缬沙坦联合金匮肾气丸治疗糖尿病勃起功能障碍疗效观察
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摘要
目的观察缬沙坦联合金匮肾气丸治疗糖尿病性勃起功能障碍(Erectile Dysfunction,ED)的临床疗效。方法选取糖尿病ED患者67例,其中肾阳虚证31例为治疗组(缬沙坦联合金匮肾气丸)、设置对照组36例(缬沙坦),疗程3个月,利用IIEF-5评分,并做统计学分析。结果治疗组的总有效率67.7%,对照组的总有效率38.9%,治疗组疗效优于对照组,差异有统计学意义(P<0.05);IIEF-5评分显示,治疗组勃起障碍改善明显优于对照组,差异有统计学意义(P<0.05)。结论缬沙坦联合金匮肾气丸可有效改善肾阳虚证的糖尿病ED患者的勃起功能障碍,提高性生活质量。
Objective To observe the clinical effect of Valsartan combined with Jinguishenqi Bolus on Diabetic patients with ED;Methods A total of 67 cases of ED patients with Diabetes, including Kidney-yang Deficiency syndrome 31 cases as treatment group(Valsartan combined with Jinguishenqi Bolus),36 cases in the control group(Valsartan), Using IIEF-5 score after 3 months of treatment,and do statistical analysis;Results The efficiency of the treatment group was higher than the control group[67.7% VS 38.9%,the difference was statistically significant(P<0.05)];The IIEF-5 score showed that treatment group improved the erectile dysfunction significantly better than the control group, the difference was statistically significant(P<0.05).Conclusion Valsartan combined with Jinkuishenqi Bolus can effectively improve erectile dysfunction in Diabetic patients with ED and the quality of sexual life.
Objective To observe the clinical effect of Valsartan combined with Jinguishenqi Bolus on Diabetic patients with ED;Methods A total of 67 cases of ED patients with Diabetes, including Kidney-yang Deficiency syndrome 31 cases as treatment group(Valsartan combined with Jinguishenqi Bolus),36 cases in the control group(Valsartan), Using IIEF-5 score after 3 months of treatment,and do statistical analysis;Results The efficiency of the treatment group was higher than the control group[67.7% VS 38.9%,the difference was statistically significant(P<0.05)];The IIEF-5 score showed that treatment group improved the erectile dysfunction significantly better than the control group, the difference was statistically significant(P<0.05).Conclusion Valsartan combined with Jinkuishenqi Bolus can effectively improve erectile dysfunction in Diabetic patients with ED and the quality of sexual life.
引文
[1]郭应禄,胡礼泉.男科学[M].北京:人民卫生出版社,2004:663-671.
[2]张凯,刘德风,姜辉,等.不同年龄勃起功能障碍患者勃起功能的调查[J].中国性科学,2014,23(2):21-23.
[3]刘剑新,夏仁惠,傅梧,等.糖尿病大鼠阴茎细胞凋亡及血流动力学变化的研究[J].中华男科学杂志,2004,10(6):445-448.
[4]Hecht MJ,Neundorfer B,Kiesewetter F,et al. Neuropathy is a major contributing factor to diabetic erectile dysfunction.Neurological Research[J].2001,23(6):651-654.
[5]Park KH,KimSW,KimKD,et al. Effect of androgens on the expression of nitric oxide synthase mRNAs in rat corpus cavernous.BJU International[J].1999,83(3):327-333.
[6]唐正和,杨燕,邹延新,等.α-硫辛酸治疗伴腹型肥胖的2型糖尿病勃起功能障碍临床研究[J].疑难病杂志,2012,11(9):665-667.
[7]张翼,刘保兴.坦索罗辛联合金匮肾气丸治疗前列腺增生伴勃起功能障碍疗效观察[J].中国性科学,2015,(7):3-5.
[8]高天舒,任平,于世家,等.2型糖尿病患者男性勃起功能障碍(ED)的病因简析[C].//第七次中国中西医结合糖尿病学术会议论文汇编.2004:357-358.
[9]孙宁玲,丁文惠,刘国树,等.血管紧张素Ⅱ受体拮抗剂缬沙坦对性功能影响的分析[J].中华内科杂志,2002,41(10):694.
[10]张晓红,董海军,吴雷涛,等.金匮肾气丸对肾阳虚大鼠睾丸转化生长因子-β1和细胞色素P-19表达的影响[J].中国中医药信息杂志,2015,(9):72-75.
[11]付正丰,龚明,苗家伟,等.金匮肾气丸温补肾阳药理作用的实验研究[J].中成药,2015,37(5):1111-1114.
[12]车文骏,何小舟,经浩,等.金匮肾气丸治疗中老年男性部分雄激素缺乏综合征的临床研究[J].中华全科医师杂志,2007,6(7):435-436.
[2]张凯,刘德风,姜辉,等.不同年龄勃起功能障碍患者勃起功能的调查[J].中国性科学,2014,23(2):21-23.
[3]刘剑新,夏仁惠,傅梧,等.糖尿病大鼠阴茎细胞凋亡及血流动力学变化的研究[J].中华男科学杂志,2004,10(6):445-448.
[4]Hecht MJ,Neundorfer B,Kiesewetter F,et al. Neuropathy is a major contributing factor to diabetic erectile dysfunction.Neurological Research[J].2001,23(6):651-654.
[5]Park KH,KimSW,KimKD,et al. Effect of androgens on the expression of nitric oxide synthase mRNAs in rat corpus cavernous.BJU International[J].1999,83(3):327-333.
[6]唐正和,杨燕,邹延新,等.α-硫辛酸治疗伴腹型肥胖的2型糖尿病勃起功能障碍临床研究[J].疑难病杂志,2012,11(9):665-667.
[7]张翼,刘保兴.坦索罗辛联合金匮肾气丸治疗前列腺增生伴勃起功能障碍疗效观察[J].中国性科学,2015,(7):3-5.
[8]高天舒,任平,于世家,等.2型糖尿病患者男性勃起功能障碍(ED)的病因简析[C].//第七次中国中西医结合糖尿病学术会议论文汇编.2004:357-358.
[9]孙宁玲,丁文惠,刘国树,等.血管紧张素Ⅱ受体拮抗剂缬沙坦对性功能影响的分析[J].中华内科杂志,2002,41(10):694.
[10]张晓红,董海军,吴雷涛,等.金匮肾气丸对肾阳虚大鼠睾丸转化生长因子-β1和细胞色素P-19表达的影响[J].中国中医药信息杂志,2015,(9):72-75.
[11]付正丰,龚明,苗家伟,等.金匮肾气丸温补肾阳药理作用的实验研究[J].中成药,2015,37(5):1111-1114.
[12]车文骏,何小舟,经浩,等.金匮肾气丸治疗中老年男性部分雄激素缺乏综合征的临床研究[J].中华全科医师杂志,2007,6(7):435-436.