尼莫地平联合多奈哌齐治疗老年痴呆的临床效果
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摘要
目的探讨尼莫地平联合多奈哌齐治疗老年痴呆(AD)的临床效果。方法选取2014年1月至2018年1月我院收治的98例AD患者为研究对象,按照用药方式的不同将其分为对照组(n=49,多奈哌齐治疗)与观察组(n=49,尼莫地平+多奈哌齐治疗)。对比两组患者的治疗效果。结果观察组的治疗总有效率高于对照组(P<0.05);治疗后,两组的MMSE、ADAS-Cog、ADL及CDR评分均较治疗前明显改善,且观察组明显优于对照组(P<0.05);治疗后,两组的全血粘度高切、全血粘度低切、血浆粘度、纤维蛋白原、TC及TG水平均较治疗前显著降低,且观察组明显低于对照组(P<0.05);治疗后,两组的SF-36各项评分均较治疗前显著升高,且观察组明显高于对照组(P<0.05)。结论尼莫地平联合多奈哌齐治疗AD的效果显著,可以提高患者的智力水平、认知功能及日常生活能力,降低患者的痴呆程度及血脂水平,改善患者的血流流变学指标及生活质量水平,值得临床推广与应用。
Objective To investigate the clinical effect of nimodipine combined with donepezil in the treatment of Alzheimer's disease(AD). Methods A total of 98 AD patients admitted in our hospital from January 2014 to January 2018 were selected as the research objects. The patients were divided into control group(n =49, donepezil treatment) and observation group(n =49, nimodipine +donepezil treatment) according to different medication methods. The therapeutic effects of the two groups were compared. Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05). After treatment, the scores of MMSE, ADAS-Cog, ADL and CDR of the two groups improved significantly, and those in the observation group were significantly better than the control group(P<0.05). After treatment, the levels of whole blood viscosity at high shear rate, whole blood viscosity at low shear rate, plasma viscosity,fibrinogen, TC and TG decreased significantly in both groups, and those in the observation group were significantly lower than the control group(P<0.05). After treatment, the scores of SF-36 in both groups were significantly higher than those before treatment, and those in the observation group were significantly higher than the control group(P<0.05). Conclusion Nimodipine combined with donepezil in the treatment of AD has a significant effect, which can improve the intelligence levels, cognitive function and daily life ability, reduce the degree of dementia and blood lipid levels, and ameliorate the blood flow rheological indexes and quality of life of patients. It is worthy of clinical promotion and application.
Objective To investigate the clinical effect of nimodipine combined with donepezil in the treatment of Alzheimer's disease(AD). Methods A total of 98 AD patients admitted in our hospital from January 2014 to January 2018 were selected as the research objects. The patients were divided into control group(n =49, donepezil treatment) and observation group(n =49, nimodipine +donepezil treatment) according to different medication methods. The therapeutic effects of the two groups were compared. Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05). After treatment, the scores of MMSE, ADAS-Cog, ADL and CDR of the two groups improved significantly, and those in the observation group were significantly better than the control group(P<0.05). After treatment, the levels of whole blood viscosity at high shear rate, whole blood viscosity at low shear rate, plasma viscosity,fibrinogen, TC and TG decreased significantly in both groups, and those in the observation group were significantly lower than the control group(P<0.05). After treatment, the scores of SF-36 in both groups were significantly higher than those before treatment, and those in the observation group were significantly higher than the control group(P<0.05). Conclusion Nimodipine combined with donepezil in the treatment of AD has a significant effect, which can improve the intelligence levels, cognitive function and daily life ability, reduce the degree of dementia and blood lipid levels, and ameliorate the blood flow rheological indexes and quality of life of patients. It is worthy of clinical promotion and application.
引文
[1]刘杰.靳三针联合盐酸多奈哌齐、尼莫地平治疗老年痴呆症疗效观察[J].现代中西医结合杂志,2018,27(32):3587-3590.
[2]林昱良,余皖琴,何相成.多奈哌齐联合尼莫地平对老年痴呆精神行为障碍患者认知功能及生活能力的影响[J].中国医学工程,2018,26(7):95-96.
[3]林玉全,王升武,辜忠灵.尼莫地平联合多感官刺激技术治疗血管性痴呆的临床疗效及生活质量评价[J].脑与神经疾病杂志,2018,26(4):236-240.
