摘要
目的评价我国国产脊髓灰质炎灭活疫苗(Sabin株)和口服脊髓灰质炎减毒活疫苗序贯接种基础免疫的效果。方法采用同期非随机对照实验研究方法,于2015年9~12月期间,在宁夏回族自治区吴忠市同心县选择满2月龄健康儿童180人,按照国家规定的免疫程序,分别在2、3、4月龄各接种1剂次脊髓灰质炎疫苗。将上述儿童分为两组:一组采用t OPV+t OPV+t OPV的基础免疫程序(简称O-O-O组),另一组采用国产IPV(Sabin株)+t OPV+t OPV(简称I-O-O组)序贯接种的基础免疫程序。分别采集同一受种者免疫前和完成3剂次脊髓灰质炎疫苗基础免疫后30 d的血清标本,采用微量中和试验测定血清中3个脊髓灰质炎型别(Ⅰ、Ⅱ、Ⅲ型)的抗体滴度,计算GMT及抗体保护率。结果 3剂次脊髓灰质炎疫苗基础免疫程序接种完成后,I-O-O组脊髓灰质炎Ⅱ、Ⅲ型抗体滴度均高于O-O-O组;两组均获得较好的针对3种型别脊髓灰质炎病毒的抗体保护率,差异无统计学意义(P>0.05)。结论国产IPV(Sabin株)和t OPV序贯接种的免疫程序能够提供与全程接种t OPV相似甚至更高的针对脊髓灰质炎病毒的免疫保护能力。
Objective To evaluate the effect of sequential immunization with domestic inactivated poliovirus vaccine and oral live attenuated poliomyelitis vaccine. Methods A non-randomized controlled experimental study was carried out.During the period from September to December 2015,180 healthy children at age of 2 months in Tongxin County,Ningxia Hui Autonomous Region,China were selected,and immunized with poliovirus vaccine at ages of 2,3 and 4 months according to the national immunization schedule. The children were divided into two groups,one for a immunization schedule of t OPV + t OPV + t OPV(O-O-O) while another one for IPV(Sabin) + t OPV + t OPV(I-O-O). The serum samples were collected before the first dose and 30 d after the third dose,and determined for antibody titers against poliovirus of types Ⅰ,Ⅱ and Ⅲ,based on which the GMT and protection rate were calculated. Results After 3 doses of vaccines were given,the antibody titers against poliovirus of typesⅡand Ⅲ in I-O-O group were higher than those in O-O-O group. However,high protective rates against the three types of poliovirus were observed in the two groups,which showed no significant difference(P > 0. 05). Conclusion Compared with full course of immunization with t OPV,the sequential immunization with domestic IPV(Sabin)and t OPV provided similar or even higher immune protection against poliovirus.
引文
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