磷酸川芎嗪片在糖尿病肾病基础治疗中的应用效果及对肾血流动力学的影响
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摘要
目的探究磷酸川芎嗪片在糖尿病肾病(DN)基础治疗中的应用效果及对肾血流动力学的影响。方法随机选取我院收治的73例DN患者,根据随机数表法将其分为对照组(36例,给予基础治疗)与观察组(37例,在基础治疗的基础上联用磷酸川芎嗪片治疗)。比较两组的治疗效果。结果观察组治疗总有效率显著高于对照组(P<0.05)。治疗后,两组肾主动脉、肾段动脉、叶间动脉的Vmax、Vmin及RI值均改善,且观察组均显著优于对照组(P<0.05)。治疗后,两组全血高切黏度、全血低切黏度及血浆比黏度均降低,且观察组均低于对照组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论磷酸川芎嗪片在DN基础治疗中效果显著,能显著改善肾血流动力学及血液流变学指标,且安全性高。
Objective To investigate the effect of ligustrazine phosphate tablets in basic treatment of diabetic nephropathy(DN) and its effect on renal hemodynamics. Methods A total of 73 patients with DN in our hospital were randomly selected and divided into control group(36 cases, given basic treatment) and observation group(37 cases,combined with ligustrazine phosphate tablets on the basis of basic treatment). The therapeutie effects of the two groups were compared. Results The total effective rate of treatment of the observation group was significantly higher than that of the control group(P<0.05). After treatment, the Vmax, Vmin and RI values of main renal arteries, segmental renal artery and interlobar artery of the two groups improved, and those in the observation group were better than the control group(P<0.05).After treatment, the whole blood high shear viscosity, whole blood low shear viscosity and plasma specific viscosity in the two groups decreased, and those in the observation group were lower than the control group(P <0.05). There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05). Conclusion Ligustrazine phosphate tablets in basic treatment of DN has a significant effect, it can significantly improve renal hemodynamics and hemorheology indicators, and with a high safety.
Objective To investigate the effect of ligustrazine phosphate tablets in basic treatment of diabetic nephropathy(DN) and its effect on renal hemodynamics. Methods A total of 73 patients with DN in our hospital were randomly selected and divided into control group(36 cases, given basic treatment) and observation group(37 cases,combined with ligustrazine phosphate tablets on the basis of basic treatment). The therapeutie effects of the two groups were compared. Results The total effective rate of treatment of the observation group was significantly higher than that of the control group(P<0.05). After treatment, the Vmax, Vmin and RI values of main renal arteries, segmental renal artery and interlobar artery of the two groups improved, and those in the observation group were better than the control group(P<0.05).After treatment, the whole blood high shear viscosity, whole blood low shear viscosity and plasma specific viscosity in the two groups decreased, and those in the observation group were lower than the control group(P <0.05). There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05). Conclusion Ligustrazine phosphate tablets in basic treatment of DN has a significant effect, it can significantly improve renal hemodynamics and hemorheology indicators, and with a high safety.
引文
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[2]OATES PJ.Aldose reductase inhibitors and diabetic kidney disease[J].Curr Opin Investig Drugs,2010,11(4):402.
[3]姜宇懋,王丹巧.川芎嗪药理作用研究进展[J].中国现代中药,2016,18(10):1364-1370.
[4]中华医学会糖尿病学分会.中国2型糖尿病防治指南(2013年版)[J].中国糖尿病杂志,2014,30(10):893-942.
[5]陈新斌.肾复汤对2型糖尿病肾病痰瘀互结证患者血管内皮生长因子影响的相关研究[D].福州:福建中医药大学,2013.
[6]王娇,关清华,周月宏.艾塞那肽联合川芎嗪对肾功能正常2型糖尿病患者肾内血流动力学的影响[J].现代中西医结合杂志,2016,25(28):3091-3094.
[7]SHIMA A,MIYAMOTO M,KUBOTA Y,et al.Beraprost sodium protects against diabetic nephropathy in patients with arteriosclerosis obliterans:a prospective,randomized,open-label study[J].J Nippon Med Sch,2015,82(2):84-91.
[8]赵健嫦.中药川芎中有效成分川芎嗪的药理作用研究[J].海峡药学,2015,27(8):145-146.