统计基因组学中的作图函数和重组率(Ⅱ)
|
摘要
重组率的估计是遗传图谱中的关键步骤。对于连锁图谱的构建,必须将非加性重组分数转换为加性图谱距离。两种最常用的转换是Kosambi和Haldane的映射函数。通过报告与估算重组率,Kosambi距离和Haldane距离相关的计算细节。可以作为研究者学习统计基因组学中的作图函数和重组率的基础。
The estimation of recombination frequencies is a crucial step in genetic mapping. For the construction of linkage maps, nonadditive recombination fractions must be transformed into additive map distances. Two of the most commonly used transformations are Kosambi's and Haldane's mapping functions.This paper reports the computational details associated with estimating recombination rates, Kosambi distances, and Haldane distances. The paper can be used as a basis for researchers to study mapping functions and recombination rates in statistical genomics.
The estimation of recombination frequencies is a crucial step in genetic mapping. For the construction of linkage maps, nonadditive recombination fractions must be transformed into additive map distances. Two of the most commonly used transformations are Kosambi's and Haldane's mapping functions.This paper reports the computational details associated with estimating recombination rates, Kosambi distances, and Haldane distances. The paper can be used as a basis for researchers to study mapping functions and recombination rates in statistical genomics.
引文
[1]Bolling DR,Murphy EA.Finite sample properties of maximum likelihood estimates of the recombination fraction in double backcross matings in man[J].Am.J.Med.Genet.1979.3(1):81-95.
[2]Haldane JBS.The combination of linkage values,and the calculation of distances between the loci of linked factors[J].J.Genet.1919.8:299-309.
[3]Hühn M,Piepho HP.A note on the bias of genetic distances in linkage maps based on small samples for backcrosses and intercrosses with complete dominance[J].Genome.2008.51(12):1054-1061.
[4]Kosambi DD.The estimation of map distances from recombination values[J].Ann.Eugen.1944.12:172-175.
[5]Liu,B.H.Statistical genomics:linkage,mapping and QTL analysis[M].CRC Press,Boca Raton,Fla.1998.
[6]Ott,J.Analysis of human genetic linkage.2nd ed[M].Johns Hopkins University Press,Baltimore,Md.and London,UK.1991.
[7]S?ll T,Nilsson NO.The robustness of recombination frequency estimates in intercrosses with dominant markers[J].Genetics 1994.137(2):589-596 Medline.
[8]Strickberger,M.W.Genetik[M].Carl Hanser Publishers,Munich,Germany,and Vienna,Austria.1988.
[9]Weir,B.S.Genetic data analysis.Methods for discrete population genetic data[M].Sinauer Associates Inc.,Sunderland,Mass.1990.
[2]Haldane JBS.The combination of linkage values,and the calculation of distances between the loci of linked factors[J].J.Genet.1919.8:299-309.
[3]Hühn M,Piepho HP.A note on the bias of genetic distances in linkage maps based on small samples for backcrosses and intercrosses with complete dominance[J].Genome.2008.51(12):1054-1061.
[4]Kosambi DD.The estimation of map distances from recombination values[J].Ann.Eugen.1944.12:172-175.
[5]Liu,B.H.Statistical genomics:linkage,mapping and QTL analysis[M].CRC Press,Boca Raton,Fla.1998.
[6]Ott,J.Analysis of human genetic linkage.2nd ed[M].Johns Hopkins University Press,Baltimore,Md.and London,UK.1991.
[7]S?ll T,Nilsson NO.The robustness of recombination frequency estimates in intercrosses with dominant markers[J].Genetics 1994.137(2):589-596 Medline.
[8]Strickberger,M.W.Genetik[M].Carl Hanser Publishers,Munich,Germany,and Vienna,Austria.1988.
[9]Weir,B.S.Genetic data analysis.Methods for discrete population genetic data[M].Sinauer Associates Inc.,Sunderland,Mass.1990.