根据INTERGROWTH-21st标准评价广州市新生儿发育状况
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摘要
目的根据INTERGROWTH-21st标准,评价广州市新生儿发育状况。方法回顾性研究2009年—2015年在广州医科大学附属第三医院住院分娩的共32 316例单胎新生儿的发育状况。结果根据INTERGROWTH-21st标准,32 316例新生儿体重及身长发育状况大致符合INTERGROWTH-21st标准。头围的发育状况偏离INTERGROWTH-21st标准尺度,小于第10百分位数有6 861个胎儿,占21. 2%,并发现153例头小畸形,占0. 5%。结论广州市的新生儿出现头小畸形的比例较其他人群偏高,这说明需重新评估该人群的胎头发育,以确保做好孕期管理及保证胎儿充分发育。
Objective Our study aimed to evaluate the development of newborns delivered in Guangzhou according to the INTERGROWTH-21 st standard. Methods We conducted a retrospective study to evaluate development status of 32 316 singleton newborns delivered in the Third Affiliated Hospital of Guangzhou Medical University from 2009 to 2015.Results The weight and length development status of 32 316 newborns were basically consistent with the INTERGROWTH-21 ststandard. The head circumference (HC) deviated from the INTERGROWTH-21 st standard. There were 6 861 infants below the 10 thpercentile of HC,accounting for 21. 2%. A total of 153 cases was identified as microcephaly,accounting for 0. 5% of the newborns. Conclusion The proportion of newborns with small head or microcephaly in Guangzhou is higher than that of other populations. Our results indicate that we should re-evaluate the fetal head growth of this population to ensure proper pregnancy care and adequate fetal development.
Objective Our study aimed to evaluate the development of newborns delivered in Guangzhou according to the INTERGROWTH-21 st standard. Methods We conducted a retrospective study to evaluate development status of 32 316 singleton newborns delivered in the Third Affiliated Hospital of Guangzhou Medical University from 2009 to 2015.Results The weight and length development status of 32 316 newborns were basically consistent with the INTERGROWTH-21 ststandard. The head circumference (HC) deviated from the INTERGROWTH-21 st standard. There were 6 861 infants below the 10 thpercentile of HC,accounting for 21. 2%. A total of 153 cases was identified as microcephaly,accounting for 0. 5% of the newborns. Conclusion The proportion of newborns with small head or microcephaly in Guangzhou is higher than that of other populations. Our results indicate that we should re-evaluate the fetal head growth of this population to ensure proper pregnancy care and adequate fetal development.
引文
1 deOnis M,Garza C,Onyango AW,et al.WHO Child Growth Standards.Acta Paediatr suppl,2006,450:100-101.
2 Villar J,Cheikh Ismail L,Victora CG,et al.International standards for newborn weight,length,and head circumference by gestational age and sex:the Newborn Cross-Sectional Study of the INTERGROWTH-21st Project.Lancet,2014,384:857-868.
3中国l5城市新生儿体格发育科研协作组.我国不同胎龄新生儿体格发育的现状.临床儿科杂志,1991,9:72-77.
4 Heppe DH,Steegers EA,Timmermans S,et al.Maternal fish consumption,fetal growth and the risks of neonatal complications:the Generation R Study.Br J Nutr,2011,105:938-949.
5 Hjortebjerg D1,Andersen AM2,Ketzel M3,et al.Associations between maternal exposure to air pollution and traffic noise and newborn's size at birth:A Cohort study.Environ Int,2016,95:1-7.
6 Van Den Bosch J.Microcephaly in the Netherlands a clinical and genetical study.Ann Hum genetic,1959,23:91-116.
7 Kaindl AM,Passemard S,Kumar P,et al.Many roads lead to primary autosomal recessive microcephaly.Prog Neurobiol,2010,90:363-383.
8 SzabóN,Pap C,Kóbor J,et al.Primary microcephaly in Hungary:epidemiology and clinical features.Acta Paediatr,2010,99:690-693.
9 Komai T,Kishimoto K,Ozaki Y.Genetic study of microcephaly based on Japanese material.Am J Hum Genet,1955,7:51-65.
10吴白燕.胚胎发育畸形及其相关因素.中国实用妇科与产科杂志,2002,18:535-536.
11梁娟,王艳萍,缪蕾,等.中国围生儿小头畸形的调查研究.现代中西医结合杂志,2002,11:568-569.
2 Villar J,Cheikh Ismail L,Victora CG,et al.International standards for newborn weight,length,and head circumference by gestational age and sex:the Newborn Cross-Sectional Study of the INTERGROWTH-21st Project.Lancet,2014,384:857-868.
3中国l5城市新生儿体格发育科研协作组.我国不同胎龄新生儿体格发育的现状.临床儿科杂志,1991,9:72-77.
4 Heppe DH,Steegers EA,Timmermans S,et al.Maternal fish consumption,fetal growth and the risks of neonatal complications:the Generation R Study.Br J Nutr,2011,105:938-949.
5 Hjortebjerg D1,Andersen AM2,Ketzel M3,et al.Associations between maternal exposure to air pollution and traffic noise and newborn's size at birth:A Cohort study.Environ Int,2016,95:1-7.
6 Van Den Bosch J.Microcephaly in the Netherlands a clinical and genetical study.Ann Hum genetic,1959,23:91-116.
7 Kaindl AM,Passemard S,Kumar P,et al.Many roads lead to primary autosomal recessive microcephaly.Prog Neurobiol,2010,90:363-383.
8 SzabóN,Pap C,Kóbor J,et al.Primary microcephaly in Hungary:epidemiology and clinical features.Acta Paediatr,2010,99:690-693.
9 Komai T,Kishimoto K,Ozaki Y.Genetic study of microcephaly based on Japanese material.Am J Hum Genet,1955,7:51-65.
10吴白燕.胚胎发育畸形及其相关因素.中国实用妇科与产科杂志,2002,18:535-536.
11梁娟,王艳萍,缪蕾,等.中国围生儿小头畸形的调查研究.现代中西医结合杂志,2002,11:568-569.