[4]周贺伟.尼莫地平联合盐酸多奈哌齐对老年痴呆患者认知功能及日常生活能力的影响[J].现代诊断与治疗,2018,29(7):1044-1046.
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[7]袁筛存.尼莫地平联合多奈哌齐治疗阿尔茨海默病的疗效分析[J].实用中西医结合临床,2017,17(12):52-53,61.
[8]叶渊,冯睿琦,于海燕.尼莫地平对改善老年痴呆患者WMS、HDS、Mo CA及MMSE的影响分析[J].医学理论与实践,2017,30(18):2703-2704.
[9]赵真真.多奈哌齐与尼莫地平治疗老年性痴呆症患者的临床疗效比较[J].中国药物经济学,2017,12(7):59-61.
[10]李小雷.石杉碱甲与尼莫地平分别联合多奈哌齐治疗轻中度血管性老年痴呆的疗效对比[J].中国实用神经疾病杂志,2016,19(19):108-109.
[11]崔蓓,王梦茹.尼莫地平对改善老年痴呆患者记忆功能及神经功能的影响[J].中国继续医学教育,2016,8(22):140-141.
[12]马玲梅.尼莫地平联合多奈哌齐治疗老年痴呆的效果观察[J].中西医结合心脑血管病杂志,2016,14(11):1298-1300.
[13]张翠云,卢祖能,章军建,等.盐酸多奈哌齐联合尼莫地平在改善血管性痴呆患者认知功能和自理能力中的作用[J].中国临床保健杂志,2016,19(3):236-239.
[14]张媛媛,白森,江新媛.尼莫地平联合脑复康对老年痴呆记忆恢复的影响效果分析[J].中国医药指南,2015,13(30):161-162.
[15]陈臻.尼莫地平对老年慢性脑供血不足患者认知功能及脑血流的影响研究[J].牡丹江医学院学报,2014,35(2):17-19.
[2]林昱良,余皖琴,何相成.多奈哌齐联合尼莫地平对老年痴呆精神行为障碍患者认知功能及生活能力的影响[J].中国医学工程,2018,26(7):95-96.
[3]林玉全,王升武,辜忠灵.尼莫地平联合多感官刺激技术治疗血管性痴呆的临床疗效及生活质量评价[J].脑与神经疾病杂志,2018,26(4):236-240.
[4]周贺伟.尼莫地平联合盐酸多奈哌齐对老年痴呆患者认知功能及日常生活能力的影响[J].现代诊断与治疗,2018,29(7):1044-1046.
[5]许贤豪.神经免疫学[M].武汉:湖北科学技术出版社,2000:327-333.
[6]尹晓刚.尼莫地平联合盐酸多奈哌齐对老年痴呆患者认知功能及日常生活能力的影响[J].中国地方病防治杂志,2018,33(1):94-95.
[7]袁筛存.尼莫地平联合多奈哌齐治疗阿尔茨海默病的疗效分析[J].实用中西医结合临床,2017,17(12):52-53,61.
[8]叶渊,冯睿琦,于海燕.尼莫地平对改善老年痴呆患者WMS、HDS、Mo CA及MMSE的影响分析[J].医学理论与实践,2017,30(18):2703-2704.
[9]赵真真.多奈哌齐与尼莫地平治疗老年性痴呆症患者的临床疗效比较[J].中国药物经济学,2017,12(7):59-61.
[10]李小雷.石杉碱甲与尼莫地平分别联合多奈哌齐治疗轻中度血管性老年痴呆的疗效对比[J].中国实用神经疾病杂志,2016,19(19):108-109.
[11]崔蓓,王梦茹.尼莫地平对改善老年痴呆患者记忆功能及神经功能的影响[J].中国继续医学教育,2016,8(22):140-141.
[12]马玲梅.尼莫地平联合多奈哌齐治疗老年痴呆的效果观察[J].中西医结合心脑血管病杂志,2016,14(11):1298-1300.
[13]张翠云,卢祖能,章军建,等.盐酸多奈哌齐联合尼莫地平在改善血管性痴呆患者认知功能和自理能力中的作用[J].中国临床保健杂志,2016,19(3):236-239.
[14]张媛媛,白森,江新媛.尼莫地平联合脑复康对老年痴呆记忆恢复的影响效果分析[J].中国医药指南,2015,13(30):161-162.
[15]陈臻.尼莫地平对老年慢性脑供血不足患者认知功能及脑血流的影响研究[J].牡丹江医学院学报,2014,35(2):17-19.