三七通舒胶囊联合阿司匹林治疗老年冠心病的安全性及对凝血酶原时间国际标准化比率、D-二聚体和凝血酶原时间的影响
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摘要
目的探究三七通舒胶囊联合阿司匹林治疗老年冠心病的安全性及对凝血酶原时间国际标准化比率(PT-INR)、D-二聚体(D-D)、凝血酶原时间(PT)的影响。方法选取绵阳市中医医院在2012年1月—2015年12月收治的、符合纳入标准的老年冠心病患者90例。根据治疗方法不同分为对照组(n=45)及观察组(n=45)。对照组给予患者控制血压、血糖、血脂等常规治疗,同时口服拜阿司匹林0.1 g/次,1次/d,睡前服用;观察组在对照组基础上联合三七通舒胶囊200 mg/次,3次/d;疗程均为6个月。对比两组治疗前后PT-INR、D-D、PT、血小板聚集功能(PAgT)、肝肾功能指标及不良反应情况。结果治疗后,两组PAgT及D-D降低,PT及PT-INR延长,同组治疗前后比较差异均有统计学意义(P<0.05);观察组PAgT、PT、PT-INR均高于对照组,差异具有统计学意义(P<0.05)。两组治疗前后的丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、血尿素氮(BUN)及血肌酐(Cr)差异无统计学意义。观察组的不良反应发生率(4.44%)明显低于对照组(24.44%),差异有统计学意义(P<0.05)。结论三七通舒胶囊联合阿司匹林治疗老年冠心病是安全、有效的。
Objective To explore the effect of sanqi saponins on the safety of elderly patients with coronary heart disease and its effects on PT-INR, D-D and PT. Methods 90 elderly patients with coronary heart disease in our hospital from January 2012 to December 2015 were selected into the clinical data. The patients were divided into the control group(n = 45) and the experimental group(n = 45) by random number table. The control group was treated with aspirin, the experimental group was treated with Sanqi Tongshu Capsule. The PT-INR, D-D, PT, PAgT, liver and kidney indexes and adverse reactions were compared between the two groups before and after treatment. Results After treatment, PAgT and D-D decreased significantly(P < 0.05), PT and PT-INR prolongation significantly(P < 0.05). The PAgT, PT and PT-INR in the experimental group were higher than those in the control group(P < 0.05). The difference of ALT, AST, BUN and Cr between the two groups before and after treatment were not statistically significant. The incidence of adverse reactions in the experimental group was significantly lower than that in the control group(24.44% vs 4.44%, P = 0.02). Conclusions Sanqi Tongshu Capsule is safe and effective in the treatment of senile coronary heart disease.
Objective To explore the effect of sanqi saponins on the safety of elderly patients with coronary heart disease and its effects on PT-INR, D-D and PT. Methods 90 elderly patients with coronary heart disease in our hospital from January 2012 to December 2015 were selected into the clinical data. The patients were divided into the control group(n = 45) and the experimental group(n = 45) by random number table. The control group was treated with aspirin, the experimental group was treated with Sanqi Tongshu Capsule. The PT-INR, D-D, PT, PAgT, liver and kidney indexes and adverse reactions were compared between the two groups before and after treatment. Results After treatment, PAgT and D-D decreased significantly(P < 0.05), PT and PT-INR prolongation significantly(P < 0.05). The PAgT, PT and PT-INR in the experimental group were higher than those in the control group(P < 0.05). The difference of ALT, AST, BUN and Cr between the two groups before and after treatment were not statistically significant. The incidence of adverse reactions in the experimental group was significantly lower than that in the control group(24.44% vs 4.44%, P = 0.02). Conclusions Sanqi Tongshu Capsule is safe and effective in the treatment of senile coronary heart disease.
引文
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[3]戴友平,郭良玉,徐燕.羊藿三七胶囊治疗稳定型心绞痛临床观察[J].中西医结合心脑血管病杂志, 2016, 14(13):1551-1553.
[4]白以琳,孙涛,王颖娴,等.景天三七对阿司匹林所致胃出血大鼠血小板及血管壁功能的影响[J].检验医学,2016, 31(2):131-134.
[5]杨清峰,崔德芝,阎小燕.血栓弹力图评测三七皂苷联合阿司匹林对老年冠心病患者抗栓疗效的影响[J].南京中医药大学学报, 2016, 32(5):425-427.
[6]涂雪松,余芾成,赵涛,等.三七通舒胶囊联合马来酸桂哌齐特注射液对后循环缺血患者血液流变学和血流动力学的影响[J].现代中西医结合杂志, 2016, 1(7):774-776.
[7]王登芹,张晓雪,宋国红,等.天麻三七汤对伴有焦虑症状高血压病患者血压变异性的影响[J].中华行为医学与脑科学杂志, 2016, 25(8):718-722.
[8]霍瑞民,李炜莉,王廉昌,等.三七总皂苷治疗脑出血疗效观察及对高敏C反应蛋白的影响[J].中西医结合心脑血管病杂志, 2017, 15(5):622-624.
[9]陈赫军,张霄,李洁,等.疏血通与三七总皂苷治疗急性脑梗死临床疗效及安全性比较的Meta分析[J].实用心脑肺血管病杂志, 2016, 24(5):1-5.
[10]王栋梅.三七总皂苷干预颅脑外伤术后深静脉血栓形成的效果分析[J].辽宁中医药大学学报, 2016, 1(7):197-199.
[11]张毅,戴胜云,徐冰,等.三七总皂苷抗心肌缺血再灌注损伤的药理研究进展[J].江苏中医药, 2017, 49(1):82-85.
[12]荣星,吴婷婷,夏天和,等.MT1-MMP在病毒性心肌炎小鼠中的表达及三七总皂苷的干预作用[J].浙江医学,2016, 38(6):405-408.