金露梅对T2DM大鼠糖脂代谢关键酶和激素表达的影响
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摘要
<正>糖尿病是以升高血糖为特征的代谢性疾病,由胰岛素分泌缺陷或其生物作用受损引起,可引发多种并发症~([1-2]),主要分为1型糖尿病(type 1 diabetes mellitus,T1DM)和2型糖尿病(type 2 diabetes mellitus,T2DM)。我国糖尿病以T2DM为主,病因和发病机制目前均不明确~([3]),明显特征是既有胰岛素抵抗,又有胰岛素分泌不足~([4])。近年来,T2DM已成为威胁人类健康的常见疾病~([5])。金露梅(Fr
引文
[1] 李骋,何金枝,周学东,等.黄连素调控胰岛素抵抗相关2型糖尿病的研究进展[J].中国中药杂志,2017,42(12):2254-60. Li P, He J Z, Zhou X D, et al. Berberine regulates type 2 diabetes mellitus related with insulin resistance[J]. Chin J Chin Mater Med, 2017, 42(12): 2254-60.
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[3] 中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2017年版)[J].中华糖尿病杂志,2018, 10(1):4-6. Chinese Diabetes Society. Guidelines for the prevention and treatment of type 2 diabetes in China(the 2017 edition)[J]. Chin J Diabetes Mellitus, 2018, 10(1): 4-6.
[4] 洪勇涛,杨晔,赵丹玉.2 型糖尿病治疗简况[J].实用中医内科杂志,2017,31(1):84-6. Hong Y T,Yang Y, Zhao D Y. Review of the treatment of type 2 diabetes mellitus[J]. J Pract Tradit Chin Intern Med, 2017,31(1):84-6.
[5] 许啸虎,周俪姗,邹欣,等.交泰丸对2型糖尿病大鼠糖脂代谢及肾脏保护作用的实验研究[J].中国医院药学杂志,2018,38(2):111-5. Xu X H, Zhou L S, Zou X, et al. Effects of Jiaotai pills against glucolipid metabolism disturbance and renal impairment in type 2 diabetic rats[J]. Chin J Hosp Pharm, 2018,38(2):111-5.
[6] 孙玉侠.金露梅化学成分及生物活性的研究[D].西宁:青海师范大学,2017. Sun Y X. Research on chemical constituents and pharmacological activities of Potentilla fruticose L.[D]. Xining: Qinghai Normal University,2017.
[7] 唐勋. 矮生二裂委陵菜抗2型糖尿病作用机制研究[D]. 西宁:青海师范大学,2015. Tang X. Study on the mechanism of effect of Potentilla bifurca var. humilior in treatment of T2DM[D]. Xining: Qinghai Normal University,2015.
[8] Livak K J, Schmittgen T D. Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCt method[J]. Methods, 2001,25(4): 402-8.
[2] 麦云珮,张淑允,窦纪梁,等.香芹酚对STZ诱导的1型糖尿病小鼠糖脂代谢的影响[J].中国药理学通报,2016,32(9):1306-10. Mai Y P, Zhang S Y, Dou J L, et al. Effect of CAR on STZ-induced type 1 diabetic mice[J]. Chin Pharmacol Bull, 2016, 32(9):1306-10.
[3] 中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2017年版)[J].中华糖尿病杂志,2018, 10(1):4-6. Chinese Diabetes Society. Guidelines for the prevention and treatment of type 2 diabetes in China(the 2017 edition)[J]. Chin J Diabetes Mellitus, 2018, 10(1): 4-6.
[4] 洪勇涛,杨晔,赵丹玉.2 型糖尿病治疗简况[J].实用中医内科杂志,2017,31(1):84-6. Hong Y T,Yang Y, Zhao D Y. Review of the treatment of type 2 diabetes mellitus[J]. J Pract Tradit Chin Intern Med, 2017,31(1):84-6.
[5] 许啸虎,周俪姗,邹欣,等.交泰丸对2型糖尿病大鼠糖脂代谢及肾脏保护作用的实验研究[J].中国医院药学杂志,2018,38(2):111-5. Xu X H, Zhou L S, Zou X, et al. Effects of Jiaotai pills against glucolipid metabolism disturbance and renal impairment in type 2 diabetic rats[J]. Chin J Hosp Pharm, 2018,38(2):111-5.
[6] 孙玉侠.金露梅化学成分及生物活性的研究[D].西宁:青海师范大学,2017. Sun Y X. Research on chemical constituents and pharmacological activities of Potentilla fruticose L.[D]. Xining: Qinghai Normal University,2017.
[7] 唐勋. 矮生二裂委陵菜抗2型糖尿病作用机制研究[D]. 西宁:青海师范大学,2015. Tang X. Study on the mechanism of effect of Potentilla bifurca var. humilior in treatment of T2DM[D]. Xining: Qinghai Normal University,2015.
[8] Livak K J, Schmittgen T D. Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCt method[J]. Methods, 2001,25(4): 402-8.