液治疗复发性口腔溃疡的疗效观察[J].第三军医大学学报,2004,26(8):709,713.
[25]Sitheeque MA,Panagoda GJ,Yau J,et al.Antifungal activity of black tea polyphenols(catechins and theaflavins)against Candida species[J].Chemotherapy,2009,55(3):189-196.
[26]Dsouza S,ddepalli V.Preventive measures in oral cancer:An overview[J].Biomedicine&Pharmacotherapy,2018,107:72-80.
[27]倪成励,张晨,陶冶.儿茶素EGCG对口腔癌细胞体外增殖的抑制作用及相关机制研究[J].宜春学院学报,2017,39(3):70-72.
[28]李宁,孙正,刘立军,等.茶对口腔癌前病变的干预试验研究[J].卫生研究,2002,31(6):428-430.
[29]Halder A,Raychowdhury R,Ghosh A,et al.Black tea(Camellia sinensis)as a chemopreventive agent in oral precancerous lesions[J].J Environ Pathol Toxicol Oncol,2005,24(2):141-144.
[30]Pal D,Sur S,Mandal S,et al.Regular black tea habit could reduce tobacco associated ROS generation and DNA damage in oral mucosa of normal population[J].Food Chem Toxicol,2012,50(9):2996-3003.
[31]安舟,周建英.茶多酚抑制口腔上皮癌细胞增殖机理研究[J].浙江预防医学,2006,18(11):3-4,12.
[32]Morita T,Kourembanas S.Endothelial cell expression of vasoconstrictors and growth factors is regulated by smooth muscle cell-derived carbon monoxide[J].J Clin Invest,1995,96:2676.