维生素A与儿童免疫功能及肺部疾病关系的研究进展
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摘要
维生素A(Vit A)作为人体所必需的一种微量营养素,与机体正常功能维持密切相关。在中国,典型的Vit A缺乏症已很少见,然而不典型缺乏发病率仍较高,其缺乏与人体易患感染性疾病尤其与呼吸道感染密切相关。近年来关于Vit A与感染性疾病关系的研究众多,主要集中在免疫方面。本文就Vit A对免疫及肺部疾病影响进行相关综述。
Vitamin A(Vit A)is a micronutrient that plays an important role in organism,and it is closely related to the maintenance of the normal function of the body.In China,the typical Vit A deficiency has been rare,but the prevalence of atypical lack is still high.Vitamin A deficiency would lead to infectious diseases,particularly respiratory infections.In recent years,there have been many researches on the relationship between Vit A and infectious diseases,most in the aspect of immunity.This review summarizes the effects of Vit A on immunity and the lungs.
Vitamin A(Vit A)is a micronutrient that plays an important role in organism,and it is closely related to the maintenance of the normal function of the body.In China,the typical Vit A deficiency has been rare,but the prevalence of atypical lack is still high.Vitamin A deficiency would lead to infectious diseases,particularly respiratory infections.In recent years,there have been many researches on the relationship between Vit A and infectious diseases,most in the aspect of immunity.This review summarizes the effects of Vit A on immunity and the lungs.
引文
[1]桂永浩,薛辛东.儿科学[M].3版.北京:人民卫生出版社,2016:79-83.
[2]张丹,杨少萍,姚顺芳,等.武汉市集体儿童维生素A营养水平的现状调查[J].中国妇幼保健,2010,25(4):524-526.
[3] Song P,Wang JW,Wei W,et al.The prevalence of vitamin A deficiency in Chinese children:a systematic review and Bayesian Meta-analysis[J].Nutrients,2017,9(12):1285.
[4] Qi YJ,Niu QL,Zhu XL,et al.Relationship between deficiencies in vitamin A and E and occurrence of infectious diseases among children[J].Eur Rev Med Pharmacol Sci,2016,20(23):5009-5012.
[5]张之晗.河北省农村地区学龄儿童营养状况与智力发育水平研究[D].石家庄:河北医科大学,2017.
[6] Penker RR,Jones BG,Hacker H,et al.Vitamin A differentially regulates cytokine expression in respiratory epithelial and macrophage cell lines[J].Cytokine,2017,91:1-5.
[7] Surman SL,Jones BG,Rudraraju R.Intranasal administration of retinyl palmitate with a respiratory virus vaccine corrects impaired mucosal IgA response in the vitamin A deficient host[J].Clinical and Vaccine Immunology,2014,21:598-601.
[8] Iwata M,Hirakiyama A,Eshima Y,et al.Retinoicacid imprints gut-homing specificity on Tcells[J].Immunity,2004,21(4):527-38.
[9]李玉芬.维生素A对小鼠Th1/Th2免疫应答模式平衡影响的研究[D].长春:吉林大学,2004.
[10]潘筱.学龄前反复呼吸道感染儿童维生素A水平与免疫功能变化研究[J].中国妇幼保健,2015,30(35):6241-6243.
[11] Marquez HA,Cardoso WV.Vitamin A-retinoid signaling in pulmonary development and disease[J].Mol Cell Pediatr,2016,3(1):28.
[12] Gong X,Marisiddaiah R,Rubin LP.Inhibition of pulmonaryβ-carotene 15,15′-oxygenase expression by glucocorticoid involves PPARα[J].PLoS One 2017,21:12(7):e0181466.
[13] Marquez HA,Cardoso WV.Vitamin A-retinoid signaling in pulmonary development and disease[J].Mol Cell Pediatr,2016,3:28.
[14] Wei H,Huang HM,Li TY,et al.Marginal vitamin A deficiency affects lung maturation in rats from prenatal to adult stage[J].J Nutr Sci Vitaminol(Tokyo),2009,55(3):208-214.
[15] Penkert RR,Jones BG,Hacker H.Vitamin A differentially regulates cytokine expression in respiratory epithelial and macrophage cell lines[J].Cytokine,2017,91:1-5.
[2]张丹,杨少萍,姚顺芳,等.武汉市集体儿童维生素A营养水平的现状调查[J].中国妇幼保健,2010,25(4):524-526.
[3] Song P,Wang JW,Wei W,et al.The prevalence of vitamin A deficiency in Chinese children:a systematic review and Bayesian Meta-analysis[J].Nutrients,2017,9(12):1285.
[4] Qi YJ,Niu QL,Zhu XL,et al.Relationship between deficiencies in vitamin A and E and occurrence of infectious diseases among children[J].Eur Rev Med Pharmacol Sci,2016,20(23):5009-5012.
[5]张之晗.河北省农村地区学龄儿童营养状况与智力发育水平研究[D].石家庄:河北医科大学,2017.
[6] Penker RR,Jones BG,Hacker H,et al.Vitamin A differentially regulates cytokine expression in respiratory epithelial and macrophage cell lines[J].Cytokine,2017,91:1-5.
[7] Surman SL,Jones BG,Rudraraju R.Intranasal administration of retinyl palmitate with a respiratory virus vaccine corrects impaired mucosal IgA response in the vitamin A deficient host[J].Clinical and Vaccine Immunology,2014,21:598-601.
[8] Iwata M,Hirakiyama A,Eshima Y,et al.Retinoicacid imprints gut-homing specificity on Tcells[J].Immunity,2004,21(4):527-38.
[9]李玉芬.维生素A对小鼠Th1/Th2免疫应答模式平衡影响的研究[D].长春:吉林大学,2004.
[10]潘筱.学龄前反复呼吸道感染儿童维生素A水平与免疫功能变化研究[J].中国妇幼保健,2015,30(35):6241-6243.
[11] Marquez HA,Cardoso WV.Vitamin A-retinoid signaling in pulmonary development and disease[J].Mol Cell Pediatr,2016,3(1):28.
[12] Gong X,Marisiddaiah R,Rubin LP.Inhibition of pulmonaryβ-carotene 15,15′-oxygenase expression by glucocorticoid involves PPARα[J].PLoS One 2017,21:12(7):e0181466.
[13] Marquez HA,Cardoso WV.Vitamin A-retinoid signaling in pulmonary development and disease[J].Mol Cell Pediatr,2016,3:28.
[14] Wei H,Huang HM,Li TY,et al.Marginal vitamin A deficiency affects lung maturation in rats from prenatal to adult stage[J].J Nutr Sci Vitaminol(Tokyo),2009,55(3):208-214.
[15] Penkert RR,Jones BG,Hacker H.Vitamin A differentially regulates cytokine expression in respiratory epithelial and macrophage cell lines[J].Cytokine,2017,91:1-5.