OCT在高度近视合并早期及可疑开角型青光眼中的应用
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摘要
目的:讨论OCT对高度近视合并早期及可疑开角型青光眼诊断中的应用。方法:选取高度近视合并早期开角型青光眼的患者50例,100只眼,高度近视合并可疑开角型青光眼的患者50例共有73只眼,高度近视合并可疑开角型青光眼的患者50例共有73只眼,正常人50例100只眼分别分为A组,B组,C组。使用OCT检测三组中的视盘,RNFL厚度,黄斑等情况.结果:A组的患者的杯/盘的面积比大于B组和C组,差别具有统计学意义(P<0.05)。A组的平均的RNFL厚度小于B组和C组,差别具有统计学意义(P<0.05)。A组的黄斑的厚度小于B组和C组,差别具有统计学意义(P <0.05)。结论:使用OCT可以将患有高度近视合并早期开角型青光眼和高度近视合并可疑开角型青光眼患者分辨出来,具有重要的临床诊断价值。
Objective: To investigate the application of OCT in early stage of high myopia and suspicious open angle glaucoma. Methods: Fifty patients with high myopia combined with early open angle glaucoma and100 eyes with high myopia combined with suspected open angle glaucoma were enrolled in this study. There were 73 eyes in 50 patients with normal myopia and 50 eyes(100 eyes) Group A,Group B,Group C. OCT was used to detect the optic disc,RNFL thickness,macular and so on in the three groups. Results: The area ratio of cup/plate in group A was greater than that in group B and group C,the difference was statistically significant(P <0.05). The average RNFL thickness of group A was less than that of group B and group C,the difference was statistically significant(P <0.05). The thickness of macula in group A was smaller than that in group B and group C,the difference was statistically significant(P <0.05). Conclusion: OCT can be used to distinguish patients with high myopia and early open-angle glaucoma from those with high myopia and suspicious open-angle glaucoma,which has important clinical diagnostic value.
Objective: To investigate the application of OCT in early stage of high myopia and suspicious open angle glaucoma. Methods: Fifty patients with high myopia combined with early open angle glaucoma and100 eyes with high myopia combined with suspected open angle glaucoma were enrolled in this study. There were 73 eyes in 50 patients with normal myopia and 50 eyes(100 eyes) Group A,Group B,Group C. OCT was used to detect the optic disc,RNFL thickness,macular and so on in the three groups. Results: The area ratio of cup/plate in group A was greater than that in group B and group C,the difference was statistically significant(P <0.05). The average RNFL thickness of group A was less than that of group B and group C,the difference was statistically significant(P <0.05). The thickness of macula in group A was smaller than that in group B and group C,the difference was statistically significant(P <0.05). Conclusion: OCT can be used to distinguish patients with high myopia and early open-angle glaucoma from those with high myopia and suspicious open-angle glaucoma,which has important clinical diagnostic value.
引文
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[6]李汉林,邵毅,彭志优,等.正常眼压性青光眼的rsf MRIf ALFF研究及其与OCT及视野相关性分析[J].眼科新进展,2016,36(1):56~60.
[7] Jung Hwa Na,Kyoung Sub Lee,Jong Rak Lee,et al. The glaucoma detection capability of spectral-domain OCT and GDx-VCC deviation maps in early glaucoma patients with localized visual field defects[J].Graefe's archive for clinical and experimental ophthalmo Logy:Albrecht von Graefes Archiv fur klinische und experimentelle Opthalmo Logie,2013,251(10):2371~2382.
[2]赵桂玲,庞燕华,周舟,等.慢性青光眼和非青光眼视神经萎缩环视盘视网膜神经纤维层厚度和视盘参数比较[J].中国实用眼科杂志,2015,33(7):743~747.
[3] Asaad A.Ghanem,Dalia Sabry,Rania Kamel,et al.比较应用SD-OCT检测青光眼患者黄斑区节细胞与视盘周围视网膜神经纤维层的改变[J].国际眼科杂志,2016,16(3):409~415.
[4] Nakanishi,Hideo,Akagi,Tadamichi,Hangai,Masanori et al.Sensitivity and specificity for detecting early glaucoma in eyes with high myopia from normative database of macular ganglion cell complex thickness obtained from normal nonmyopic or highly myopic Asian eyes[J].Graefe's archive for clinical and experimental ophthalmo Logy:Albrecht von Graefes Archiv fur klinische und experimentelle Opthalmo Logie,2015,253(7):1143~1152.
[5]郝琳琳,肖辉,陈翔熙,等.原发性开角型青光眼与原发性慢性闭角型青光眼活体筛板厚度和筛板前表面深度的比较[J].中华眼底病杂志,2016,32(6):619~623.
[6]李汉林,邵毅,彭志优,等.正常眼压性青光眼的rsf MRIf ALFF研究及其与OCT及视野相关性分析[J].眼科新进展,2016,36(1):56~60.
[7] Jung Hwa Na,Kyoung Sub Lee,Jong Rak Lee,et al. The glaucoma detection capability of spectral-domain OCT and GDx-VCC deviation maps in early glaucoma patients with localized visual field defects[J].Graefe's archive for clinical and experimental ophthalmo Logy:Albrecht von Graefes Archiv fur klinische und experimentelle Opthalmo Logie,2013,251(10):2371~2382.